Result of FASTA (omim) for
pFN21AE1226
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1226, 300 aa
1>>>pF1KE1226 300 - 300 aa - 300 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4079+/-0.000284; mu= 15.6587+/- 0.018
mean_var=71.0956+/-14.146, 0's: 0 Z-trim(118.5): 30 B-trim: 0 in 0/59
Lambda= 0.152108
statistics sampled from 31575 (31606) to 31575 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.371), width: 16
Scan time: 7.930
The best scores are: opt bits E(85289)
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 2077 464.3 1.3e-130
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 797 183.4 4.4e-46
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 778 179.2 7.8e-45
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 771 177.7 2.2e-44
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 577 135.0 9.6e-32
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 426 101.9 9.4e-22
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 426 101.9 1.1e-21
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 354 86.1 7.2e-17
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 314 77.4 3.5e-14
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 295 73.2 5.3e-13
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 290 72.1 1.1e-12
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 277 69.3 9.7e-12
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 157 42.9 0.00074
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 155 42.4 0.00088
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 2077 init1: 2077 opt: 2077 Z-score: 2465.9 bits: 464.3 E(85289): 1.3e-130
Smith-Waterman score: 2077; 100.0% identity (100.0% similar) in 300 aa overlap (1-300:1-300)
10 20 30 40 50 60
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 SPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV
250 260 270 280 290 300
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 857 init1: 769 opt: 797 Z-score: 948.4 bits: 183.4 E(85289): 4.4e-46
Smith-Waterman score: 817; 49.4% identity (69.4% similar) in 265 aa overlap (1-240:1-263)
10 20 30 40
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGG-----------------WAVPRGCDPQTFLQI--
::: ::: .: : : :: ::. :.::: .: :.:
NP_683 MALLDVC--GAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLG
10 20 30 40 50
50 60 70 80 90
pF1KE1 -HGPR-----LAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTS
: : .:::::::::.:.::::::.:.:.: :::.. ::: .. .:::: :
NP_683 GDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMS
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE1 GTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDR
: .::: : :.: .: :: ::.:. ::..:.:::: :: ::::. : ... .::::.
NP_683 GCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDK
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 SGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHR
.:: :.:: ::::.:..::.:::. :::::.: ::: ..: .::: :.: :.:.::::
NP_683 KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHR
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE1 DAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAE
:.:::: :...:..:.:: .: .:
NP_683 DSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
240 250 260 270
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 766 init1: 766 opt: 778 Z-score: 925.9 bits: 179.2 E(85289): 7.8e-45
Smith-Waterman score: 779; 50.2% identity (72.0% similar) in 239 aa overlap (13-240:30-259)
10 20 30 40
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGC---DPQTFLQ
:: :.: : :: .: :.:
NP_004 MLIGTPTPRDTTPSSWLTSSLLVEAAPLDDTTLPTP---------VSSGCPGLEPTEFFQ
10 20 30 40 50
50 60 70 80 90
pF1KE1 IHGP--------RLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLG
: ..:::::::::.:.::::::.:.:.: :::.. ::: .. .:::
NP_004 SLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLG
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE1 TTSGTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCG
: :: .::: : :.: .: :: ::.:. ::..:.:::: :: ::::. : ... .::
NP_004 TMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICG
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 WDRSGPELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHA
::..:: :.:: ::::.:..::.:::. :::::.: ::: ..: .::: :.: :.:.:
NP_004 WDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYA
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE1 THRDAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHR
::::.:::: :...:..:.:: .: .:
NP_004 THRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
240 250 260 270
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 790 init1: 763 opt: 771 Z-score: 917.8 bits: 177.7 E(85289): 2.2e-44
Smith-Waterman score: 786; 52.7% identity (77.9% similar) in 222 aa overlap (24-245:43-255)
10 20 30 40 50
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTL
: ::.::. .: : .. ::::::
NP_002 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPE--EP-------GIEMLHGTTTL
20 30 40 50 60
60 70 80 90 100 110
pF1KE1 AFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELR
::.::::::.:::.:.. :.:.: . ::: .. .:::: .: .:::. : :.: :. :
NP_002 AFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 LRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGD
. :::. . :::.:.:::. :. ::.:. : ..: .::::. :: :.:: :.:.:..:
NP_002 IYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 IFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGW
::::::: :::::.:::: ::. ...:: ::: :. .::.:::::::.:.:.::::.::
NP_002 TFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGW
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 EHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRM
.:: ... :.
NP_002 IRVSSDNVADLHEKYSGSTP
250 260
>>NP_001124197 (OMIM: 600306) proteasome subunit beta ty (160 aa)
initn: 567 init1: 567 opt: 577 Z-score: 690.9 bits: 135.0 E(85289): 9.6e-32
Smith-Waterman score: 577; 54.3% identity (80.8% similar) in 151 aa overlap (95-245:2-152)
70 80 90 100 110 120
pF1KE1 ADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREGQLPS
.: .:::. : :.: :. :. :::. . :
NP_001 MAGGAADCSFWERLLARQCRIYELRNKERIS
10 20 30
130 140 150 160 170 180
pF1KE1 VASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVGSGSPYA
::.:.:::. :. ::.:. : ..: .::::. :: :.:: :.:.:..: ::::::: ::
NP_001 VAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYA
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE1 YGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSDACVL
:::.:::: ::. ...:: ::: :. .::.:::::::.:.:.::::.:: .:: ... :
NP_001 YGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADL
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE1 YVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV
.
NP_001 HEKYSGSTP
160
>>XP_005267928 (OMIM: 600306) PREDICTED: proteasome subu (169 aa)
initn: 453 init1: 426 opt: 426 Z-score: 511.5 bits: 101.9 E(85289): 9.4e-22
Smith-Waterman score: 441; 48.9% identity (74.1% similar) in 135 aa overlap (24-158:43-168)
10 20 30 40 50
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTL
: ::.::. .: : .. ::::::
XP_005 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPE--EP-------GIEMLHGTTTL
20 30 40 50 60
60 70 80 90 100 110
pF1KE1 AFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELR
::.::::::.:::.:.. :.:.: . ::: .. .:::: .: .:::. : :.: :. :
XP_005 AFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 LRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGD
. :::. . :::.:.:::. :. ::.:. : ..: .::::. ::
XP_005 IYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPG
130 140 150 160
180 190 200 210 220 230
pF1KE1 IFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGW
>>NP_001138404 (OMIM: 600306) proteasome subunit beta ty (203 aa)
initn: 453 init1: 426 opt: 426 Z-score: 510.3 bits: 101.9 E(85289): 1.1e-21
Smith-Waterman score: 441; 48.9% identity (74.1% similar) in 135 aa overlap (24-158:43-168)
10 20 30 40 50
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTL
: ::.::. .: : .. ::::::
NP_001 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPE--EP-------GIEMLHGTTTL
20 30 40 50 60
60 70 80 90 100 110
pF1KE1 AFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELR
::.::::::.:::.:.. :.:.: . ::: .. .:::: .: .:::. : :.: :. :
NP_001 AFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 LRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGD
. :::. . :::.:.:::. :. ::.:. : ..: .::::. ::
NP_001 IYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPVSEVLCLKPKSFGMY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 IFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGW
NP_001 LFCGCAERIGNMARPLLRGQ
190 200
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 332 init1: 305 opt: 354 Z-score: 423.9 bits: 86.1 E(85289): 7.2e-17
Smith-Waterman score: 354; 32.7% identity (60.7% similar) in 214 aa overlap (23-234:9-219)
10 20 30 40 50
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPR-LAHGTTTLAFRFRH
:..: : : :..: : .. ::: .: .:
NP_002 MAATLLAARGAGPAPAWG--PEAFTPDWESREVSTGTTIMAVQFDG
10 20 30 40
60 70 80 90 100 110
pF1KE1 GVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELRE
::. .::.:.. :::.: .. :. :.:.... ::..:: . .. .: .. ..
NP_002 GVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIEL
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 GQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWD-RSGPELFYVYSDGTRLQGDIFSVG
.. : : .::.:.. : .:: :: .. . ::: . : ... : : .. .. :
NP_002 NEPPLVHTAASLFKEMCYRYRE-DLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGG
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 SGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSR
::: : :: .: :: :. .: .. :.: : .::. ::: . : . ::: :
NP_002 SGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 SDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTE
NP_002 LGDQIPKFAVATLPPA
230
>>NP_002790 (OMIM: 604030) proteasome subunit beta type- (277 aa)
initn: 312 init1: 166 opt: 314 Z-score: 375.5 bits: 77.4 E(85289): 3.5e-14
Smith-Waterman score: 314; 29.6% identity (59.3% similar) in 216 aa overlap (18-225:5-218)
10 20 30 40 50
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQI----HGPRLAH----GTTT
: . : .::.. .: .. :. .: .: . :::
NP_002 MAAVSVYAPPVGGFSFD-NCRRNAVLEADFAKRGYKLPKVRKTGTTI
10 20 30 40
60 70 80 90 100 110
pF1KE1 LAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQREL
. .. :.. .::::.. : :: :. . .. .::.:: .... .:
NP_002 AGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNL
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 RLRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQG
.:. : :.:: :..: ..:. :. .:.: . .: .: : : .::.:. .: :. .
NP_002 ELHSLSTGRLPRVVTANRMLKQMLFRYQGY-IGAALVLGGVDVTGPHLYSIYPHGSTDKL
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE1 DIFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESG
..:::: :..:.. .: :: .:: :. :.: . : ::...::
NP_002 PYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE1 WEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSR
NP_002 LDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
230 240 250 260 270
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 312 init1: 154 opt: 295 Z-score: 354.5 bits: 73.2 E(85289): 5.3e-13
Smith-Waterman score: 297; 30.7% identity (57.2% similar) in 215 aa overlap (23-235:3-205)
10 20 30 40 50 60
pF1KE1 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG
::: .: : :.. ..: ::: .: .: :
NP_002 MLRAG---APTGDLPRAG-EVHT-----GTTIMAVEFDGG
10 20 30
70 80 90 100 110 120
pF1KE1 VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG
:. ..:.: : : :. . :. :.:... . ::..:: . . .:.:. ..
NP_002 VVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELE
40 50 60 70 80 90
130 140 150 160 170
pF1KE1 QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWD-RSGPELFYVYSDGTRLQGDIFSVG-
. : : .::... . .:: :: . . ::: : : ... . : : . :..:
NP_002 EPPLVLAAANVVRNISYKYRE-DLSAHLMVAGWDQREGGQVYGTL--GGMLTRQPFAIGG
100 110 120 130 140
180 190 200 210 220 230
pF1KE1 SGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSR
::: . :: .: .:. :: .: .. :.: : ::. ::: . : . .: .:
NP_002 SGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVI
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE1 SDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTE
NP_002 LGNELPKFYDE
210
300 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 11:06:40 2016 done: Sun Nov 6 11:06:41 2016
Total Scan time: 7.930 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]