Result of FASTA (omim) for
pFN21AE1219
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1219, 223 aa
1>>>pF1KE1219 223 - 223 aa - 223 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7943+/-0.000352; mu= 17.2275+/- 0.022
mean_var=70.8937+/-14.240, 0's: 0 Z-trim(114.2): 32 B-trim: 0 in 0/49
Lambda= 0.152325
statistics sampled from 23841 (23871) to 23841 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.28), width: 16
Scan time: 6.240
The best scores are: opt bits E(85289)
NP_001139808 (OMIM: 611579) transmembrane protein ( 223) 1426 322.2 4.4e-88
NP_001277026 (OMIM: 611579) transmembrane protein ( 142) 880 202.0 4.2e-52
NP_001277024 (OMIM: 611579) transmembrane protein ( 177) 683 158.8 5.3e-39
NP_001277027 (OMIM: 611579) transmembrane protein ( 103) 668 155.3 3.5e-38
NP_055220 (OMIM: 606404) voltage-dependent calcium ( 327) 216 56.4 6.5e-08
NP_006530 (OMIM: 606403) voltage-dependent calcium ( 315) 205 54.0 3.4e-07
NP_006069 (OMIM: 602911,614256) voltage-dependent ( 323) 205 54.0 3.4e-07
NP_114101 (OMIM: 606900) voltage-dependent calcium ( 425) 179 48.4 2.2e-05
NP_665810 (OMIM: 606405) voltage-dependent calcium ( 275) 151 42.1 0.0011
NP_057453 (OMIM: 609210) claudin-18 isoform 1 prec ( 261) 137 39.0 0.0093
>>NP_001139808 (OMIM: 611579) transmembrane protein 114 (223 aa)
initn: 1426 init1: 1426 opt: 1426 Z-score: 1702.3 bits: 322.2 E(85289): 4.4e-88
Smith-Waterman score: 1426; 100.0% identity (100.0% similar) in 223 aa overlap (1-223:1-223)
10 20 30 40 50 60
pF1KE1 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PLSSHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLSSHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 GMTGFLSFLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMTGFLSFLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLDQ
130 140 150 160 170 180
190 200 210 220
pF1KE1 VDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
:::::::::::::::::::::::::::::::::::::::::::
NP_001 VDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
190 200 210 220
>>NP_001277026 (OMIM: 611579) transmembrane protein 114 (142 aa)
initn: 880 init1: 880 opt: 880 Z-score: 1056.4 bits: 202.0 E(85289): 4.2e-52
Smith-Waterman score: 880; 100.0% identity (100.0% similar) in 142 aa overlap (82-223:1-142)
60 70 80 90 100 110
pF1KE1 GSINRSQPEPLSSHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLP
::::::::::::::::::::::::::::::
NP_001 MNPFRLENVTVSESSRQLLTMHGTFVILLP
10 20 30
120 130 140 150 160 170
pF1KE1 LSLILMVFGGMTGFLSFLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLILMVFGGMTGFLSFLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCL
40 50 60 70 80 90
180 190 200 210 220
pF1KE1 LEEKALLDQVDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEEKALLDQVDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
100 110 120 130 140
>>NP_001277024 (OMIM: 611579) transmembrane protein 114 (177 aa)
initn: 696 init1: 675 opt: 683 Z-score: 821.2 bits: 158.8 E(85289): 5.3e-39
Smith-Waterman score: 1037; 79.4% identity (79.4% similar) in 223 aa overlap (1-223:1-177)
10 20 30 40 50 60
pF1KE1 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PLSSHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFG
::::::::::::::::::::::::::::::::::::::::::
NP_001 PLSSHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTM------------------
70 80 90 100
130 140 150 160 170 180
pF1KE1 GMTGFLSFLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLDQ
::::::::::::::::::::::::::::::::
NP_001 ----------------------------VTLAGISVYIAYSAAAFREALCLLEEKALLDQ
110 120 130
190 200 210 220
pF1KE1 VDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
:::::::::::::::::::::::::::::::::::::::::::
NP_001 VDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
140 150 160 170
>>NP_001277027 (OMIM: 611579) transmembrane protein 114 (103 aa)
initn: 668 init1: 668 opt: 668 Z-score: 806.4 bits: 155.3 E(85289): 3.5e-38
Smith-Waterman score: 668; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101)
10 20 30 40 50 60
pF1KE1 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 PLSSHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLILMVFG
:::::::::::::::::::::::::::::::::::::::::
NP_001 PLSSHSGLWRTCRVQSPCTPLMNPFRLENVTVSESSRQLLTAF
70 80 90 100
130 140 150 160 170 180
pF1KE1 GMTGFLSFLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEKALLDQ
>>NP_055220 (OMIM: 606404) voltage-dependent calcium cha (327 aa)
initn: 226 init1: 65 opt: 216 Z-score: 263.0 bits: 56.4 E(85289): 6.5e-08
Smith-Waterman score: 216; 27.7% identity (55.8% similar) in 224 aa overlap (7-220:7-220)
10 20 30 40 50
pF1KE1 MRVHLGGLAGAAALTGALS-FVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQP
:: . .::.. : :.: :::::.: ... . :. .: : :
NP_055 MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHICNGTNLTMDD--GPPPRRAR
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 EPLSSHSGLWRTCRVQS----PCTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLI
:. ::::::.: ... : . : : .: .::. :: . . .. :: :
NP_055 GDLT-HSGLWRVCCIEGIYKGHCFRI-NHFPEDNDYDHDSSEYLLRIVRASSVFPILSTI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LMVFGGMT-GFLSFLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEE
:...::. : . . ..: .::::. ... .. :: :::. ... . :.
NP_055 LLLLGGLCIGAGRIYSRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDKRD--ED
120 130 140 150 160 170
180 190 200 210 220
pF1KE1 KALLDQVDISFGWSLALGWISFIAELLTGA----AFLAAARELSLRRRQDQAI
: . ..:::. .: .:::. .:. .. .:: .. ...
NP_055 K----KNHYNYGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKTKREFLKASSSSPY
180 190 200 210 220 230
NP_055 ARMPSYRYRRRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTAA
240 250 260 270 280 290
>>NP_006530 (OMIM: 606403) voltage-dependent calcium cha (315 aa)
initn: 191 init1: 74 opt: 205 Z-score: 250.2 bits: 54.0 E(85289): 3.4e-07
Smith-Waterman score: 205; 25.7% identity (55.8% similar) in 226 aa overlap (1-218:1-210)
10 20 30 40 50
pF1KE1 MRVHLGGLAGAAALTGALS-FVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQP
::. :. . .::.. : :.. :.:::.: . .. . :: ... . :
NP_006 MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYW--LYSRGVCRTKSTSDNETSRKN----
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 EPLSSHSGLWRTCRVQSP----CTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLI
: . .:::::::: ... : . . : . ..... :: . .. ::.
NP_006 EEVMTHSGLWRTCCLEGAFRGVCKKI-DHFPEDADYEQDTAEYLLRAVRASSVFPILSVT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 LMVFGGMTGFLS-FLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEE
:. :::. : : . . ..: .::.:. ... .. :: :::. .:. .
NP_006 LLFFGGLCVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISANAG---------DP
120 130 140 150 160
180 190 200 210 220
pF1KE1 KALLDQVDISFGWSLALGWISFIAELLTG--AAFLAAARELSLRRRQDQAI
.. . :.:::. .: .::: ..: :. . .. .:: .
NP_006 GQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKSHSEFLKKSTFARL
170 180 190 200 210 220
NP_006 PPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLLNSDR
230 240 250 260 270 280
>>NP_006069 (OMIM: 602911,614256) voltage-dependent calc (323 aa)
initn: 217 init1: 74 opt: 205 Z-score: 250.0 bits: 54.0 E(85289): 3.4e-07
Smith-Waterman score: 205; 26.9% identity (57.2% similar) in 208 aa overlap (16-216:16-209)
10 20 30 40 50
pF1KE1 MRVHLGGLAGAAALTGALS-FVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQP
::.. : :.. :.:::.: . .. . .: ... .. :
NP_006 MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYW--LYSRGVCKTKSVSENETSKKN----
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 EPLSSHSGLWRTCRVQSPCTPL---MNPFRLENVTVSESSRQLLTMHGTFVILLPLSLIL
: . .:::::::: ... : .. : . ..... .: . :. ::.::
NP_006 EEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVIL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 MVFGGMTGFLS-FLLQAYLLLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEEK
. .::. : : . ..: .::.:. ... .. :: :::. .:. :
NP_006 LFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGD--------PSK
120 130 140 150 160
180 190 200 210 220
pF1KE1 ALLDQVDISFGWSLALGWISFIAELLTG--AAFLAAARELSLRRRQDQAI
. . . :.:::. .: .::: ..: :. . :. .::
NP_006 SDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRI
170 180 190 200 210 220
NP_006 PSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTA
230 240 250 260 270 280
>>NP_114101 (OMIM: 606900) voltage-dependent calcium cha (425 aa)
initn: 185 init1: 63 opt: 179 Z-score: 217.6 bits: 48.4 E(85289): 2.2e-05
Smith-Waterman score: 207; 29.3% identity (55.0% similar) in 222 aa overlap (16-220:27-241)
10 20 30 40
pF1KE1 MRVHLGGLAGAAALTGALS-FVLLAAAIGTDFWY-----IIDTERLERT
::.. : :.. ::.::.: : .: :
NP_114 MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
10 20 30 40 50 60
50 60 70 80 90
pF1KE1 GP-GAQDLLGSINRSQPEPLS-SHSGLWRTCRVQS----PCTPLMNPFRLENVTVSESSR
: :. :. . .: . .:::::: : ... :. . : : .. .:..
NP_114 GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKI-NHFPEDTDYDHDSAE
70 80 90 100 110
100 110 120 130 140 150
pF1KE1 QLLTMHGTFVILLPLSLILMVFGGMTGFLSFLLQAYLLLLL-TGILFLFGAMVTLAGISV
:: . . :. :: ::...::. : . .. ..: .::::. ... .. :. :
NP_114 YLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIV
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 YIAYSAAAFREALCLLEEKALLDQVDISFGWSLALGWISFIAELLTGA----AFLAAARE
:: :: : . . ::: . :.:::. .: .::: . :. .. .::
NP_114 YI--SANAGEPGPKRDEEK----KNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSRE
180 190 200 210 220 230
220
pF1KE1 LSLRRRQDQAI
. :.:
NP_114 AHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGG
240 250 260 270 280 290
>>NP_665810 (OMIM: 606405) voltage-dependent calcium cha (275 aa)
initn: 106 init1: 68 opt: 151 Z-score: 186.8 bits: 42.1 E(85289): 0.0011
Smith-Waterman score: 167; 23.2% identity (57.5% similar) in 181 aa overlap (22-197:23-187)
10 20 30 40 50
pF1KE1 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQP
::. :..::.: .. . .. :.:
NP_665 MSACGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLE-----------EGVIVPQNQSTE
10 20 30 40
60 70 80 90 100 110
pF1KE1 EPLSSHSGLWRTCRVQSP----CTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLSLI
.: ::::::.: . . : . . ... .:::. ..: : . . . .::.
NP_665 IKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLF
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE1 LMVFGGMTGFLSFLLQAYLLL-LLTGILFLFGAMVTLAGISVYIAYSAAAFREALCLLEE
.: .: . . .. . .: ...::.:..... ..:. .::. .. . . : .
NP_665 FMFIGFILNNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYIS----SINDEM-LNRT
110 120 130 140 150 160
180 190 200 210 220
pF1KE1 KALLDQVDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
: . ..:::.:.. :::.
NP_665 KDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNC
170 180 190 200 210 220
>>NP_057453 (OMIM: 609210) claudin-18 isoform 1 precurso (261 aa)
initn: 183 init1: 60 opt: 137 Z-score: 170.5 bits: 39.0 E(85289): 0.0093
Smith-Waterman score: 139; 21.8% identity (52.0% similar) in 225 aa overlap (12-223:10-209)
10 20 30 40 50 60
pF1KE1 MRVHLGGLAGAAALTGALSFVLLAAAIGTDFWYIIDTERLERTGPGAQDLLGSINRSQPE
: : . :... :: : :.: ..::: .
NP_057 MSTTTCQVVAFLLSILGLAGCIAATGMDMW-------------STQDLYDN-------
10 20 30
70 80 90 100 110
pF1KE1 PLSS---HSGLWRTCRVQSP----CTPLMNPFRLENVTVSESSRQLLTMHGTFVILLPLS
:..: . ::::.: :: : : .. . : . .. : :. . ..: ..
NP_057 PVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAML--QAVRALMIVG---IVLGAIG
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE1 LILMVFGGMTGFLSFLLQAYL--LLLLTGILFLFGAMVTLAGISVYIAYSAAAFREALCL
:.. .:. .. . .. . : .::.:. ... ..::.::. . .. : .
NP_057 LLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTAN
100 110 120 130 140 150
180 190 200 210 220
pF1KE1 LEEK--ALLD--QVDISFGWSLALGWISFIAELLTGAAFLAAARELSLRRRQDQAI
. .... :. .:: .: .::.. :. :. . : : :. .. . .:.
NP_057 MYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHA
160 170 180 190 200 210
NP_057 SGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
220 230 240 250 260
223 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 21:34:52 2016 done: Sun Nov 6 21:34:52 2016
Total Scan time: 6.240 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]