Result of FASTA (omim) for
pFN21AE1115
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1115, 190 aa
1>>>pF1KE1115 190 - 190 aa - 190 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3477+/-0.000351; mu= 12.3265+/- 0.022
mean_var=61.4574+/-12.550, 0's: 0 Z-trim(114.7): 33 B-trim: 402 in 1/51
Lambda= 0.163601
statistics sampled from 24696 (24729) to 24696 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.29), width: 16
Scan time: 5.040
The best scores are: opt bits E(85289)
NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme ( 190) 1374 332.5 2.4e-91
NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme ( 373) 1067 260.2 2.9e-69
XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 442) 1067 260.2 3.3e-69
NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme ( 386) 1030 251.5 1.3e-66
XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 455) 1030 251.5 1.4e-66
XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 202) 810 199.4 3e-51
NP_001257340 (OMIM: 607110) DNA dC->dU-editing enz ( 357) 705 174.7 1.4e-43
NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme ( 382) 705 174.8 1.5e-43
XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 227) 627 156.2 3.4e-38
NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme ( 384) 513 129.4 6.8e-30
XP_016884392 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 524) 513 129.5 8.9e-30
NP_065712 (OMIM: 605257,605258) single-stranded DN ( 198) 485 122.7 3.7e-28
NP_663745 (OMIM: 607109) DNA dC->dU-editing enzyme ( 199) 417 106.7 2.5e-23
NP_001257335 (OMIM: 607109) DNA dC->dU-editing enz ( 181) 402 103.1 2.7e-22
NP_006780 (OMIM: 604797) C->U-editing enzyme APOBE ( 224) 383 98.7 7.3e-21
XP_006724353 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 317) 378 97.5 2.2e-20
XP_016884393 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 457) 378 97.6 3.1e-20
NP_001317272 (OMIM: 605257,605258) single-stranded ( 188) 365 94.4 1.2e-19
XP_011519075 (OMIM: 605257,605258) PREDICTED: sing ( 145) 359 92.9 2.5e-19
NP_861438 (OMIM: 610976) DNA dC->dU-editing enzyme ( 183) 353 91.5 8.3e-19
NP_001159474 (OMIM: 610976) DNA dC->dU-editing enz ( 182) 352 91.3 9.7e-19
XP_011528294 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 200) 352 91.3 1.1e-18
NP_001159475 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 352 91.3 1.1e-18
XP_011528292 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 352 91.3 1.1e-18
XP_011528293 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 352 91.3 1.1e-18
NP_001635 (OMIM: 600130) C->U-editing enzyme APOBE ( 236) 283 75.1 9.7e-14
NP_001291495 (OMIM: 600130) C->U-editing enzyme AP ( 236) 283 75.1 9.7e-14
NP_005880 (OMIM: 600130) C->U-editing enzyme APOBE ( 191) 279 74.1 1.6e-13
NP_001159476 (OMIM: 610976) DNA dC->dU-editing enz ( 154) 266 71.0 1.1e-12
NP_001006667 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 131 39.0 0.0029
XP_016884132 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 101) 131 39.0 0.0029
>>NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme APO (190 aa)
initn: 1374 init1: 1374 opt: 1374 Z-score: 1760.8 bits: 332.5 E(85289): 2.4e-91
Smith-Waterman score: 1374; 100.0% identity (100.0% similar) in 190 aa overlap (1-190:1-190)
10 20 30 40 50 60
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 ARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRL
130 140 150 160 170 180
190
pF1KE1 LKRRLRESLQ
::::::::::
NP_055 LKRRLRESLQ
190
>>NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme APO (373 aa)
initn: 1651 init1: 1065 opt: 1067 Z-score: 1364.6 bits: 260.2 E(85289): 2.9e-69
Smith-Waterman score: 1067; 79.0% identity (89.8% similar) in 186 aa overlap (5-190:188-373)
10 20 30
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETW
.::::.:::: :::.:::: .: :::.:
NP_660 NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESW
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE1 LCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSW
::::.: .:..: :::: :::::::: :::::::::::::::::::::::.:.:::::::
NP_660 LCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE1 SPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFK
::::.::::::::::::::::::::::::::: ::::::::::::..:::: :.:::
NP_660 SPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFK
280 290 300 310 320 330
160 170 180 190
pF1KE1 YCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
::::::::::.:::::::::: :: .: .:.: :.
NP_660 YCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
340 350 360 370
>--
initn: 600 init1: 503 opt: 624 Z-score: 799.5 bits: 155.6 E(85289): 8.6e-38
Smith-Waterman score: 624; 47.6% identity (71.7% similar) in 187 aa overlap (1-187:1-186)
10 20 30 40 50 60
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVD
:.:..:: .. :: :: ..: : . :: .:::. :. : : . .::.::
NP_660 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVK-TKGPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 SETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFT
:. . ::: ::::::: . : .:.::..::.:::::....:::::.: ::.::: .
NP_660 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 ARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRL
:::::. :...: ::: :. :.::: :.: ::::::::....:: :: . :. .
NP_660 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF
120 130 140 150 160 170
190
pF1KE1 LKRRLRESLQ
:.: :.:
NP_660 LHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFR
180 190 200 210 220 230
>>XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (442 aa)
initn: 1634 init1: 1065 opt: 1067 Z-score: 1363.4 bits: 260.2 E(85289): 3.3e-69
Smith-Waterman score: 1067; 79.0% identity (89.8% similar) in 186 aa overlap (5-190:257-442)
10 20 30
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETW
.::::.:::: :::.:::: .: :::.:
XP_011 NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESW
230 240 250 260 270 280
40 50 60 70 80 90
pF1KE1 LCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSW
::::.: .:..: :::: :::::::: :::::::::::::::::::::::.:.:::::::
XP_011 LCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW
290 300 310 320 330 340
100 110 120 130 140 150
pF1KE1 SPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFK
::::.::::::::::::::::::::::::::: ::::::::::::..:::: :.:::
XP_011 SPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFK
350 360 370 380 390 400
160 170 180 190
pF1KE1 YCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
::::::::::.:::::::::: :: .: .:.: :.
XP_011 YCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
410 420 430 440
>--
initn: 605 init1: 375 opt: 474 Z-score: 607.0 bits: 120.3 E(85289): 4.5e-27
Smith-Waterman score: 474; 43.3% identity (66.7% similar) in 171 aa overlap (1-171:1-170)
10 20 30 40 50 60
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVD
:.:..:: .. :: :: ..: : . :: .:::. :. : : . .::.::
XP_011 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVK-TKGPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 SETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFT
:. . ::: ::::::: . : .:.::..::.:::::....:::::.: ::.::: .
XP_011 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 ARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRL
:::::. :...: ::: :. :.::: : .. .. : . : :
XP_011 ARLYYYWERDYRRALCRLSQAGARVKIMDDEGERWRGQGSVSGRNSMKDGWICNAMAGGV
120 130 140 150 160 170
190
pF1KE1 LKRRLRESLQ
XP_011 PGQPAGAGPALTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWENFVYSEGQPFMPW
180 190 200 210 220 230
>--
initn: 141 init1: 125 opt: 155 Z-score: 200.1 bits: 45.0 E(85289): 0.00021
Smith-Waterman score: 155; 50.0% identity (77.8% similar) in 36 aa overlap (152-187:220-255)
130 140 150 160 170 180
pF1KE1 RLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRLL
.: ::::::::....:: :: . :. .:
XP_011 LTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWENFVYSEGQPFMPWYKFDDNYAFL
190 200 210 220 230 240
190
pF1KE1 KRRLRESLQ
.: :.:
XP_011 HRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFRN
250 260 270 280 290 300
>>NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme APO (386 aa)
initn: 1030 init1: 1030 opt: 1030 Z-score: 1317.2 bits: 251.5 E(85289): 1.3e-66
Smith-Waterman score: 1030; 78.0% identity (88.7% similar) in 186 aa overlap (5-190:201-386)
10 20 30
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETW
.::::.:::: :::.:::: .: :::.:
NP_689 NFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESW
180 190 200 210 220 230
40 50 60 70 80 90
pF1KE1 LCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSW
::::.: :..:.: : :::::::: :::::::::::::::::::::::.:.:::::::
NP_689 LCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW
240 250 260 270 280 290
100 110 120 130 140 150
pF1KE1 SPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFK
::::.:::::::::::::::::::::::: :: ::::: ::::::..:.:: :.::
NP_689 SPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFV
300 310 320 330 340 350
160 170 180 190
pF1KE1 YCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
::.::::.:.:::::::::.:::::::::::: ::
NP_689 SCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
360 370 380
>--
initn: 625 init1: 442 opt: 627 Z-score: 803.1 bits: 156.3 E(85289): 5.4e-38
Smith-Waterman score: 627; 48.5% identity (67.5% similar) in 200 aa overlap (1-187:1-199)
10 20 30 40 50
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRNQV
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::. :
NP_689 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGPV
10 20 30 40 50
60 70 80 90 100
pF1KE1 DSETHC------------HAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEF
. . ::: ::::::: . : : ..:.::..::.:: :. .:..:
NP_689 LPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKF
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 LARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEP
::.: ::.::: .:::::.. .. : : . :. :.::::::: ::::::: :...:
NP_689 LAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQP
120 130 140 150 160 170
170 180 190
pF1KE1 FKPWKGLKTNFRLLKRRLRESLQ
: :: . :. :.: :.:
NP_689 FMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTK
180 190 200 210 220 230
>>XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (455 aa)
initn: 1030 init1: 1030 opt: 1030 Z-score: 1316.0 bits: 251.5 E(85289): 1.4e-66
Smith-Waterman score: 1030; 78.0% identity (88.7% similar) in 186 aa overlap (5-190:270-455)
10 20 30
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETW
.::::.:::: :::.:::: .: :::.:
XP_016 NFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESW
240 250 260 270 280 290
40 50 60 70 80 90
pF1KE1 LCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSW
::::.: :..:.: : :::::::: :::::::::::::::::::::::.:.:::::::
XP_016 LCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW
300 310 320 330 340 350
100 110 120 130 140 150
pF1KE1 SPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFK
::::.:::::::::::::::::::::::: :: ::::: ::::::..:.:: :.::
XP_016 SPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFV
360 370 380 390 400 410
160 170 180 190
pF1KE1 YCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
::.::::.:.:::::::::.:::::::::::: ::
XP_016 SCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
420 430 440 450
>--
initn: 611 init1: 316 opt: 475 Z-score: 608.1 bits: 120.5 E(85289): 3.9e-27
Smith-Waterman score: 475; 47.6% identity (66.5% similar) in 164 aa overlap (1-151:1-163)
10 20 30 40 50
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRNQV
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::. :
XP_016 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGPV
10 20 30 40 50
60 70 80 90 100
pF1KE1 DSETHC------------HAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEF
. . ::: ::::::: . : : ..:.::..::.:: :. .:..:
XP_016 LPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKF
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 LARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEP
::.: ::.::: .:::::.. .. : : . :. :.:::::
XP_016 LAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSL
120 130 140 150 160 170
170 180 190
pF1KE1 FKPWKGLKTNFRLLKRRLRESLQ
XP_016 RDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWE
180 190 200 210 220 230
>--
initn: 142 init1: 126 opt: 154 Z-score: 198.6 bits: 44.7 E(85289): 0.00025
Smith-Waterman score: 154; 42.9% identity (67.3% similar) in 49 aa overlap (139-187:220-268)
110 120 130 140 150 160
pF1KE1 ARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPF
: :.... . :: ::::::: :...::
XP_016 GGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWENFVCNEGQPF
190 200 210 220 230 240
170 180 190
pF1KE1 KPWKGLKTNFRLLKRRLRESLQ
:: . :. :.: :.:
XP_016 MPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKH
250 260 270 280 290 300
>>XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (202 aa)
initn: 799 init1: 799 opt: 810 Z-score: 1041.0 bits: 199.4 E(85289): 3e-51
Smith-Waterman score: 952; 70.4% identity (80.3% similar) in 203 aa overlap (1-190:1-202)
10 20 30 40 50
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRN--
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::.
XP_005 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGPV
10 20 30 40 50
60 70 80 90 100
pF1KE1 ----------QVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEF
.:: :::::::::::::::::::::::.:.:::::::::::.::::::::
XP_005 LPKRQSNHRQEVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEF
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE1 LARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEP
:::::::::::::::: :: ::::: ::::::..:.:: :.:: ::.::::.:.::
XP_005 LARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEP
120 130 140 150 160 170
170 180 190
pF1KE1 FKPWKGLKTNFRLLKRRLRESLQ
:::::::.:::::::::::: ::
XP_005 FKPWKGLQTNFRLLKRRLREILQ
180 190 200
>>NP_001257340 (OMIM: 607110) DNA dC->dU-editing enzyme (357 aa)
initn: 671 init1: 671 opt: 705 Z-score: 903.1 bits: 174.7 E(85289): 1.4e-43
Smith-Waterman score: 705; 53.4% identity (74.3% similar) in 191 aa overlap (1-190:1-190)
10 20 30 40 50
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRNQV
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::.::
NP_001 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGQV
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 DSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIF
. . ::: ::::::: . : .:.::..::.:::::....::::..: ::.:::
NP_001 YFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTIS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFR
.:::::. :...: ::: :. :.:::::.: :::::::::... : :: . :.
NP_001 AARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYA
120 130 140 150 160 170
180 190
pF1KE1 LLKRRLRESLQ
.:.: :.: :.
NP_001 FLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLC
180 190 200 210 220 230
>--
initn: 426 init1: 212 opt: 381 Z-score: 489.8 bits: 98.3 E(85289): 1.5e-20
Smith-Waterman score: 419; 40.3% identity (65.2% similar) in 181 aa overlap (12-190:193-353)
10 20 30 40
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEG
: : :: :.:.: . : .:.::. ::
NP_001 NEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVE-
170 180 190 200 210 220
50 60 70 80 90
pF1KE1 IKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPD--
: . .: :. .: : ....:.. :.: :.:::. ::::: .
NP_001 --RLDNGTW---VLMDQ-------H-----MGFLCNE-LDPAQIYRVTWFISWSPCFSWG
230 240 250 260
100 110 120 130 140 150
pF1KE1 CAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWEN
::::: :: ....: : ::.::.: .. : :.:.:. : . :. : :: :..:.:::..
NP_001 CAGEVRAFLQENTHVRLRIFAARIYDYD-PLYKEALQMLRDAGAQVSIMTYDEFEYCWDT
270 280 290 300 310 320
160 170 180 190
pF1KE1 FVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
::: .. ::.:: ::. . . :. ::: ::
NP_001 FVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
330 340 350
>>NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme APO (382 aa)
initn: 671 init1: 671 opt: 705 Z-score: 902.7 bits: 174.8 E(85289): 1.5e-43
Smith-Waterman score: 705; 53.4% identity (74.3% similar) in 191 aa overlap (1-190:1-190)
10 20 30 40 50
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRNQV
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::.::
NP_004 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGQV
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 DSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIF
. . ::: ::::::: . : .:.::..::.:::::....::::..: ::.:::
NP_004 YFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTIS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFR
.:::::. :...: ::: :. :.:::::.: :::::::::... : :: . :.
NP_004 AARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYA
120 130 140 150 160 170
180 190
pF1KE1 LLKRRLRESLQ
.:.: :.: :.
NP_004 FLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLC
180 190 200 210 220 230
>--
initn: 449 init1: 212 opt: 433 Z-score: 555.7 bits: 110.6 E(85289): 3.3e-24
Smith-Waterman score: 433; 40.4% identity (64.9% similar) in 188 aa overlap (12-190:193-378)
10 20 30 40
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEG
: : :: :.:.: . : .:.::. ::
NP_004 NEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVER
170 180 190 200 210 220
50 60 70 80 90
pF1KE1 IKRRSVV--SWKTGVFRNQVDSETHC-----HAERCFLSWFCDDILSPNTKYQVTWYTSW
. . : . . : . :.. .. : ::: ::. . :.: :.:::. ::
NP_004 LDNGTWVLMDQHMGFLCNEA-KNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISW
230 240 250 260 270 280
100 110 120 130 140 150
pF1KE1 SPCPD--CAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYED
::: . ::::: :: ....: : ::.::.: .. : :.:.:. : . :. : :: :..
NP_004 SPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYD-PLYKEALQMLRDAGAQVSIMTYDE
290 300 310 320 330 340
160 170 180 190
pF1KE1 FKYCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
:.:::..::: .. ::.:: ::. . . :. ::: ::
NP_004 FEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
350 360 370 380
>>XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (227 aa)
initn: 600 init1: 503 opt: 627 Z-score: 806.7 bits: 156.2 E(85289): 3.4e-38
Smith-Waterman score: 627; 47.4% identity (71.6% similar) in 190 aa overlap (1-190:1-189)
10 20 30 40 50 60
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVD
:.:..:: .. :: :: ..: : . :: .:::. :. : : . .::.::
XP_016 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVK-TKGPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 SETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFT
:. . ::: ::::::: . : .:.::..::.:::::....:::::.: ::.::: .
XP_016 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE1 ARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRL
:::::. :...: ::: :. :.::: :.: ::::::::....:: :: . :. .
XP_016 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF
120 130 140 150 160 170
190
pF1KE1 LKRRLRESLQ
:.: :.: :.
XP_016 LHRTLKEILRATSIHLRGRPPHSLGSPTWLLPSPWHNRICHKTGRKWA
180 190 200 210 220
>>NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme APO (384 aa)
initn: 478 init1: 275 opt: 513 Z-score: 657.7 bits: 129.4 E(85289): 6.8e-30
Smith-Waterman score: 513; 43.6% identity (67.2% similar) in 195 aa overlap (1-190:1-194)
10 20 30 40 50 60
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVD
:.:..:: .. :: :: ..: : . :: .:::. :. : : . .::.::
NP_068 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVK-TKGPSRPPLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110
pF1KE1 SETHCHAERCFLSWFCD-DILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIF
:: . : : :. :: : . .:.:::: ::::: :. ..: :::. .:.::::
NP_068 SELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE1 TARLYYFQYPCYQEGLRSLSQ--EG--VAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLK
.:::::: : :::.:::: : .: ....::.:..:..:: .:::.. : :.::..:
NP_068 VARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLP
120 130 140 150 160 170
180 190
pF1KE1 TNFRLLKRRLRESLQ
. ::. : : :.
NP_068 KYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRR
180 190 200 210 220 230
>--
initn: 478 init1: 205 opt: 455 Z-score: 583.7 bits: 115.7 E(85289): 8.9e-26
Smith-Waterman score: 455; 41.4% identity (67.2% similar) in 186 aa overlap (11-190:196-380)
10 20 30 40
pF1KE1 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVE
.: : :: :.:.: . :.::.::. ::
NP_068 YSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVE
170 180 190 200 210 220
50 60 70 80 90
pF1KE1 GIKRRSVV--SWKTGVFRNQVDSETHC----HAERCFLSWFCDDILSPNTKYQVTWYTSW
.. . : . . : . ::. . ::: :::. . :. . :.:: .:::
NP_068 RMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSW
230 240 250 260 270 280
100 110 120 130 140 150
pF1KE1 SPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFK
::: .:: :.:.:......:.: :::::.: : : :::::.:.. :. . :: : .::
NP_068 SPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRC-QEGLRTLAEAGAKISIMTYSEFK
290 300 310 320 330 340
160 170 180 190
pF1KE1 YCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
.::..:: ... ::.:: :: . . :. ::: ::
NP_068 HCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
350 360 370 380
190 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 04:37:10 2016 done: Mon Nov 7 04:37:11 2016
Total Scan time: 5.040 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]