Result of FASTA (omim) for
pFN21AE0962
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0962, 503 aa
1>>>pF1KE0962 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1727+/-0.000557; mu= 6.5352+/- 0.033
mean_var=656.1673+/-152.270, 0's: 0 Z-trim(116.0): 236 B-trim: 0 in 0/53
Lambda= 0.050069
statistics sampled from 26573 (26797) to 26573 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.314), width: 16
Scan time: 9.980
The best scores are: opt bits E(85289)
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 3468 266.8 1e-70
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 3468 266.8 1e-70
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 3468 266.8 1e-70
XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 2022 162.2 2.6e-39
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1985 159.7 1.8e-38
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1985 159.7 1.8e-38
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1985 159.7 1.8e-38
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1454 121.4 6.6e-27
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1454 121.4 6.6e-27
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1454 121.4 6.6e-27
NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 1437 120.1 1.5e-26
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 1436 120.0 1.6e-26
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1434 119.9 1.7e-26
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1434 119.9 1.7e-26
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1434 119.9 1.7e-26
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1434 119.9 1.7e-26
NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 1434 119.9 1.8e-26
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1434 119.9 1.8e-26
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1422 118.9 3e-26
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 1422 118.9 3e-26
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 1420 118.8 3.3e-26
NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 1418 118.7 3.9e-26
NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 1404 117.6 7.5e-26
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 1392 116.7 1.4e-25
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1349 113.5 1.1e-24
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1349 113.6 1.2e-24
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 1278 108.5 4e-23
XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 978 86.7 1.3e-16
XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 911 82.1 4.1e-15
XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 911 82.1 4.1e-15
NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 911 82.2 4.3e-15
NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 888 80.1 1.1e-14
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 717 68.1 7e-11
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 717 68.1 7e-11
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 717 68.2 7.2e-11
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 717 68.2 7.2e-11
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 717 68.2 7.3e-11
NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 707 67.2 1e-10
NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 707 67.4 1.1e-10
NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 707 67.4 1.1e-10
XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 678 65.3 4.8e-10
>>XP_005269292 (OMIM: 600376,601284) PREDICTED: serine/t (503 aa)
initn: 3468 init1: 3468 opt: 3468 Z-score: 1390.5 bits: 266.8 E(85289): 1e-70
Smith-Waterman score: 3468; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
430 440 450 460 470 480
490 500
pF1KE0 TALRIKKTLQKISNSPEKPKVIQ
:::::::::::::::::::::::
XP_005 TALRIKKTLQKISNSPEKPKVIQ
490 500
>>NP_000011 (OMIM: 600376,601284) serine/threonine-prote (503 aa)
initn: 3468 init1: 3468 opt: 3468 Z-score: 1390.5 bits: 266.8 E(85289): 1e-70
Smith-Waterman score: 3468; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
430 440 450 460 470 480
490 500
pF1KE0 TALRIKKTLQKISNSPEKPKVIQ
:::::::::::::::::::::::
NP_000 TALRIKKTLQKISNSPEKPKVIQ
490 500
>>NP_001070869 (OMIM: 600376,601284) serine/threonine-pr (503 aa)
initn: 3468 init1: 3468 opt: 3468 Z-score: 1390.5 bits: 266.8 E(85289): 1e-70
Smith-Waterman score: 3468; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
430 440 450 460 470 480
490 500
pF1KE0 TALRIKKTLQKISNSPEKPKVIQ
:::::::::::::::::::::::
NP_001 TALRIKKTLQKISNSPEKPKVIQ
490 500
>>XP_011537310 (OMIM: 600376,601284) PREDICTED: serine/t (413 aa)
initn: 2781 init1: 2022 opt: 2022 Z-score: 826.6 bits: 162.2 E(85289): 2.6e-39
Smith-Waterman score: 2577; 79.3% identity (79.3% similar) in 503 aa overlap (1-503:15-413)
10 20 30 40
pF1KE0 MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTC
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALTPPLLLLSAGTMTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTC
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 RGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLE--
70 80 90 100 110
110 120 130 140 150 160
pF1KE0 QPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKA
XP_011 ------------------------------------------------------------
170 180 190 200 210 220
pF1KE0 SEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESV
::::::::::::::::::
XP_011 ------------------------------------------GKGRYGEVWRGLWHGESV
120 130
230 240 250 260 270 280
pF1KE0 AVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLY
140 150 160 170 180 190
290 300 310 320 330 340
pF1KE0 DFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCI
200 210 220 230 240 250
350 360 370 380 390 400
pF1KE0 ADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLW
260 270 280 290 300 310
410 420 430 440 450 460
pF1KE0 EIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQ
320 330 340 350 360 370
470 480 490 500
pF1KE0 MMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
:::::::::::::::::::::::::::::::::::::
XP_011 MMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
380 390 400 410
>>XP_011510410 (OMIM: 102576,135100) PREDICTED: activin (509 aa)
initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38
Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506)
10 20 30 40 50
pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR
.....:: . . . ::. .: : :.::. : . :.: : :
XP_011 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG
..: : . .:: ..... :. :. ::.. ::.:.. : :. : ::
XP_011 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ
:.. ...::. :. . :.: ::: :: ::. : : .. ...
XP_011 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK
::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.::::
XP_011 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL
:::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.:
XP_011 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL
: ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: :::::::
XP_011 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA
::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.:
XP_011 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR
:: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:.
XP_011 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK
420 430 440 450 460 470
470 480 490 500
pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
:::: ::::::::::::::: ::.:: .: :
XP_011 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
480 490 500
>>XP_006712888 (OMIM: 102576,135100) PREDICTED: activin (509 aa)
initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38
Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506)
10 20 30 40 50
pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR
.....:: . . . ::. .: : :.::. : . :.: : :
XP_006 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG
..: : . .:: ..... :. :. ::.. ::.:.. : :. : ::
XP_006 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ
:.. ...::. :. . :.: ::: :: ::. : : .. ...
XP_006 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK
::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.::::
XP_006 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL
:::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.:
XP_006 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL
: ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: :::::::
XP_006 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA
::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.:
XP_006 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR
:: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:.
XP_006 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK
420 430 440 450 460 470
470 480 490 500
pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
:::: ::::::::::::::: ::.:: .: :
XP_006 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
480 490 500
>>XP_005246996 (OMIM: 102576,135100) PREDICTED: activin (509 aa)
initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38
Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506)
10 20 30 40 50
pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR
.....:: . . . ::. .: : :.::. : . :.: : :
XP_005 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG
..: : . .:: ..... :. :. ::.. ::.:.. : :. : ::
XP_005 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ
:.. ...::. :. . :.: ::: :: ::. : : .. ...
XP_005 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK
::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.::::
XP_005 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL
:::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.:
XP_005 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL
: ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: :::::::
XP_005 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA
::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.:
XP_005 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR
:: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:.
XP_005 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK
420 430 440 450 460 470
470 480 490 500
pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
:::: ::::::::::::::: ::.:: .: :
XP_005 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
480 490 500
>>XP_011510408 (OMIM: 102576,135100) PREDICTED: activin (509 aa)
initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38
Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506)
10 20 30 40 50
pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR
.....:: . . . ::. .: : :.::. : . :.: : :
XP_011 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG
..: : . .:: ..... :. :. ::.. ::.:.. : :. : ::
XP_011 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ
:.. ...::. :. . :.: ::: :: ::. : : .. ...
XP_011 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK
::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.::::
XP_011 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL
:::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.:
XP_011 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL
: ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: :::::::
XP_011 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA
::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.:
XP_011 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR
:: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:.
XP_011 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK
420 430 440 450 460 470
470 480 490 500
pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
:::: ::::::::::::::: ::.:: .: :
XP_011 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
480 490 500
>>XP_011510409 (OMIM: 102576,135100) PREDICTED: activin (509 aa)
initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38
Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506)
10 20 30 40 50
pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR
.....:: . . . ::. .: : :.::. : . :.: : :
XP_011 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG
..: : . .:: ..... :. :. ::.. ::.:.. : :. : ::
XP_011 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ
:.. ...::. :. . :.: ::: :: ::. : : .. ...
XP_011 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK
::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.::::
XP_011 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL
:::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.:
XP_011 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL
: ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: :::::::
XP_011 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA
::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.:
XP_011 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR
:: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:.
XP_011 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK
420 430 440 450 460 470
470 480 490 500
pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
:::: ::::::::::::::: ::.:: .: :
XP_011 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
480 490 500
>>NP_001096 (OMIM: 102576,135100) activin receptor type- (509 aa)
initn: 1898 init1: 1832 opt: 1985 Z-score: 811.5 bits: 159.7 E(85289): 1.8e-38
Smith-Waterman score: 1985; 61.1% identity (79.2% similar) in 501 aa overlap (11-500:10-506)
10 20 30 40 50
pF1KE0 MTLGSPRKGLLMLLMALVTQG-DPVKPSRGP-LVTCTCESPHCKGPT-CRGAWCTVVLVR
.....:: . . . ::. .: : :.::. : . :.: : :
NP_001 MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSI
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 EEGRHPQEHRGCGNLHRE---LCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPG
..: : . .:: ..... :. :. ::.. ::.:.. : :. : ::
NP_001 NDGFHVYQ-KGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLP-TKGKSF-PG
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 TDG---QLALILGPVLALLALVA--LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQ
:.. ...::. :. . :.: ::: :: ::. : : .. ...
NP_001 TQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLI-TTNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVK
::: :.:::: .::.:::::::::::::::::..:.:::::::::::::: :.::.::::
NP_001 GDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 IFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL
:::::::.:::::::.::::.:::.:::::::::::::.::::::::::::: :::::.:
NP_001 IFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADL
: ::. ::...: : ::::::.:::::::::::::::.::.:.:::.: :::::::
NP_001 QLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 GLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA
::::::::... ::.::::::::::::::::::: :..:::.::: .:::::::::::.:
NP_001 GLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR
:: . :::::::.::::::::::::::::.:::::::: :.:::: .::.:..::..:.
NP_001 RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK
420 430 440 450 460 470
470 480 490 500
pF1KE0 ECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
:::: ::::::::::::::: ::.:: .: :
NP_001 ECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
480 490 500
503 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:06:32 2016 done: Sun Nov 6 05:06:34 2016
Total Scan time: 9.980 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]