Result of FASTA (omim) for
pFN21AE0957
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0957, 493 aa
1>>>pF1KE0957 493 - 493 aa - 493 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.5540+/-0.000779; mu= -7.0181+/- 0.045
mean_var=708.6042+/-165.429, 0's: 0 Z-trim(112.0): 166 B-trim: 949 in 1/50
Lambda= 0.048181
statistics sampled from 20723 (20830) to 20723 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.244), width: 16
Scan time: 8.370
The best scores are: opt bits E(85289)
NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 3323 247.7 5.7e-65
NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 2983 224.0 7.1e-58
NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 2185 168.6 3.8e-41
NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 2165 167.2 9.9e-41
NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 2148 166.0 2.2e-40
NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 2100 162.5 2e-39
XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 2060 159.8 1.4e-38
XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2055 159.5 1.8e-38
XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 2055 159.5 1.8e-38
NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 2051 159.2 2.3e-38
XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 1762 138.9 2.2e-32
NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 1762 139.1 2.4e-32
NP_001104503 (OMIM: 608981) activin receptor type- ( 336) 1584 126.5 1.2e-28
NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 1577 126.4 2e-28
XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1577 126.4 2e-28
XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 1577 126.4 2e-28
XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28
NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 1576 126.3 2.1e-28
XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28
NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 1576 126.3 2.1e-28
XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28
NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 1576 126.3 2.1e-28
XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28
XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 1576 126.3 2.1e-28
NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 1576 126.3 2.1e-28
XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27
XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27
XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27
XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27
XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27
NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 1539 123.7 1.2e-27
NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 1539 123.7 1.2e-27
XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 1539 123.7 1.2e-27
XP_016875690 (OMIM: 601300) PREDICTED: activin rec ( 381) 1442 116.7 1.1e-25
NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 1411 114.8 5.9e-25
NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 1411 114.8 5.9e-25
XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 1411 114.8 5.9e-25
XP_016875688 (OMIM: 601300) PREDICTED: activin rec ( 494) 1281 105.7 3.1e-22
XP_016875689 (OMIM: 601300) PREDICTED: activin rec ( 494) 1281 105.7 3.1e-22
NP_064733 (OMIM: 601300) activin receptor type-1B ( 546) 1281 105.8 3.2e-22
XP_011537310 (OMIM: 600376,601284) PREDICTED: seri ( 413) 1186 99.0 2.7e-20
XP_011537269 (OMIM: 601300) PREDICTED: activin rec ( 312) 869 76.8 1e-13
NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 788 71.3 5.7e-12
NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 788 71.5 6.5e-12
NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 788 71.5 6.5e-12
XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 758 69.4 2.8e-11
XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 758 69.4 2.8e-11
NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 758 69.5 2.9e-11
XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 758 69.5 2.9e-11
NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 758 69.5 3e-11
>>NP_660302 (OMIM: 608981) activin receptor type-1C isof (493 aa)
initn: 3323 init1: 3323 opt: 3323 Z-score: 1287.4 bits: 247.7 E(85289): 5.7e-65
Smith-Waterman score: 3323; 99.6% identity (99.8% similar) in 493 aa overlap (1-493:1-493)
10 20 30 40 50 60
pF1KE0 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQ
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
NP_660 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIA
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_660 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
430 440 450 460 470 480
490
pF1KE0 TISQLCVKEDCKA
:::::::::::::
NP_660 TISQLCVKEDCKA
490
>>NP_001104501 (OMIM: 608981) activin receptor type-1C i (443 aa)
initn: 2983 init1: 2983 opt: 2983 Z-score: 1160.1 bits: 224.0 E(85289): 7.1e-58
Smith-Waterman score: 2983; 99.5% identity (99.8% similar) in 443 aa overlap (51-493:1-443)
30 40 50 60 70 80
pF1KE0 ELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNN
::::::::::::::::::::::::::::::
NP_001 MLTNGKEQVIKSCVSLPELNAQVFCHSSNN
10 20 30
90 100 110 120 130 140
pF1KE0 VTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQ
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 CSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEI
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE0 VGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDN
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 VGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDN
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE0 GTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIA
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 GTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIA
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE0 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE0 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF
340 350 360 370 380 390
450 460 470 480 490
pF1KE0 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
400 410 420 430 440
>>NP_004603 (OMIM: 132800,190181) TGF-beta receptor type (503 aa)
initn: 2130 init1: 1881 opt: 2185 Z-score: 859.8 bits: 168.6 E(85289): 3.8e-41
Smith-Waterman score: 2191; 67.3% identity (81.5% similar) in 504 aa overlap (4-492:3-502)
10 20 30 40 50
pF1KE0 MTRALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVM
: .: : :::: :::: : :: :.: : :: ..:::: :.: :..::
NP_004 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
10 20 30 40 50
60 70 80 90 100
pF1KE0 LTNGKEQVIKSCVSLPEL---NAQVFCHSSN---NVTKTECCFTDFCNNITLHLPTASPN
:. : . :.. .: . : :. .:: : :: : ::.: .:::. .
NP_004 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKS
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 APKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGK
.: :::.::: .:. :::.. :. :: :. :..: ... :: :.: . ... :
NP_004 SPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHR--VPNEEDPSLDRPFISEGT
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 TLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFS
::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.:::::::
NP_004 TLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 SRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRN
::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.:::::
NP_004 SREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 IVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLA
::. :::::::: ::::::::::::::::::::::::.::::::::: :: :::::::
NP_004 TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 VKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRC
:.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.:::::::
NP_004 VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 SVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECW
:.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..::::::
NP_004 SIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW
420 430 440 450 460 470
470 480 490
pF1KE0 YANGAARLTALRIKKTISQLCVKEDCKA
::::::::::::::::.::: .: :
NP_004 YANGAARLTALRIKKTLSQLSQQEGIKM
480 490 500
>>NP_001293139 (OMIM: 132800,190181) TGF-beta receptor t (507 aa)
initn: 2136 init1: 1909 opt: 2165 Z-score: 852.2 bits: 167.2 E(85289): 9.9e-41
Smith-Waterman score: 2186; 66.9% identity (81.3% similar) in 508 aa overlap (4-492:3-506)
10 20 30 40 50
pF1KE0 MTRALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVM
: .: : :::: :::: : :: :.: : :: ..:::: :.: :..::
NP_001 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVT
10 20 30 40 50
60 70 80 90 100
pF1KE0 LTNGKEQVIKSCVSLPEL---NAQVFCHSSN---NVTKTECCFTDFCNNITLHLPTASP-
:. : . :.. .: . : :. .:: : :: : ::.: .:::..:
NP_001 ETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTGPF
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 ---NAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLV
..: :::.::: .:. :::.. :. :: :. :..: ... :: :.: . ..
NP_001 SVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHR--VPNEEDPSLDRPFI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 NAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAV
. : ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.:::
NP_001 SEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 KIFSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDY
::::::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::
NP_001 KIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 LNRNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIAD
::: ::. :::::::: ::::::::::::::::::::::::.::::::::: :: :::
NP_001 LNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIAD
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 LGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEI
:::::.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.:::
NP_001 LGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEI
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 ARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIM
:::::.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..::
NP_001 ARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIM
420 430 440 450 460 470
470 480 490
pF1KE0 RECWYANGAARLTALRIKKTISQLCVKEDCKA
::::::::::::::::::::.::: .: :
NP_001 RECWYANGAARLTALRIKKTLSQLSQQEGIKM
480 490 500
>>NP_004293 (OMIM: 601300) activin receptor type-1B isof (505 aa)
initn: 2099 init1: 1838 opt: 2148 Z-score: 845.9 bits: 166.0 E(85289): 2.2e-40
Smith-Waterman score: 2156; 65.6% identity (84.5% similar) in 491 aa overlap (13-492:15-504)
10 20 30 40 50
pF1KE0 MTRALCSALRQALLLLAAAAELSP----GLKCVCLLCDSSNFTCQTEGACWASVMLTN
.::::... .: .: :.: : ..:.::.:.::: .:.. .
NP_004 MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLD
10 20 30 40 50 60
60 70 80 90 100
pF1KE0 GKEQVIKSCVSLPEL---NAQVFCHSSNNVTKTECCFTDFCNNITLHLPTAS---PNAPK
: :. ...:. :: . .: ::... .:.::.::.:: : :..:.. :. :.
NP_004 GMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 L-GPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTL
. ::.::. ::. :: :: . ... . . .: :....: ..:.: : : . :::
NP_004 MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTL
130 140 150 160 170
170 180 190 200 210 220
pF1KE0 KDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSR
.::.::...:::::::::.::::.:::::::::.:::::::::.::: : ::::::::::
NP_004 QDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSR
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 DERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIV
.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::::: :
NP_004 EERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 TMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVK
:. :::::::: ::::::::::::::::::.:::::.::::::::: ::::::::::.
NP_004 TIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVR
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE0 HDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV
::.. .:::: : .::::::::::.::.:.:.. :.::: ::::..:::::::::::.
NP_004 HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE0 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA
::. :::::::::.::::::::::::::::::.::.::: ::: :::::::..:::::::
NP_004 GGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYA
420 430 440 450 460 470
470 480 490
pF1KE0 NGAARLTALRIKKTISQLCVKEDCKA
::::::::::::::.::: :.:: :
NP_004 NGAARLTALRIKKTLSQLSVQEDVKI
480 490 500
>>NP_001104502 (OMIM: 608981) activin receptor type-1C i (413 aa)
initn: 2100 init1: 2100 opt: 2100 Z-score: 828.6 bits: 162.5 E(85289): 2e-39
Smith-Waterman score: 2622; 83.4% identity (83.6% similar) in 493 aa overlap (1-493:1-413)
10 20 30 40 50 60
pF1KE0 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITV
:::::::::::::::::::::::::::::::::::::::::
NP_001 KSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPT-------------------
70 80 90 100
130 140 150 160 170 180
pF1KE0 PVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSG
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KE0 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQ
::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
NP_001 -GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE0 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIA
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_001 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE0 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE0 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE0 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK
350 360 370 380 390 400
490
pF1KE0 TISQLCVKEDCKA
:::::::::::::
NP_001 TISQLCVKEDCKA
410
>>XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF-beta (434 aa)
initn: 2011 init1: 1881 opt: 2060 Z-score: 813.4 bits: 159.8 E(85289): 1.4e-38
Smith-Waterman score: 2060; 73.5% identity (88.2% similar) in 415 aa overlap (78-492:23-433)
50 60 70 80 90 100
pF1KE0 ASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAP
...:: : :: : ::.: .:::. ..:
XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKSSP
10 20 30 40 50
110 120 130 140 150 160
pF1KE0 KLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTL
:::.::: .:. :::.. :. :: :. :..: . ... :: :.: . ... : ::
XP_011 GLGPVELAAVIAGPVCFVCISLMLMVYICHNR--TVIHHRVPNEEDPSLDRPFISEGTTL
60 70 80 90 100
170 180 190 200 210 220
pF1KE0 KDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSR
::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.:::::::::
XP_011 KDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSR
110 120 130 140 150 160
230 240 250 260 270 280
pF1KE0 DERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIV
.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::::: :
XP_011 EERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV
170 180 190 200 210 220
290 300 310 320 330 340
pF1KE0 TMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVK
:. :::::::: ::::::::::::::::::::::::.::::::::: :: ::::::::.
XP_011 TVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVR
230 240 250 260 270 280
350 360 370 380 390 400
pF1KE0 HDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV
::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.::::::::.
XP_011 HDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI
290 300 310 320 330 340
410 420 430 440 450 460
pF1KE0 GGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYA
::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..::::::::
XP_011 GGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYA
350 360 370 380 390 400
470 480 490
pF1KE0 NGAARLTALRIKKTISQLCVKEDCKA
::::::::::::::.::: .: :
XP_011 NGAARLTALRIKKTLSQLSQQEGIKM
410 420 430
>>XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa)
initn: 2026 init1: 1909 opt: 2055 Z-score: 811.5 bits: 159.5 E(85289): 1.8e-38
Smith-Waterman score: 2055; 73.0% identity (87.8% similar) in 419 aa overlap (78-492:23-437)
50 60 70 80 90 100
pF1KE0 ASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP---
...:: : :: : ::.: .:::..:
XP_011 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTGPFSV
10 20 30 40 50
110 120 130 140 150 160
pF1KE0 -NAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNA
..: :::.::: .:. :::.. :. :: :. :..: . ... :: :.: . ...
XP_011 KSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNR--TVIHHRVPNEEDPSLDRPFISE
60 70 80 90 100
170 180 190 200 210 220
pF1KE0 GKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKI
: ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.:::::
XP_011 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI
110 120 130 140 150 160
230 240 250 260 270 280
pF1KE0 FSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLN
::::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::::
XP_011 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN
170 180 190 200 210 220
290 300 310 320 330 340
pF1KE0 RNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLG
: ::. :::::::: ::::::::::::::::::::::::.::::::::: :: :::::
XP_011 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG
230 240 250 260 270 280
350 360 370 380 390 400
pF1KE0 LAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIAR
:::.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.:::::
XP_011 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR
290 300 310 320 330 340
410 420 430 440 450 460
pF1KE0 RCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRE
:::.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..::::
XP_011 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRE
350 360 370 380 390 400
470 480 490
pF1KE0 CWYANGAARLTALRIKKTISQLCVKEDCKA
::::::::::::::::::.::: .: :
XP_011 CWYANGAARLTALRIKKTLSQLSQQEGIKM
410 420 430
>>XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF-beta (438 aa)
initn: 2026 init1: 1909 opt: 2055 Z-score: 811.5 bits: 159.5 E(85289): 1.8e-38
Smith-Waterman score: 2055; 73.0% identity (87.8% similar) in 419 aa overlap (78-492:23-437)
50 60 70 80 90 100
pF1KE0 ASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASP---
...:: : :: : ::.: .:::..:
XP_016 MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTGPFSV
10 20 30 40 50
110 120 130 140 150 160
pF1KE0 -NAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNA
..: :::.::: .:. :::.. :. :: :. :..: . ... :: :.: . ...
XP_016 KSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNR--TVIHHRVPNEEDPSLDRPFISE
60 70 80 90 100
170 180 190 200 210 220
pF1KE0 GKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKI
: ::::::::.:.::::::::::::::::::::::: .:::::::::.:.: ::.:::::
XP_016 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI
110 120 130 140 150 160
230 240 250 260 270 280
pF1KE0 FSSRDERYWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLN
::::.:: :::::::::::::::::::::::::::::::::::::::.:::.:::.::::
XP_016 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN
170 180 190 200 210 220
290 300 310 320 330 340
pF1KE0 RNIVTMAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLG
: ::. :::::::: ::::::::::::::::::::::::.::::::::: :: :::::
XP_016 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG
230 240 250 260 270 280
350 360 370 380 390 400
pF1KE0 LAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIAR
:::.::: .:::: : .::::::::::.:::..:.. ::::::::::..:::.:::::
XP_016 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR
290 300 310 320 330 340
410 420 430 440 450 460
pF1KE0 RCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRE
:::.::: :.:::::::.::::::.::::::::.::.::.:::.::::::::::..::::
XP_016 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRE
350 360 370 380 390 400
470 480 490
pF1KE0 CWYANGAARLTALRIKKTISQLCVKEDCKA
::::::::::::::::::.::: .: :
XP_016 CWYANGAARLTALRIKKTLSQLSQQEGIKM
410 420 430
>>NP_064732 (OMIM: 601300) activin receptor type-1B isof (453 aa)
initn: 1971 init1: 1838 opt: 2051 Z-score: 809.9 bits: 159.2 E(85289): 2.3e-38
Smith-Waterman score: 2051; 67.8% identity (85.6% similar) in 451 aa overlap (49-492:3-452)
20 30 40 50 60 70
pF1KE0 AAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPEL---NAQVFC
:.. .: :. ...:. :: . .:
NP_064 MVSIFNLDGMEHHVRTCIPKVELVPAGKPFYC
10 20 30
80 90 100 110 120 130
pF1KE0 HSSNNVTKTECCFTDFCNNITLHLPTAS---PNAPKL-GPMELAIIITVPVCLLSIAAML
::... .:.::.::.:: : :..:.. :. :.. ::.::. ::. :: :: . ..
NP_064 LSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIII
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE0 TVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTI
. . . .: :....: ..:.: : : . :::.::.::...:::::::::.::::.
NP_064 VFLVINYHQRVYHNRQRLDMEDPSCEMCL-SKDKTLQDLVYDLSTSGSGSGLPLFVQRTV
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE0 ARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERYWFREAEIYQTVMLRHENILG
:::::::::.:::::::::.::: : ::::::::::.:: ::::::::::::::::::::
NP_064 ARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILG
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE0 FIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTMAGMIKLALSIASGLAHLHMEIV
:::::::::::::::::::.:::.:::.::::: ::. :::::::: ::::::::::::
NP_064 FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIV
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE0 GTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAP
::::::.:::::.::::::::: ::::::::::.::.. .:::: : .:::::::::
NP_064 GTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE0 EMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEM
:.::.:.:.. :.::: ::::..:::::::::::. ::. :::::::::.::::::::::
NP_064 EVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEM
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE0 RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDC
::::::::.::.::: ::: :::::::..:::::::::::::::::::::.::: :.::
NP_064 RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDV
400 410 420 430 440 450
pF1KE0 KA
:
NP_064 KI
493 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:38:05 2016 done: Mon Nov 7 00:38:06 2016
Total Scan time: 8.370 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]