Result of FASTA (omim) for
pFN21AE0955
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0955, 483 aa
1>>>pF1KE0955 483 - 483 aa - 483 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.6265+/-0.000583; mu= -12.7936+/- 0.036
mean_var=900.3660+/-195.656, 0's: 0 Z-trim(121.6): 750 B-trim: 0 in 0/58
Lambda= 0.042743
statistics sampled from 37413 (38357) to 37413 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.45), width: 16
Scan time: 11.100
The best scores are: opt bits E(85289)
NP_063937 (OMIM: 606784) glycogen synthase kinase- ( 483) 3250 216.2 1.6e-55
NP_001139628 (OMIM: 605004) glycogen synthase kina ( 420) 2082 144.1 7.3e-34
XP_006713674 (OMIM: 605004) PREDICTED: glycogen sy ( 387) 1983 137.9 4.8e-32
XP_006713673 (OMIM: 605004) PREDICTED: glycogen sy ( 400) 1676 119.0 2.4e-26
NP_002084 (OMIM: 605004) glycogen synthase kinase- ( 433) 1676 119.1 2.6e-26
NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 605 52.8 1.6e-06
NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 594 52.1 2.6e-06
NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346) 582 51.5 4.6e-06
NP_002737 (OMIM: 601795) mitogen-activated protein ( 379) 583 51.6 4.6e-06
NP_001035145 (OMIM: 601795) mitogen-activated prot ( 357) 582 51.5 4.7e-06
NP_001310218 (OMIM: 300203,300672) cyclin-dependen ( 960) 573 51.6 1.2e-05
NP_003150 (OMIM: 300203,300672) cyclin-dependent k (1030) 573 51.6 1.2e-05
NP_001032420 (OMIM: 300203,300672) cyclin-dependen (1030) 573 51.6 1.2e-05
NP_002736 (OMIM: 176948) mitogen-activated protein ( 360) 557 49.9 1.4e-05
NP_620407 (OMIM: 176948) mitogen-activated protein ( 360) 557 49.9 1.4e-05
XP_016865978 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05
XP_016865980 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05
XP_016865977 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05
XP_016865981 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05
XP_016865979 (OMIM: 612325,612651) PREDICTED: seri ( 632) 562 50.6 1.5e-05
NP_055735 (OMIM: 612325,612651) serine/threonine-p ( 632) 562 50.6 1.5e-05
NP_057597 (OMIM: 612325,612651) serine/threonine-p ( 632) 562 50.6 1.5e-05
XP_011512721 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05
XP_011512723 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05
XP_016865976 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05
XP_011512722 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05
XP_016865975 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05
XP_016865974 (OMIM: 612325,612651) PREDICTED: seri ( 639) 562 50.6 1.5e-05
NP_002742 (OMIM: 602898) mitogen-activated protein ( 364) 551 49.6 1.8e-05
NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346) 550 49.5 1.8e-05
XP_016866355 (OMIM: 154235,614181) PREDICTED: seri ( 439) 553 49.8 1.8e-05
XP_016864300 (OMIM: 603442) PREDICTED: cyclin-depe ( 479) 553 49.9 1.9e-05
NP_003939 (OMIM: 603442) cyclin-dependent kinase-l ( 493) 553 49.9 1.9e-05
XP_016864299 (OMIM: 603442) PREDICTED: cyclin-depe ( 493) 553 49.9 1.9e-05
XP_006714469 (OMIM: 603442) PREDICTED: cyclin-depe ( 530) 553 50.0 2e-05
XP_016870050 (OMIM: 610076) PREDICTED: cyclin-depe ( 351) 547 49.3 2.1e-05
NP_001317653 (OMIM: 603442) cyclin-dependent kinas ( 570) 553 50.0 2.1e-05
XP_016864298 (OMIM: 603442) PREDICTED: cyclin-depe ( 570) 553 50.0 2.1e-05
NP_001229314 (OMIM: 154235,614181) serine/threonin ( 583) 553 50.0 2.1e-05
XP_011512924 (OMIM: 154235,614181) PREDICTED: seri ( 583) 553 50.0 2.1e-05
XP_016866353 (OMIM: 154235,614181) PREDICTED: seri ( 623) 553 50.1 2.2e-05
NP_005897 (OMIM: 154235,614181) serine/threonine-p ( 623) 553 50.1 2.2e-05
NP_002740 (OMIM: 602521) mitogen-activated protein ( 816) 556 50.4 2.2e-05
NP_620602 (OMIM: 602521) mitogen-activated protein ( 816) 556 50.4 2.2e-05
NP_620603 (OMIM: 602521) mitogen-activated protein ( 816) 556 50.4 2.2e-05
XP_016866352 (OMIM: 154235,614181) PREDICTED: seri ( 648) 553 50.1 2.2e-05
XP_011512922 (OMIM: 154235,614181) PREDICTED: seri ( 648) 553 50.1 2.2e-05
XP_011512921 (OMIM: 154235,614181) PREDICTED: seri ( 648) 553 50.1 2.2e-05
NP_001229886 (OMIM: 154235,614181) serine/threonin ( 648) 553 50.1 2.2e-05
NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 540 48.8 2.5e-05
>>NP_063937 (OMIM: 606784) glycogen synthase kinase-3 al (483 aa)
initn: 3250 init1: 3250 opt: 3250 Z-score: 1117.6 bits: 216.2 E(85289): 1.6e-55
Smith-Waterman score: 3250; 100.0% identity (100.0% similar) in 483 aa overlap (1-483:1-483)
10 20 30 40 50 60
pF1KE0 MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
430 440 450 460 470 480
pF1KE0 NSS
:::
NP_063 NSS
>>NP_001139628 (OMIM: 605004) glycogen synthase kinase-3 (420 aa)
initn: 2131 init1: 2065 opt: 2082 Z-score: 728.9 bits: 144.1 E(85289): 7.3e-34
Smith-Waterman score: 2082; 78.1% identity (90.8% similar) in 401 aa overlap (84-483:21-420)
60 70 80 90 100 110
pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER
..: :. .:..:::::::: ::::.:
NP_001 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR
10 20 30 40 50
120 130 140 150 160 170
pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
:::.::: ::::::::::::::.: .. :::::::::::::::::::::::::::::::
NP_001 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA
:::::::::::::::.::::::.::::::::::::...:: :.:..:::.::::::::::
NP_001 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
:::: :.:::::::::::.:::::::::::::::::::::::::::::::::::::::::
NP_001 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
240 250 260 270 280 290
360 370 380 390 400 410
pF1KE0 FKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQL
:::::::::::::::. ::::::::::: ::::::..::.:::::::::::::: ...:
NP_001 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE0 PNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQST
::.: : ::::.. ::: .: : .:::::: : :...: : .. : ... :.. :..
NP_001 PNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAA-SDANTGDRGQTN
360 370 380 390 400
480
pF1KE0 DA-TPTLTNSS
.: . . .::.
NP_001 NAASASASNST
410 420
>>XP_006713674 (OMIM: 605004) PREDICTED: glycogen syntha (387 aa)
initn: 2034 init1: 1968 opt: 1983 Z-score: 696.3 bits: 137.9 E(85289): 4.8e-32
Smith-Waterman score: 1983; 85.1% identity (94.2% similar) in 343 aa overlap (84-426:21-363)
60 70 80 90 100 110
pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER
..: :. .:..:::::::: ::::.:
XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR
10 20 30 40 50
120 130 140 150 160 170
pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
:::.::: ::::::::::::::.: .. :::::::::::::::::::::::::::::::
XP_006 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA
:::::::::::::::.::::::.::::::::::::...:: :.:..:::.::::::::::
XP_006 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
:::: :.:::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_006 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
240 250 260 270 280 290
360 370 380 390 400 410
pF1KE0 FKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQL
:::::::::::::::. ::::::::::: ::::::..::.:::::::::::::: ...:
XP_006 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE0 PNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQST
::.: : ::::.
XP_006 PNGRDTPALFNFTTQDANTGDRGQTNNAASASASNST
360 370 380
>>XP_006713673 (OMIM: 605004) PREDICTED: glycogen syntha (400 aa)
initn: 2009 init1: 1673 opt: 1676 Z-score: 593.8 bits: 119.0 E(85289): 2.4e-26
Smith-Waterman score: 1947; 82.0% identity (90.7% similar) in 356 aa overlap (84-426:21-376)
60 70 80 90 100 110
pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER
..: :. .:..:::::::: ::::.:
XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR
10 20 30 40 50
120 130 140 150 160 170
pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
:::.::: ::::::::::::::.: .. :::::::::::::::::::::::::::::::
XP_006 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA
:::::::::::::::.::::::.::::::::::::...:: :.:..:::.::::::::::
XP_006 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
:::: :.:::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_006 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
240 250 260 270 280 290
360 370 380 390 400
pF1KE0 FKFPQIKAHPWTK-------------VFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAH
::::::::::::: ::. ::::::::::: ::::::..::.:::::::
XP_006 FKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH
300 310 320 330 340 350
410 420 430 440 450 460
pF1KE0 SFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQA
::::::: ...:::.: : ::::.
XP_006 SFFDELRDPNVKLPNGRDTPALFNFTTQDANTGDRGQTNNAASASASNST
360 370 380 390 400
>>NP_002084 (OMIM: 605004) glycogen synthase kinase-3 be (433 aa)
initn: 2106 init1: 1673 opt: 1676 Z-score: 593.5 bits: 119.1 E(85289): 2.6e-26
Smith-Waterman score: 2046; 75.6% identity (87.9% similar) in 414 aa overlap (84-483:21-433)
60 70 80 90 100 110
pF1KE0 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER
..: :. .:..:::::::: ::::.:
NP_002 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR
10 20 30 40 50
120 130 140 150 160 170
pF1KE0 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
:::.::: ::::::::::::::.: .. :::::::::::::::::::::::::::::::
NP_002 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE0 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA
:::::::::::::::.::::::.::::::::::::...:: :.:..:::.::::::::::
NP_002 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE0 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
:::: :.:::::::::::.:::::::::::::::::::::::::::::::::::::::::
NP_002 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE0 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
240 250 260 270 280 290
360 370 380 390 400
pF1KE0 FKFPQIKAHPWTK-------------VFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAH
::::::::::::: ::. ::::::::::: ::::::..::.:::::::
NP_002 FKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH
300 310 320 330 340 350
410 420 430 440 450 460
pF1KE0 SFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQA
::::::: ...:::.: : ::::.. ::: .: : .:::::: : :...: : .. :
NP_002 SFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAA
360 370 380 390 400 410
470 480
pF1KE0 LTETPTSSDWQSTDA-TPTLTNSS
... :.. :...: . . .::.
NP_002 -SDANTGDRGQTNNAASASASNST
420 430
>>NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 iso (298 aa)
initn: 525 init1: 362 opt: 605 Z-score: 238.1 bits: 52.8 E(85289): 1.6e-06
Smith-Waterman score: 605; 36.4% identity (67.5% similar) in 305 aa overlap (119-406:4-289)
90 100 110 120 130 140
pF1KE0 PGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIK
. .. ::.:..::::.:: : :.::.:
NP_001 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALK
10 20 30
150 160 170 180 190 200
pF1KE0 KVLQDKRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETV
:. : . .. ::......:.: :::.: ... ...:: ::.:.. . .
NP_001 KIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT----ENKLY--LVFEFLHQDL
40 50 60 70 80
210 220 230 240 250 260
pF1KE0 YRVARHFTKAK-LT-IPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLK
..: :. :: ::. .: :..::...::. ::. : :::.::::::.. . :. :
NP_001 ----KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-K
90 100 110 120 130 140
270 280 290 300 310
pF1KE0 LCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ
: ::: :. . : : .: . . .:::::...: :....:.:: ::..::.. .
NP_001 LADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR
150 160 170 180 190 200
320 330 340 350 360 370
pF1KE0 PIFPGDSGVDQLVEIIKVLGTPTR---EQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPP
.::::: .::: .:...:::: . . : :.: .::. . ..:: .::
NP_001 ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM-PDYKP-SFPKWARQDFSKV----VPP
210 220 230 240 250
380 390 400 410 420 430
pF1KE0 ---EAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELS
.. .: :..:.: :..:.: : :: ::...
NP_001 LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
260 270 280 290
440 450 460 470 480
pF1KE0 IQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
>>NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 [Ho (305 aa)
initn: 490 init1: 331 opt: 594 Z-score: 234.4 bits: 52.1 E(85289): 2.6e-06
Smith-Waterman score: 594; 35.9% identity (67.4% similar) in 301 aa overlap (119-403:4-286)
90 100 110 120 130 140
pF1KE0 PGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIK
. .. ::.:..::::.:. :: .:::.:
NP_001 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALK
10 20 30
150 160 170 180 190 200
pF1KE0 KVLQDKRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETV
:. : .... ::......: : ::::: .. :.: ::: :.:.. . .
NP_001 KIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHN--ERK--LYL--VFEFLSQDL
40 50 60 70 80
210 220 230 240 250 260
pF1KE0 YRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLC
. ..: :. .: :..::...... ::. : :::.::::::.. . ...::
NP_001 KKYMDSTPGSEL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLA
90 100 110 120 130 140
270 280 290 300 310
pF1KE0 DFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPI
::: :. . : : .: . . .:::::...:. ::...:.:: ::..::.. . .
NP_001 DFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKAL
150 160 170 180 190 200
320 330 340 350 360 370
pF1KE0 FPGDSGVDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWT-KVFKSRTP--
::::: .::: .:...::::... . .. :.: . .::. :: : .. .:
NP_001 FPGDSEIDQLFRIFRMLGTPSEDTWPGVTQL-PDY-KGSFPK-----WTRKGLEEIVPNL
210 220 230 240 250
380 390 400 410 420 430
pF1KE0 -PEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSI
::. : .::.: ::.:.. : :: .:
NP_001 EPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH
260 270 280 290 300
440 450 460 470 480
pF1KE0 QPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
>>NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 iso (346 aa)
initn: 347 init1: 347 opt: 582 Z-score: 229.9 bits: 51.5 E(85289): 4.6e-06
Smith-Waterman score: 615; 36.6% identity (66.4% similar) in 339 aa overlap (113-433:6-328)
90 100 110 120 130 140
pF1KE0 GTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETR
.:. : . .:.:.:..::.:: .:
NP_001 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTN
10 20 30
150 160 170 180 190
pF1KE0 ELVAIKKVLQDKRFKN---------RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNL
..:::::. .: . ::......:.: ::. : : :.:.. ..:
NP_001 QIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAF---GHKSN---ISL
40 50 60 70 80
200 210 220 230 240 250
pF1KE0 VLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVD
:.... :: .: . .:.. ..:.:: . ...: :.:.. . :::.::.:::.:
NP_001 VFDFM-ETDLEVI--IKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD
90 100 110 120 130 140
260 270 280 290 300 310
pF1KE0 PDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVL
...:::: ::: ::.. : :: .: . .:.::::::.::: : ..:.:..::.:
NP_001 -ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCIL
150 160 170 180 190 200
320 330 340 350 360
pF1KE0 AELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFK-FPQIKAHPWTKV
::::: :..:::: .:::..:...:::::.:: .: :.:. :: :: : : ..
NP_001 AELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLH---HI
210 220 230 240 250 260
370 380 390 400 410 420
pF1KE0 FKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELR--CLGTQLPN-NRPLPPLFN
: : . . . : ..:. ..: .:.. .: ..:.. : ::: : :. : .
NP_001 F-SAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKE
270 280 290 300 310
430 440 450 460 470 480
pF1KE0 FSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
: :.:.
NP_001 QSNPALAIKRKRTEALEQGGLPKKLIF
320 330 340
>>NP_002737 (OMIM: 601795) mitogen-activated protein kin (379 aa)
initn: 464 init1: 263 opt: 583 Z-score: 229.8 bits: 51.6 E(85289): 4.6e-06
Smith-Waterman score: 583; 32.4% identity (62.6% similar) in 377 aa overlap (75-434:8-356)
50 60 70 80 90 100
pF1KE0 GTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVV
::.:: : ::: :.: :
NP_002 MAAAAAQGGGGGEPRRTEGVGPGV-----PGEVEMVK
10 20 30
110 120 130 140 150
pF1KE0 AT-LGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKV--LQDKRFKNR--
. . ::. ::... ::.:..:.: .: . :::::. .. . . .:
NP_002 GQPFDVGPR------YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL
40 50 60 70 80
160 170 180 190 200 210
pF1KE0 -ELQIMRKLDHCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFTKAKLTIP
:.::. .. : :.. .: .. .: : ..:. : . . .:.. . . .:.
NP_002 REIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK---SQQLSND
90 100 110 120 130 140
220 230 240 250 260 270
pF1KE0 ILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN-
.. ..::..:.: :::: .: :::.::.:::.. : ::.:::: :. .. : .
NP_002 --HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDH
150 160 170 180 190
280 290 300 310 320 330
pF1KE0 ----VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI
. :. .:.:::::..... ::.:::.::.::.:::.: ..::::: .::: .:
NP_002 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
200 210 220 230 240 250
340 350 360 370 380
pF1KE0 IKVLGTPTREQIR---EMNP-NYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTP
. .::.:..:.. .:. :: . ..:. :.:.: .. .:. : . .: ..:
NP_002 LGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLFP-KSDSKALDLLDRMLTFNP
260 270 280 290 300 310
390 400 410 420 430 440
pF1KE0 SSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPL-FNFSAGELSIQPSLNAILIPPHLRS
..:.. :: :: .... :...:. :.: : ::. :
NP_002 NKRITVEEALAHPYLEQY-----YDPTDEPVAEEPFTF-AMELDDLPKERLKELIFQETA
320 330 340 350 360
450 460 470 480
pF1KE0 PAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
NP_002 RFQPGVLEAP
370
>>NP_001035145 (OMIM: 601795) mitogen-activated protein (357 aa)
initn: 464 init1: 263 opt: 582 Z-score: 229.7 bits: 51.5 E(85289): 4.7e-06
Smith-Waterman score: 582; 32.9% identity (64.0% similar) in 347 aa overlap (75-405:8-332)
50 60 70 80 90 100
pF1KE0 GTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVV
::.:: : ::: :.: :
NP_001 MAAAAAQGGGGGEPRRTEGVGPGVP-----GEVEMVK
10 20 30
110 120 130 140 150
pF1KE0 AT-LGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKV--LQDKRFKNR--
. . ::. ::... ::.:..:.: .: . :::::. .. . . .:
NP_001 GQPFDVGPR------YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL
40 50 60 70 80
160 170 180 190 200 210
pF1KE0 -ELQIMRKLDHCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFTKAKLTIP
:.::. .. : :.. .: .. .: : ..:. : . . .:.. . . .:.
NP_001 REIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK---SQQLSND
90 100 110 120 130 140
220 230 240 250 260 270
pF1KE0 ILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN-
.. ..::..:.: :::: .: :::.::.:::.. : ::.:::: :. .. : .
NP_001 --HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDH
150 160 170 180 190
280 290 300 310 320 330
pF1KE0 ----VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEI
. :. .:.:::::..... ::.:::.::.::.:::.: ..::::: .::: .:
NP_001 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
200 210 220 230 240 250
340 350 360 370 380
pF1KE0 IKVLGTPTREQIR---EMNP-NYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTP
. .::.:..:.. .:. :: . ..:. :.:.: .. .:. : . .: ..:
NP_001 LGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLFP-KSDSKALDLLDRMLTFNP
260 270 280 290 300 310
390 400 410 420 430 440
pF1KE0 SSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSP
..:.. :: :: ....
NP_001 NKRITVEEALAHPYLEQYYDPTDEVGQSPAAVGLGAGEQGGT
320 330 340 350
483 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:09:29 2016 done: Sun Nov 6 06:09:30 2016
Total Scan time: 11.100 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]