Result of FASTA (omim) for
pFN21AE0765
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0765, 339 aa
1>>>pF1KE0765 339 - 339 aa - 339 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8583+/-0.000537; mu= 18.5150+/- 0.033
mean_var=101.8482+/-26.006, 0's: 0 Z-trim(107.7): 544 B-trim: 1789 in 2/47
Lambda= 0.127086
statistics sampled from 14963 (15736) to 14963 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.519), E-opt: 0.2 (0.185), width: 16
Scan time: 6.330
The best scores are: opt bits E(85289)
NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 2315 435.9 5.7e-122
NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 983 191.7 1.9e-48
NP_778237 (OMIM: 608923) trace amine-associated re ( 345) 941 184.0 4e-46
NP_444508 (OMIM: 606927) trace amine-associated re ( 342) 920 180.2 5.7e-45
NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 755 149.9 7.4e-36
NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 712 142.0 1.6e-33
NP_003958 (OMIM: 607405) trace amine-associated re ( 337) 561 114.4 3.7e-25
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 450 94.0 5.1e-19
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 450 94.0 5.1e-19
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 450 94.1 5.4e-19
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 403 85.5 2.3e-16
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 392 83.5 8.9e-16
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 379 81.0 4.4e-15
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 379 81.2 5.1e-15
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 377 80.7 5.9e-15
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 372 79.9 1.2e-14
NP_940799 (OMIM: 601898) growth hormone secretagog ( 366) 361 77.7 4.2e-14
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 357 77.1 8.1e-14
NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 356 76.9 8.7e-14
NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 356 76.9 8.7e-14
NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 356 77.0 9.9e-14
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 355 76.7 1e-13
NP_000667 (OMIM: 600446) adenosine receptor A2b [H ( 332) 352 76.0 1.2e-13
NP_001265427 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13
NP_001265428 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13
NP_001265426 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13
NP_000666 (OMIM: 102776) adenosine receptor A2a [H ( 412) 353 76.3 1.3e-13
NP_001265429 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 348 75.4 2.3e-13
NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 346 75.0 3e-13
NP_005305 (OMIM: 305670) gastrin-releasing peptide ( 384) 345 74.8 3.3e-13
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 344 74.6 3.6e-13
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 344 74.6 3.7e-13
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 344 74.6 3.7e-13
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 344 74.6 3.7e-13
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 344 74.6 3.8e-13
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 344 74.6 3.8e-13
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 344 74.7 3.9e-13
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 344 74.7 4e-13
NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 330 72.1 2.3e-12
NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 329 72.0 2.7e-12
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 328 71.8 3.2e-12
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 328 71.8 3.2e-12
NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 327 71.6 3.5e-12
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 320 70.3 8.7e-12
>>NP_612200 (OMIM: 609333) trace amine-associated recept (339 aa)
initn: 2315 init1: 2315 opt: 2315 Z-score: 2310.7 bits: 435.9 E(85289): 5.7e-122
Smith-Waterman score: 2315; 100.0% identity (100.0% similar) in 339 aa overlap (1-339:1-339)
10 20 30 40 50 60
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN
250 260 270 280 290 300
310 320 330
pF1KE0 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
:::::::::::::::::::::::::::::::::::::::
NP_612 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
310 320 330
>>NP_778227 (OMIM: 608282) trace amine-associated recept (348 aa)
initn: 981 init1: 512 opt: 983 Z-score: 990.7 bits: 191.7 E(85289): 1.9e-48
Smith-Waterman score: 983; 42.8% identity (73.1% similar) in 334 aa overlap (4-336:13-343)
10 20 30 40 50
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHF
.:.. .: ::.:. .: :. ::... . . . :::.:...: ::
NP_778 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 KQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASI
::::::::.:: :.: .:::.: :::.: :::.: :::::. .::.:: : . ::.
NP_778 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 FHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEI
::: ::.::: :: ::: : .:... : . : .:: ....:.... : .: ::.
NP_778 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 YYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLI-SDANQK
. : :::.. ... .: :. :.::. :. .: .:.:.::.::: : : :.:
NP_778 VVA-LTCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIESTASQA
190 200 210 220 230
240 250 260 270 280 290
pF1KE0 LQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLI
. . .:. ... .::::.:::::.:..::. : :... .:.: ....: :: . ..:.
NP_778 QSSSESYKERVAK-RERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILV
240 250 260 270 280 290
300 310 320 330
pF1KE0 WFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
: : ::..::..::::: :: ::.:... ::... ::: .:: :
NP_778 WCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD
300 310 320 330 340
>>NP_778237 (OMIM: 608923) trace amine-associated recept (345 aa)
initn: 932 init1: 506 opt: 941 Z-score: 949.1 bits: 184.0 E(85289): 4e-46
Smith-Waterman score: 941; 41.1% identity (71.2% similar) in 333 aa overlap (4-336:13-343)
10 20 30 40 50
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHF
.:. .: :::: .: :. :: .. . . .. :::.:..:: ::
NP_778 MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 KQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASI
::::.:::.:. :.: .:::.: :::.::::..: :::::. :: .:: :. . .:.
NP_778 KQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 FHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEI
::: ::::::: :: ::: : .:... : . : .:: .: ... : .: . . :
NP_778 FHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYS-GAVFYTGVYDDGLEE
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 YYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKL
..: :::.. .. . ::: . ::.:: ::. .: :.:.:..::. : ....:
NP_778 LSDALNCIGGCQTVVNQ-NWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSKT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 QIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIW
. . : .. .::::.::::... .:.: : :. : ...: :. .: : . .. :
NP_778 ESSSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCW
240 250 260 270 280 290
300 310 320 330
pF1KE0 FGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
.: ::..::..::.::::::::.:... :......:. .:: :
NP_778 CAYYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNSSATMNLFSEHI
300 310 320 330 340
>>NP_444508 (OMIM: 606927) trace amine-associated recept (342 aa)
initn: 887 init1: 481 opt: 920 Z-score: 928.4 bits: 180.2 E(85289): 5.7e-45
Smith-Waterman score: 920; 39.3% identity (71.4% similar) in 336 aa overlap (1-336:9-342)
10 20 30 40 50
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFK
.. .:.. .: ::... .: :. ::. . . : .. :::.:..:. :::
NP_444 MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 QLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIF
:::.:::.:: :.: .:::.: :: .::::..: ::::: :: .:. :. . .:..
NP_444 QLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 HLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIY
:: :: :::: .: ::: : .:... : . : .:: .: ... .... .: : ::.
NP_444 HLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 YKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQ
. ..: :::... :. .. :. :.:: .:. .: .:.::::.:: : ...:..
NP_444 -SALNCVGGCQIIVSQGWVLIDFLL-FFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVE
190 200 210 220 230
240 250 260 270 280 290
pF1KE0 IGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWF
. : . ..::::.::::... .:.: : :. . ..: :. .. : . .. :
NP_444 SSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWS
240 250 260 270 280 290
300 310 320 330
pF1KE0 GYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
.: ::..::..::.::::::::.:..: : ... .:: .::::
NP_444 AYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE
300 310 320 330 340
>>NP_001028252 (OMIM: 604849) trace amine-associated rec (351 aa)
initn: 1065 init1: 610 opt: 755 Z-score: 764.7 bits: 149.9 E(85289): 7.4e-36
Smith-Waterman score: 1111; 50.6% identity (76.7% similar) in 322 aa overlap (5-324:25-335)
10 20 30 40
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVG
: . : :: .:. : ::...::.:. :. :. :
NP_001 MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 NLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHT
:: .:.:::.:::::::::.:: ::: .::::: .:::::.::.:.::::: .::::.
NP_001 NLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYY
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 STDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIF
: :.::: .::::: ..:::.::.: :: :..:..: :: .... ::::..::::..:
NP_001 SFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVF
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 LELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQ
: : : : : : ..: :.:.:. :. ::..:. :::.:. .: .:. .....
NP_001 SEAYADGIEG-YDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKH
190 200 210 220 230
230 240 250 260 270
pF1KE0 ARLISD--ANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLH
:. :.. ::. :. .:..::.::::::.::::.:: : :. ..::::.
NP_001 AHAINNLRENQNNQV----------KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLN
240 250 260 270 280
280 290 300 310 320 330
pF1KE0 YIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELS
. : .: :.: ::::.::: ::..:.:::::::.:::..:.::::
NP_001 FSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKE
290 300 310 320 330 340
pF1KE0 S
NP_001 SE
350
>>NP_055441 (OMIM: 604849) trace amine-associated recept (306 aa)
initn: 1029 init1: 574 opt: 712 Z-score: 722.8 bits: 142.0 E(85289): 1.6e-33
Smith-Waterman score: 1068; 51.5% identity (77.7% similar) in 301 aa overlap (26-324:1-290)
10 20 30 40 50 60
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW
.::.:. :. :. ::: .:.:::.:::::::::.
NP_055 MYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNF
10 20 30
70 80 90 100 110 120
pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID
:: ::: .::::: .:::::.::.:.::::: .::::. : :.::: .::::: ..::
NP_055 LILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAID
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG
:.::.: :: :..:..: :: .... ::::..::::..: : : : : : : .
NP_055 RFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEG-YDILVACSS
100 110 120 130 140 150
190 200 210 220 230
pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISD--ANQKLQIGLEMK
.: :.:.:. :. ::..:. :::.:. .: .:. .....:. :.. ::. :.
NP_055 SCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQV-----
160 170 180 190 200
240 250 260 270 280 290
pF1KE0 NGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNST
.:..::.::::::.::::.:: : :. ..::::.. : .: :.: ::::.:::
NP_055 -----KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNST
210 220 230 240 250 260
300 310 320 330
pF1KE0 FNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
::..:.:::::::.:::..:.::::
NP_055 CNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE
270 280 290 300
>>NP_003958 (OMIM: 607405) trace amine-associated recept (337 aa)
initn: 762 init1: 440 opt: 561 Z-score: 572.7 bits: 114.4 E(85289): 3.7e-25
Smith-Waterman score: 893; 39.8% identity (71.0% similar) in 334 aa overlap (4-336:16-337)
10 20 30 40
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSI
::... : :: .. . .. .: . .: ..::..: ..
NP_003 MRAVFIQGAEEHPAAFCYQV-NGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV
10 20 30 40 50
50 60 70 80 90 100
pF1KE0 SHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSS
:.:: ::::::.:. :.: .:..:: ::.: : .::.: ::.::. .:..:: : ..
NP_003 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 ASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGA
.::::: ::::::. :.:::: : .:... : .:. .:.::: :. .:: . .
NP_003 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPA--AYTSLFLYTDVVET
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 E-EIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDA
. . ... : :.:.....:. : :.: :..: ::. .: .:...: .::. :.
NP_003 RLSQWLEEMPCVGSCQLLLNKFWGWLNF-PLFFVPCLIMISLYVKIFVVATRQAQQITTL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 NQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLND
...: : .. .::::.:::::..:..:.:: :: : :..: .::.: :: . :
NP_003 SKSLA-------GAAK-HERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD
240 250 260 270 280
290 300 310 320 330
pF1KE0 VLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
..:::.:.::. ::..:.: : :::::::. : :.:. .. :. :
NP_003 IFIWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
290 300 310 320 330
>>NP_071640 (OMIM: 142703) histamine H2 receptor isoform (359 aa)
initn: 570 init1: 345 opt: 450 Z-score: 462.4 bits: 94.0 E(85289): 5.1e-19
Smith-Waterman score: 608; 32.3% identity (65.5% similar) in 316 aa overlap (19-333:14-317)
10 20 30 40 50 60
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW
:. . .. .....:: :..::..: .... ..:.. ::
NP_071 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID
.: :.: .:.::: ::.:.: . . : ::.:::.:.:: :.:: .:::..: .::.:
NP_071 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG
:: :: ::::: . .. . . . . . : . ...: : : : .. : : .
NP_071 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG
:.: ... :.. ...::.: :: .::::. .:..::. :. .. .
NP_071 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI-----
180 190 200 210 220
250 260 270 280 290
pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTF
.:.::. ::. :::.:.::: :.: :. . : .:. ...:.:: ::..
NP_071 ----REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL
230 240 250 260 270 280
300 310 320 330
pF1KE0 NPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
::..:: . :: . .... .. ...: . .:
NP_071 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ
290 300 310 320 330 340
NP_071 VWSGTEVTAPQGATDR
350
>>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re (362 aa)
initn: 570 init1: 345 opt: 450 Z-score: 462.4 bits: 94.0 E(85289): 5.1e-19
Smith-Waterman score: 608; 32.3% identity (65.5% similar) in 316 aa overlap (19-333:14-317)
10 20 30 40 50 60
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW
:. . .. .....:: :..::..: .... ..:.. ::
XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID
.: :.: .:.::: ::.:.: . . : ::.:::.:.:: :.:: .:::..: .::.:
XP_006 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG
:: :: ::::: . .. . . . . . : . ...: : : : .. : : .
XP_006 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG
:.: ... :.. ...::.: :: .::::. .:..::. :. .. .
XP_006 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI-----
180 190 200 210 220
250 260 270 280 290
pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTF
.:.::. ::. :::.:.::: :.: :. . : .:. ...:.:: ::..
XP_006 ----REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL
230 240 250 260 270 280
300 310 320 330
pF1KE0 NPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
::..:: . :: . .... .. ...: . .:
XP_006 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ
290 300 310 320 330 340
XP_006 VWSGTEVTAPQGATDRNSS
350 360
>>NP_001124527 (OMIM: 142703) histamine H2 receptor isof (397 aa)
initn: 570 init1: 345 opt: 450 Z-score: 461.9 bits: 94.1 E(85289): 5.4e-19
Smith-Waterman score: 608; 32.3% identity (65.5% similar) in 316 aa overlap (19-333:14-317)
10 20 30 40 50 60
pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW
:. . .. .....:: :..::..: .... ..:.. ::
NP_001 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID
.: :.: .:.::: ::.:.: . . : ::.:::.:.:: :.:: .:::..: .::.:
NP_001 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG
:: :: ::::: . .. . . . . . : . ...: : : : .. : : .
NP_001 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG
:.: ... :.. ...::.: :: .::::. .:..::. :. .. .
NP_001 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI-----
180 190 200 210 220
250 260 270 280 290
pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTF
.:.::. ::. :::.:.::: :.: :. . : .:. ...:.:: ::..
NP_001 ----REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL
230 240 250 260 270 280
300 310 320 330
pF1KE0 NPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
::..:: . :: . .... .. ...: . .:
NP_001 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ
290 300 310 320 330 340
NP_001 VWSGTEVTAPQGATDRPWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
350 360 370 380 390
339 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 07:53:33 2016 done: Sun Nov 6 07:53:34 2016
Total Scan time: 6.330 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]