Result of FASTA (omim) for
pFN21AE0609
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0609, 171 aa
1>>>pF1KE0609 171 - 171 aa - 171 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2161+/-0.000321; mu= 13.7192+/- 0.020
mean_var=104.5933+/-24.728, 0's: 0 Z-trim(116.3): 628 B-trim: 1180 in 1/54
Lambda= 0.125407
statistics sampled from 26604 (27366) to 26604 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.321), width: 16
Scan time: 4.090
The best scores are: opt bits E(85289)
NP_001123370 (OMIM: 300585) KRAB domain-containing ( 171) 1176 222.7 2.2e-58
NP_060246 (OMIM: 300585) KRAB domain-containing pr ( 166) 1117 212.1 3.5e-55
NP_001034980 (OMIM: 300573) zinc finger protein 67 ( 581) 946 181.7 1.7e-45
XP_011542243 (OMIM: 300573) PREDICTED: zinc finger ( 581) 946 181.7 1.7e-45
XP_011542245 (OMIM: 300573) PREDICTED: zinc finger ( 580) 928 178.5 1.6e-44
NP_001177346 (OMIM: 300573) zinc finger protein 67 ( 576) 887 171.1 2.7e-42
NP_001139763 (OMIM: 300573) zinc finger protein 67 ( 575) 879 169.6 7.3e-42
XP_011542246 (OMIM: 300573) PREDICTED: zinc finger ( 545) 711 139.2 1e-32
NP_001123371 (OMIM: 300585) KRAB domain-containing ( 98) 578 114.3 5.7e-26
NP_001123372 (OMIM: 300585) KRAB domain-containing ( 93) 532 105.9 1.8e-23
NP_008885 (OMIM: 194521) zinc finger protein 33A i ( 811) 396 82.4 1.9e-15
XP_011517952 (OMIM: 194521) PREDICTED: zinc finger ( 811) 396 82.4 1.9e-15
XP_016872106 (OMIM: 194521) PREDICTED: zinc finger ( 818) 396 82.4 1.9e-15
NP_001311107 (OMIM: 194521) zinc finger protein 33 ( 818) 396 82.4 1.9e-15
NP_001265102 (OMIM: 194521) zinc finger protein 33 ( 829) 396 82.4 1.9e-15
NP_001265106 (OMIM: 194521) zinc finger protein 33 ( 832) 396 82.4 1.9e-15
XP_016885219 (OMIM: 300573) PREDICTED: zinc finger ( 514) 390 81.1 2.9e-15
XP_016885220 (OMIM: 300573) PREDICTED: zinc finger ( 514) 390 81.1 2.9e-15
XP_016885217 (OMIM: 300573) PREDICTED: zinc finger ( 514) 390 81.1 2.9e-15
XP_011542247 (OMIM: 300573) PREDICTED: zinc finger ( 514) 390 81.1 2.9e-15
XP_016885218 (OMIM: 300573) PREDICTED: zinc finger ( 514) 390 81.1 2.9e-15
NP_066986 (OMIM: 608191) RB-associated KRAB zinc f ( 714) 388 80.9 4.7e-15
NP_001191385 (OMIM: 608191) RB-associated KRAB zin ( 714) 388 80.9 4.7e-15
XP_016885222 (OMIM: 300573) PREDICTED: zinc finger ( 513) 385 80.2 5.5e-15
XP_016885221 (OMIM: 300573) PREDICTED: zinc finger ( 513) 385 80.2 5.5e-15
XP_011517953 (OMIM: 194521) PREDICTED: zinc finger ( 810) 378 79.1 1.8e-14
NP_008905 (OMIM: 194521) zinc finger protein 33A i ( 810) 378 79.1 1.8e-14
NP_001265099 (OMIM: 194521) zinc finger protein 33 ( 817) 378 79.1 1.8e-14
NP_008886 (OMIM: 194522) zinc finger protein 33B i ( 778) 375 78.6 2.5e-14
NP_001291962 (OMIM: 194522) zinc finger protein 33 ( 785) 375 78.6 2.5e-14
XP_016881866 (OMIM: 613904) PREDICTED: zinc finger ( 686) 365 76.7 8.1e-14
XP_016881865 (OMIM: 613904) PREDICTED: zinc finger ( 686) 365 76.7 8.1e-14
NP_689697 (OMIM: 613904) zinc finger protein 569 i ( 686) 365 76.7 8.1e-14
XP_011524841 (OMIM: 613904) PREDICTED: zinc finger ( 686) 365 76.7 8.1e-14
XP_006723110 (OMIM: 613904) PREDICTED: zinc finger ( 710) 365 76.7 8.3e-14
XP_006723109 (OMIM: 613904) PREDICTED: zinc finger ( 710) 365 76.7 8.3e-14
XP_011524840 (OMIM: 613904) PREDICTED: zinc finger ( 710) 365 76.7 8.3e-14
XP_006723111 (OMIM: 613904) PREDICTED: zinc finger ( 710) 365 76.7 8.3e-14
NP_057349 (OMIM: 194536) zinc finger protein 12 is ( 697) 361 76.0 1.4e-13
NP_008887 (OMIM: 194536) zinc finger protein 12 is ( 659) 354 74.7 3.1e-13
NP_003406 (OMIM: 604753) zinc finger protein 268 i ( 947) 349 74.0 7.5e-13
NP_001159353 (OMIM: 604753) zinc finger protein 26 ( 947) 349 74.0 7.5e-13
NP_001292136 (OMIM: 609451) zinc finger protein 90 ( 92) 330 69.4 1.8e-12
NP_001292135 (OMIM: 609451) zinc finger protein 90 ( 93) 330 69.4 1.8e-12
NP_001292137 (OMIM: 609451) zinc finger protein 90 ( 93) 330 69.4 1.8e-12
NP_001292133 (OMIM: 609451) zinc finger protein 90 ( 113) 330 69.5 2e-12
NP_001311188 (OMIM: 616085) zinc finger protein 37 ( 97) 327 68.9 2.7e-12
XP_016872111 (OMIM: 616085) PREDICTED: zinc finger ( 97) 327 68.9 2.7e-12
NP_001311189 (OMIM: 616085) zinc finger protein 37 ( 97) 327 68.9 2.7e-12
NP_001311182 (OMIM: 616085) zinc finger protein 37 ( 120) 327 69.0 3e-12
>>NP_001123370 (OMIM: 300585) KRAB domain-containing pro (171 aa)
initn: 1176 init1: 1176 opt: 1176 Z-score: 1169.1 bits: 222.7 E(85289): 2.2e-58
Smith-Waterman score: 1176; 100.0% identity (100.0% similar) in 171 aa overlap (1-171:1-171)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
130 140 150 160 170
>>NP_060246 (OMIM: 300585) KRAB domain-containing protei (166 aa)
initn: 1123 init1: 605 opt: 1117 Z-score: 1111.6 bits: 212.1 E(85289): 3.5e-55
Smith-Waterman score: 1117; 97.1% identity (97.1% similar) in 171 aa overlap (1-171:1-166)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
NP_060 GPGEESWMADGGTPVRTCA-----EVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
70 80 90 100 110
130 140 150 160 170
pF1KE0 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
120 130 140 150 160
>>NP_001034980 (OMIM: 300573) zinc finger protein 674 is (581 aa)
initn: 973 init1: 946 opt: 946 Z-score: 938.0 bits: 181.7 E(85289): 1.7e-45
Smith-Waterman score: 946; 89.0% identity (95.5% similar) in 154 aa overlap (1-154:1-154)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::
NP_001 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGHLVGKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
:::.:::::::::::::::::::::::.::::::::::::::. ::::::::::::::::
NP_001 GPGDESWMADGGTPVRTCAGEDRPEVWEVDEQIDHYKESQDKFLWQAAFIGKETLKDESG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:: . ::: :::.:.: ::.::::::::::. :
NP_001 QECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKV
130 140 150 160 170 180
NP_001 CLHYNLHKAQPAERFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLV
190 200 210 220 230 240
>>XP_011542243 (OMIM: 300573) PREDICTED: zinc finger pro (581 aa)
initn: 973 init1: 946 opt: 946 Z-score: 938.0 bits: 181.7 E(85289): 1.7e-45
Smith-Waterman score: 946; 89.0% identity (95.5% similar) in 154 aa overlap (1-154:1-154)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::
XP_011 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGHLVGKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
:::.:::::::::::::::::::::::.::::::::::::::. ::::::::::::::::
XP_011 GPGDESWMADGGTPVRTCAGEDRPEVWEVDEQIDHYKESQDKFLWQAAFIGKETLKDESG
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:: . ::: :::.:.: ::.::::::::::. :
XP_011 QECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKV
130 140 150 160 170 180
XP_011 CLHYNLHKAQPAERFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLV
190 200 210 220 230 240
>>XP_011542245 (OMIM: 300573) PREDICTED: zinc finger pro (580 aa)
initn: 953 init1: 556 opt: 928 Z-score: 920.4 bits: 178.5 E(85289): 1.6e-44
Smith-Waterman score: 928; 88.3% identity (94.8% similar) in 154 aa overlap (1-154:1-153)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::
XP_011 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGHLVGKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
:::.:::::::::::::::::::: ::.::::::::::::::. ::::::::::::::::
XP_011 GPGDESWMADGGTPVRTCAGEDRP-VWEVDEQIDHYKESQDKFLWQAAFIGKETLKDESG
70 80 90 100 110
130 140 150 160 170
pF1KE0 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:: . ::: :::.:.: ::.::::::::::. :
XP_011 QECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKV
120 130 140 150 160 170
XP_011 CLHYNLHKAQPAERFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLV
180 190 200 210 220 230
>>NP_001177346 (OMIM: 300573) zinc finger protein 674 is (576 aa)
initn: 920 init1: 517 opt: 887 Z-score: 880.3 bits: 171.1 E(85289): 2.7e-42
Smith-Waterman score: 887; 85.7% identity (92.2% similar) in 154 aa overlap (1-154:1-149)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::
NP_001 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGHLVGKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
:::.::::::::::::::: :::.::::::::::::::. ::::::::::::::::
NP_001 GPGDESWMADGGTPVRTCA-----EVWEVDEQIDHYKESQDKFLWQAAFIGKETLKDESG
70 80 90 100 110
130 140 150 160 170
pF1KE0 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:: . ::: :::.:.: ::.::::::::::. :
NP_001 QECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKV
120 130 140 150 160 170
NP_001 CLHYNLHKAQPAERFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLV
180 190 200 210 220 230
>>NP_001139763 (OMIM: 300573) zinc finger protein 674 is (575 aa)
initn: 914 init1: 517 opt: 879 Z-score: 872.5 bits: 169.6 E(85289): 7.3e-42
Smith-Waterman score: 879; 85.1% identity (91.6% similar) in 154 aa overlap (1-154:1-148)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::
NP_001 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGHLVGKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
:::.::::::::::::::: ::.::::::::::::::. ::::::::::::::::
NP_001 GPGDESWMADGGTPVRTCA------VWEVDEQIDHYKESQDKFLWQAAFIGKETLKDESG
70 80 90 100 110
130 140 150 160 170
pF1KE0 QESRTCRKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:: . ::: :::.:.: ::.::::::::::. :
NP_001 QECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKV
120 130 140 150 160 170
NP_001 CLHYNLHKAQPAERFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLV
180 190 200 210 220 230
>>XP_011542246 (OMIM: 300573) PREDICTED: zinc finger pro (545 aa)
initn: 738 init1: 711 opt: 711 Z-score: 708.5 bits: 139.2 E(85289): 1e-32
Smith-Waterman score: 711; 85.6% identity (94.1% similar) in 118 aa overlap (37-154:1-118)
10 20 30 40 50 60
pF1KE0 SLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRLGPGEES
::::::::::::.::.:::::::::::.::
XP_011 MLENYSHLVSVGHLVGKPDVIFRLGPGDES
10 20 30
70 80 90 100 110 120
pF1KE0 WMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESGQESRTC
:::::::::::::::::::::.::::::::::::::. :::::::::::::::::: . :
XP_011 WMADGGTPVRTCAGEDRPEVWEVDEQIDHYKESQDKFLWQAAFIGKETLKDESGQECKIC
40 50 60 70 80 90
130 140 150 160 170
pF1KE0 RKSIYLSTEFDSVRQRLPKYYSWEKAFKTSFKLSWSKWKLCKKER
:: :::.:.: ::.::::::::::. :
XP_011 RKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKVCLHYNL
100 110 120 130 140 150
>>NP_001123371 (OMIM: 300585) KRAB domain-containing pro (98 aa)
initn: 578 init1: 578 opt: 578 Z-score: 587.2 bits: 114.3 E(85289): 5.7e-26
Smith-Waterman score: 578; 98.8% identity (100.0% similar) in 86 aa overlap (1-86:1-86)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
::::::::::::::::::::::::.:
NP_001 GPGEESWMADGGTPVRTCAGEDRPDVSIFASCILKCCY
70 80 90
>>NP_001123372 (OMIM: 300585) KRAB domain-containing pro (93 aa)
initn: 532 init1: 532 opt: 532 Z-score: 542.5 bits: 105.9 E(85289): 1.8e-23
Smith-Waterman score: 532; 100.0% identity (100.0% similar) in 79 aa overlap (1-79:1-79)
10 20 30 40 50 60
pF1KE0 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGYLVAKPDVIFRL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GPGEESWMADGGTPVRTCAGEDRPEVWQVDEQIDHYKESQDKLPWQAAFIGKETLKDESG
:::::::::::::::::::
NP_001 GPGEESWMADGGTPVRTCADVSIFASCILKCCY
70 80 90
171 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 04:01:33 2016 done: Mon Nov 7 04:01:34 2016
Total Scan time: 4.090 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]