Result of FASTA (omim) for
pFN21AE0591
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0591, 412 aa
1>>>pF1KE0591 412 - 412 aa - 412 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0837+/-0.000366; mu= 2.9383+/- 0.023
mean_var=286.1237+/-60.030, 0's: 0 Z-trim(123.0): 328 B-trim: 796 in 1/56
Lambda= 0.075822
statistics sampled from 41621 (41981) to 41621 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.786), E-opt: 0.2 (0.492), width: 16
Scan time: 10.650
The best scores are: opt bits E(85289)
NP_003576 (OMIM: 604568) double C2-like domain-con ( 412) 2819 321.3 2.8e-87
XP_016880716 (OMIM: 604568) PREDICTED: double C2-l ( 340) 1770 206.5 8.5e-53
XP_011533665 (OMIM: 604568) PREDICTED: double C2-l ( 387) 1591 186.9 7.3e-47
NP_055769 (OMIM: 612159) rabphilin-3A isoform 2 [H ( 690) 896 111.2 8.3e-24
NP_001137326 (OMIM: 612159) rabphilin-3A isoform 1 ( 694) 896 111.2 8.3e-24
XP_011536350 (OMIM: 612159) PREDICTED: rabphilin-3 ( 694) 896 111.2 8.3e-24
XP_016874523 (OMIM: 612159) PREDICTED: rabphilin-3 ( 346) 831 103.7 7.1e-22
XP_016879267 (OMIM: 604567) PREDICTED: double C2-l ( 282) 801 100.4 6e-21
NP_001268991 (OMIM: 604567) double C2-like domain- ( 400) 803 100.7 6.6e-21
XP_011544277 (OMIM: 604567) PREDICTED: double C2-l ( 400) 803 100.7 6.6e-21
NP_001268997 (OMIM: 604567) double C2-like domain- ( 400) 803 100.7 6.6e-21
NP_003577 (OMIM: 604567) double C2-like domain-con ( 400) 803 100.7 6.6e-21
NP_001268992 (OMIM: 604567) double C2-like domain- ( 400) 803 100.7 6.6e-21
XP_016879266 (OMIM: 604567) PREDICTED: double C2-l ( 400) 803 100.7 6.6e-21
XP_016879265 (OMIM: 604567) PREDICTED: double C2-l ( 400) 803 100.7 6.6e-21
NP_065834 (OMIM: 600103) synaptotagmin-4 [Homo sap ( 425) 558 74.0 8e-13
XP_005245071 (OMIM: 608741) PREDICTED: synaptotagm ( 430) 557 73.9 8.7e-13
NP_995320 (OMIM: 607718) synaptotagmin-6 [Homo sap ( 425) 556 73.8 9.3e-13
NP_001257734 (OMIM: 607718) synaptotagmin-6 [Homo ( 425) 556 73.8 9.3e-13
XP_016855860 (OMIM: 607718) PREDICTED: synaptotagm ( 443) 556 73.8 9.6e-13
NP_689493 (OMIM: 608741) synaptotagmin-11 [Homo sa ( 431) 539 71.9 3.4e-12
XP_016856248 (OMIM: 608741) PREDICTED: synaptotagm ( 434) 539 71.9 3.4e-12
XP_005269170 (OMIM: 185605) PREDICTED: synaptotagm ( 419) 486 66.1 1.9e-10
XP_006719639 (OMIM: 185605) PREDICTED: synaptotagm ( 419) 486 66.1 1.9e-10
NP_001278830 (OMIM: 185605) synaptotagmin-1 isofor ( 419) 486 66.1 1.9e-10
NP_001129277 (OMIM: 185605) synaptotagmin-1 isofor ( 422) 486 66.1 1.9e-10
XP_011537012 (OMIM: 185605) PREDICTED: synaptotagm ( 422) 486 66.1 1.9e-10
NP_001129278 (OMIM: 185605) synaptotagmin-1 isofor ( 422) 486 66.1 1.9e-10
NP_005630 (OMIM: 185605) synaptotagmin-1 isoform 1 ( 422) 486 66.1 1.9e-10
XP_016875398 (OMIM: 185605) PREDICTED: synaptotagm ( 422) 486 66.1 1.9e-10
XP_016855802 (OMIM: 600104,616040) PREDICTED: syna ( 419) 484 65.9 2.2e-10
NP_001129976 (OMIM: 600104,616040) synaptotagmin-2 ( 419) 484 65.9 2.2e-10
NP_796376 (OMIM: 600104,616040) synaptotagmin-2 [H ( 419) 484 65.9 2.2e-10
XP_011507494 (OMIM: 600104,616040) PREDICTED: syna ( 422) 484 65.9 2.2e-10
XP_016855801 (OMIM: 600104,616040) PREDICTED: syna ( 422) 484 65.9 2.2e-10
XP_016855800 (OMIM: 600104,616040) PREDICTED: syna ( 422) 484 65.9 2.2e-10
XP_016855799 (OMIM: 600104,616040) PREDICTED: syna ( 476) 484 65.9 2.4e-10
XP_016855798 (OMIM: 600104,616040) PREDICTED: syna ( 479) 484 65.9 2.4e-10
XP_011525693 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 479 65.5 4e-10
NP_001153800 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 479 65.5 4e-10
NP_001153801 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 479 65.5 4e-10
NP_115674 (OMIM: 600327) synaptotagmin-3 [Homo sap ( 590) 479 65.5 4e-10
XP_011525692 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 479 65.5 4e-10
XP_005274447 (OMIM: 604146) PREDICTED: synaptotagm ( 247) 469 64.0 4.7e-10
XP_006718799 (OMIM: 604146) PREDICTED: synaptotagm ( 293) 469 64.1 5.3e-10
NP_004191 (OMIM: 604146) synaptotagmin-7 isoform 2 ( 403) 469 64.2 6.6e-10
XP_011543645 (OMIM: 604146) PREDICTED: synaptotagm ( 409) 469 64.2 6.7e-10
NP_001287702 (OMIM: 604146) synaptotagmin-7 isofor ( 447) 469 64.3 7.1e-10
XP_005274444 (OMIM: 604146) PREDICTED: synaptotagm ( 449) 469 64.3 7.1e-10
XP_011543643 (OMIM: 604146) PREDICTED: synaptotagm ( 453) 469 64.3 7.2e-10
>>NP_003576 (OMIM: 604568) double C2-like domain-contain (412 aa)
initn: 2819 init1: 2819 opt: 2819 Z-score: 1688.0 bits: 321.3 E(85289): 2.8e-87
Smith-Waterman score: 2819; 99.8% identity (100.0% similar) in 412 aa overlap (1-412:1-412)
10 20 30 40 50 60
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 NHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI
310 320 330 340 350 360
370 380 390 400 410
pF1KE0 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD
370 380 390 400 410
>>XP_016880716 (OMIM: 604568) PREDICTED: double C2-like (340 aa)
initn: 1766 init1: 1766 opt: 1770 Z-score: 1068.9 bits: 206.5 E(85289): 8.5e-53
Smith-Waterman score: 1770; 90.5% identity (95.1% similar) in 285 aa overlap (1-282:1-285)
10 20 30 40 50 60
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
190 200 210 220 230 240
250 260 270 280 290
pF1KE0 NHTKTFNICLEKQLPVDKTE---DKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMD
::::::.:::::::: . :.. .:.. ...:. ..:
XP_016 NHTKTFSICLEKQLPRTQQGPRVDRTRKEHAWNMLDLSACEIRRGDSRVSFPRNGICLNV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 ANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWD
XP_016 MSEQICPRPAPAATPSESWSLCPSSLPHPPLSMASPSPGS
310 320 330 340
>>XP_011533665 (OMIM: 604568) PREDICTED: double C2-like (387 aa)
initn: 1589 init1: 1589 opt: 1591 Z-score: 962.4 bits: 186.9 E(85289): 7.3e-47
Smith-Waterman score: 2584; 93.7% identity (93.9% similar) in 412 aa overlap (1-412:1-387)
10 20 30 40 50 60
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
::::::::::::::::::::::::::::::: ::::
XP_011 SDDCTALGTLDFSLLYDQENNALHCTITKAK-------------------------ANKL
130 140 150
190 200 210 220 230 240
pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE0 NHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE0 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI
280 290 300 310 320 330
370 380 390 400 410
pF1KE0 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD
340 350 360 370 380
>>NP_055769 (OMIM: 612159) rabphilin-3A isoform 2 [Homo (690 aa)
initn: 1588 init1: 830 opt: 896 Z-score: 548.4 bits: 111.2 E(85289): 8.3e-24
Smith-Waterman score: 1623; 62.2% identity (79.0% similar) in 400 aa overlap (24-404:293-684)
10 20 30 40 50
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFP-RFPRGLPPDAGPRA
:: :: . :: . :. : : : .
NP_055 LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG--T
270 280 290 300 310 320
60 70 80 90 100 110
pF1KE0 AAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPED
.::: .:.: :. ::::: ... : :... . .: :. :: : : :.
NP_055 TAPPREERTGGVGG----YPAVGAREDR--MSHPSGPYSQASAAAPQPAAARQPPPPEEE
330 340 350 360 370
120 130 140 150 160 170
pF1KE0 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP
: .:..:.::. :.::.:.:::::::.:..:.::: ::::::::: ::::::::::::::
NP_055 EEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLP
380 390 400 410 420 430
180 190 200 210 220 230
pF1KE0 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR
::::.::::::::::: :: :::::.:.::::::: :::::::::::::: :::::::::
NP_055 GASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETR
440 450 460 470 480 490
240 250 260 270
pF1KE0 VPLKKLKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISL
:::::::. :.::::::. .:. .. :.. ..::::.::.::
NP_055 FSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSL
500 510 520 530 540 550
280 290 300 310 320 330
pF1KE0 KYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN
::.:. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .::::::::::
NP_055 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFN
560 570 580 590 600 610
340 350 360 370 380 390
pF1KE0 EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKR
::: :.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::.
NP_055 EEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKK
620 630 640 650 660 670
400 410
pF1KE0 IERWHTLTSELPGAVLSD
::::: : .:
NP_055 IERWHQLQNENHVSSD
680 690
>>NP_001137326 (OMIM: 612159) rabphilin-3A isoform 1 [Ho (694 aa)
initn: 1588 init1: 830 opt: 896 Z-score: 548.4 bits: 111.2 E(85289): 8.3e-24
Smith-Waterman score: 1623; 62.2% identity (79.0% similar) in 400 aa overlap (24-404:297-688)
10 20 30 40 50
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFP-RFPRGLPPDAGPRA
:: :: . :: . :. : : : .
NP_001 LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG--T
270 280 290 300 310 320
60 70 80 90 100 110
pF1KE0 AAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPED
.::: .:.: :. ::::: ... : :... . .: :. :: : : :.
NP_001 TAPPREERTGGVGG----YPAVGAREDR--MSHPSGPYSQASAAAPQPAAARQPPPPEEE
330 340 350 360 370
120 130 140 150 160 170
pF1KE0 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP
: .:..:.::. :.::.:.:::::::.:..:.::: ::::::::: ::::::::::::::
NP_001 EEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLP
380 390 400 410 420 430
180 190 200 210 220 230
pF1KE0 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR
::::.::::::::::: :: :::::.:.::::::: :::::::::::::: :::::::::
NP_001 GASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETR
440 450 460 470 480 490
240 250 260 270
pF1KE0 VPLKKLKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISL
:::::::. :.::::::. .:. .. :.. ..::::.::.::
NP_001 FSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSL
500 510 520 530 540 550
280 290 300 310 320 330
pF1KE0 KYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN
::.:. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .::::::::::
NP_001 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFN
560 570 580 590 600 610
340 350 360 370 380 390
pF1KE0 EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKR
::: :.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::.
NP_001 EEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKK
620 630 640 650 660 670
400 410
pF1KE0 IERWHTLTSELPGAVLSD
::::: : .:
NP_001 IERWHQLQNENHVSSD
680 690
>>XP_011536350 (OMIM: 612159) PREDICTED: rabphilin-3A is (694 aa)
initn: 1588 init1: 830 opt: 896 Z-score: 548.4 bits: 111.2 E(85289): 8.3e-24
Smith-Waterman score: 1623; 62.2% identity (79.0% similar) in 400 aa overlap (24-404:297-688)
10 20 30 40 50
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFP-RFPRGLPPDAGPRA
:: :: . :: . :. : : : .
XP_011 LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG--T
270 280 290 300 310 320
60 70 80 90 100 110
pF1KE0 AAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPED
.::: .:.: :. ::::: ... : :... . .: :. :: : : :.
XP_011 TAPPREERTGGVGG----YPAVGAREDR--MSHPSGPYSQASAAAPQPAAARQPPPPEEE
330 340 350 360 370
120 130 140 150 160 170
pF1KE0 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP
: .:..:.::. :.::.:.:::::::.:..:.::: ::::::::: ::::::::::::::
XP_011 EEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLP
380 390 400 410 420 430
180 190 200 210 220 230
pF1KE0 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR
::::.::::::::::: :: :::::.:.::::::: :::::::::::::: :::::::::
XP_011 GASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETR
440 450 460 470 480 490
240 250 260 270
pF1KE0 VPLKKLKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISL
:::::::. :.::::::. .:. .. :.. ..::::.::.::
XP_011 FSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSL
500 510 520 530 540 550
280 290 300 310 320 330
pF1KE0 KYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN
::.:. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .::::::::::
XP_011 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFN
560 570 580 590 600 610
340 350 360 370 380 390
pF1KE0 EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKR
::: :.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::.
XP_011 EEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKK
620 630 640 650 660 670
400 410
pF1KE0 IERWHTLTSELPGAVLSD
::::: : .:
XP_011 IERWHQLQNENHVSSD
680 690
>>XP_016874523 (OMIM: 612159) PREDICTED: rabphilin-3A is (346 aa)
initn: 1588 init1: 830 opt: 831 Z-score: 513.7 bits: 103.7 E(85289): 7.1e-22
Smith-Waterman score: 1558; 68.1% identity (84.8% similar) in 335 aa overlap (88-404:6-340)
60 70 80 90 100 110
pF1KE0 APARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDAD
: :... . .: :. :: : : :.: .:.
XP_016 MSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEAN
10 20 30
120 130 140 150 160 170
pF1KE0 GYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKA
.:.::. :.::.:.:::::::.:..:.::: ::::::::: ::::::::::::::::::.
XP_016 SYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKS
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE0 NKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKK
::::::::::: :: :::::.:.::::::: :::::::::::::: ::::::::: :::
XP_016 NKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKK
100 110 120 130 140 150
240 250 260 270
pF1KE0 LKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISLKYSSQ
::::. :.::::::. .:. .. :.. ..::::.::.:: ::.:
XP_016 LKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQ
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE0 KQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCY
. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .::::::::::::: :
XP_016 QGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFY
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE0 EIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWH
.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::.:::::
XP_016 DIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWH
280 290 300 310 320 330
400 410
pF1KE0 TLTSELPGAVLSD
: .:
XP_016 QLQNENHVSSD
340
>>XP_016879267 (OMIM: 604567) PREDICTED: double C2-like (282 aa)
initn: 1305 init1: 777 opt: 801 Z-score: 497.0 bits: 100.4 E(85289): 6e-21
Smith-Waterman score: 1256; 70.2% identity (81.5% similar) in 275 aa overlap (156-408:1-275)
130 140 150 160 170 180
pF1KE0 ALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTL
:: :::::::::::::::: :::::.:::
XP_016 MDFNGLADPYVKLHLLPGACKANKLKTKTQ
10 20 30
190 200 210 220 230 240
pF1KE0 RNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKT
::::::.::: ::: ::::.:. .:.:::.::::::. ::::::: ::::..:::.. :
XP_016 RNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKH
40 50 60 70 80 90
250 260 270 280
pF1KE0 FNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSSQKQGL
::::::.:.:. . . : ::::::::.::.:::...::
XP_016 FNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGL
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE0 LVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKH
::::.:::::::::.:::::::::::::::::::::::: :::::::::::::: :::.
XP_016 LVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIEL
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE0 GDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTS
. :: :.:::::::::::::::::::: :: :.:: ::: :::.. : .::::::::
XP_016 STLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTS
220 230 240 250 260 270
410
pF1KE0 ELPGAVLSD
::: :
XP_016 ELPPAAGALSSA
280
>>NP_001268991 (OMIM: 604567) double C2-like domain-cont (400 aa)
initn: 1723 init1: 777 opt: 803 Z-score: 496.3 bits: 100.7 E(85289): 6.6e-21
Smith-Waterman score: 1624; 61.3% identity (74.9% similar) in 426 aa overlap (5-408:4-393)
10 20 30 40 50 60
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
:::.. ::.:::::::.:::::::::.:::::::: : ::....
NP_001 MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGP-------GPEGGG------
10 20 30 40
70 80 90 100 110 120
pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
:.: ..:. .: . :. : : ::: ..:.:.
NP_001 -----GGGGEAPA-----------HLVPLALAPPAALLG-------ATTPEDGAEVDSYD
50 60 70 80
130 140 150 160 170 180
pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
::: ::::::.:.::::. . .:::.: .:::::::: :::::::::::::::: :::::
NP_001 SDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKL
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
.::: ::::::.::: ::: ::::.:. .:.:::.::::::. ::::::: ::::..:::
NP_001 KTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKP
150 160 170 180 190 200
250 260 270
pF1KE0 NHTKTFNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSS
.. : ::::::.:.:. . . : ::::::::.::.:::
NP_001 SQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSS
210 220 230 240 250 260
280 290 300 310 320 330
pF1KE0 QKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFC
...::::::.:::::::::.:::::::::::::::::::::::: ::::::::::::::
NP_001 RRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFF
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE0 YEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERW
:::. . :: :.:::::::::::::::::::: :: :.:: ::: :::.. : .:::
NP_001 YEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERW
330 340 350 360 370 380
400 410
pF1KE0 HTLTSELPGAVLSD
:::::::: :
NP_001 HTLTSELPPAAGALSSA
390 400
>>XP_011544277 (OMIM: 604567) PREDICTED: double C2-like (400 aa)
initn: 1723 init1: 777 opt: 803 Z-score: 496.3 bits: 100.7 E(85289): 6.6e-21
Smith-Waterman score: 1624; 61.3% identity (74.9% similar) in 426 aa overlap (5-408:4-393)
10 20 30 40 50 60
pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA
:::.. ::.:::::::.:::::::::.:::::::: : ::....
XP_011 MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGP-------GPEGGG------
10 20 30 40
70 80 90 100 110 120
pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE
:.: ..:. .: . :. : : ::: ..:.:.
XP_011 -----GGGGEAPA-----------HLVPLALAPPAALLG-------ATTPEDGAEVDSYD
50 60 70 80
130 140 150 160 170 180
pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL
::: ::::::.:.::::. . .:::.: .:::::::: :::::::::::::::: :::::
XP_011 SDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKL
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP
.::: ::::::.::: ::: ::::.:. .:.:::.::::::. ::::::: ::::..:::
XP_011 KTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKP
150 160 170 180 190 200
250 260 270
pF1KE0 NHTKTFNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSS
.. : ::::::.:.:. . . : ::::::::.::.:::
XP_011 SQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSS
210 220 230 240 250 260
280 290 300 310 320 330
pF1KE0 QKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFC
...::::::.:::::::::.:::::::::::::::::::::::: ::::::::::::::
XP_011 RRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFF
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE0 YEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERW
:::. . :: :.:::::::::::::::::::: :: :.:: ::: :::.. : .:::
XP_011 YEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERW
330 340 350 360 370 380
400 410
pF1KE0 HTLTSELPGAVLSD
:::::::: :
XP_011 HTLTSELPPAAGALSSA
390 400
412 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 04:42:08 2016 done: Mon Nov 7 04:42:10 2016
Total Scan time: 10.650 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]