Result of FASTA (omim) for
pFN21AE0353
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0353, 543 aa
1>>>pF1KE0353 543 - 543 aa - 543 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2818+/-0.000347; mu= 14.3244+/- 0.022
mean_var=96.0136+/-19.985, 0's: 0 Z-trim(117.4): 62 B-trim: 2136 in 2/52
Lambda= 0.130890
statistics sampled from 29287 (29349) to 29287 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.344), width: 16
Scan time: 9.160
The best scores are: opt bits E(85289)
NP_115991 (OMIM: 611924) gap junction alpha-10 pro ( 543) 3781 724.4 2.2e-208
NP_110399 (OMIM: 611923) gap junction alpha-9 prot ( 515) 1213 239.4 2e-62
XP_011507719 (OMIM: 116200,600897,612474) PREDICTE ( 427) 955 190.6 8.1e-48
XP_011507718 (OMIM: 116200,600897,612474) PREDICTE ( 433) 955 190.6 8.2e-48
NP_005258 (OMIM: 116200,600897,612474) gap junctio ( 433) 955 190.6 8.2e-48
NP_068773 (OMIM: 121015,601885) gap junction alpha ( 435) 955 190.6 8.2e-48
XP_011533350 (OMIM: 121015,601885) PREDICTED: gap ( 435) 955 190.6 8.2e-48
NP_859054 (OMIM: 108770,121013,612474,614049) gap ( 358) 916 183.2 1.2e-45
XP_016856533 (OMIM: 108770,121013,612474,614049) P ( 358) 916 183.2 1.2e-45
NP_005257 (OMIM: 108770,121013,612474,614049) gap ( 358) 916 183.2 1.2e-45
XP_005273008 (OMIM: 108770,121013,612474,614049) P ( 358) 916 183.2 1.2e-45
NP_002051 (OMIM: 121012) gap junction alpha-4 prot ( 333) 881 176.6 1.1e-43
XP_016856532 (OMIM: 121012) PREDICTED: gap junctio ( 333) 881 176.6 1.1e-43
XP_005270807 (OMIM: 121012) PREDICTED: gap junctio ( 333) 881 176.6 1.1e-43
NP_000156 (OMIM: 104100,121014,133200,164200,18610 ( 382) 847 170.2 1e-41
XP_011533351 (OMIM: 121011,124500,148210,148350,14 ( 226) 457 96.4 9.7e-20
NP_003995 (OMIM: 121011,124500,148210,148350,14920 ( 226) 457 96.4 9.7e-20
NP_065168 (OMIM: 608803,608804,613206,613480) gap ( 439) 455 96.2 2.2e-19
NP_694944 (OMIM: 133200,605425) gap junction beta- ( 266) 441 93.5 9e-19
XP_011538981 (OMIM: 133200,605425) PREDICTED: gap ( 266) 441 93.5 9e-19
XP_005256978 (OMIM: 608655) PREDICTED: gap junctio ( 396) 438 93.0 1.9e-18
NP_005488 (OMIM: 608655) gap junction gamma-1 prot ( 396) 438 93.0 1.9e-18
NP_001073852 (OMIM: 608655) gap junction gamma-1 p ( 396) 438 93.0 1.9e-18
XP_005256977 (OMIM: 608655) PREDICTED: gap junctio ( 396) 438 93.0 1.9e-18
NP_001005752 (OMIM: 133200,220290,603324,612644) g ( 270) 431 91.6 3.4e-18
NP_076872 (OMIM: 133200,220290,603324,612644) gap ( 270) 431 91.6 3.4e-18
XP_016875847 (OMIM: 129500,220290,304400,604418,61 ( 261) 427 90.8 5.6e-18
NP_006774 (OMIM: 129500,220290,304400,604418,61264 ( 261) 427 90.8 5.6e-18
XP_016875848 (OMIM: 129500,220290,304400,604418,61 ( 261) 427 90.8 5.6e-18
XP_016875849 (OMIM: 129500,220290,304400,604418,61 ( 261) 427 90.8 5.6e-18
NP_001103691 (OMIM: 129500,220290,304400,604418,61 ( 261) 427 90.8 5.6e-18
NP_001103690 (OMIM: 129500,220290,304400,604418,61 ( 261) 427 90.8 5.6e-18
XP_016875846 (OMIM: 129500,220290,304400,604418,61 ( 261) 427 90.8 5.6e-18
NP_001103689 (OMIM: 129500,220290,304400,604418,61 ( 261) 427 90.8 5.6e-18
NP_000157 (OMIM: 302800,304040) gap junction beta- ( 283) 413 88.2 3.7e-17
XP_016884897 (OMIM: 302800,304040) PREDICTED: gap ( 283) 413 88.2 3.7e-17
XP_011529209 (OMIM: 302800,304040) PREDICTED: gap ( 283) 413 88.2 3.7e-17
NP_001091111 (OMIM: 302800,304040) gap junction be ( 283) 413 88.2 3.7e-17
XP_005248773 (OMIM: 611921) PREDICTED: gap junctio ( 223) 407 87.0 6.7e-17
NP_940970 (OMIM: 611921) gap junction beta-7 prote ( 223) 407 87.0 6.7e-17
NP_005259 (OMIM: 604493) gap junction beta-5 prote ( 273) 398 85.3 2.6e-16
XP_005270808 (OMIM: 604493) PREDICTED: gap junctio ( 273) 398 85.3 2.6e-16
NP_065711 (OMIM: 607058) gap junction delta-2 prot ( 321) 399 85.6 2.6e-16
NP_689343 (OMIM: 607425) gap junction delta-3 prot ( 294) 362 78.6 3e-14
XP_016877927 (OMIM: 607058) PREDICTED: gap junctio ( 270) 331 72.7 1.6e-12
NP_699199 (OMIM: 611922) gap junction delta-4 prot ( 370) 300 66.9 1.2e-10
NP_853516 (OMIM: 611925) gap junction gamma-3 prot ( 279) 298 66.5 1.3e-10
>>NP_115991 (OMIM: 611924) gap junction alpha-10 protein (543 aa)
initn: 3781 init1: 3781 opt: 3781 Z-score: 3862.0 bits: 724.4 E(85289): 2.2e-208
Smith-Waterman score: 3781; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:1-543)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 TMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSSFGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSSFGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 QNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMRESGVWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 QNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMRESGVWI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 DRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 DRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 VRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGGGDYLWRDKIIHSIHSVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGGGDYLWRDKIIHSIHSVK
490 500 510 520 530 540
pF1KE0 FNS
:::
NP_115 FNS
>>NP_110399 (OMIM: 611923) gap junction alpha-9 protein (515 aa)
initn: 1190 init1: 1190 opt: 1213 Z-score: 1241.6 bits: 239.4 E(85289): 2e-62
Smith-Waterman score: 1219; 47.7% identity (70.1% similar) in 461 aa overlap (1-414:1-453)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
:::::::: ::::: :::..:::::::::::::::: :::::::.::::.: :::.:::
NP_110 MGDWNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
: :.:::.::::::::.::::.:::::::::::::::::::..:..::: :..::...:.
NP_110 CRNVCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQLRVELEE
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 PDLDL-EEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY
.... ....:...:: .::..: ..:.::.: :: :::.::.::::.:::::::::.::
NP_110 VEFEMPRDRRRLEQELCQLEKRK-LNKAPLRGTLLCTYVIHIFTRSVVEVGFMIGQYLLY
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
::...::.:: :::: .:::::::::::::.:::.:::.:::.::::::::::..::
NP_110 GFHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATISLFLNILEIFHLGFKKIK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKK--YSVAQ-QCMICSSLPERISPLQAN--NQQQVIRV
: :. : . . ..: :: .: .::. : .:: . : . : ..:. .
NP_110 RGLWGKYKLKKEHNE----FHANKAKQNVAKYQSTSANSLKRLPSAPDYNLLVEKQTHTA
240 250 260 270 280 290
300 310 320
pF1KE0 NVPK--SKTMWQIPQPRQLEVDP------------------------------SNGKKDW
:. :....: :.: . :. ::..::
NP_110 VYPSLNSSSVFQ-PNPDNHSVNDEKCILDEQETVLSNEISTLSTSCSHFQHISSNNNKDT
300 310 320 330 340 350
330 340 350 360 370
pF1KE0 SE---KDQHSGQLHVHSPCPWAGSAGNQHL-GQQS-DHSSFGLQNTMSQSWLGTTTAPRN
. :. ...:: . : : . :..: .. .:.: :: . . : :
NP_110 HKIFGKELNGNQLMEKRETEGKDSKRNYYSRGHRSIPGVAIDGENNMRQSPQTVFSLPAN
360 370 380 390 400 410
380 390 400 410 420 430
pF1KE0 C---PSFAVGTWEQSQDPEPSGEPLT-DLHSHCRDSEGSMRESGVWIDRSRPGSRKASFL
: : . .:: .: . : : : .:... : .:..:
NP_110 CDWKPRWLRATWGSSTEHENRGSPPKGNLKGQFR--KGTVRTLPPSQGDSQSLDIPNTAD
420 430 440 450 460 470
440 450 460 470 480 490
pF1KE0 SRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSMVRQAALPIMELSQ
NP_110 SLGGLSFEPGLVRTCNNPVCPPNHVVSLTNNLIGRRVPTDLQI
480 490 500 510
>>XP_011507719 (OMIM: 116200,600897,612474) PREDICTED: g (427 aa)
initn: 973 init1: 557 opt: 955 Z-score: 979.5 bits: 190.6 E(85289): 8.1e-48
Smith-Waterman score: 961; 38.4% identity (66.4% similar) in 450 aa overlap (1-435:1-425)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::.:::::. :::..:..:::.:::::.:.: .::: :: :::: :.:::.:::
XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQM-E
:.:.:::.::::: ::.:::::::::.:::.:.:::.. .: :: ..:. .: :
XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 NPDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY
: : : . .. .: .: :.: :::::. ::. ....::::..:.:.::
XP_011 NGGPD---QGSV----KKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLY
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
::.. :::.:.. ::::.::::::::::::::.::: :.:..::.::..:. :::.. :
XP_011 GFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGI-
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKS
:. :. .:. : . . .:.: ::. .. . : ...... : .
XP_011 RSALKRP----VEQPLGEIPEKSLHSIA-----VSSI-QKAKGYQLLEEEKIVSHYFPLT
240 250 260 270 280
300 310 320 330 340
pF1KE0 KT-MWQI-PQP----RQLEVDPSNGK-KDWSEKDQHS-------GQLHVHSPCPWAGSAG
.. : . : : :.: :.: : :. :.. : .:.. : : ..
XP_011 EVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGA
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 NQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSH
. ..:...... . .. ...:.. . :. .... ::..: ..
XP_011 EPEVGEKKEEA-----ERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLP
350 360 370 380 390
410 420 430 440 450 460
pF1KE0 CRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWEN
. . . : . : .:: :: .. ::
XP_011 AEKTPSLCPE--LTTDDARPLSRLSKASSRAR
400 410 420
>>XP_011507718 (OMIM: 116200,600897,612474) PREDICTED: g (433 aa)
initn: 973 init1: 557 opt: 955 Z-score: 979.4 bits: 190.6 E(85289): 8.2e-48
Smith-Waterman score: 963; 38.2% identity (66.2% similar) in 456 aa overlap (1-439:1-429)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::.:::::. :::..:..:::.:::::.:.: .::: :: :::: :.:::.:::
XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.:::.::::: ::.:::::::::.:::.:.:::.. .: :: ..:. .: : .
XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 ---PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI
:: : . .. .: .: :.: :::::. ::. ....::::..:.:.
XP_011 NGGPD-----QGSV----KKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYF
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK
::::.. :::.:.. ::::.::::::::::::::.::: :.:..::.::..:. :::..
XP_011 LYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 IMRTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
: :. :. .:. : . . .:.: ::. .. . : ...... :
XP_011 I-RSALKRP----VEQPLGEIPEKSLHSIA-----VSSI-QKAKGYQLLEEEKIVSHYFP
240 250 260 270 280
300 310 320 330 340
pF1KE0 KSKT-MWQI-PQP----RQLEVDPSNGK-KDWSEKDQHS-------GQLHVHSPCPWAGS
... : . : : :.: :.: : :. :.. : .:.. : :
XP_011 LTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEE
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 AGNQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLH
... ..:...... . .. ...:.. . :. .... ::..: ..
XP_011 GAEPEVGEKKEEA-----ERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQG
350 360 370 380 390
410 420 430 440 450 460
pF1KE0 SHCRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHW
. . . : . : .:: :: .. :: :.
XP_011 LPAEKTPSLCPE--LTTDDARPLSRLSKASSRARSDDLTV
400 410 420 430
470 480 490 500 510 520
pF1KE0 ENSPSPLPSVTGHRTSMVRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGG
>>NP_005258 (OMIM: 116200,600897,612474) gap junction al (433 aa)
initn: 973 init1: 557 opt: 955 Z-score: 979.4 bits: 190.6 E(85289): 8.2e-48
Smith-Waterman score: 963; 38.2% identity (66.2% similar) in 456 aa overlap (1-439:1-429)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::.:::::. :::..:..:::.:::::.:.: .::: :: :::: :.:::.:::
NP_005 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.:::.::::: ::.:::::::::.:::.:.:::.. .: :: ..:. .: : .
NP_005 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 ---PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI
:: : . .. .: .: :.: :::::. ::. ....::::..:.:.
NP_005 NGGPD-----QGSV----KKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYF
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK
::::.. :::.:.. ::::.::::::::::::::.::: :.:..::.::..:. :::..
NP_005 LYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE0 IMRTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
: :. :. .:. : . . .:.: ::. .. . : ...... :
NP_005 I-RSALKRP----VEQPLGEIPEKSLHSIA-----VSSI-QKAKGYQLLEEEKIVSHYFP
240 250 260 270 280
300 310 320 330 340
pF1KE0 KSKT-MWQI-PQP----RQLEVDPSNGK-KDWSEKDQHS-------GQLHVHSPCPWAGS
... : . : : :.: :.: : :. :.. : .:.. : :
NP_005 LTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEE
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 AGNQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLH
... ..:...... . .. ...:.. . :. .... ::..: ..
NP_005 GAEPEVGEKKEEA-----ERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQG
350 360 370 380 390
410 420 430 440 450 460
pF1KE0 SHCRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHW
. . . : . : .:: :: .. :: :.
NP_005 LPAEKTPSLCPE--LTTDDARPLSRLSKASSRARSDDLTV
400 410 420 430
470 480 490 500 510 520
pF1KE0 ENSPSPLPSVTGHRTSMVRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGG
>>NP_068773 (OMIM: 121015,601885) gap junction alpha-3 p (435 aa)
initn: 945 init1: 551 opt: 955 Z-score: 979.4 bits: 190.6 E(85289): 8.2e-48
Smith-Waterman score: 955; 52.9% identity (79.7% similar) in 261 aa overlap (1-258:1-253)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..:: .::... :::..::.:::.:::::.::: .:::::: :::: :.:::.:::
NP_068 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.::: ::::: ::::.:::::::.:.:.:.::.:. .: :: ..:.. . . . :.
NP_068 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEE-QLKRES
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
:. : : : : ... :.. . : ::::::..:. ....::::. :::.:::
NP_068 PS-PKEPPQ--DNPSSR-DDRGRVR---MAGALLRTYVFNIIFKTLFEVGFIAGQYFLYG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
:...:::.: . ::::.::::.:::::::::..:: ..: :::::.:::.::: .:. .
NP_068 FELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQ
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 TLYKKSSSEGIEDETG---PPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
. .. . .. : : ::
NP_068 GVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPP
240 250 260 270 280 290
>>XP_011533350 (OMIM: 121015,601885) PREDICTED: gap junc (435 aa)
initn: 945 init1: 551 opt: 955 Z-score: 979.4 bits: 190.6 E(85289): 8.2e-48
Smith-Waterman score: 955; 52.9% identity (79.7% similar) in 261 aa overlap (1-258:1-253)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..:: .::... :::..::.:::.:::::.::: .:::::: :::: :.:::.:::
XP_011 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.::: ::::: ::::.:::::::.:.:.:.::.:. .: :: ..:.. . . . :.
XP_011 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEE-QLKRES
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
:. : : : : ... :.. . : ::::::..:. ....::::. :::.:::
XP_011 PS-PKEPPQ--DNPSSR-DDRGRVR---MAGALLRTYVFNIIFKTLFEVGFIAGQYFLYG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
:...:::.: . ::::.::::.:::::::::..:: ..: :::::.:::.::: .:. .
XP_011 FELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQ
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 TLYKKSSSEGIEDETG---PPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
. .. . .. : : ::
XP_011 GVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPP
240 250 260 270 280 290
>>NP_859054 (OMIM: 108770,121013,612474,614049) gap junc (358 aa)
initn: 917 init1: 558 opt: 916 Z-score: 940.8 bits: 183.2 E(85289): 1.2e-45
Smith-Waterman score: 916; 44.4% identity (69.1% similar) in 324 aa overlap (1-320:1-320)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::..:::::.:::.:::.:::.::::::::: .:::. : :::. : :.: :::
NP_859 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.:::.::::: ::.:::::::::.:::::::::.. .: :: . :. ::.
NP_859 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAE--RAKEVR
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
. . : :: :: . .. :.: :: ::: :: :...::::..:::..::
NP_859 GSGSYEYPVAEKAELSCWEEGN--GRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
. . :. : . :::. :.:.:::::::..:..:: ..::.::::.. :..::: .:: .
NP_859 IFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQ
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVA----QQCMICSSLPERISPLQANNQQQVIRVNV
. : . . . .:: . . . .::. . . ..:.. : .: :.
NP_859 RFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 PKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHS
.. : : . .. :.:
NP_859 VTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDL
300 310 320 330 340 350
>>XP_016856533 (OMIM: 108770,121013,612474,614049) PREDI (358 aa)
initn: 917 init1: 558 opt: 916 Z-score: 940.8 bits: 183.2 E(85289): 1.2e-45
Smith-Waterman score: 916; 44.4% identity (69.1% similar) in 324 aa overlap (1-320:1-320)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::..:::::.:::.:::.:::.::::::::: .:::. : :::. : :.: :::
XP_016 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.:::.::::: ::.:::::::::.:::::::::.. .: :: . :. ::.
XP_016 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAE--RAKEVR
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
. . : :: :: . .. :.: :: ::: :: :...::::..:::..::
XP_016 GSGSYEYPVAEKAELSCWEEGN--GRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
. . :. : . :::. :.:.:::::::..:..:: ..::.::::.. :..::: .:: .
XP_016 IFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQ
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVA----QQCMICSSLPERISPLQANNQQQVIRVNV
. : . . . .:: . . . .::. . . ..:.. : .: :.
XP_016 RFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 PKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHS
.. : : . .. :.:
XP_016 VTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDL
300 310 320 330 340 350
>>NP_005257 (OMIM: 108770,121013,612474,614049) gap junc (358 aa)
initn: 917 init1: 558 opt: 916 Z-score: 940.8 bits: 183.2 E(85289): 1.2e-45
Smith-Waterman score: 916; 44.4% identity (69.1% similar) in 324 aa overlap (1-320:1-320)
10 20 30 40 50 60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
::::..::..:::::.:::.:::.:::.::::::::: .:::. : :::. : :.: :::
NP_005 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
:.:.:::.::::: ::.:::::::::.:::::::::.. .: :: . :. ::.
NP_005 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAE--RAKEVR
70 80 90 100 110
130 140 150 160 170 180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
. . : :: :: . .. :.: :: ::: :: :...::::..:::..::
NP_005 GSGSYEYPVAEKAELSCWEEGN--GRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
. . :. : . :::. :.:.:::::::..:..:: ..::.::::.. :..::: .:: .
NP_005 IFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQ
180 190 200 210 220 230
250 260 270 280 290
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVA----QQCMICSSLPERISPLQANNQQQVIRVNV
. : . . . .:: . . . .::. . . ..:.. : .: :.
NP_005 RFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE0 PKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHS
.. : : . .. :.:
NP_005 VTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDL
300 310 320 330 340 350
543 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:34:28 2016 done: Thu Nov 3 14:34:30 2016
Total Scan time: 9.160 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]