Result of FASTA (omim) for
pFN21AE0233
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0233, 407 aa
1>>>pF1KE0233 407 - 407 aa - 407 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1299+/-0.000281; mu= 15.0090+/- 0.018
mean_var=108.3493+/-21.752, 0's: 0 Z-trim(120.9): 67 B-trim: 0 in 0/56
Lambda= 0.123214
statistics sampled from 36669 (36737) to 36669 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.431), width: 16
Scan time: 8.920
The best scores are: opt bits E(85289)
NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 2825 512.3 8.3e-145
XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 2825 512.3 8.3e-145
NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 1383 256.0 1.1e-67
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 314 66.0 2e-10
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 310 65.3 3.4e-10
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 308 65.0 4.8e-10
NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 302 63.9 8.6e-10
NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 302 63.9 9e-10
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 299 63.4 1.3e-09
NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 298 63.1 1.4e-09
NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 298 63.1 1.4e-09
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 293 62.1 1.7e-09
NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 293 62.2 2.5e-09
XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 293 62.2 2.5e-09
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 293 62.2 2.5e-09
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 294 62.5 2.7e-09
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 294 62.5 2.7e-09
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 294 62.5 2.7e-09
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 287 61.0 3.6e-09
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 287 61.2 5.6e-09
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 287 61.2 5.8e-09
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 275 59.1 2.6e-08
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 270 58.1 3.9e-08
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 270 58.1 3.9e-08
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 270 58.1 4e-08
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 270 58.2 4.4e-08
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 270 58.2 4.4e-08
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 270 58.2 4.4e-08
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 270 58.2 4.4e-08
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 263 57.0 1.2e-07
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 259 56.2 1.7e-07
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 259 56.2 1.8e-07
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 250 54.6 5.3e-07
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 247 54.1 7.2e-07
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 238 52.3 1.4e-06
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 238 52.4 2e-06
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 232 51.4 4.2e-06
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 217 48.7 3e-05
NP_001316683 (OMIM: 112265) bone morphogenetic pro ( 417) 210 47.5 7.2e-05
XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 206 46.7 8.7e-05
NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 205 46.5 0.00011
XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011
NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011
XP_006714648 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011
NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011
XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011
NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011
NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011
XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 46.8 0.00011
NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 206 46.8 0.00011
>>NP_005802 (OMIM: 603936) growth/differentiation factor (407 aa)
initn: 2825 init1: 2825 opt: 2825 Z-score: 2720.7 bits: 512.3 E(85289): 8.3e-145
Smith-Waterman score: 2825; 100.0% identity (100.0% similar) in 407 aa overlap (1-407:1-407)
10 20 30 40 50 60
pF1KE0 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ
310 320 330 340 350 360
370 380 390 400
pF1KE0 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
:::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
370 380 390 400
>>XP_006719257 (OMIM: 603936) PREDICTED: growth/differen (407 aa)
initn: 2825 init1: 2825 opt: 2825 Z-score: 2720.7 bits: 512.3 E(85289): 8.3e-145
Smith-Waterman score: 2825; 100.0% identity (100.0% similar) in 407 aa overlap (1-407:1-407)
10 20 30 40 50 60
pF1KE0 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ
310 320 330 340 350 360
370 380 390 400
pF1KE0 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
:::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
370 380 390 400
>>NP_005250 (OMIM: 601788,614160) growth/differentiation (375 aa)
initn: 1349 init1: 1088 opt: 1383 Z-score: 1335.9 bits: 256.0 E(85289): 1.1e-67
Smith-Waterman score: 1645; 65.1% identity (84.9% similar) in 352 aa overlap (58-407:34-375)
30 40 50 60 70 80
pF1KE0 PAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDG-CPVCVWRQHSRELRLESIKSQILSK
: .: : .:.:::... :.:.:: :::::
NP_005 LQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSK
10 20 30 40 50 60
90 100 110 120 130 140
pF1KE0 LRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMA
:::. :::::..:..:::::::::....: .: : : . . ::.:.:::::::.:.:
NP_005 LRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDD-SSDGSLEDDDYHATTETIITMP
70 80 90 100 110 120
150 160 170 180 190 200
pF1KE0 QETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRL-KPLTG
:.: .:.::.: :: :.:: :....::.:::::.::::: :.::..::::: ::.
NP_005 TESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKD
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE0 EGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPS
: :. :::::.... .: ::::: : ::..:..::.:: ::::.:.: .
NP_005 ---------GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDEN
190 200 210 220 230
270 280 290 300 310 320
pF1KE0 GTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAF
: ::::: ::: .::.::.:..: .. :::::..::::::::.::::::::::::::::
NP_005 GHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAF
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE0 GWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYF
::::::::::::::::::.::..:.:::::::::.:::::::::::::::::::::::::
NP_005 GWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYF
300 310 320 330 340 350
390 400
pF1KE0 NDKQQIIYGKIPGMVVDRCGCS
: :.::::::::.:::::::::
NP_005 NGKEQIIYGKIPAMVVDRCGCS
360 370
>>NP_055297 (OMIM: 608748) bone morphogenetic protein 10 (424 aa)
initn: 315 init1: 136 opt: 314 Z-score: 308.2 bits: 66.0 E(85289): 2e-10
Smith-Waterman score: 314; 36.9% identity (57.3% similar) in 157 aa overlap (258-406:278-423)
230 240 250 260 270 280
pF1KE0 LHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMEL
.. .: : : : ::: :.: .
NP_055 KHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLD--SFSSGPGEEALLQMRSN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 RVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCE
. ..: : ::: .. . : : :: .::. .::: ::::: :.: : : :.
NP_055 IIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCN
310 320 330 340 350
350 360 370 380 390
pF1KE0 YMFMQKY-PHTHLVQQA-----NPRGSAGPCCTPTKMSPINMLYFNDKQQIIYG-KIPGM
: . .. : : . :: : . .. ::.:::. ::..::. :: . : : ::
NP_055 YPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYL-DKGVVTYKFKYEGM
360 370 380 390 400 410
400
pF1KE0 VVDRCGCS
.:..:::
NP_055 AVSECGCR
420
>>NP_878248 (OMIM: 604651) growth/differentiation factor (450 aa)
initn: 320 init1: 152 opt: 310 Z-score: 304.0 bits: 65.3 E(85289): 3.4e-10
Smith-Waterman score: 320; 30.4% identity (57.0% similar) in 230 aa overlap (186-406:240-449)
160 170 180 190 200 210
pF1KE0 DGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGG
::: : : . :: : : ::::..
NP_878 AFDVADAMRRHRREPRPPRAFCLLLRAVAGPVPSP----LALRRL----GFGWPGGGGSA
210 220 230 240 250 260
220 230 240 250 260 270
pF1KE0 RRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLG
.. :.. . . ::. . .:. :... : : . : .: : .. . .
NP_878 AEE---RAVLV-VSSRTQRKESL-FREI-----RAQARALGAAL-ASEPL-PDPGTGTAS
270 280 290 300
280 290 300 310 320 330
pF1KE0 PGAEGLHPFMELRVLENTKRSRRNLGLDCDEHS--SESRCCRYPLTVDFEAFGWD-WIIA
: : . .: .:. .. . : :. ..::: : :: :::. .::: ::::
NP_878 PRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIA
310 320 330 340 350 360
340 350 360 370 380
pF1KE0 PKRYKANYCSGQCEYMFMQKY-PHTHLVQQA-----NPRGSAGPCCTPTKMSPINMLYFN
: :.: .: : :.. . .. : .: . :. : .. . ::.:...:::..::..
NP_878 PLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYID
370 380 390 400 410 420
390 400
pF1KE0 DKQQIIYGKIPGMVVDRCGCS
....: . :::. :::
NP_878 AANNVVYKQYEDMVVEACGCR
430 440 450
>>NP_001709 (OMIM: 112266) bone morphogenetic protein 6 (513 aa)
initn: 314 init1: 170 opt: 308 Z-score: 301.3 bits: 65.0 E(85289): 4.8e-10
Smith-Waterman score: 335; 31.7% identity (56.2% similar) in 208 aa overlap (235-406:305-512)
210 220 230 240 250 260
pF1KE0 GEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDP
: .:. . . : :: : :.....
NP_001 SIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTR
280 290 300 310 320 330
270 280 290 300
pF1KE0 SGTDLAVTSLG-PGAEGLH---PFM---------ELRVLENTKRSRRNLGLD--------
.:. . . : : .: . ::: ..:. .... ::. . .
NP_001 DGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDV
340 350 360 370 380 390
310 320 330 340 350
pF1KE0 ------CDEHSSESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMF---MQ
: .::: . : .. : :.:. .:: ::::::: : ::::.:.: . . :.
NP_001 ARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMN
400 410 420 430 440 450
360 370 380 390 400
pF1KE0 KYPHT---HLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
:. ::. ::. :::.:::.. :..:::.:....: : .::: :::
NP_001 ATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
460 470 480 490 500 510
>>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa)
initn: 325 init1: 119 opt: 302 Z-score: 296.8 bits: 63.9 E(85289): 8.6e-10
Smith-Waterman score: 353; 25.5% identity (49.2% similar) in 419 aa overlap (54-407:16-414)
30 40 50 60 70 80
pF1KE0 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI
.:: . : . : :. :.:.:..::
NP_003 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI
10 20 30 40
90 100 110 120 130
pF1KE0 LSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP---------EDFLEEDE
::::.: :. : ..:: ....... : :: : ..:
NP_003 LSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDEE
50 60 70 80 90
140 150 160 170 180
pF1KE0 YHATTETVISMAQ--ETDPAVQ-TDGSPLCCHFHFSPKVMF---TKVLKAQLWVY--LRP
:.: :.: .. :. : : .:. ..: ....::.. :. :
NP_003 YYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE0 ---VPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQV
::. :::. : ::. .:.: . .: . . :.: :.: ..
NP_003 KARVPEQRIELYQILKSKDLTSPT--------QRYIDSKVVKTRAE---GEWLSFDVTDA
160 170 180 190 200
250 260 270
pF1KE0 LHSWFRQPQSNWGIEIN------AFDPS---------------------------GTDLA
.: :... . : :..:. .: :: : . .
NP_003 VHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKT
210 220 230 240 250 260
280 290 300 310 320
pF1KE0 VTSLGPGAEGLHPFMELRVL--------ENTKRSRRNLGLDCDEHSSESRCCRYPLTVDF
. : : : . : .: ....:..: : .. .. :: :: .::
NP_003 IKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDF
270 280 290 300 310 320
330 340 350 360 370
pF1KE0 EA-FGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMS
. .:: :: :: :.::.:.: : :.. . :.. : . ::..::.:::. .
NP_003 KRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLE
330 340 350 360 370 380
380 390 400
pF1KE0 PINMLYFNDKQQIIYGKIPGMVVDRCGCS
:...::. : : .. .:.: : ::
NP_003 PLTILYYIGKTPKIE-QLSNMIVKSCKCS
390 400 410
>>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa)
initn: 325 init1: 119 opt: 302 Z-score: 296.4 bits: 63.9 E(85289): 9e-10
Smith-Waterman score: 330; 25.3% identity (47.4% similar) in 447 aa overlap (54-407:16-442)
30 40 50 60 70 80
pF1KE0 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI
.:: . : . : :. :.:.:..::
NP_001 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI
10 20 30 40
90 100 110 120 130
pF1KE0 LSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQP---------EDFLEEDE
::::.: :. : ..:: ....... : :: : ..:
NP_001 LSKLKLTSPPEDYPEP-----EEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDEE
50 60 70 80 90
140 150 160
pF1KE0 YHATTETVISM-----AQETDPAVQT-DGS--PLC-------CHF-------HFSPK---
:.: :.: .. . :.: : .:: :: : . . :
NP_001 YYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRI
100 110 120 130 140 150
170 180 190 200 210
pF1KE0 VMF---------TKVLKAQLWVY--LRP---VPRPATVYLQILRLKPLTGEGTAGGGGGG
: : ....::.. :. : ::. :::. : ::.
NP_001 VRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPT--------
160 170 180 190 200
220 230 240 250 260
pF1KE0 RRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN------AFDPS----
.:.: . .: . . :.: :.: ...: :... . : :..:. .: ::
NP_001 QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYI
210 220 230 240 250 260
270 280 290
pF1KE0 -----------------------GTDLAVTSLGPGAEGLHPFMELRVL--------ENTK
: . .. : : : . : .: ....
NP_001 IPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNR
270 280 290 300 310 320
300 310 320 330 340 350
pF1KE0 RSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQKY
:..: : .. .. :: :: .::. .:: :: :: :.::.:.: : :.. .
NP_001 RKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDT
330 340 350 360 370 380
360 370 380 390 400
pF1KE0 PHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
:.. : . ::..::.:::. . :...::. : : .. .:.: : ::
NP_001 QHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS
390 400 410 420 430 440
>>NP_001001557 (OMIM: 118100,601147,613094,613703,615360 (455 aa)
initn: 250 init1: 146 opt: 299 Z-score: 293.4 bits: 63.4 E(85289): 1.3e-09
Smith-Waterman score: 306; 36.7% identity (62.0% similar) in 150 aa overlap (275-406:306-454)
250 260 270 280 290
pF1KE0 HSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHP----FMELRV-LENTKRSRRN
: :::: : . : : . : ::
NP_001 ALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRR
280 290 300 310 320 330
300 310 320 330 340 350
pF1KE0 LGLDC---DEHSSESR--CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKY
.. .:...:: : . :: :.:. .::: ::::: .:.: .: : :.. . ..
NP_001 TAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHL
340 350 360 370 380 390
360 370 380 390 400
pF1KE0 -PHTHLVQQA-----NPRGSAGP-CCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC
: .: . :. .: ::. : ::.:::..::..::.. ....: . :::. :::
NP_001 EPTNHAIIQTLMNSMDP-GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC
400 410 420 430 440 450
pF1KE0 S
NP_001 R
>>NP_003230 (OMIM: 107970,190230,615582) transforming gr (412 aa)
initn: 325 init1: 119 opt: 298 Z-score: 293.0 bits: 63.1 E(85289): 1.4e-09
Smith-Waterman score: 377; 27.8% identity (51.8% similar) in 396 aa overlap (70-407:34-412)
40 50 60 70 80 90
pF1KE0 AAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPN--ISR
: .. :.:.:..:::::::: :. .
NP_003 HLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMT
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE0 EVVKQLLPKAPPLQQILD-LHDFQGDALQPEDFLEEDEYHATT----ETVISMAQETDPA
.: :.: ...:. .: . .. :. :.::.: . . ..:.... :
NP_003 HVPYQVLALYNSTRELLEEMHGEREEGCTQEN--TESEYYAKEIHKFDMIQGLAEHNELA
70 80 90 100 110 120
160 170 180 190 200
pF1KE0 VQTDG-SPLCCHFHFSP-KVMFTKVLKAQLWVYLRPVPRPAT------VYL-QILRLKPL
: : . .:. : . :....:.. : :: :: :.. . : :::: :
NP_003 VCPKGITSKVFRFNVSSVEKNRTNLFRAEFRV-LR-VPNPSSKRNEQRIELFQILR--P-
130 140 150 160 170
210 220 230 240 250 260
pF1KE0 TGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN---
: : .:.: ..: . ...: :.: .... :. . .:: :.::.
NP_003 -DEHIAK-----QRYIGGKNLPTR---GTAEWLSFDVTDTVREWLLRRESNLGLEISIHC
180 190 200 210 220
270 280
pF1KE0 ---AFDPSGTDLA-------VTSLGPGAEGLH----------------PFMELRV-----
.:.:.: : . : : : : . : .
NP_003 PCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHR
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE0 LENT----KRSRRNLGLDCDEHSSESRCCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQ
:.: .:..: : . .. : :: :: .:: . .:: :. :: : ::.:::
NP_003 LDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE0 CEYMFMQKYPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVV
: :. :. : . ::..::.:::.: . :...::. . . .. .:::
NP_003 CPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVV
350 360 370 380 390 400
pF1KE0 DRCGCS
: ::
NP_003 KSCKCS
410
407 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 01:30:01 2016 done: Tue Nov 8 01:30:02 2016
Total Scan time: 8.920 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]