FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9813, 272 aa
  1>>>pF1KB9813 272 - 272 aa - 272 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.1227+/-0.000286; mu= 13.0199+/- 0.018
 mean_var=113.1788+/-22.768, 0's: 0 Z-trim(121.1): 24  B-trim: 33 in 1/56
 Lambda= 0.120557
 statistics sampled from 37255 (37280) to 37255 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.437), width:  16
 Scan time:  8.460

The best scores are:                                      opt bits E(85289)
NP_478126 (OMIM: 606490) exosome complex component ( 272) 1805 323.9   2e-88
NP_061910 (OMIM: 606491) exosome complex component ( 245)  274 57.6 2.6e-08
XP_011515436 (OMIM: 606491) PREDICTED: exosome com ( 147)  202 44.9 0.00011
NP_064543 (OMIM: 606492) exosome complex component ( 235)  188 42.6 0.00081


>>NP_478126 (OMIM: 606490) exosome complex component MTR  (272 aa)
 initn: 1805 init1: 1805 opt: 1805  Z-score: 1708.6  bits: 323.9 E(85289): 2e-88
Smith-Waterman score: 1805; 100.0% identity (100.0% similar) in 272 aa overlap (1-272:1-272)

               10        20        30        40        50        60
pF1KB9 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_478 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_478 KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 ELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_478 ELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDLV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 VGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_478 VGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAEA
              190       200       210       220       230       240

              250       260       270  
pF1KB9 VRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP
       ::::::::::::::::::::::::::::::::
NP_478 VRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP
              250       260       270  

>>NP_061910 (OMIM: 606491) exosome complex component RRP  (245 aa)
 initn: 256 init1: 136 opt: 274  Z-score: 270.1  bits: 57.6 E(85289): 2.6e-08
Smith-Waterman score: 359; 34.2% identity (65.8% similar) in 196 aa overlap (31-225:17-199)

               10        20        30        40        50        60
pF1KB9 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAGGT
                                     :   .:: . :: :...:: ::::.: :.:
NP_061               MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNT
                             10        20        30        40      

               70        80        90       100        110         
pF1KB9 KVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFA-GRRRRAPPGGCEE
       :.: .: ::.. .:..  . :           :. . :..  : :. :.:.: : :  . 
NP_061 KALAVVYGPHEIRGSRARALPD----------RALVNCQYSSATFSTGERKRRPHGDRKS
         50        60                  70        80        90      

     120       130       140       150       160       170         
pF1KB9 RELALALQEALEPAVRLGRYPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYDL
        :..: :....: :.    .::.:... . .:.  :.. :: ..::.::. :::. : :.
NP_061 CEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDF
        100       110       120       130       140       150      

     180       190       200       210       220       230         
pF1KB9 VVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTESWAE
       : .:. ... : :   : : ...::  ..  :..::.:. .:.: :              
NP_061 VCACSAGFVDGTA---LADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERV
        160          170       180       190       200       210   

     240       250       260       270  
pF1KB9 AVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP
                                        
NP_061 LEAAAQAARDVHTLLDRVVRQHVREASILLGD 
           220       230       240      

>>XP_011515436 (OMIM: 606491) PREDICTED: exosome complex  (147 aa)
 initn: 152 init1: 136 opt: 202  Z-score: 205.4  bits: 44.9 E(85289): 0.00011
Smith-Waterman score: 202; 33.7% identity (71.2% similar) in 104 aa overlap (122-225:1-101)

             100       110       120       130       140       150 
pF1KB9 LRGRLLCDFRRAPFAGRRRRAPPGGCEERELALALQEALEPAVRLGRYPRAQLEVSALLL
                                     ..: :....: :.    .::.:... . .:
XP_011                               MGLQLRQTFEAAILTQLHPRSQIDIYVQVL
                                             10        20        30

             160       170       180       190       200       210 
pF1KB9 EDGGSALAAALTAAALALADAGVEMYDLVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGL
       .  :.. :: ..::.::. :::. : :.: .:. ... : :   : : ...::  ..  :
XP_011 QADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTA---LADLSHVEEAAGGPQL
               40        50        60        70           80       

             220       230       240       250       260       270 
pF1KB9 TVALMPVLNQVAGLLGSGEGGLTESWAEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQ
       ..::.:. .:.: :                                              
XP_011 ALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD
        90       100       110       120       130       140       

>>NP_064543 (OMIM: 606492) exosome complex component RRP  (235 aa)
 initn: 182 init1: 121 opt: 188  Z-score: 189.5  bits: 42.6 E(85289): 0.00081
Smith-Waterman score: 213; 30.0% identity (53.4% similar) in 253 aa overlap (12-261:3-230)

               10        20        30         40        50         
pF1KB9 MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDP-TRLRPVYARAGLLSQAKGSAYLEAGG
                  ::..      :..  . . : :   ::    . .:::.  ::: .  : 
NP_064          MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGD
                        10        20        30        40        50 

      60        70        80        90       100       110         
pF1KB9 TKVLCAVSGPRQAEGGERGGGPAGAGGEAPAALRGRLLCDFRRAPFAGRRRRAPPGGCEE
       :.:: .: :: ... ...  . :       . ::          :  :      ::  :.
NP_064 TSVLAGVYGPAEVKVSKEIFNKA----TLEVILR----------PKIGL-----PGVAEK
              60        70            80                       90  

     120       130        140       150       160       170        
pF1KB9 RELALALQEALEPAVRLGR-YPRAQLEVSALLLEDGGSALAAALTAAALALADAGVEMYD
        .  : .... : :: ::  .::... :   .. :.:: ::  :.:: .::.:::: :  
NP_064 SRERL-IRNTCE-AVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRA
             100        110       120       130       140       150

      180       190       200       210       220       230        
pF1KB9 LVVGCGLSLAPGPAPTWLLDPTRLEEERAAAGLTVALMPVLNQVAGLLGSGEGGLTES-W
       :   ::.. :     : .::::  .:..: : :: ::  :  ..  :..: .:  ...  
NP_064 LF--CGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKL--LMSSTKGLYSDTEL
                160       170       180       190         200      

       240       250       260       270  
pF1KB9 AEAVRLGLEGCQRLYPVLQQSLVRAARRRGAAAQP
        . .  .  . :...   ..:: :           
NP_064 QQCLAAAQAASQHVFRFYRESLQRRYSKS      
        210       220       230           




272 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 07:38:49 2016 done: Tue Nov  8 07:38:50 2016
 Total Scan time:  8.460 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]