Result of FASTA (omim) for
pFN21AB9099
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9099, 222 aa
1>>>pF1KB9099 222 - 222 aa - 222 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.5578+/-0.000381; mu= 18.1679+/- 0.023
mean_var=64.7872+/-13.093, 0's: 0 Z-trim(112.2): 38 B-trim: 0 in 0/50
Lambda= 0.159342
statistics sampled from 21057 (21081) to 21057 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.247), width: 16
Scan time: 6.050
The best scores are: opt bits E(85289)
NP_000718 (OMIM: 114209) voltage-dependent calcium ( 222) 1518 357.6 9.7e-99
NP_665813 (OMIM: 606898) voltage-dependent calcium ( 260) 559 137.2 2.5e-32
XP_006723379 (OMIM: 606898) PREDICTED: voltage-dep ( 189) 414 103.7 2.2e-22
NP_665814 (OMIM: 606898) voltage-dependent calcium ( 214) 302 78.0 1.3e-14
NP_114103 (OMIM: 606898) voltage-dependent calcium ( 189) 204 55.4 7.4e-08
XP_016882582 (OMIM: 606899) PREDICTED: voltage-dep ( 275) 158 45.0 0.00015
NP_114102 (OMIM: 606899) voltage-dependent calcium ( 275) 158 45.0 0.00015
NP_085915 (OMIM: 154045,615277) lens fiber membran ( 215) 144 41.7 0.0011
NP_006069 (OMIM: 602911,614256) voltage-dependent ( 323) 138 40.5 0.004
>>NP_000718 (OMIM: 114209) voltage-dependent calcium cha (222 aa)
initn: 1518 init1: 1518 opt: 1518 Z-score: 1893.7 bits: 357.6 E(85289): 9.7e-99
Smith-Waterman score: 1518; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222)
10 20 30 40 50 60
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 IPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GSLCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GSLCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSW
130 140 150 160 170 180
190 200 210 220
pF1KB9 SFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH
::::::::::::::::::::::::::::::::::::::::::
NP_000 SFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH
190 200 210 220
>>NP_665813 (OMIM: 606898) voltage-dependent calcium cha (260 aa)
initn: 584 init1: 328 opt: 559 Z-score: 701.3 bits: 137.2 E(85289): 2.5e-32
Smith-Waterman score: 559; 39.7% identity (72.1% similar) in 219 aa overlap (8-215:38-252)
10 20 30
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP
::...:. .: .::. .: :. :. :.
NP_665 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS
. . ...:::::.:::. :::: .:.: :::: :::: ::.::. :. ::..
NP_665 YKANGSAVCEAAHLGLWKACTKRLWQADVPVD-RDTCGPAELPGEANCTYFKFFTTGENA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL
.::. ::.:: ...::.::...:. . :: ::... :.: ..::: ... ....:: .:
NP_665 RIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSGLLLL
130 140 150 160 170 180
160 170 180 190 200
pF1KB9 VSVEVMRQSVKRMI-----DSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRM
::.::.:.::. .. . . . : ::::..:. .: ..:.::. .::..::
NP_665 VSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSW
190 200 210 220 230 240
210 220
pF1KB9 PRNPWES-CMDAEPEH
: : : :
NP_665 P---WGSLCPKRGHRAT
250 260
>>XP_006723379 (OMIM: 606898) PREDICTED: voltage-depende (189 aa)
initn: 425 init1: 264 opt: 414 Z-score: 523.0 bits: 103.7 E(85289): 2.2e-22
Smith-Waterman score: 414; 39.2% identity (75.2% similar) in 153 aa overlap (8-155:38-189)
10 20 30
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP
::...:. .: .::. .: :. :. :.
XP_006 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS
. . ...:::::.:::. :::: .:.: . :::: :::: ::.::. :. ::..
XP_006 YKANGSAVCEAAHLGLWKACTKRLWQADVPVDRD-TCGPAELPGEANCTYFKFFTTGENA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL
.::. ::.:: ...::.::...:. . :: ::... :.: ..::: ... ..... .:
XP_006 RIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSASQML
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 VSVEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRNPW
..
XP_006 PAI
>>NP_665814 (OMIM: 606898) voltage-dependent calcium cha (214 aa)
initn: 467 init1: 161 opt: 302 Z-score: 383.1 bits: 78.0 E(85289): 1.3e-14
Smith-Waterman score: 348; 32.9% identity (55.3% similar) in 219 aa overlap (8-215:38-206)
10 20 30
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP
::...:. .: .::. .: :. :. :.
NP_665 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS
. . ...:::::.:::. :::: .:.: :::: :::: ::.::. :. ::..
NP_665 YKANGSAVCEAAHLGLWKACTKRLWQADVPVD-RDTCGPAELPGEANCTYFKFFTTGENA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL
.::. ::.: :: .:
NP_665 RIFQRTTKK----------------------------------------------GLLLL
130 140
160 170 180 190 200
pF1KB9 VSVEVMRQSVKRMI-----DSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRM
::.::.:.::. .. . . . : ::::..:. .: ..:.::. .::..::
NP_665 VSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSW
150 160 170 180 190 200
210 220
pF1KB9 PRNPWES-CMDAEPEH
: : : :
NP_665 P---WGSLCPKRGHRAT
210
>>NP_114103 (OMIM: 606898) voltage-dependent calcium cha (189 aa)
initn: 322 init1: 162 opt: 204 Z-score: 262.1 bits: 55.4 E(85289): 7.4e-08
Smith-Waterman score: 204; 41.9% identity (68.9% similar) in 74 aa overlap (8-76:38-110)
10 20 30
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP
::...:. .: .::. .: :. :. :.
NP_114 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS
. . ...:::::.:::. :::: .:.: :::: :::
NP_114 YKANGSAVCEAAHLGLWKACTKRLWQADVPVD-RDTCGPAELPGGLLLLVSLEVFRHSVR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL
NP_114 ALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSWPWGSLCPKRGH
130 140 150 160 170 180
>>XP_016882582 (OMIM: 606899) PREDICTED: voltage-depende (275 aa)
initn: 114 init1: 52 opt: 158 Z-score: 202.8 bits: 45.0 E(85289): 0.00015
Smith-Waterman score: 158; 25.6% identity (55.8% similar) in 199 aa overlap (19-203:20-201)
10 20 30 40 50
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPH-MEHHNTTCE---AAHFGLWR
:..:. :: ::.: . . .: : : : : ::::
XP_016 MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQNQTTEVKMALHAGLWR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 ICTKRIPMDDSKTCGPITLPG-EKN-CSYFRHFNPGESSEIFEFTTQKEYSI-SAAAIAI
.: . : ::. : ..: : . . : : . .. .:. . .
XP_016 VCF---------------FAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATPFPM
70 80 90 100
120 130 140 150 160
pF1KB9 FSLGFIILGSLCVLLSLGK---KRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMI---
:: :... .. :. ..:. .: : ...:. ..:: ..:.. .. .:.. .
XP_016 VSL-FLVFTAF-VISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNR
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB9 DSEDTVWIEYYYSWSFACACAAFILLFLGG-LALLLFSLPRMPRNPWESCMDAEPEH
: . ...: :.:::: : ..:.: .: ... ::.
XP_016 PSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSD
170 180 190 200 210 220
XP_016 CSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC
230 240 250 260 270
>>NP_114102 (OMIM: 606899) voltage-dependent calcium cha (275 aa)
initn: 114 init1: 52 opt: 158 Z-score: 202.8 bits: 45.0 E(85289): 0.00015
Smith-Waterman score: 158; 25.6% identity (55.8% similar) in 199 aa overlap (19-203:20-201)
10 20 30 40 50
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPH-MEHHNTTCE---AAHFGLWR
:..:. :: ::.: . . .: : : : : ::::
NP_114 MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQNQTTEVKMALHAGLWR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 ICTKRIPMDDSKTCGPITLPG-EKN-CSYFRHFNPGESSEIFEFTTQKEYSI-SAAAIAI
.: . : ::. : ..: : . . : : . .. .:. . .
NP_114 VCF---------------FAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATPFPM
70 80 90 100
120 130 140 150 160
pF1KB9 FSLGFIILGSLCVLLSLGK---KRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMI---
:: :... .. :. ..:. .: : ...:. ..:: ..:.. .. .:.. .
NP_114 VSL-FLVFTAF-VISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNR
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB9 DSEDTVWIEYYYSWSFACACAAFILLFLGG-LALLLFSLPRMPRNPWESCMDAEPEH
: . ...: :.:::: : ..:.: .: ... ::.
NP_114 PSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSD
170 180 190 200 210 220
NP_114 CSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC
230 240 250 260 270
>>NP_085915 (OMIM: 154045,615277) lens fiber membrane in (215 aa)
initn: 169 init1: 82 opt: 144 Z-score: 186.8 bits: 41.7 E(85289): 0.0011
Smith-Waterman score: 144; 23.0% identity (51.5% similar) in 200 aa overlap (13-197:9-197)
10 20 30 40 50
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRIC--T
::: .: .: ..:..:::: .. . :: :::: : .
NP_085 MYSFMGGGLFCAWVGTILLVVAMATDHWM-------QYRLSGSFAHQGLWRYCLGN
10 20 30 40
60 70 80 90 100 110
pF1KB9 KRIPMDDSKTCGPITLPGEK-NCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGF
: . :: : ::. . : :. .. :: . .. : . .:
NP_085 KCYLQTDSIGEPPGQGPGRAWGKSRADLGAQGHLYSRWRTLRLKEGKGATQAYWNATRAF
50 60 70 80 90 100
120 130 140 150 160
pF1KB9 IILGSLCVL-------LSLGKKRDY--LLRPAS---MFYAFAGLCILVSVEVMRQSVKRM
.::..::.. ...... . . :: : ::.. . : ..... .. . .
NP_085 MILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFS-STLFVVLALAIYTGVTVSF
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB9 IDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH
. . : .:::. . .: .. :..:.
NP_085 LGRRFGDW---RFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR
170 180 190 200 210
>>NP_006069 (OMIM: 602911,614256) voltage-dependent calc (323 aa)
initn: 152 init1: 58 opt: 138 Z-score: 177.1 bits: 40.5 E(85289): 0.004
Smith-Waterman score: 167; 26.4% identity (53.8% similar) in 212 aa overlap (5-202:9-201)
10 20 30 40
pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHW----AVLSPHMEHHNTTCEA----
.:: . : : :.. : :: ::.: .: . . .: : .
NP_006 MGLFDRGVQMLLTTVGAF---AAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEV
10 20 30 40 50
50 60 70 80 90 100
pF1KB9 -AHFGLWRICTKRIPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEY--SI
.: :::: : : .. : :. . :: : ... .: : . . ..
NP_006 MTHSGLWRTC-----------CLEGNFKGL--CKQIDHF-PEDAD--YEADTAEYFLRAV
60 70 80 90 100
110 120 130 140 150 160
pF1KB9 SAAAI-AIFSLGFIILGSLCVLLS-LGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVK
:..: :.:. ....:.::. : . : : .. :..:.. ::: .... :. ..
NP_006 RASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANA
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB9 RMIDSEDTVWIEYYYSWSFACACAAFILL-FLGGLALLLFSLPRMPRNPWESCMDAEPEH
.. :. : :.::: . .::. ..: ::. .:
NP_006 GDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQAS
170 180 190 200 210 220
NP_006 AITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAA
230 240 250 260 270 280
222 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:20:14 2016 done: Sat Nov 5 19:20:15 2016
Total Scan time: 6.050 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]