Result of FASTA (omim) for
pFN21AB8949
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8949, 324 aa
1>>>pF1KB8949 324 - 324 aa - 324 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4500+/-0.000322; mu= 6.2097+/- 0.020
mean_var=269.9676+/-54.642, 0's: 0 Z-trim(124.8): 7 B-trim: 0 in 0/60
Lambda= 0.078058
statistics sampled from 47066 (47076) to 47066 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.83), E-opt: 0.2 (0.552), width: 16
Scan time: 8.970
The best scores are: opt bits E(85289)
NP_005058 (OMIM: 602213) E3 ubiquitin-protein liga ( 324) 2288 269.8 5.3e-72
XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1552 186.9 4.3e-47
NP_003022 (OMIM: 602212) E3 ubiquitin-protein liga ( 282) 1552 186.9 4.3e-47
XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1552 186.9 4.3e-47
NP_001006611 (OMIM: 602212) E3 ubiquitin-protein l ( 313) 1552 186.9 4.6e-47
NP_942146 (OMIM: 615609) seven in absentia homolog ( 269) 660 86.4 7.3e-17
>>NP_005058 (OMIM: 602213) E3 ubiquitin-protein ligase S (324 aa)
initn: 2288 init1: 2288 opt: 2288 Z-score: 1413.6 bits: 269.8 E(85289): 5.3e-72
Smith-Waterman score: 2288; 100.0% identity (100.0% similar) in 324 aa overlap (1-324:1-324)
10 20 30 40 50 60
pF1KB8 MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 GGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 SIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 GHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFD
250 260 270 280 290 300
310 320
pF1KB8 TAIAHLFADNGNLGINVTISTCCP
::::::::::::::::::::::::
NP_005 TAIAHLFADNGNLGINVTISTCCP
310 320
>>XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa)
initn: 1563 init1: 1243 opt: 1552 Z-score: 966.4 bits: 186.9 E(85289): 4.3e-47
Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:5-282)
10 20 30 40 50 60
pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP
: .: :.: : . : :. :
XP_011 MSRQTATALPTGTSKCPPSQRV---PALTG----
10 20
70 80 90 100 110 120
pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA
.. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : ::::::
XP_011 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA
30 40 50 60 70 80
130 140 150 160 170 180
pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS
:::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.:::
XP_011 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP
90 100 110 120 130 140
190 200 210 220 230 240
pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF
:::: ::::::::::::::::::::::::::::::::::: ::::::::::::.::::::
XP_011 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF
150 160 170 180 190 200
250 260 270 280 290 300
pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL
::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.:
XP_011 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL
210 220 230 240 250 260
310 320
pF1KB8 FADNGNLGINVTISTCCP
::.::::::::::: :
XP_011 FAENGNLGINVTISMC
270 280
>>NP_003022 (OMIM: 602212) E3 ubiquitin-protein ligase S (282 aa)
initn: 1563 init1: 1243 opt: 1552 Z-score: 966.4 bits: 186.9 E(85289): 4.3e-47
Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:5-282)
10 20 30 40 50 60
pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP
: .: :.: : . : :. :
NP_003 MSRQTATALPTGTSKCPPSQRV---PALTG----
10 20
70 80 90 100 110 120
pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA
.. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : ::::::
NP_003 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA
30 40 50 60 70 80
130 140 150 160 170 180
pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS
:::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.:::
NP_003 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP
90 100 110 120 130 140
190 200 210 220 230 240
pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF
:::: ::::::::::::::::::::::::::::::::::: ::::::::::::.::::::
NP_003 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF
150 160 170 180 190 200
250 260 270 280 290 300
pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL
::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.:
NP_003 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL
210 220 230 240 250 260
310 320
pF1KB8 FADNGNLGINVTISTCCP
::.::::::::::: :
NP_003 FAENGNLGINVTISMC
270 280
>>XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa)
initn: 1563 init1: 1243 opt: 1552 Z-score: 966.4 bits: 186.9 E(85289): 4.3e-47
Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:5-282)
10 20 30 40 50 60
pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP
: .: :.: : . : :. :
XP_006 MSRQTATALPTGTSKCPPSQRV---PALTG----
10 20
70 80 90 100 110 120
pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA
.. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : ::::::
XP_006 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA
30 40 50 60 70 80
130 140 150 160 170 180
pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS
:::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.:::
XP_006 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP
90 100 110 120 130 140
190 200 210 220 230 240
pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF
:::: ::::::::::::::::::::::::::::::::::: ::::::::::::.::::::
XP_006 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF
150 160 170 180 190 200
250 260 270 280 290 300
pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL
::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.:
XP_006 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL
210 220 230 240 250 260
310 320
pF1KB8 FADNGNLGINVTISTCCP
::.::::::::::: :
XP_006 FAENGNLGINVTISMC
270 280
>>NP_001006611 (OMIM: 602212) E3 ubiquitin-protein ligas (313 aa)
initn: 1563 init1: 1243 opt: 1552 Z-score: 965.9 bits: 186.9 E(85289): 4.6e-47
Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:36-313)
10 20 30 40 50 60
pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP
: .: :.: : . : :. :
NP_001 TPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRV---PALTG----
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA
.. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : ::::::
NP_001 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS
:::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.:::
NP_001 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF
:::: ::::::::::::::::::::::::::::::::::: ::::::::::::.::::::
NP_001 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL
::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.:
NP_001 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL
240 250 260 270 280 290
310 320
pF1KB8 FADNGNLGINVTISTCCP
::.::::::::::: :
NP_001 FAENGNLGINVTISMC
300 310
>>NP_942146 (OMIM: 615609) seven in absentia homolog 3 [ (269 aa)
initn: 657 init1: 536 opt: 660 Z-score: 423.8 bits: 86.4 E(85289): 7.3e-17
Smith-Waterman score: 660; 54.1% identity (79.7% similar) in 172 aa overlap (149-320:90-258)
120 130 140 150 160 170
pF1KB8 TPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQ
::: : : . : : :: ::.:.
NP_942 QGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHAN--PVTPCLCMCPLFSCQWE
60 70 80 90 100 110
180 190 200 210 220 230
pF1KB8 GSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEK
: ::.:. :: . :. . ::: .:::::::..::. .::..:.::.::::.:::.:::.
NP_942 GRLEVVVPHLRQIHR-VDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQER
120 130 140 150 160 170
240 250 260 270 280 290
pF1KB8 YEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLV
.::: :::: ..:::: ::. :.:::::: :.::: :::::::. . : ..: ..::::
NP_942 HEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLV
180 190 200 210 220 230
300 310 320
pF1KB8 FDTAIAHLFADNGNLGINVTISTCCP
..:..:.::.:::.:.:...:.
NP_942 LNTSLAQLFSDNGSLAIGIAITATEVLPSEAEM
240 250 260
324 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:40:39 2016 done: Sun Nov 6 17:40:40 2016
Total Scan time: 8.970 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]