Result of FASTA (omim) for
pFN21AB8943
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8943, 301 aa
1>>>pF1KB8943 301 - 301 aa - 301 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.0860+/-0.000277; mu= 5.2780+/- 0.018
mean_var=182.8796+/-37.084, 0's: 0 Z-trim(124.7): 6 B-trim: 0 in 0/61
Lambda= 0.094840
statistics sampled from 46821 (46827) to 46821 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.823), E-opt: 0.2 (0.549), width: 16
Scan time: 7.970
The best scores are: opt bits E(85289)
NP_116179 (OMIM: 610277,612782,615883) calcium rel ( 301) 2021 287.7 2e-77
NP_116220 (OMIM: 610929) protein orai-2 isoform a ( 254) 875 130.8 2.8e-30
NP_001119812 (OMIM: 610929) protein orai-2 isoform ( 254) 875 130.8 2.8e-30
NP_001258747 (OMIM: 610929) protein orai-2 isoform ( 254) 875 130.8 2.8e-30
NP_689501 (OMIM: 610930) protein orai-3 [Homo sapi ( 295) 832 125.0 1.8e-28
NP_001258748 (OMIM: 610929) protein orai-2 isoform ( 177) 585 91.0 1.8e-18
>>NP_116179 (OMIM: 610277,612782,615883) calcium release (301 aa)
initn: 2021 init1: 2021 opt: 2021 Z-score: 1511.1 bits: 287.7 E(85289): 2e-77
Smith-Waterman score: 2021; 100.0% identity (100.0% similar) in 301 aa overlap (1-301:1-301)
10 20 30 40 50 60
pF1KB8 MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
250 260 270 280 290 300
pF1KB8 A
:
NP_116 A
>>NP_116220 (OMIM: 610929) protein orai-2 isoform a [Hom (254 aa)
initn: 842 init1: 842 opt: 875 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30
Smith-Waterman score: 1032; 65.0% identity (81.9% similar) in 254 aa overlap (36-287:10-245)
10 20 30 40 50 60
pF1KB8 APPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMS
: :. : : ... : ::. .:: :...
NP_116 MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVT
10 20 30
70 80 90 100 110 120
pF1KB8 LNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSA
:.::.::::::::::::::::::::::::::::::::::::::.....:: :::::::
NP_116 SNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 CTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTL
:::::::::::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: :
NP_116 CTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGIL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB8 LFLAEVVLLCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIM
:::::::::::.::::. ..::: : ::. :. . : ::..:: ::
NP_116 LFLAEVVLLCWIKFLPVDARRQPG---P---PPGPGSHT---------GWQAALVSTIIM
160 170 180 190 200
250 260 270 280 290 300
pF1KB8 VPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
:: ::::.::..::::::: :::.:. .:..:: .:. :::
NP_116 VPVGLIFVVFTIHFYRSLVRHKTERHNREIEEL---HKLKVQLDGHERSLQVL
210 220 230 240 250
>>NP_001119812 (OMIM: 610929) protein orai-2 isoform a [ (254 aa)
initn: 842 init1: 842 opt: 875 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30
Smith-Waterman score: 1032; 65.0% identity (81.9% similar) in 254 aa overlap (36-287:10-245)
10 20 30 40 50 60
pF1KB8 APPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMS
: :. : : ... : ::. .:: :...
NP_001 MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVT
10 20 30
70 80 90 100 110 120
pF1KB8 LNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSA
:.::.::::::::::::::::::::::::::::::::::::::.....:: :::::::
NP_001 SNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 CTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTL
:::::::::::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: :
NP_001 CTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGIL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB8 LFLAEVVLLCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIM
:::::::::::.::::. ..::: : ::. :. . : ::..:: ::
NP_001 LFLAEVVLLCWIKFLPVDARRQPG---P---PPGPGSHT---------GWQAALVSTIIM
160 170 180 190 200
250 260 270 280 290 300
pF1KB8 VPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
:: ::::.::..::::::: :::.:. .:..:: .:. :::
NP_001 VPVGLIFVVFTIHFYRSLVRHKTERHNREIEEL---HKLKVQLDGHERSLQVL
210 220 230 240 250
>>NP_001258747 (OMIM: 610929) protein orai-2 isoform a [ (254 aa)
initn: 842 init1: 842 opt: 875 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30
Smith-Waterman score: 1032; 65.0% identity (81.9% similar) in 254 aa overlap (36-287:10-245)
10 20 30 40 50 60
pF1KB8 APPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMS
: :. : : ... : ::. .:: :...
NP_001 MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVT
10 20 30
70 80 90 100 110 120
pF1KB8 LNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSA
:.::.::::::::::::::::::::::::::::::::::::::.....:: :::::::
NP_001 SNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 CTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTL
:::::::::::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: :
NP_001 CTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGIL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB8 LFLAEVVLLCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIM
:::::::::::.::::. ..::: : ::. :. . : ::..:: ::
NP_001 LFLAEVVLLCWIKFLPVDARRQPG---P---PPGPGSHT---------GWQAALVSTIIM
160 170 180 190 200
250 260 270 280 290 300
pF1KB8 VPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
:: ::::.::..::::::: :::.:. .:..:: .:. :::
NP_001 VPVGLIFVVFTIHFYRSLVRHKTERHNREIEEL---HKLKVQLDGHERSLQVL
210 220 230 240 250
>>NP_689501 (OMIM: 610930) protein orai-3 [Homo sapiens] (295 aa)
initn: 1023 init1: 789 opt: 832 Z-score: 632.0 bits: 125.0 E(85289): 1.8e-28
Smith-Waterman score: 984; 57.1% identity (75.4% similar) in 289 aa overlap (34-286:8-292)
10 20 30 40 50 60
pF1KB8 EPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEP--PGAPPPPPSAVTYPDWIGQSYS
.:. : : . : :: :: ... ..:
NP_689 MKGGEGDAGEQAPLNPEGESPAGSA-TYREFVHRGYL
10 20 30
70 80 90 100 110 120
pF1KB8 EVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLI
..:. ..::..:::::.:::::::::::::::::::::::::::::::..::.::::::.
NP_689 DLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 AFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTV
::::::::::::::::::.:::.::.::::::.::::::..:::.:.::..::::.:::.
NP_689 AFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTA
100 110 120 130 140 150
190 200 210 220 230
pF1KB8 IGTLLFLAEVVLLCWVKFLPLKKQPGQPRP---TSKPPASGA--------AANVSTSGIT
.::.::::::::. ::::.:. : : ::. :.. : :.:. :. .
NP_689 LGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSAS
160 170 180 190 200 210
240 250 260
pF1KB8 -----------------------PGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTD
:: ::.:::.:::: ::.:..::.:::::::.::::
NP_689 AAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTD
220 230 240 250 260 270
270 280 290 300
pF1KB8 RQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
: :::.:: ::: .:
NP_689 RYKQELEELN---RLQGELQAV
280 290
>>NP_001258748 (OMIM: 610929) protein orai-2 isoform b [ (177 aa)
initn: 552 init1: 552 opt: 585 Z-score: 452.4 bits: 91.0 E(85289): 1.8e-18
Smith-Waterman score: 742; 64.5% identity (81.7% similar) in 186 aa overlap (104-287:1-168)
80 90 100 110 120 130
pF1KB8 LSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAV
::::::.....:: :::::::::::::::
NP_001 MVEVQLETQYQYPRPLLIAFSACTTVLVAV
10 20 30
140 150 160 170 180 190
pF1KB8 HLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVL
:::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: :::::::::
NP_001 HLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVL
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB8 LCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFI
:::.::::. ..::: : ::. :. . : ::..:: :::: ::::.
NP_001 LCWIKFLPVDARRQPG-P-----PPGPGSHT---------GWQAALVSTIIMVPVGLIFV
100 110 120 130
260 270 280 290 300
pF1KB8 VFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
::..::::::: :::.:. .:..:: .:. :::
NP_001 VFTIHFYRSLVRHKTERHNREIEELH---KLKVQLDGHERSLQVL
140 150 160 170
301 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:22:46 2016 done: Tue Nov 8 04:22:47 2016
Total Scan time: 7.970 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]