Result of FASTA (omim) for
pFN21AB8559
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8559, 1006 aa
1>>>pF1KB8559 1006 - 1006 aa - 1006 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9125+/-0.000704; mu= 10.1207+/- 0.043
mean_var=342.4803+/-73.114, 0's: 0 Z-trim(113.2): 630 B-trim: 571 in 1/51
Lambda= 0.069304
statistics sampled from 21692 (22488) to 21692 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.264), width: 16
Scan time: 10.790
The best scores are: opt bits E(85289)
NP_065825 (OMIM: 608677,615092) E3 ubiquitin-prote (1006) 6891 705.2 4.4e-202
XP_016881362 (OMIM: 608677,615092) PREDICTED: E3 u ( 834) 5388 554.8 6.9e-157
XP_011524400 (OMIM: 608677,615092) PREDICTED: E3 u ( 516) 3506 366.3 2.3e-100
XP_016881364 (OMIM: 608677,615092) PREDICTED: E3 u ( 503) 3385 354.2 1e-96
XP_016881363 (OMIM: 608677,615092) PREDICTED: E3 u ( 511) 3385 354.2 1e-96
XP_016855842 (OMIM: 611141) PREDICTED: E3 ubiquiti (1276) 1685 184.9 2.5e-45
NP_001164158 (OMIM: 611141) E3 ubiquitin-protein l (1056) 1679 184.1 3.4e-45
NP_543151 (OMIM: 611141) E3 ubiquitin-protein liga (1070) 1679 184.1 3.4e-45
XP_016855855 (OMIM: 611141) PREDICTED: E3 ubiquiti ( 911) 1618 177.9 2.1e-43
XP_016855850 (OMIM: 611141) PREDICTED: E3 ubiquiti (1094) 1605 176.8 5.8e-43
XP_011539039 (OMIM: 611141) PREDICTED: E3 ubiquiti (1219) 1572 173.5 6.1e-42
NP_001164157 (OMIM: 611141) E3 ubiquitin-protein l (1066) 1309 147.1 4.7e-34
XP_016855848 (OMIM: 611141) PREDICTED: E3 ubiquiti (1144) 1079 124.2 4e-27
XP_006710435 (OMIM: 611141) PREDICTED: E3 ubiquiti (1034) 1020 118.2 2.3e-25
XP_011539043 (OMIM: 611141) PREDICTED: E3 ubiquiti (1184) 1018 118.1 2.8e-25
XP_016855839 (OMIM: 611141) PREDICTED: E3 ubiquiti (1293) 972 113.6 7.2e-24
XP_016855844 (OMIM: 611141) PREDICTED: E3 ubiquiti (1241) 968 113.1 9.3e-24
XP_011539044 (OMIM: 611141) PREDICTED: E3 ubiquiti (1183) 913 107.6 4.1e-22
XP_016855852 (OMIM: 611141) PREDICTED: E3 ubiquiti (1033) 881 104.3 3.5e-21
XP_016855851 (OMIM: 611141) PREDICTED: E3 ubiquiti (1047) 881 104.3 3.5e-21
XP_016855849 (OMIM: 611141) PREDICTED: E3 ubiquiti (1134) 881 104.4 3.7e-21
XP_016855847 (OMIM: 611141) PREDICTED: E3 ubiquiti (1148) 881 104.4 3.7e-21
XP_016855845 (OMIM: 611141) PREDICTED: E3 ubiquiti (1240) 863 102.6 1.3e-20
XP_011539033 (OMIM: 611141) PREDICTED: E3 ubiquiti (1273) 778 94.2 4.9e-18
XP_011539038 (OMIM: 611141) PREDICTED: E3 ubiquiti (1240) 774 93.7 6.4e-18
XP_016855843 (OMIM: 611141) PREDICTED: E3 ubiquiti (1264) 774 93.8 6.5e-18
XP_016855841 (OMIM: 611141) PREDICTED: E3 ubiquiti (1283) 774 93.8 6.5e-18
XP_016855840 (OMIM: 611141) PREDICTED: E3 ubiquiti (1291) 774 93.8 6.5e-18
XP_016855838 (OMIM: 611141) PREDICTED: E3 ubiquiti (1297) 774 93.8 6.6e-18
XP_016855854 (OMIM: 611141) PREDICTED: E3 ubiquiti ( 932) 707 86.9 5.7e-16
XP_016855853 (OMIM: 611141) PREDICTED: E3 ubiquiti (1029) 657 81.9 1.9e-14
NP_001164159 (OMIM: 611141) E3 ubiquitin-protein l (1005) 560 72.2 1.6e-11
NP_001164160 (OMIM: 611141) E3 ubiquitin-protein l ( 753) 555 71.5 1.9e-11
XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 499 66.5 1.5e-09
XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 499 66.5 1.5e-09
XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 499 66.5 1.5e-09
XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 499 66.5 1.5e-09
XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 499 66.5 1.5e-09
XP_016863597 (OMIM: 106410,600919) PREDICTED: anky (1772) 496 66.2 1.8e-09
XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 496 66.2 1.8e-09
XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 496 66.2 1.8e-09
XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 496 66.2 1.9e-09
XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 496 66.2 1.9e-09
NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 496 66.2 1.9e-09
XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 496 66.2 1.9e-09
XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 496 66.2 1.9e-09
XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 496 66.2 1.9e-09
XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 496 66.2 1.9e-09
XP_016863570 (OMIM: 106410,600919) PREDICTED: anky (1931) 496 66.2 1.9e-09
XP_016863567 (OMIM: 106410,600919) PREDICTED: anky (2020) 496 66.3 1.9e-09
>>NP_065825 (OMIM: 608677,615092) E3 ubiquitin-protein l (1006 aa)
initn: 6891 init1: 6891 opt: 6891 Z-score: 3749.0 bits: 705.2 E(85289): 4.4e-202
Smith-Waterman score: 6891; 100.0% identity (100.0% similar) in 1006 aa overlap (1-1006:1-1006)
10 20 30 40 50 60
pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB8 SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB8 RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ
910 920 930 940 950 960
970 980 990 1000
pF1KB8 TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
970 980 990 1000
>>XP_016881362 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (834 aa)
initn: 5386 init1: 5386 opt: 5388 Z-score: 2937.6 bits: 554.8 E(85289): 6.9e-157
Smith-Waterman score: 5388; 97.8% identity (98.7% similar) in 816 aa overlap (191-1006:19-834)
170 180 190 200 210 220
pF1KB8 VDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQD
:.: . : . . .:..::::::::
XP_016 MEVYSMSCPMFLYFMDHCSSADLGWARWLTPVIPALWEAQSDLKCVQD
10 20 30 40
230 240 250 260 270 280
pF1KB8 AKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKGGSFYRDHCPVLGEQNGNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLT
50 60 70 80 90 100
290 300 310 320 330 340
pF1KB8 TTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQ
110 120 130 140 150 160
350 360 370 380 390 400
pF1KB8 VCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKV
170 180 190 200 210 220
410 420 430 440 450 460
pF1KB8 ASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAGSAISNASGERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNG
230 240 250 260 270 280
470 480 490 500 510 520
pF1KB8 QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS
290 300 310 320 330 340
530 540 550 560 570 580
pF1KB8 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA
350 360 370 380 390 400
590 600 610 620 630 640
pF1KB8 VLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAA
410 420 430 440 450 460
650 660 670 680 690 700
pF1KB8 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD
470 480 490 500 510 520
710 720 730 740 750 760
pF1KB8 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLA
530 540 550 560 570 580
770 780 790 800 810 820
pF1KB8 ANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECM
590 600 610 620 630 640
830 840 850 860 870 880
pF1KB8 VCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQP
650 660 670 680 690 700
890 900 910 920 930 940
pF1KB8 CGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDN
710 720 730 740 750 760
950 960 970 980 990 1000
pF1KB8 TNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIE
770 780 790 800 810 820
pF1KB8 RRILLY
::::::
XP_016 RRILLY
830
>>XP_011524400 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (516 aa)
initn: 3506 init1: 3506 opt: 3506 Z-score: 1922.7 bits: 366.3 E(85289): 2.3e-100
Smith-Waterman score: 3506; 100.0% identity (100.0% similar) in 513 aa overlap (494-1006:4-516)
470 480 490 500 510 520
pF1KB8 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL
::::::::::::::::::::::::::::::
XP_011 MVLDKDGDRAVHHAAFGDEGAVIEVLHRGSADL
10 20 30
530 540 550 560 570 580
pF1KB8 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLL
40 50 60 70 80 90
590 600 610 620 630 640
pF1KB8 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNN
100 110 120 130 140 150
650 660 670 680 690 700
pF1KB8 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPL
160 170 180 190 200 210
710 720 730 740 750 760
pF1KB8 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANG
220 230 240 250 260 270
770 780 790 800 810 820
pF1KB8 ADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCS
280 290 300 310 320 330
830 840 850 860 870 880
pF1KB8 DMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGH
340 350 360 370 380 390
890 900 910 920 930 940
pF1KB8 MCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNV
400 410 420 430 440 450
950 960 970 980 990 1000
pF1KB8 NADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRI
460 470 480 490 500 510
pF1KB8 LLY
:::
XP_011 LLY
>>XP_016881364 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (503 aa)
initn: 3385 init1: 3385 opt: 3385 Z-score: 1857.4 bits: 354.2 E(85289): 1e-96
Smith-Waterman score: 3385; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493)
10 20 30 40 50 60
pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK
:::::::::::::
XP_016 KLLLKQNVDVEAEFYLVEWYEIS
490 500
>>XP_016881363 (OMIM: 608677,615092) PREDICTED: E3 ubiqu (511 aa)
initn: 3385 init1: 3385 opt: 3385 Z-score: 1857.4 bits: 354.2 E(85289): 1e-96
Smith-Waterman score: 3385; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493)
10 20 30 40 50 60
pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK
:::::::::::::
XP_016 KLLLKQNVDVEAEGNLKELFWKVDCLHILTY
490 500 510
>>XP_016855842 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1276 aa)
initn: 2046 init1: 581 opt: 1685 Z-score: 934.9 bits: 184.9 E(85289): 2.5e-45
Smith-Waterman score: 2012; 35.8% identity (61.2% similar) in 1015 aa overlap (58-1006:321-1275)
30 40 50 60 70
pF1KB8 KQDGGEGHVGTVRSFESPEEVVVVWDNGTAANYRCSGAYDLRILDSAPTG--------IK
:.. :::. : .::. ..
XP_016 TGSGASRTAARAAWARWWSLAATAAPRHPTAQWSCSGTRA-RAPTTAPATRARTTCCCVR
300 310 320 330 340
80 90 100 110 120 130
pF1KB8 HDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLES
: . .:: :... . :.:::: : .::::: :: .::.: : : : : :. : :
XP_016 HPNIICDCCKKHGLRGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSP
350 360 370 380 390 400
140 150 160 170 180 190
pF1KB8 RRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDN
:. .: :::: ::.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : .
XP_016 RQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWAD
410 420 430 440 450 460
200 210 220 230 240 250
pF1KB8 GAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLG-----EQNGNRNPGGLQIGDLVNI
:. :.:::: .: ::::: .: :: .:.:: : :: .. . . .: :: :.
XP_016 GTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQPFQHGDKVKC
470 480 490 500 510 520
260 270 280 290 300 310
pF1KB8 DLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKA
:: .... .:.:::::. : : . :::: : . :. ::. .::::.:..:::
XP_016 LLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKH
530 540 550 560 570 580
320 330 340 350 360 370
pF1KB8 NIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQ
. .: :::.:.: ::. .: :: :::::.. : :.::.::.: .
XP_016 H----------------SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVK
590 600 610 620 630
380 390 400 410 420
pF1KB8 IYSDSDLKVEVCGTSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQES
...:..:.: : : ::..:. : .:. ... . : :.: : :: . .
XP_016 VFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSD
640 650 660 670 680 690
430 440 450 460 470 480
pF1KB8 GDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNV
. .:: .: :..:.. :::.: .:. . :.::.:.:. :.:....:::. .
XP_016 PEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARA
700 710 720 730 740 750
490 500 510 520 530 540
pF1KB8 DVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKT
:. : .:. :.:.::.:.. . .:: .. .: :. ..: ::.::..: :.::..
XP_016 GVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRA
760 770 780 790 800 810
550 560 570 580 590 600
pF1KB8 LLDFGCHPSLQDSEGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAAL
: . :: .: :...:::::.::: . :. :: :. . ::: ::..::. ::::.:
XP_016 LCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASL
820 830 840 850 860 870
610 620 630 640 650 660
pF1KB8 RGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVN
.:. :.: .:.. . .:: ::.::.::::::::::: :::..:...: .....: .
XP_016 KGHALAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRK
880 890 900 910 920 930
670 680 690 700 710
pF1KB8 QQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTL------------S
:. :::::.. :. .: ::: :: ... .:..::: :: ::..: : .
XP_016 LQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAGGDPG
940 950 960 970 980 990
720 730 740 750
pF1KB8 QLRQLQDMQDVG----KV--DAAWEPSKNTLIMGL---------GTQG-AEKKSAASIAC
:. :. .: .: ::. :. . :. : : :: .:..::
XP_016 PLQLLSRTWGAGCWGCQVPGDASLGPAPAPALTGVCPAAQLQASGLPGSAELTVGAAVAC
1000 1010 1020 1030 1040 1050
760 770 780 790 800
pF1KB8 FLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC---HKEKVSG---QVGSR----SPS
::: .:::.: :..:.::::: . . ::: : .:. .: : : .:.
XP_016 FLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGGAAPGPRQTLGTPN
1060 1070 1080 1090 1100 1110
810 820 830 840 850 860
pF1KB8 MISN------DSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRT
..: . ::.:::.. .::.:: : ..: :
XP_016 TVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCE------------GEWGAPGW
1120 1130 1140 1150
870 880 890 900 910 920
pF1KB8 KIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFIMCCGGKSSED
. ... :.:: .:: ::::..:..:: ... :
XP_016 GGPASRAAANR--ALLF---------AECARRMKKCIRCQVVVSKKL----------RPD
1160 1170 1180 1190
930 940 950 960 970 980
pF1KB8 ATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLKNMIFLCGHGT
... :.. : .. :..::.. ....:. ::.:.: ..: ::::.
XP_016 GSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPICIDSHIRLVFQCGHGA
1200 1210 1220 1230 1240 1250
990 1000
pF1KB8 CQLCGDRMSECPICRKAIERRILLY
: ::. .: :::::. :. :: ..
XP_016 CAPCGSALSACPICRQPIRDRIQIFV
1260 1270
>>NP_001164158 (OMIM: 611141) E3 ubiquitin-protein ligas (1056 aa)
initn: 2320 init1: 627 opt: 1679 Z-score: 932.4 bits: 184.1 E(85289): 3.4e-45
Smith-Waterman score: 2308; 38.5% identity (64.0% similar) in 1025 aa overlap (14-1006:112-1055)
10 20 30 40
pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVR---
:: ::::: :::::.:::::: ::::
NP_001 LKAARRATGRPDRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELG
90 100 110 120 130 140
50 60 70 80 90
pF1KB8 ---SFESPEEVVVV-WDNGTAANYRCS--GAYDLRILDSAPTGIKHDGTMCDTCRQQPII
: .:...::: ::.:: .::: . ::.:: . :.: :..: . .:: :... .
NP_001 RHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLR
150 160 170 180 190 200
100 110 120 130 140 150
pF1KB8 GIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAG
:.:::: : .::::: :: .::.: : : : : :. : : :. .: :::: :
NP_001 GMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQG
210 220 230 240 250 260
160 170 180 190 200 210
pF1KB8 ARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSD
:.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : .:. :.:::: .: :
NP_001 AKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVD
270 280 290 300 310 320
220 230 240 250 260
pF1KB8 LKCVQDAKGGSFYRDHCPVLGEQ-------NGNRNPGGLQIGDLVNIDLDLEIVQSLQHG
:::: .: :: .:.:: : ::. ... .: .: :: :. :: .... .:.:
NP_001 LKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQP--FQHGDKVKCLLDTDVLREMQEG
330 340 350 360 370
270 280 290 300 310 320
pF1KB8 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAE
::::. : : . :::: : . :. ::. .::::.:..::: .
NP_001 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHH------------
380 390 400 410 420
330 340 350 360 370 380
pF1KB8 GGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG
.: :::.:.: ::. .: :: :::::.. : :.::.::.: ....:..:.: : :
NP_001 ----SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAG
430 440 450 460 470 480
390 400 410 420 430 440
pF1KB8 TSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQESGDLNEELVKAAAN
::..:. : .:. ... . : :.: : :: . . . .:: .:
NP_001 QRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL
490 500 510 520 530 540
450 460 470 480 490 500
pF1KB8 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAV
:..:.. :::.: .:. . :.::.:.:. :.:....:::. . :. : .:. :.
NP_001 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL
550 560 570 580 590 600
510 520 530 540 550 560
pF1KB8 HHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDS
:.::.:.. . .:: .. .: :. ..: ::.::..: :.::..: . :: .: :.
NP_001 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA
610 620 630 640 650 660
570 580 590 600 610
pF1KB8 EGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK
..:::::.::: . :. :: :. . ::: ::..::. ::::.:.:. :.: .:..
NP_001 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR
670 680 690 700 710 720
620 630 640 650 660 670
pF1KB8 LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQH
. .:: ::.::.::::::::::: :::..:...: .....: . :. :::::.. :
NP_001 ARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAH
730 740 750 760 770 780
680 690 700 710 720 730
pF1KB8 TQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTL
. .: ::: :: ... .:..::: :: ::..: : : . : :. .:. :
NP_001 VGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPL--VAD-------GAGGDPGPLQL
790 800 810 820 830
740 750 760 770 780 790
pF1KB8 IMGLGTQG----AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC--
. : ..: :: .:..::::: .:::.: :..:.::::: . . ::: :
NP_001 LSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQ
840 850 860 870 880 890
800 810 820 830 840 850
pF1KB8 -HKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCL
.:. .: :. .:. .:: . .... . ::
NP_001 RFRERQAG--GGAAPG----PRQTLGTPNTVTNLHVGAAPGP------------------
900 910 920
860 870 880 890 900 910
pF1KB8 ICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFI
. ::.:::. :::.:: : .::.:: ::::..:..:: ...
NP_001 ----------EAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKL---
930 940 950 960 970
920 930 940 950 960 970
pF1KB8 MCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLK
:... :.. : .. :..::.. ....:. ::.:.:
NP_001 -------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPICIDSHI
980 990 1000 1010 1020
980 990 1000
pF1KB8 NMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
..: ::::.: ::. .: :::::. :. :: ..
NP_001 RLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV
1030 1040 1050
>>NP_543151 (OMIM: 611141) E3 ubiquitin-protein ligase M (1070 aa)
initn: 2320 init1: 627 opt: 1679 Z-score: 932.4 bits: 184.1 E(85289): 3.4e-45
Smith-Waterman score: 2308; 38.5% identity (64.0% similar) in 1025 aa overlap (14-1006:126-1069)
10 20 30 40
pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVR---
:: ::::: :::::.:::::: ::::
NP_543 RAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELG
100 110 120 130 140 150
50 60 70 80 90
pF1KB8 ---SFESPEEVVVV-WDNGTAANYRCS--GAYDLRILDSAPTGIKHDGTMCDTCRQQPII
: .:...::: ::.:: .::: . ::.:: . :.: :..: . .:: :... .
NP_543 RHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLR
160 170 180 190 200 210
100 110 120 130 140 150
pF1KB8 GIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAG
:.:::: : .::::: :: .::.: : : : : :. : : :. .: :::: :
NP_543 GMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQG
220 230 240 250 260 270
160 170 180 190 200 210
pF1KB8 ARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSD
:.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : .:. :.:::: .: :
NP_543 AKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVD
280 290 300 310 320 330
220 230 240 250 260
pF1KB8 LKCVQDAKGGSFYRDHCPVLGEQ-------NGNRNPGGLQIGDLVNIDLDLEIVQSLQHG
:::: .: :: .:.:: : ::. ... .: .: :: :. :: .... .:.:
NP_543 LKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQP--FQHGDKVKCLLDTDVLREMQEG
340 350 360 370 380 390
270 280 290 300 310 320
pF1KB8 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAE
::::. : : . :::: : . :. ::. .::::.:..::: .
NP_543 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHH------------
400 410 420 430 440
330 340 350 360 370 380
pF1KB8 GGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG
.: :::.:.: ::. .: :: :::::.. : :.::.::.: ....:..:.: : :
NP_543 ----SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAG
450 460 470 480 490
390 400 410 420 430 440
pF1KB8 TSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQESGDLNEELVKAAAN
::..:. : .:. ... . : :.: : :: . . . .:: .:
NP_543 QRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL
500 510 520 530 540 550
450 460 470 480 490 500
pF1KB8 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAV
:..:.. :::.: .:. . :.::.:.:. :.:....:::. . :. : .:. :.
NP_543 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL
560 570 580 590 600 610
510 520 530 540 550 560
pF1KB8 HHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDS
:.::.:.. . .:: .. .: :. ..: ::.::..: :.::..: . :: .: :.
NP_543 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA
620 630 640 650 660 670
570 580 590 600 610
pF1KB8 EGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK
..:::::.::: . :. :: :. . ::: ::..::. ::::.:.:. :.: .:..
NP_543 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR
680 690 700 710 720 730
620 630 640 650 660 670
pF1KB8 LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQH
. .:: ::.::.::::::::::: :::..:...: .....: . :. :::::.. :
NP_543 ARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAH
740 750 760 770 780 790
680 690 700 710 720 730
pF1KB8 TQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTL
. .: ::: :: ... .:..::: :: ::..: : : . : :. .:. :
NP_543 VGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPL--VAD-------GAGGDPGPLQL
800 810 820 830 840
740 750 760 770 780 790
pF1KB8 IMGLGTQG----AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC--
. : ..: :: .:..::::: .:::.: :..:.::::: . . ::: :
NP_543 LSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQ
850 860 870 880 890 900
800 810 820 830 840 850
pF1KB8 -HKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCL
.:. .: :. .:. .:: . .... . ::
NP_543 RFRERQAG--GGAAPG----PRQTLGTPNTVTNLHVGAAPGP------------------
910 920 930 940
860 870 880 890 900 910
pF1KB8 ICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERRVPFI
. ::.:::. :::.:: : .::.:: ::::..:..:: ...
NP_543 ----------EAAECLVCSELALLVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKL---
950 960 970 980
920 930 940 950 960 970
pF1KB8 MCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPVCLDRLK
:... :.. : .. :..::.. ....:. ::.:.:
NP_543 -------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPICIDSHI
990 1000 1010 1020 1030
980 990 1000
pF1KB8 NMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
..: ::::.: ::. .: :::::. :. :: ..
NP_543 RLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV
1040 1050 1060 1070
>>XP_016855855 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (911 aa)
initn: 1986 init1: 521 opt: 1618 Z-score: 900.1 bits: 177.9 E(85289): 2.1e-43
Smith-Waterman score: 1945; 36.3% identity (61.6% similar) in 971 aa overlap (96-1006:1-910)
70 80 90 100 110 120
pF1KB8 YDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHLRHRFY
.:::: : .::::: :: .::.: : :
XP_016 MRWKCRVCLDYDLCTQCYMHNKHELAHAFD
10 20 30
130 140 150 160 170 180
pF1KB8 RITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTEIQDWS
: : :. : : :. .: :::: ::.:::: ::.: .::::.:. :.:..:. :.
XP_016 RYETAHSRPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGGEGKPGRVVDIRGWD
40 50 60 70 80 90
190 200 210 220 230
pF1KB8 ASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQ-------N
. . .:.: : : .:. :.:::: .: ::::: .: :: .:.:: : ::. .
XP_016 VETGRSVASVTWADGTTNVYRVGHKGKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVS
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB8 GNRNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQY
.. .: .: :: :. :: .... .:.:::::. : : . :::: : . :. ::.
XP_016 ADSQP--FQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTGTVHRITDRGDVRVQF
160 170 180 190 200
300 310 320 330 340 350
pF1KB8 PSGNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEW
.::::.:..::: . .: :::.:.: ::. .: :: :::::
XP_016 NHETRWTFHPGALTKHH----------------SFWVGDVVRVIGDLDTVKRLQAGHGEW
210 220 230 240 250
360 370 380 390 400 410
pF1KB8 AEAMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPA---AVSKVASAGSAISNASGERL
.. : :.::.::.: ....:..:.: : : ::..:. : .:. ... . :
XP_016 TDDMAPALGRVGKVVKVFGDGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARENK
260 270 280 290 300 310
420 430 440 450 460 470
pF1KB8 SQL---LKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAAS
:.: : :: . . . .:: .: :..:.. :::.: .:. . :.::.:.:.
XP_016 SSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAA
320 330 340 350 360 370
480 490 500 510 520 530
pF1KB8 QNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQT
:.:....:::. . :. : .:. :.:.::.:.. . .:: .. .: :. ..:
XP_016 YLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQST
380 390 400 410 420 430
540 550 560 570 580
pF1KB8 PLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKR--DDILAVLLEA-GADV
::.::..: :.::..: . :: .: :...:::::.::: . :. :: :. . ::
XP_016 ALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAGTGASGIVEVLTEVPNIDV
440 450 460 470 480 490
590 600 610 620 630 640
pF1KB8 TITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE
: ::..::. ::::.:.:. :.: .:.. . .:: ::.::.::::::::::: :::.
XP_016 TATNSQGFTLLHHASLKGHALAVRKILARARQ--LVDAKKEDGFTALHLAALNNHREVAQ
500 510 520 530 540 550
650 660 670 680 690 700
pF1KB8 LLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRH
.:...: .....: . :. :::::.. :. .: ::: :: ... .:..::: :: ::..
XP_016 ILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVALQR
560 570 580 590 600 610
710 720 730 740
pF1KB8 HTL------------SQLRQLQDMQDVG----KV--DAAWEPSKNTLIMGL---------
: : . :. :. .: .: ::. :. . :.
XP_016 HQLLPLVADGAGGDPGPLQLLSRTWGAGCWGCQVPGDASLGPAPAPALTGVCPAAQLQAS
620 630 640 650 660 670
750 760 770 780 790
pF1KB8 GTQG-AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC---HKEKVS
: : :: .:..::::: .:::.: :..:.::::: . . ::: : .:. .
XP_016 GLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQA
680 690 700 710 720 730
800 810 820 830 840
pF1KB8 G---QVGSR----SPSMISN------DSETLEECMVCSDMKRDTLFGPCGHIATCSLCSP
: : : .:. ..: . ::.:::.. .::.:: : ..:
XP_016 GGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRTVCE----
740 750 760 770 780
850 860 870 880 890 900
pF1KB8 RVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVE
: . ... :.:: .:: ::::..:..::
XP_016 --------GEWGAPGWGGPASRAAANR--ALLFA---------ECARRMKKCIRCQVVVS
790 800 810 820
910 920 930 940 950 960
pF1KB8 RRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQTMCPV
... :... :.. : .. :..::.. ....:. ::.
XP_016 KKL----------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQMEERITCPI
830 840 850 860
970 980 990 1000
pF1KB8 CLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
:.: ..: ::::.: ::. .: :::::. :. :: ..
XP_016 CIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV
870 880 890 900 910
>>XP_016855850 (OMIM: 611141) PREDICTED: E3 ubiquitin-pr (1094 aa)
initn: 2297 init1: 627 opt: 1605 Z-score: 892.3 bits: 176.8 E(85289): 5.8e-43
Smith-Waterman score: 2267; 38.2% identity (63.5% similar) in 1040 aa overlap (14-1006:126-1093)
10 20 30 40
pF1KB8 MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVR---
:: ::::: :::::.:::::: ::::
XP_016 RAARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDWKWGQQDGGEGGVGTVVELG
100 110 120 130 140 150
50 60 70 80 90
pF1KB8 ---SFESPEEVVVV-WDNGTAANYRCS--GAYDLRILDSAPTGIKHDGTMCDTCRQQPII
: .:...::: ::.:: .::: . ::.:: . :.: :..: . .:: :... .
XP_016 RHGSPSTPDRTVVVQWDQGTRTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGLR
160 170 180 190 200 210
100 110 120 130 140 150
pF1KB8 GIRWKCAECTNYDLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAG
:.:::: : .::::: :: .::.: : : : : :. : : :. .: :::: :
XP_016 GMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHSRPVTLSPRQGLPRIPLRGIFQG
220 230 240 250 260 270
160 170 180 190 200 210
pF1KB8 ARVVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSD
:.:::: ::.: .::::.:. :.:..:. :.. . .:.: : : .:. :.:::: .: :
XP_016 AKVVRGPDWEWGSQDGGEGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHKGKVD
280 290 300 310 320 330
220 230 240 250 260
pF1KB8 LKCVQDAKGGSFYRDHCPVLGEQ-------NGNRNPGGLQIGDLVNIDLDLEIVQSLQHG
:::: .: :: .:.:: : ::. ... .: .: :: :. :: .... .:.:
XP_016 LKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQP--FQHGDKVKCLLDTDVLREMQEG
340 350 360 370 380 390
270 280 290 300 310 320
pF1KB8 HGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKANIVRSGDAAQGAE
::::. : : . :::: : . :. ::. .::::.:..::: .
XP_016 HGGWNPRMAEFIGQTGTVHRITDRGDVRVQFNHETRWTFHPGALTKHH------------
400 410 420 430 440
330 340 350 360 370 380
pF1KB8 GGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG
.: :::.:.: ::. .: :: :::::.. : :.::.::.: ....:..:.: : :
XP_016 ----SFWVGDVVRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFGDGNLRVAVAG
450 460 470 480 490
390 400 410 420 430 440
pF1KB8 TSWTYNPA---AVSKVASAGSAISNASGERLSQL---LKKLFETQESGDLNEELVKAAAN
::..:. : .:. ... . : :.: : :: . . . .:: .:
XP_016 QRWTFSPSCLVAYRPEEDANLDVAERARENKSSLSVALDKLRAQKSDPEHPGRLVVEVAL
500 510 520 530 540 550
450 460 470 480 490 500
pF1KB8 GDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAV
:..:.. :::.: .:. . :.::.:.:. :.:....:::. . :. : .:. :.
XP_016 GNAARALDLLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTAL
560 570 580 590 600 610
510 520 530 540 550 560
pF1KB8 HHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDS
:.::.:.. . .:: .. .: :. ..: ::.::..: :.::..: . :: .: :.
XP_016 HYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDA
620 630 640 650 660 670
570 580 590 600 610
pF1KB8 EGDTPLHDAISKKR--DDILAVLLEA-GADVTITNNNGFNALHHAALRGNPSAMRVLLSK
..:::::.::: . :. :: :. . ::: ::..::. ::::.:.:. :.: .:..
XP_016 HSDTPLHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILAR
680 690 700 710 720 730
620 630 640 650 660 670
pF1KB8 LPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQH
. .:: ::.::.::::::::::: :::..:...: .....: . :. :::::.. :
XP_016 ARQ--LVDAKKEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAH
740 750 760 770 780 790
680 690 700 710 720 730
pF1KB8 TQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTL
. .: ::: :: ... .:..::: :: ::..: : : . : :. .:. :
XP_016 VGLVPLLVDAGCSVNAEDEEGDTALHVALQRHQLLPL--VAD-------GAGGDPGPLQL
800 810 820 830 840
740 750 760 770 780 790
pF1KB8 IMGLGTQG----AEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKC--
. : ..: :: .:..::::: .:::.: :..:.::::: . . ::: :
XP_016 LSRLQASGLPGSAELTVGAAVACFLALEGADVSYTNHRGRSPLDLAAEGRVLKALQGCAQ
850 860 870 880 890 900
800 810 820 830
pF1KB8 -HKEKVSG---QVGSR----SPSMISN------DSETLEECMVCSDMKRDTLFGPCGHIA
.:. .: : : .:. ..: . ::.:::.. .::.:: : .
XP_016 RFRERQAGGGAAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELALLVLFSPCQHRT
910 920 930 940 950 960
840 850 860 870 880 890
pF1KB8 TCS--LCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKK
.: .: ::. .. :.:: .:: :::
XP_016 VCEGEWGAPGWGG-------PASRAAANR---------ALLFA---------ECARRMKK
970 980 990 1000
900 910 920 930 940 950
pF1KB8 CVQCRAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQD
:..:..:: ... :... :.. : .. :..::.. ..
XP_016 CIRCQVVVSKKL----------RPDGSEVASAAPAPGPPRQL--------VEELQSRYRQ
1010 1020 1030 1040
960 970 980 990 1000
pF1KB8 IKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
..:. ::.:.: ..: ::::.: ::. .: :::::. :. :: ..
XP_016 MEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDRIQIFV
1050 1060 1070 1080 1090
1006 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:44:17 2016 done: Sun Nov 6 05:44:18 2016
Total Scan time: 10.790 Total Display time: 0.310
Function used was FASTA [36.3.4 Apr, 2011]