Result of FASTA (omim) for
pFN21AB8414
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8414, 913 aa
1>>>pF1KB8414 913 - 913 aa - 913 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7436+/-0.000624; mu= 9.2691+/- 0.038
mean_var=211.3155+/-42.393, 0's: 0 Z-trim(112.9): 282 B-trim: 340 in 3/50
Lambda= 0.088228
statistics sampled from 21719 (22058) to 21719 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.259), width: 16
Scan time: 10.620
The best scores are: opt bits E(85289)
NP_006191 (OMIM: 600488) proprotein convertase sub ( 913) 6576 851.6 0
NP_001177411 (OMIM: 600488) proprotein convertase (1860) 6322 819.6 0
XP_011517071 (OMIM: 600488) PREDICTED: proprotein (1886) 6322 819.6 0
XP_005252096 (OMIM: 600488) PREDICTED: proprotein (1887) 6322 819.6 0
XP_016870289 (OMIM: 600488) PREDICTED: proprotein (1450) 3272 431.2 1.7e-119
XP_011517072 (OMIM: 600488) PREDICTED: proprotein (1441) 3214 423.9 2.9e-117
NP_612192 (OMIM: 167405) proprotein convertase sub ( 956) 3014 398.2 9.9e-110
NP_002561 (OMIM: 167405) proprotein convertase sub ( 969) 2948 389.8 3.4e-107
NP_612196 (OMIM: 167405) proprotein convertase sub ( 623) 2785 368.9 4.4e-101
NP_612197 (OMIM: 167405) proprotein convertase sub ( 652) 2785 368.9 4.5e-101
NP_612198 (OMIM: 167405) proprotein convertase sub ( 664) 2785 368.9 4.6e-101
NP_001278238 (OMIM: 167405) proprotein convertase ( 895) 2175 291.4 1.3e-77
NP_612195 (OMIM: 167405) proprotein convertase sub ( 487) 2128 285.1 5.6e-76
NP_000430 (OMIM: 162150,600955,612362) neuroendocr ( 753) 1968 265.0 1e-69
NP_001276753 (OMIM: 136950) furin preproprotein [H ( 794) 1941 261.6 1.1e-68
NP_001276752 (OMIM: 136950) furin preproprotein [H ( 794) 1941 261.6 1.1e-68
NP_002560 (OMIM: 136950) furin preproprotein [Homo ( 794) 1941 261.6 1.1e-68
NP_001171346 (OMIM: 162150,600955,612362) neuroend ( 706) 1893 255.4 7.2e-67
XP_011526394 (OMIM: 600487) PREDICTED: proprotein ( 644) 1776 240.5 2.1e-62
XP_011526393 (OMIM: 600487) PREDICTED: proprotein ( 658) 1776 240.5 2.1e-62
XP_011526390 (OMIM: 600487) PREDICTED: proprotein ( 720) 1776 240.5 2.2e-62
NP_060043 (OMIM: 600487) proprotein convertase sub ( 755) 1776 240.5 2.3e-62
XP_011526387 (OMIM: 600487) PREDICTED: proprotein ( 782) 1776 240.5 2.4e-62
XP_011526395 (OMIM: 600487) PREDICTED: proprotein ( 593) 1642 223.4 2.7e-57
XP_011526389 (OMIM: 600487) PREDICTED: proprotein ( 724) 1642 223.5 3.1e-57
NP_001188457 (OMIM: 162151) neuroendocrine convert ( 619) 1623 221.0 1.5e-56
NP_002585 (OMIM: 162151) neuroendocrine convertase ( 638) 1623 221.0 1.5e-56
NP_004707 (OMIM: 604872) proprotein convertase sub ( 785) 1545 211.1 1.7e-53
NP_001188458 (OMIM: 162151) neuroendocrine convert ( 603) 1528 208.9 6.3e-53
XP_011526388 (OMIM: 600487) PREDICTED: proprotein ( 773) 1511 206.8 3.3e-52
XP_011526396 (OMIM: 600487) PREDICTED: proprotein ( 567) 1332 183.9 2e-45
XP_005259643 (OMIM: 600487) PREDICTED: proprotein ( 567) 1332 183.9 2e-45
XP_016882386 (OMIM: 600487) PREDICTED: proprotein ( 377) 1198 166.6 2e-40
XP_016874035 (OMIM: 604872) PREDICTED: proprotein ( 426) 680 100.8 1.5e-20
XP_006719003 (OMIM: 604872) PREDICTED: proprotein ( 426) 680 100.8 1.5e-20
XP_011526398 (OMIM: 600487) PREDICTED: proprotein ( 533) 526 81.3 1.4e-14
XP_011526392 (OMIM: 600487) PREDICTED: proprotein ( 661) 526 81.4 1.7e-14
XP_011526391 (OMIM: 600487) PREDICTED: proprotein ( 688) 526 81.4 1.7e-14
NP_001159605 (OMIM: 219000,607830) extracellular m (1976) 342 58.4 3.9e-07
XP_006714379 (OMIM: 219000,607830) PREDICTED: extr (3936) 342 58.8 6.3e-07
NP_079350 (OMIM: 219000,607830) extracellular matr (4012) 342 58.8 6.4e-07
XP_011526397 (OMIM: 600487) PREDICTED: proprotein ( 537) 297 52.1 8.6e-06
XP_005261794 (OMIM: 607171) PREDICTED: cysteine-ri ( 403) 275 49.2 4.9e-05
NP_001128573 (OMIM: 607171) cysteine-rich with EGF ( 402) 268 48.3 9.1e-05
XP_016884427 (OMIM: 607171) PREDICTED: cysteine-ri ( 252) 263 47.4 0.0001
NP_077300 (OMIM: 607171) cysteine-rich with EGF-li ( 353) 263 47.6 0.00013
XP_005261795 (OMIM: 607171) PREDICTED: cysteine-ri ( 373) 263 47.6 0.00013
XP_011518550 (OMIM: 611747) PREDICTED: signal pept ( 695) 266 48.3 0.00016
XP_016873571 (OMIM: 611747) PREDICTED: signal pept ( 844) 266 48.4 0.00018
XP_016873570 (OMIM: 611747) PREDICTED: signal pept ( 892) 266 48.4 0.00019
>>NP_006191 (OMIM: 600488) proprotein convertase subtili (913 aa)
initn: 6576 init1: 6576 opt: 6576 Z-score: 4541.6 bits: 851.6 E(85289): 0
Smith-Waterman score: 6576; 100.0% identity (100.0% similar) in 913 aa overlap (1-913:1-913)
10 20 30 40 50 60
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKV
850 860 870 880 890 900
910
pF1KB8 LQQLCCKTCTFQG
:::::::::::::
NP_006 LQQLCCKTCTFQG
910
>>NP_001177411 (OMIM: 600488) proprotein convertase subt (1860 aa)
initn: 6298 init1: 6298 opt: 6322 Z-score: 4363.1 bits: 819.6 E(85289): 0
Smith-Waterman score: 6322; 97.1% identity (97.9% similar) in 910 aa overlap (1-909:1-906)
10 20 30 40 50 60
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
790 800 810 820 830 840
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL-CQRK
:::::::::::::::::::::::::::::::::::. : : : :. . . ::
NP_001 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAKCQGP
850 860 870 880 890
900 910
pF1KB8 VLQQLCCKTCTFQG
. .. : ::
NP_001 TQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGAD
900 910 920 930 940 950
>--
initn: 436 init1: 187 opt: 422 Z-score: 304.4 bits: 68.6 E(85289): 3.3e-10
Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1459-1720)
600 610 620 630 640 650
pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC
.: :: : :: .: . : ::. :.:
NP_001 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC
1430 1440 1450 1460 1470 1480
660 670 680 690 700 710
pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF
. : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.:
NP_001 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF
1490 1500 1510 1520 1530 1540
720 730 740 750 760
pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C
:..: :. .: .: : :.. . :..:...:: : . .: : . : :. :
NP_001 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC
1550 1560 1570 1580 1590 1600
770 780 790 800 810 820
pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD
:: : : . : :. :: : : : :: .:..:. .: . : :...: .. :
NP_001 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY--
1610 1620 1630 1640 1650
830 840 850 860 870 880
pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG
. .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : :
NP_001 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC
1660 1670 1680 1690 1700 1710
890 900 910
pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG
:
NP_001 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG
1720 1730 1740 1750 1760 1770
>--
initn: 375 init1: 149 opt: 292 Z-score: 214.9 bits: 52.0 E(85289): 3.1e-05
Smith-Waterman score: 590; 31.9% identity (51.3% similar) in 298 aa overlap (623-909:922-1190)
600 610 620 630 640 650
pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH
:. . :. :: :.. :.: :: :
NP_001 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH
900 910 920 930 940
660 670 680 690 700
pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM
:..: :. :. . : .::: ::: .. . : : ::: : . : :
NP_001 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT
950 960 970 980 990 1000
710 720 730 740 750 760
pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL
: :::. ...: .: .: :: . : : :.: :. . .:: : :
NP_001 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR
1010 1020 1030 1040 1050 1060
770 780 790 800 810 820
pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY
.: .: . : . .:. : :..: .:: : ::.:. : ::..:. ..
NP_001 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF
1070 1080 1090 1100 1110
830 840 850 860 870 880
pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA
: :. : : :..: .: ::.::: .:.:: : : ::: . :.:
NP_001 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC----VHATKTQE---
1120 1130 1140 1150 1160
890 900 910
pF1KB8 EGGF-CMLVKKNNLCQRKVLQQLCCKTCTFQG
:: : ...: . :. . ::::
NP_001 EGKFWNDILRKLQPCHSS------CKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPS
1170 1180 1190 1200 1210 1220
>--
initn: 386 init1: 149 opt: 292 Z-score: 214.9 bits: 52.0 E(85289): 3.1e-05
Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:1225-1455)
610 620 630 640 650 660
pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY
.: :. .:.:. : : :. : .. .
NP_001 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH
1200 1210 1220 1230 1240 1250
670 680 690 700 710 720
pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV
: . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . :
NP_001 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ
1260 1270 1280 1290 1300
730 740 750 760 770 780
pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD
.::. . . :..:..: : :. : . ..: :: . :. . : :: : : ...
NP_001 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH
1310 1320 1330 1340 1350 1360
790 800 810 820 830 840
pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
: :::. : :.: :: : : :. . . :: :.. : . :... . : :. :
NP_001 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK
1370 1380 1390 1400 1410 1420
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK
:::::.. : .::.: .: ... : :. . :
NP_001 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP
1430 1440 1450 1460 1470 1480
900 910
pF1KB8 VLQQLCCKTCTFQG
NP_001 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG
1490 1500 1510 1520 1530 1540
>>XP_011517071 (OMIM: 600488) PREDICTED: proprotein conv (1886 aa)
initn: 6298 init1: 6298 opt: 6322 Z-score: 4363.0 bits: 819.6 E(85289): 0
Smith-Waterman score: 6322; 97.1% identity (97.9% similar) in 910 aa overlap (1-909:1-906)
10 20 30 40 50 60
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
790 800 810 820 830 840
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL-CQRK
:::::::::::::::::::::::::::::::::::. : : : :. . . ::
XP_011 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAKCQGP
850 860 870 880 890
900 910
pF1KB8 VLQQLCCKTCTFQG
. .. : ::
XP_011 TQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGAD
900 910 920 930 940 950
>--
initn: 436 init1: 187 opt: 422 Z-score: 304.3 bits: 68.6 E(85289): 3.3e-10
Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1485-1746)
600 610 620 630 640 650
pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC
.: :: : :: .: . : ::. :.:
XP_011 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC
1460 1470 1480 1490 1500 1510
660 670 680 690 700 710
pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF
. : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.:
XP_011 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF
1520 1530 1540 1550 1560
720 730 740 750 760
pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C
:..: :. .: .: : :.. . :..:...:: : . .: : . : :. :
XP_011 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC
1570 1580 1590 1600 1610 1620
770 780 790 800 810 820
pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD
:: : : . : :. :: : : : :: .:..:. .: . : :...: .. :
XP_011 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY--
1630 1640 1650 1660 1670 1680
830 840 850 860 870 880
pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG
. .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : :
XP_011 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC
1690 1700 1710 1720 1730 1740
890 900 910
pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG
:
XP_011 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG
1750 1760 1770 1780 1790 1800
>--
initn: 375 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05
Smith-Waterman score: 589; 32.6% identity (50.9% similar) in 291 aa overlap (623-903:922-1189)
600 610 620 630 640 650
pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH
:. . :. :: :.. :.: :: :
XP_011 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH
900 910 920 930 940
660 670 680 690 700
pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM
:..: :. :. . : .::: ::: .. . : : ::: : . : :
XP_011 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT
950 960 970 980 990 1000
710 720 730 740 750 760
pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL
: :::. ...: .: .: :: . : : :.: :. . .:: : :
XP_011 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR
1010 1020 1030 1040 1050 1060
770 780 790 800 810 820
pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY
.: .: . : . .:. : :..: .:: : ::.:. : ::..:. ..
XP_011 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF
1070 1080 1090 1100 1110
830 840 850 860 870 880
pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA
: :. : : :..: .: ::.::: .:.:: : : ::: . :.:
XP_011 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC----VHATKTQE---
1120 1130 1140 1150 1160
890 900 910
pF1KB8 EGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG
:: : :. :: : : :
XP_011 EGKFWNAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPK
1170 1180 1190 1200 1210 1220
>--
initn: 303 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05
Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:1251-1481)
610 620 630 640 650 660
pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY
.: :. .:.:. : : :. : .. .
XP_011 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH
1230 1240 1250 1260 1270
670 680 690 700 710 720
pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV
: . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . :
XP_011 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ
1280 1290 1300 1310 1320 1330
730 740 750 760 770 780
pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD
.::. . . :..:..: : :. : . ..: :: . :. . : :: : : ...
XP_011 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH
1340 1350 1360 1370 1380 1390
790 800 810 820 830 840
pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
: :::. : :.: :: : : :. . . :: :.. : . :... . : :. :
XP_011 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK
1400 1410 1420 1430 1440
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK
:::::.. : .::.: .: ... : :. . :
XP_011 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP
1450 1460 1470 1480 1490 1500
900 910
pF1KB8 VLQQLCCKTCTFQG
XP_011 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG
1510 1520 1530 1540 1550 1560
>>XP_005252096 (OMIM: 600488) PREDICTED: proprotein conv (1887 aa)
initn: 6298 init1: 6298 opt: 6322 Z-score: 4363.0 bits: 819.6 E(85289): 0
Smith-Waterman score: 6322; 97.1% identity (97.9% similar) in 910 aa overlap (1-909:1-906)
10 20 30 40 50 60
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
790 800 810 820 830 840
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL-CQRK
:::::::::::::::::::::::::::::::::::. : : : :. . . ::
XP_005 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAKCQGP
850 860 870 880 890
900 910
pF1KB8 VLQQLCCKTCTFQG
. .. : ::
XP_005 TQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGAD
900 910 920 930 940 950
>--
initn: 436 init1: 187 opt: 422 Z-score: 304.3 bits: 68.6 E(85289): 3.3e-10
Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1486-1747)
600 610 620 630 640 650
pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC
.: :: : :: .: . : ::. :.:
XP_005 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC
1460 1470 1480 1490 1500 1510
660 670 680 690 700 710
pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF
. : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.:
XP_005 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF
1520 1530 1540 1550 1560 1570
720 730 740 750 760
pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C
:..: :. .: .: : :.. . :..:...:: : . .: : . : :. :
XP_005 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC
1580 1590 1600 1610 1620
770 780 790 800 810 820
pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD
:: : : . : :. :: : : : :: .:..:. .: . : :...: .. :
XP_005 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY--
1630 1640 1650 1660 1670 1680
830 840 850 860 870 880
pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG
. .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : :
XP_005 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC
1690 1700 1710 1720 1730 1740
890 900 910
pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG
:
XP_005 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG
1750 1760 1770 1780 1790 1800
>--
initn: 375 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05
Smith-Waterman score: 586; 31.3% identity (50.8% similar) in 313 aa overlap (623-909:922-1217)
600 610 620 630 640 650
pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH
:. . :. :: :.. :.: :: :
XP_005 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH
900 910 920 930 940
660 670 680 690 700
pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM
:..: :. :. . : .::: ::: .. . : : ::: : . : :
XP_005 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT
950 960 970 980 990 1000
710 720 730 740 750 760
pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL
: :::. ...: .: .: :: . : : :.: :. . .:: : :
XP_005 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR
1010 1020 1030 1040 1050 1060
770 780 790 800 810 820
pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY
.: .: . : . .:. : :..: .:: : ::.:. : ::..:. ..
XP_005 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF
1070 1080 1090 1100 1110
830 840 850 860 870 880
pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA
: :. : : :..: .: ::.::: .:.:: : : ::: . : . . :
XP_005 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC-VHATKTQEEGKFWN
1120 1130 1140 1150 1160 1170
890 900 910
pF1KB8 EG--GFCMLVKKNNLCQRK---------VLQQL--C---CKTCTFQG
:. . : :. : .:. .:..: : ::::
XP_005 EAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL
1180 1190 1200 1210 1220 1230
XP_005 AQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCP
1240 1250 1260 1270 1280 1290
>--
initn: 386 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05
Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:1252-1482)
610 620 630 640 650 660
pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY
.: :. .:.:. : : :. : .. .
XP_005 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH
1230 1240 1250 1260 1270 1280
670 680 690 700 710 720
pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV
: . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . :
XP_005 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ
1290 1300 1310 1320 1330
730 740 750 760 770 780
pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD
.::. . . :..:..: : :. : . ..: :: . :. . : :: : : ...
XP_005 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH
1340 1350 1360 1370 1380 1390
790 800 810 820 830 840
pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
: :::. : :.: :: : : :. . . :: :.. : . :... . : :. :
XP_005 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK
1400 1410 1420 1430 1440 1450
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK
:::::.. : .::.: .: ... : :. . :
XP_005 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP
1460 1470 1480 1490 1500
900 910
pF1KB8 VLQQLCCKTCTFQG
XP_005 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG
1510 1520 1530 1540 1550 1560
>>XP_016870289 (OMIM: 600488) PREDICTED: proprotein conv (1450 aa)
initn: 3248 init1: 3248 opt: 3272 Z-score: 2266.2 bits: 431.2 E(85289): 1.7e-119
Smith-Waterman score: 3272; 94.3% identity (96.0% similar) in 473 aa overlap (438-909:1-469)
410 420 430 440 450 460
pF1KB8 WRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHV
.:::::::::::::::::::::::::::::
XP_016 MSHLYGFGLMDAEAMVMEAEKWTTVPRQHV
10 20 30
470 480 490 500 510 520
pF1KB8 CVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLT
40 50 60 70 80 90
530 540 550 560 570 580
pF1KB8 SPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGK
100 110 120 130 140 150
590 600 610 620 630 640
pF1KB8 LKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDG
160 170 180 190 200 210
650 660 670 680 690 700
pF1KB8 PGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSC
220 230 240 250 260 270
710 720 730 740 750 760
pF1KB8 KYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRC
280 290 300 310 320 330
770 780 790 800 810 820
pF1KB8 SVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHS
340 350 360 370 380 390
830 840 850 860 870 880
pF1KB8 SENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFC
::::::::::::::::::::::::::::::::::::::::::::::::. : : : :
XP_016 SENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHC
400 410 420 430 440
890 900 910
pF1KB8 MLVKKNNL-CQRKVLQQLCCKTCTFQG
. . . :: . .. : ::
XP_016 QTCEASCAKCQGPTQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQ
450 460 470 480 490 500
>--
initn: 436 init1: 187 opt: 422 Z-score: 305.7 bits: 68.5 E(85289): 2.7e-10
Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1049-1310)
600 610 620 630 640 650
pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC
.: :: : :: .: . : ::. :.:
XP_016 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC
1020 1030 1040 1050 1060 1070
660 670 680 690 700 710
pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF
. : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.:
XP_016 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF
1080 1090 1100 1110 1120 1130
720 730 740 750 760
pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C
:..: :. .: .: : :.. . :..:...:: : . .: : . : :. :
XP_016 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC
1140 1150 1160 1170 1180 1190
770 780 790 800 810 820
pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD
:: : : . : :. :: : : : :: .:..:. .: . : :...: .. :
XP_016 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY--
1200 1210 1220 1230 1240
830 840 850 860 870 880
pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG
. .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : :
XP_016 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC
1250 1260 1270 1280 1290 1300
890 900 910
pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG
:
XP_016 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG
1310 1320 1330 1340 1350 1360
>--
initn: 375 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05
Smith-Waterman score: 586; 31.3% identity (50.8% similar) in 313 aa overlap (623-909:485-780)
600 610 620 630 640 650
pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH
:. . :. :: :.. :.: :: :
XP_016 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH
460 470 480 490 500 510
660 670 680 690 700
pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM
:..: :. :. . : .::: ::: .. . : : ::: : . : :
XP_016 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT
520 530 540 550 560
710 720 730 740 750 760
pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL
: :::. ...: .: .: :: . : : :.: :. . .:: : :
XP_016 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR
570 580 590 600 610 620
770 780 790 800 810 820
pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY
.: .: . : . .:. : :..: .:: : ::.:. : ::..:. ..
XP_016 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF
630 640 650 660 670 680
830 840 850 860 870 880
pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA
: :. : : :..: .: ::.::: .:.:: : : ::: . : . . :
XP_016 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC-VHATKTQEEGKFWN
690 700 710 720 730
890 900 910
pF1KB8 EG--GFCMLVKKNNLCQRK---------VLQQL--C---CKTCTFQG
:. . : :. : .:. .:..: : ::::
XP_016 EAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL
740 750 760 770 780 790
XP_016 AQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCP
800 810 820 830 840 850
>--
initn: 386 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05
Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:815-1045)
610 620 630 640 650 660
pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY
.: :. .:.:. : : :. : .. .
XP_016 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH
790 800 810 820 830 840
670 680 690 700 710 720
pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV
: . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . :
XP_016 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ
850 860 870 880 890
730 740 750 760 770 780
pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD
.::. . . :..:..: : :. : . ..: :: . :. . : :: : : ...
XP_016 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH
900 910 920 930 940 950
790 800 810 820 830 840
pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
: :::. : :.: :: : : :. . . :: :.. : . :... . : :. :
XP_016 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK
960 970 980 990 1000 1010
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK
:::::.. : .::.: .: ... : :. . :
XP_016 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP
1020 1030 1040 1050 1060 1070
900 910
pF1KB8 VLQQLCCKTCTFQG
XP_016 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG
1080 1090 1100 1110 1120 1130
>>XP_011517072 (OMIM: 600488) PREDICTED: proprotein conv (1441 aa)
initn: 3190 init1: 3190 opt: 3214 Z-score: 2226.4 bits: 423.9 E(85289): 2.9e-117
Smith-Waterman score: 3214; 94.4% identity (95.9% similar) in 464 aa overlap (447-909:1-460)
420 430 440 450 460 470
pF1KB8 RTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQI
::::::::::::::::::::::::::::::
XP_011 MDAEAMVMEAEKWTTVPRQHVCVESTDRQI
10 20 30
480 490 500 510 520 530
pF1KB8 KTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQL
40 50 60 70 80 90
540 550 560 570 580 590
pF1KB8 LANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLY
100 110 120 130 140 150
600 610 620 630 640 650
pF1KB8 GTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC
160 170 180 190 200 210
660 670 680 690 700 710
pF1KB8 LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEE
220 230 240 250 260 270
720 730 740 750 760 770
pF1KB8 TNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRY
280 290 300 310 320 330
780 790 800 810 820 830
pF1KB8 FNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCK
340 350 360 370 380 390
840 850 860 870 880 890
pF1KB8 KCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL-
:::::::::::::::::::::::::::::::::::::::. : : : :. . .
XP_011 KCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAK
400 410 420 430 440
900 910
pF1KB8 CQRKVLQQLCCKTCTFQG
:: . .. : ::
XP_011 CQGPTQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTS
450 460 470 480 490 500
>--
initn: 436 init1: 187 opt: 422 Z-score: 305.7 bits: 68.5 E(85289): 2.7e-10
Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1040-1301)
600 610 620 630 640 650
pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC
.: :: : :: .: . : ::. :.:
XP_011 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC
1010 1020 1030 1040 1050 1060
660 670 680 690 700 710
pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF
. : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.:
XP_011 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF
1070 1080 1090 1100 1110 1120
720 730 740 750 760
pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C
:..: :. .: .: : :.. . :..:...:: : . .: : . : :. :
XP_011 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC
1130 1140 1150 1160 1170 1180
770 780 790 800 810 820
pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD
:: : : . : :. :: : : : :: .:..:. .: . : :...: .. :
XP_011 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY--
1190 1200 1210 1220 1230
830 840 850 860 870 880
pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG
. .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : :
XP_011 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC
1240 1250 1260 1270 1280 1290
890 900 910
pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG
:
XP_011 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG
1300 1310 1320 1330 1340 1350
>--
initn: 375 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05
Smith-Waterman score: 586; 31.3% identity (50.8% similar) in 313 aa overlap (623-909:476-771)
600 610 620 630 640 650
pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH
:. . :. :: :.. :.: :: :
XP_011 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH
450 460 470 480 490 500
660 670 680 690 700
pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM
:..: :. :. . : .::: ::: .. . : : ::: : . : :
XP_011 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT
510 520 530 540 550
710 720 730 740 750 760
pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL
: :::. ...: .: .: :: . : : :.: :. . .:: : :
XP_011 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR
560 570 580 590 600 610
770 780 790 800 810 820
pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY
.: .: . : . .:. : :..: .:: : ::.:. : ::..:. ..
XP_011 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF
620 630 640 650 660 670
830 840 850 860 870 880
pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA
: :. : : :..: .: ::.::: .:.:: : : ::: . : . . :
XP_011 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC-VHATKTQEEGKFWN
680 690 700 710 720
890 900 910
pF1KB8 EG--GFCMLVKKNNLCQRK---------VLQQL--C---CKTCTFQG
:. . : :. : .:. .:..: : ::::
XP_011 EAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL
730 740 750 760 770 780
XP_011 AQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCP
790 800 810 820 830 840
>--
initn: 386 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05
Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:806-1036)
610 620 630 640 650 660
pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY
.: :. .:.:. : : :. : .. .
XP_011 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH
780 790 800 810 820 830
670 680 690 700 710 720
pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV
: . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . :
XP_011 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ
840 850 860 870 880 890
730 740 750 760 770 780
pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD
.::. . . :..:..: : :. : . ..: :: . :. . : :: : : ...
XP_011 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH
900 910 920 930 940
790 800 810 820 830 840
pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI
: :::. : :.: :: : : :. . . :: :.. : . :... . : :. :
XP_011 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK
950 960 970 980 990 1000
850 860 870 880 890
pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK
:::::.. : .::.: .: ... : :. . :
XP_011 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP
1010 1020 1030 1040 1050 1060
900 910
pF1KB8 VLQQLCCKTCTFQG
XP_011 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG
1070 1080 1090 1100 1110 1120
>>NP_612192 (OMIM: 167405) proprotein convertase subtili (956 aa)
initn: 3329 init1: 2474 opt: 3014 Z-score: 2091.0 bits: 398.2 E(85289): 9.9e-110
Smith-Waterman score: 3777; 56.3% identity (78.3% similar) in 932 aa overlap (2-913:38-956)
10 20 30
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR
: : : : : .::: ..: : :
NP_612 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH
::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: :
NP_612 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN
.:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.::
NP_612 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK
...::::::::::.:::::::::::.:::: :::. :: :::::: :: ::::::::::
NP_612 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS
:::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... :::::
NP_612 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY
:::::::::::::. :..:::: :.. ::.::::.:::::::::: :.:::::::::::
NP_612 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM
:::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.::::
NP_612 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA
.::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.::::
NP_612 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR
.:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: ::::::::
NP_612 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE
.:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.::
NP_612 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE
550 560 570 580 590 600
580 590 600 610
pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY----------------SPTNEFPKVERF
. : :::.:: . ::::::::.::::. .:: .: : ::. .
NP_612 IQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAA-L
610 620 630 640 650 660
620 630 640 650 660 670
pF1KB8 RYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCP
:.:: : :. :::.: : :::.. :::::. :.: .:.:. ...: ::: ::
NP_612 SPSQVEVPEDE---EDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCP
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB8 PGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKK
:.. . .:::.: .::.: . . ::.::. :.. ..: :.::: :: : : : ..
NP_612 LGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ
730 740 750 760 770 780
740 750 760 770 780 790
pF1KB8 NLCRKCSENCKTCT-EFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ--DCQPCHRFCAT
. : :: .:: :. : ..:: :..:.:: . : .:: : ::... : ::. :.:
NP_612 KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGT
790 800 810 820 830 840
800 810 820 830 840 850
pF1KB8 CAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFK
:.: : . ::.:.... ..: .:: .:. ..: .. .: :..:: .::.: : . .
NP_612 CVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSS-R
850 860 870 880 890 900
860 870 880 890 900 910
pF1KB8 NCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTF
::. : .:. :.:. : : :. :: .::.: ::.::.. :.::.:: .
NP_612 NCSRCKTGFT------QLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLL
910 920 930 940 950
pF1KB8 QG
:
NP_612 AG
>>NP_002561 (OMIM: 167405) proprotein convertase subtili (969 aa)
initn: 3290 init1: 2474 opt: 2948 Z-score: 2045.5 bits: 389.8 E(85289): 3.4e-107
Smith-Waterman score: 3744; 55.6% identity (77.5% similar) in 942 aa overlap (2-913:38-969)
10 20 30
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR
: : : : : .::: ..: : :
NP_002 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH
::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: :
NP_002 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN
.:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.::
NP_002 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK
...::::::::::.:::::::::::.:::: :::. :: :::::: :: ::::::::::
NP_002 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS
:::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... :::::
NP_002 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY
:::::::::::::. :..:::: :.. ::.::::.:::::::::: :.:::::::::::
NP_002 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM
:::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.::::
NP_002 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA
.::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.::::
NP_002 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR
.:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: ::::::::
NP_002 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE
.:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.::
NP_002 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE
550 560 570 580 590 600
580 590 600 610
pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY----------------SPTNEFPKVERF
. : :::.:: . ::::::::.::::. .:: .: : ::. .
NP_002 IQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAA-L
610 620 630 640 650 660
620 630 640 650 660
pF1KB8 RYSRVEDPTD--DYGTEDYAGP--------CDPECSEVGCDGPGPDHCNDCLHYYYKLKN
:.:: : : :: ... : : :::.. :::::. :.: .:.:. .
NP_002 SPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVK
670 680 690 700 710 720
670 680 690 700 710 720
pF1KB8 NTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHC
..: ::: :: :.. . .:::.: .::.: . . ::.::. :.. ..: :.::: :
NP_002 TSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLC
730 740 750 760 770 780
730 740 750 760 770 780
pF1KB8 PDGSYQDTKKNLCRKCSENCKTCT-EFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ--D
: : : : ... : :: .:: :. : ..:: :..:.:: . : .:: : ::...
NP_002 PAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIR
790 800 810 820 830 840
790 800 810 820 830 840
pF1KB8 CQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDIS
: ::. :.::.: : . ::.:.... ..: .:: .:. ..: .. .: :..:: .
NP_002 CGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDEN
850 860 870 880 890 900
850 860 870 880 890 900
pF1KB8 CLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVL
::.: : . .::. : .:. :.:. : : :. :: .::.: ::.::..
NP_002 CLSCAGSS-RNCSRCKTGFT------QLGTSCITNHTCSNADETFCEMVKSNRLCERKLF
910 920 930 940 950
910
pF1KB8 QQLCCKTCTFQG
:.::.:: . :
NP_002 IQFCCRTCLLAG
960
>>NP_612196 (OMIM: 167405) proprotein convertase subtili (623 aa)
initn: 2376 init1: 2376 opt: 2785 Z-score: 1935.7 bits: 368.9 E(85289): 4.4e-101
Smith-Waterman score: 2785; 66.6% identity (86.5% similar) in 587 aa overlap (2-588:38-622)
10 20 30
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR
: : : : : .::: ..: : :
NP_612 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH
::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: :
NP_612 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN
.:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.::
NP_612 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK
...::::::::::.:::::::::::.:::: :::. :: :::::: :: ::::::::::
NP_612 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS
:::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... :::::
NP_612 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY
:::::::::::::. :..:::: :.. ::.::::.:::::::::: :.:::::::::::
NP_612 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM
:::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.::::
NP_612 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA
.::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.::::
NP_612 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR
.:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: ::::::::
NP_612 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE
.:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.::
NP_612 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTED
. : :::.:: . :.:
NP_612 IQDLPSQVRNPEKQGNLD
610 620
>>NP_612197 (OMIM: 167405) proprotein convertase subtili (652 aa)
initn: 2376 init1: 2376 opt: 2785 Z-score: 1935.5 bits: 368.9 E(85289): 4.5e-101
Smith-Waterman score: 2785; 66.5% identity (86.4% similar) in 588 aa overlap (2-589:38-623)
10 20 30
pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR
: : : : : .::: ..: : :
NP_612 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH
::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: :
NP_612 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN
.:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.::
NP_612 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK
...::::::::::.:::::::::::.:::: :::. :: :::::: :: ::::::::::
NP_612 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS
:::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... :::::
NP_612 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY
:::::::::::::. :..:::: :.. ::.::::.:::::::::: :.:::::::::::
NP_612 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM
:::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.::::
NP_612 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA
.::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.::::
NP_612 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR
.:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: ::::::::
NP_612 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE
.:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.::
NP_612 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE
550 560 570 580 590 600
580 590 600 610 620 630
pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTED
. : :::.:: . : :.
NP_612 IQDLPSQVRNPEKQGDLETPVANQLTTEEREPGLKHVFRWQIEQELW
610 620 630 640 650
913 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:43:45 2016 done: Tue Nov 8 06:43:47 2016
Total Scan time: 10.620 Total Display time: 0.450
Function used was FASTA [36.3.4 Apr, 2011]