Result of FASTA (omim) for
pFN21AB8012
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8012, 708 aa
1>>>pF1KB8012 708 - 708 aa - 708 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6865+/-0.000339; mu= 5.5719+/- 0.021
mean_var=218.2857+/-44.197, 0's: 0 Z-trim(121.8): 64 B-trim: 1978 in 1/61
Lambda= 0.086808
statistics sampled from 38792 (38856) to 38792 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.456), width: 16
Scan time: 11.460
The best scores are: opt bits E(85289)
XP_016873130 (OMIM: 602709) PREDICTED: amyloid bet ( 708) 4833 618.3 3.1e-176
NP_663722 (OMIM: 602709) amyloid beta A4 precursor ( 708) 4833 618.3 3.1e-176
NP_001155 (OMIM: 602709) amyloid beta A4 precursor ( 710) 4819 616.6 1e-175
XP_006718278 (OMIM: 602709) PREDICTED: amyloid bet ( 802) 4819 616.6 1.1e-175
XP_016873129 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 4813 615.8 1.8e-175
XP_006718277 (OMIM: 602709) PREDICTED: amyloid bet ( 713) 4813 615.8 1.8e-175
XP_016873128 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 4799 614.1 6e-175
XP_006718275 (OMIM: 602709) PREDICTED: amyloid bet ( 715) 4799 614.1 6e-175
NP_001244252 (OMIM: 602709) amyloid beta A4 precur ( 488) 3243 419.1 2.1e-116
NP_001244254 (OMIM: 602709) amyloid beta A4 precur ( 475) 3229 417.3 6.8e-116
NP_001244248 (OMIM: 602709) amyloid beta A4 precur ( 490) 3229 417.3 7e-116
XP_006718276 (OMIM: 602709) PREDICTED: amyloid bet ( 806) 3160 408.9 4e-113
XP_006718273 (OMIM: 602709) PREDICTED: amyloid bet ( 806) 3160 408.9 4e-113
XP_016873131 (OMIM: 602709) PREDICTED: amyloid bet ( 449) 3095 400.5 7.3e-111
NP_001244250 (OMIM: 602709) amyloid beta A4 precur ( 451) 3081 398.8 2.5e-110
NP_001244249 (OMIM: 602709) amyloid beta A4 precur ( 451) 3081 398.8 2.5e-110
XP_011518342 (OMIM: 602709) PREDICTED: amyloid bet ( 451) 3081 398.8 2.5e-110
NP_001244255 (OMIM: 602709) amyloid beta A4 precur ( 451) 3081 398.8 2.5e-110
XP_016863645 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1924 254.0 1.5e-66
XP_016863646 (OMIM: 104300,602710) PREDICTED: amyl ( 723) 1924 254.0 1.5e-66
XP_006714074 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1924 254.0 1.5e-66
XP_016863640 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1924 254.0 1.5e-66
XP_016863639 (OMIM: 104300,602710) PREDICTED: amyl ( 740) 1924 254.0 1.5e-66
XP_016863641 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1922 253.8 1.8e-66
XP_006714075 (OMIM: 104300,602710) PREDICTED: amyl ( 739) 1922 253.8 1.8e-66
XP_011518340 (OMIM: 602709) PREDICTED: amyloid bet ( 547) 1685 224.0 1.2e-57
XP_011518339 (OMIM: 602709) PREDICTED: amyloid bet ( 547) 1685 224.0 1.2e-57
XP_011518344 (OMIM: 602709) PREDICTED: amyloid bet ( 586) 1685 224.0 1.3e-57
XP_006718274 (OMIM: 602709) PREDICTED: amyloid bet ( 811) 1685 224.1 1.6e-57
XP_006718272 (OMIM: 602709) PREDICTED: amyloid bet ( 811) 1685 224.1 1.6e-57
NP_001159522 (OMIM: 104300,602710) amyloid beta A4 ( 758) 1619 215.8 4.8e-55
XP_016863634 (OMIM: 104300,602710) PREDICTED: amyl ( 759) 1616 215.5 6.3e-55
NP_004298 (OMIM: 104300,602710) amyloid beta A4 pr ( 759) 1616 215.5 6.3e-55
XP_016863638 (OMIM: 104300,602710) PREDICTED: amyl ( 743) 1609 214.6 1.1e-54
XP_006714073 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1609 214.6 1.2e-54
XP_016863632 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1609 214.6 1.2e-54
XP_016863633 (OMIM: 104300,602710) PREDICTED: amyl ( 760) 1609 214.6 1.2e-54
XP_016863637 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1603 213.8 1.9e-54
XP_016863635 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1603 213.8 1.9e-54
XP_016863636 (OMIM: 104300,602710) PREDICTED: amyl ( 744) 1603 213.8 1.9e-54
XP_016863631 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54
XP_006714070 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54
XP_006714068 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54
XP_011511988 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54
XP_006714072 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54
XP_006714071 (OMIM: 104300,602710) PREDICTED: amyl ( 761) 1603 213.8 1.9e-54
XP_016863647 (OMIM: 104300,602710) PREDICTED: amyl ( 721) 1587 211.8 7.5e-54
XP_011511989 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1587 211.8 7.6e-54
XP_016863642 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1587 211.8 7.6e-54
XP_016863643 (OMIM: 104300,602710) PREDICTED: amyl ( 738) 1587 211.8 7.6e-54
>>XP_016873130 (OMIM: 602709) PREDICTED: amyloid beta A4 (708 aa)
initn: 4833 init1: 4833 opt: 4833 Z-score: 3285.0 bits: 618.3 E(85289): 3.1e-176
Smith-Waterman score: 4833; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708)
10 20 30 40 50 60
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL
610 620 630 640 650 660
670 680 690 700
pF1KB8 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
670 680 690 700
>>NP_663722 (OMIM: 602709) amyloid beta A4 precursor pro (708 aa)
initn: 4833 init1: 4833 opt: 4833 Z-score: 3285.0 bits: 618.3 E(85289): 3.1e-176
Smith-Waterman score: 4833; 100.0% identity (100.0% similar) in 708 aa overlap (1-708:1-708)
10 20 30 40 50 60
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 RCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 FQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB8 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 ECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCL
610 620 630 640 650 660
670 680 690 700
pF1KB8 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 DARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
670 680 690 700
>>NP_001155 (OMIM: 602709) amyloid beta A4 precursor pro (710 aa)
initn: 3209 init1: 3157 opt: 4819 Z-score: 3275.5 bits: 616.6 E(85289): 1e-175
Smith-Waterman score: 4819; 99.7% identity (99.7% similar) in 710 aa overlap (1-708:1-710)
10 20 30 40 50 60
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGK
370 380 390 400 410 420
430 440 450 460 470
pF1KB8 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGR--DFAYVARDKLTQMLKCH
::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
NP_001 DLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCH
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 VFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELV
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 QKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAV
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 LGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQK
610 620 630 640 650 660
660 670 680 690 700
pF1KB8 CLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
670 680 690 700 710
>>XP_006718278 (OMIM: 602709) PREDICTED: amyloid beta A4 (802 aa)
initn: 3209 init1: 3157 opt: 4819 Z-score: 3274.7 bits: 616.6 E(85289): 1.1e-175
Smith-Waterman score: 4819; 99.7% identity (99.7% similar) in 710 aa overlap (1-708:93-802)
10 20 30
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHA
::::::::::::::::::::::::::::::
XP_006 PPFGLQPRPRVSRRGCGTRALRGAQGAAKAMSVPSSLSQSAINANSHGGPALSLPLPLHA
70 80 90 100 110 120
40 50 60 70 80 90
pF1KB8 AHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRN
130 140 150 160 170 180
100 110 120 130 140 150
pF1KB8 VTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGE
190 200 210 220 230 240
160 170 180 190 200 210
pF1KB8 EKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLF
250 260 270 280 290 300
220 230 240 250 260 270
pF1KB8 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY
310 320 330 340 350 360
280 290 300 310 320 330
pF1KB8 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG
370 380 390 400 410 420
340 350 360 370 380 390
pF1KB8 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS
430 440 450 460 470 480
400 410 420 430 440 450
pF1KB8 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
490 500 510 520 530 540
460 470 480 490 500
pF1KB8 RVWGVGRDSGR--DFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR
::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR
550 560 570 580 590 600
510 520 530 540 550 560
pF1KB8 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL
610 620 630 640 650 660
570 580 590 600 610 620
pF1KB8 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA
670 680 690 700 710 720
630 640 650 660 670 680
pF1KB8 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR
730 740 750 760 770 780
690 700
pF1KB8 RGVQSLWGSLKPKRLGAHTP
::::::::::::::::::::
XP_006 RGVQSLWGSLKPKRLGAHTP
790 800
>>XP_016873129 (OMIM: 602709) PREDICTED: amyloid beta A4 (713 aa)
initn: 3374 init1: 3262 opt: 4813 Z-score: 3271.4 bits: 615.8 E(85289): 1.8e-175
Smith-Waterman score: 4813; 99.3% identity (99.3% similar) in 713 aa overlap (1-708:1-713)
10 20 30 40 50 60
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
190 200 210 220 230 240
250 260 270 280 290
pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR
610 620 630 640 650 660
660 670 680 690 700
pF1KB8 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
670 680 690 700 710
>>XP_006718277 (OMIM: 602709) PREDICTED: amyloid beta A4 (713 aa)
initn: 3374 init1: 3262 opt: 4813 Z-score: 3271.4 bits: 615.8 E(85289): 1.8e-175
Smith-Waterman score: 4813; 99.3% identity (99.3% similar) in 713 aa overlap (1-708:1-713)
10 20 30 40 50 60
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
190 200 210 220 230 240
250 260 270 280 290
pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQML
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKN
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQT
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLR
610 620 630 640 650 660
660 670 680 690 700
pF1KB8 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
670 680 690 700 710
>>XP_016873128 (OMIM: 602709) PREDICTED: amyloid beta A4 (715 aa)
initn: 3264 init1: 1685 opt: 4799 Z-score: 3261.9 bits: 614.1 E(85289): 6e-175
Smith-Waterman score: 4799; 99.0% identity (99.0% similar) in 715 aa overlap (1-708:1-715)
10 20 30 40 50 60
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
190 200 210 220 230 240
250 260 270 280 290
pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGR--DFAYVARDKLTQ
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM
610 620 630 640 650 660
660 670 680 690 700
pF1KB8 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
670 680 690 700 710
>>XP_006718275 (OMIM: 602709) PREDICTED: amyloid beta A4 (715 aa)
initn: 3264 init1: 1685 opt: 4799 Z-score: 3261.9 bits: 614.1 E(85289): 6e-175
Smith-Waterman score: 4799; 99.0% identity (99.0% similar) in 715 aa overlap (1-708:1-715)
10 20 30 40 50 60
pF1KB8 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDT
190 200 210 220 230 240
250 260 270 280 290
pF1KB8 -----DSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASHLADSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGG
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGR--DFAYVARDKLTQ
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_006 WGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQ
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB8 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACM
610 620 630 640 650 660
660 670 680 690 700
pF1KB8 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP
670 680 690 700 710
>>NP_001244252 (OMIM: 602709) amyloid beta A4 precursor (488 aa)
initn: 3243 init1: 3243 opt: 3243 Z-score: 2211.0 bits: 419.1 E(85289): 2.1e-116
Smith-Waterman score: 3243; 100.0% identity (100.0% similar) in 468 aa overlap (241-708:21-488)
220 230 240 250 260 270
pF1KB8 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY
::::::::::::::::::::::::::::::
NP_001 MSAMFSQDFFLAIILQDSSADSFWNPNAFETDSDLPAGWMRVQDTSGTYY
10 20 30 40 50
280 290 300 310 320 330
pF1KB8 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG
60 70 80 90 100 110
340 350 360 370 380 390
pF1KB8 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS
120 130 140 150 160 170
400 410 420 430 440 450
pF1KB8 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
180 190 200 210 220 230
460 470 480 490 500 510
pF1KB8 RVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCL
240 250 260 270 280 290
520 530 540 550 560 570
pF1KB8 VNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSS
300 310 320 330 340 350
580 590 600 610 620 630
pF1KB8 SSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASF
360 370 380 390 400 410
640 650 660 670 680 690
pF1KB8 CCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRG
420 430 440 450 460 470
700
pF1KB8 VQSLWGSLKPKRLGAHTP
::::::::::::::::::
NP_001 VQSLWGSLKPKRLGAHTP
480
>>NP_001244254 (OMIM: 602709) amyloid beta A4 precursor (475 aa)
initn: 1685 init1: 1685 opt: 3229 Z-score: 2201.6 bits: 417.3 E(85289): 6.8e-116
Smith-Waterman score: 3229; 99.6% identity (99.6% similar) in 470 aa overlap (241-708:6-475)
220 230 240 250 260 270
pF1KB8 GMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYY
::::::::::::::::::::::::::::::
NP_001 MTQMRDSFWNPNAFETDSDLPAGWMRVQDTSGTYY
10 20 30
280 290 300 310 320 330
pF1KB8 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELG
40 50 60 70 80 90
340 350 360 370 380 390
pF1KB8 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRS
100 110 120 130 140 150
400 410 420 430 440 450
pF1KB8 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISI
160 170 180 190 200 210
460 470 480 490 500
pF1KB8 RVWGVGRDSGR--DFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR
::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNAR
220 230 240 250 260 270
510 520 530 540 550 560
pF1KB8 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVL
280 290 300 310 320 330
570 580 590 600 610 620
pF1KB8 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPA
340 350 360 370 380 390
630 640 650 660 670 680
pF1KB8 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVR
400 410 420 430 440 450
690 700
pF1KB8 RGVQSLWGSLKPKRLGAHTP
::::::::::::::::::::
NP_001 RGVQSLWGSLKPKRLGAHTP
460 470
708 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:54:37 2016 done: Mon Nov 7 01:54:39 2016
Total Scan time: 11.460 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]