Result of FASTA (omim) for
pFN21AB6536
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6536, 390 aa
1>>>pF1KB6536 390 - 390 aa - 390 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9662+/-0.000479; mu= 14.6125+/- 0.030
mean_var=140.1128+/-36.628, 0's: 0 Z-trim(111.3): 525 B-trim: 1110 in 1/49
Lambda= 0.108352
statistics sampled from 19166 (19827) to 19166 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.57), E-opt: 0.2 (0.232), width: 16
Scan time: 8.190
The best scores are: opt bits E(85289)
NP_067637 (OMIM: 606792) histamine H4 receptor iso ( 390) 2584 416.2 6.5e-116
NP_001137300 (OMIM: 606792) histamine H4 receptor ( 302) 1612 264.2 3e-70
XP_011524435 (OMIM: 606792) PREDICTED: histamine H ( 127) 766 131.5 1.1e-30
NP_009163 (OMIM: 604525) histamine H3 receptor [Ho ( 445) 635 111.6 3.7e-24
XP_005260323 (OMIM: 604525) PREDICTED: histamine H ( 453) 635 111.6 3.7e-24
XP_016883112 (OMIM: 604525) PREDICTED: histamine H ( 399) 421 78.1 4e-14
NP_001153638 (OMIM: 606792) histamine H4 receptor ( 67) 407 75.0 5.8e-14
XP_016855649 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855645 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_005273089 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855648 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855643 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855647 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855651 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
NP_000731 (OMIM: 100100,118494) muscarinic acetylc ( 590) 417 77.7 8e-14
XP_016855644 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_011542343 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855641 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_011542345 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_011542347 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855652 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_011542346 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855642 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_011542349 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855650 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_011542348 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_016855646 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 416 77.5 8.6e-14
NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 379 71.7 4.6e-12
NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 379 71.7 4.6e-12
NP_001006632 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11
NP_001006627 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11
NP_001006633 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11
NP_001006628 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11
NP_001006631 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11
NP_001006630 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11
XP_011514071 (OMIM: 118493) PREDICTED: muscarinic ( 466) 369 70.1 1.2e-11
NP_000730 (OMIM: 118493) muscarinic acetylcholine ( 466) 369 70.1 1.2e-11
NP_001006629 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11
XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 353 67.6 7e-11
NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 353 67.6 7e-11
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 331 64.0 6.1e-10
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 331 64.0 6.1e-10
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 331 64.0 6.5e-10
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 333 64.5 6.6e-10
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 331 64.0 6.8e-10
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 331 64.1 7e-10
NP_000732 (OMIM: 118495) muscarinic acetylcholine ( 479) 332 64.3 7e-10
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 324 63.0 1.6e-09
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 324 63.0 1.6e-09
>>NP_067637 (OMIM: 606792) histamine H4 receptor isoform (390 aa)
initn: 2584 init1: 2584 opt: 2584 Z-score: 2202.0 bits: 416.2 E(85289): 6.5e-116
Smith-Waterman score: 2584; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:1-390)
10 20 30 40 50 60
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
310 320 330 340 350 360
370 380 390
pF1KB6 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
::::::::::::::::::::::::::::::
NP_067 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
370 380 390
>>NP_001137300 (OMIM: 606792) histamine H4 receptor isof (302 aa)
initn: 1612 init1: 1612 opt: 1612 Z-score: 1382.1 bits: 264.2 E(85289): 3e-70
Smith-Waterman score: 1816; 77.4% identity (77.4% similar) in 390 aa overlap (1-390:1-302)
10 20 30 40 50 60
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
::::
NP_001 DFFV--------------------------------------------------------
130 140 150 160 170 180
pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
::::::::::::::::::::::::::::
NP_001 --------------------------------VSESWKDEGSECEPGFFSEWYILAITSF
70 80 90
190 200 210 220 230 240
pF1KB6 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB6 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB6 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
220 230 240 250 260 270
370 380 390
pF1KB6 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
::::::::::::::::::::::::::::::
NP_001 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
280 290 300
>>XP_011524435 (OMIM: 606792) PREDICTED: histamine H4 re (127 aa)
initn: 766 init1: 766 opt: 766 Z-score: 671.7 bits: 131.5 E(85289): 1.1e-30
Smith-Waterman score: 766; 100.0% identity (100.0% similar) in 119 aa overlap (1-119:1-119)
10 20 30 40 50 60
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
XP_011 HMDDLKF
>>NP_009163 (OMIM: 604525) histamine H3 receptor [Homo s (445 aa)
initn: 961 init1: 312 opt: 635 Z-score: 554.8 bits: 111.6 E(85289): 3.7e-24
Smith-Waterman score: 896; 39.5% identity (63.6% similar) in 423 aa overlap (10-382:29-439)
10 20 30 40
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFV
.: . ..:: .:.:. : .::::::.::::
NP_009 MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 VDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTA
.:..:: ....:.::::::::.::.. ::::.:..: .: ::. .: .::..::::::.
NP_009 ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
70 80 90 100 110 120
110 120 130 140 150
pF1KB6 SVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK--
:..:::::::::.:::. :::::.:. . . : :. :::::::. :: :: ::.
NP_009 SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAIL---SWEYL
130 140 150 160 170
160 170 180 190
pF1KB6 DEGS-----ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIY---------------
. :: .: :: .::.: .: ::: : . :..::..::
NP_009 SGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAR
180 190 200 210 220 230
200 210 220 230
pF1KB6 ---------------------WSLWKRDHLSRCQSHP---GLTAVSSNICGHSFRGRLSS
:. :.. : : : .::... :.. : ..
NP_009 EAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEA-GEATLGGGGG
240 250 260 270 280 290
240 250 260 270 280 290
pF1KB6 RRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVE
:... : .: :. .: :: .:. . .: .. ..: ::: . :: .
NP_009 GGSVASPTSSSGS-SSRGTERPRSLKRGSKPSASSASLEKRMKMVSQS----FTQR--FR
300 310 320 330 340
300 310 320 330 340 350
pF1KB6 LLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVN
: : :..:::::.....:..:::::.:. :. . . : . ::. .::: : :: ::
NP_009 LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVP-DYWYETSFWLLWANSAVN
350 360 370 380 390 400
360 370 380 390
pF1KB6 PLLYPLCHKRFQKAFLKIFCIKK---QPLPSQHSRSVSS
:.::::::. :..:: :..: .: :: :
NP_009 PVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
410 420 430 440
>>XP_005260323 (OMIM: 604525) PREDICTED: histamine H3 re (453 aa)
initn: 961 init1: 312 opt: 635 Z-score: 554.7 bits: 111.6 E(85289): 3.7e-24
Smith-Waterman score: 896; 39.5% identity (63.6% similar) in 423 aa overlap (10-382:29-439)
10 20 30 40
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFV
.: . ..:: .:.:. : .::::::.::::
XP_005 MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 VDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTA
.:..:: ....:.::::::::.::.. ::::.:..: .: ::. .: .::..::::::.
XP_005 ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
70 80 90 100 110 120
110 120 130 140 150
pF1KB6 SVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK--
:..:::::::::.:::. :::::.:. . . : :. :::::::. :: :: ::.
XP_005 SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAIL---SWEYL
130 140 150 160 170
160 170 180 190
pF1KB6 DEGS-----ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIY---------------
. :: .: :: .::.: .: ::: : . :..::..::
XP_005 SGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAR
180 190 200 210 220 230
200 210 220 230
pF1KB6 ---------------------WSLWKRDHLSRCQSHP---GLTAVSSNICGHSFRGRLSS
:. :.. : : : .::... :.. : ..
XP_005 EAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEA-GEATLGGGGG
240 250 260 270 280 290
240 250 260 270 280 290
pF1KB6 RRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVE
:... : .: :. .: :: .:. . .: .. ..: ::: . :: .
XP_005 GGSVASPTSSSGS-SSRGTERPRSLKRGSKPSASSASLEKRMKMVSQS----FTQR--FR
300 310 320 330 340
300 310 320 330 340 350
pF1KB6 LLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVN
: : :..:::::.....:..:::::.:. :. . . : . ::. .::: : :: ::
XP_005 LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVP-DYWYETSFWLLWANSAVN
350 360 370 380 390 400
360 370 380 390
pF1KB6 PLLYPLCHKRFQKAFLKIFCIKK---QPLPSQHSRSVSS
:.::::::. :..:: :..: .: :: :
XP_005 PVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWKKMKKKTCL
410 420 430 440 450
>>XP_016883112 (OMIM: 604525) PREDICTED: histamine H3 re (399 aa)
initn: 905 init1: 312 opt: 421 Z-score: 374.5 bits: 78.1 E(85289): 4e-14
Smith-Waterman score: 817; 38.5% identity (61.0% similar) in 410 aa overlap (22-382:1-385)
10 20 30 40 50 60
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
:.:. : .::::::.::::.:..:: ....:.::::::
XP_016 MALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAIS
10 20 30
70 80 90 100 110 120
pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
::.:: .: ::. .: .::..::::::.:..:::::::::.:::. ::
XP_016 DFLVG-------------RWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAV
40 50 60 70 80
130 140 150 160 170
pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK--DEGS-----ECEPGFFSEWY
:::.:. . . : :. :::::::. :: :: ::. . :: .: :: .::
XP_016 SYRAQQGDTRRAVRKMLLVWVLAFLLYGPAIL---SWEYLSGGSSIPEGHCYAEFFYNWY
90 100 110 120 130 140
180 190
pF1KB6 ILAITSFLEFVIPVILVAYFNMNIY-----------------------------------
.: .: ::: : . :..::..::
XP_016 FLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPG
150 160 170 180 190 200
200 210 220 230 240 250
pF1KB6 -WSLWKRDHLSRCQSHP---GLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQR
:. :.. : : : .::... :.. : .. :... : .: :. .
XP_016 CWGCWQKGHGEAMPLHRYGVGEAAVGAEA-GEATLGGGGGGGSVASPTSSSGS-SSRGTE
210 220 230 240 250 260
260 270 280 290 300 310
pF1KB6 RKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAV
: :: .:. . .: .. ..: ::: . :: .: : :..:::::.....:..
XP_016 RPRSLKRGSKPSASSASLEKRMKMVSQS----FTQR--FRLSRDRKVAKSLAVIVSIFGL
270 280 290 300 310
320 330 340 350 360 370
pF1KB6 CWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFC
:::::.:. :. . . : . ::. .::: : :: :::.::::::. :..:: :..:
XP_016 CWAPYTLLMIIRAACHGHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLC
320 330 340 350 360 370
380 390
pF1KB6 IKK---QPLPSQHSRSVSS
.: :: :
XP_016 PQKLKIQPHSSLEHCWKKMKKKTCL
380 390
>>NP_001153638 (OMIM: 606792) histamine H4 receptor isof (67 aa)
initn: 407 init1: 407 opt: 407 Z-score: 371.7 bits: 75.0 E(85289): 5.8e-14
Smith-Waterman score: 407; 98.5% identity (100.0% similar) in 67 aa overlap (1-67:1-67)
10 20 30 40 50 60
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
::::::.
NP_001 DFFVGVL
>>XP_016855649 (OMIM: 100100,118494) PREDICTED: muscarin (590 aa)
initn: 449 init1: 162 opt: 417 Z-score: 369.2 bits: 77.7 E(85289): 8e-14
Smith-Waterman score: 417; 30.6% identity (65.5% similar) in 278 aa overlap (16-284:69-336)
10 20 30 40
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKN
: .::. ...:.. ..:: :::..: :.:.
XP_016 SYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQ
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB6 LRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYN
:. ..::.:.:: .:...::::. :. . ... : .:. : .::. ::. .:::.:
XP_016 LKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMN
100 110 120 130 140 150
110 120 130 140 150 160
pF1KB6 IVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAV-WVLAFLVNGPMILVSESWKDEGS-
...::.:::.:.. ..::...: : . .:... ::..:.. .: :: . . . .
XP_016 LLVISFDRYFSITRPLTYRAKRT--TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTV
160 170 180 190 200 210
170 180 190 200 210
pF1KB6 ---ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAV
:: :.:: : :.. : .:: ... .:: ..:. . .: . :: :
XP_016 PPGECFIQFLSEPTITFGTAIAAFYMPVTIMTI----LYWRIYKETE-KRTKELAGLQAS
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB6 SSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSS---LMFSSRTKMNSNTIASKM
... ..: .: :: : : :. . .. .::: . . :.... :. ..
XP_016 GTEAETENFVHPTGSSRSCS-SYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQ-
280 290 300 310 320
280 290 300 310 320 330
pF1KB6 GSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPK
. :.:::
XP_016 -DHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDN
330 340 350 360 370 380
>--
initn: 153 init1: 105 opt: 224 Z-score: 206.1 bits: 47.5 E(85289): 9.7e-05
Smith-Waterman score: 224; 26.4% identity (62.6% similar) in 174 aa overlap (231-389:407-578)
210 220 230 240 250 260
pF1KB6 LWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLM
.:....:.. . : :: . . .:..
XP_016 ILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVD
380 390 400 410 420 430
270 280 290 300
pF1KB6 FSSRTKMNSN---TIASKMGSFSQSD---SVALH------QREHVELLRARRLAKSLAIL
.. . .::. . :. ::... ::. .:... :.. .. :..:. .
XP_016 TAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAI
440 450 460 470 480 490
310 320 330 340 350 360
pF1KB6 LGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKA
: .: . :.::.....: .: .: ::. : ...:: ..:: :::. : ::.: :. .
XP_016 LLAFIITWTPYNIMVLVNTFCDSCI-PKTFW-NLGYWLCYINSTVNPVCYALCNKTFRTT
500 510 520 530 540 550
370 380 390
pF1KB6 FLKIF---CIKKQPLPSQHSRSVSS
: .. : ::. .:... :
XP_016 FKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
560 570 580 590
>>XP_016855645 (OMIM: 100100,118494) PREDICTED: muscarin (590 aa)
initn: 449 init1: 162 opt: 417 Z-score: 369.2 bits: 77.7 E(85289): 8e-14
Smith-Waterman score: 417; 30.6% identity (65.5% similar) in 278 aa overlap (16-284:69-336)
10 20 30 40
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKN
: .::. ...:.. ..:: :::..: :.:.
XP_016 SYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQ
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB6 LRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYN
:. ..::.:.:: .:...::::. :. . ... : .:. : .::. ::. .:::.:
XP_016 LKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMN
100 110 120 130 140 150
110 120 130 140 150 160
pF1KB6 IVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAV-WVLAFLVNGPMILVSESWKDEGS-
...::.:::.:.. ..::...: : . .:... ::..:.. .: :: . . . .
XP_016 LLVISFDRYFSITRPLTYRAKRT--TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTV
160 170 180 190 200 210
170 180 190 200 210
pF1KB6 ---ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAV
:: :.:: : :.. : .:: ... .:: ..:. . .: . :: :
XP_016 PPGECFIQFLSEPTITFGTAIAAFYMPVTIMTI----LYWRIYKETE-KRTKELAGLQAS
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB6 SSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSS---LMFSSRTKMNSNTIASKM
... ..: .: :: : : :. . .. .::: . . :.... :. ..
XP_016 GTEAETENFVHPTGSSRSCS-SYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQ-
280 290 300 310 320
280 290 300 310 320 330
pF1KB6 GSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPK
. :.:::
XP_016 -DHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDN
330 340 350 360 370 380
>--
initn: 153 init1: 105 opt: 224 Z-score: 206.1 bits: 47.5 E(85289): 9.7e-05
Smith-Waterman score: 224; 26.4% identity (62.6% similar) in 174 aa overlap (231-389:407-578)
210 220 230 240 250 260
pF1KB6 LWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLM
.:....:.. . : :: . . .:..
XP_016 ILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVD
380 390 400 410 420 430
270 280 290 300
pF1KB6 FSSRTKMNSN---TIASKMGSFSQSD---SVALH------QREHVELLRARRLAKSLAIL
.. . .::. . :. ::... ::. .:... :.. .. :..:. .
XP_016 TAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAI
440 450 460 470 480 490
310 320 330 340 350 360
pF1KB6 LGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKA
: .: . :.::.....: .: .: ::. : ...:: ..:: :::. : ::.: :. .
XP_016 LLAFIITWTPYNIMVLVNTFCDSCI-PKTFW-NLGYWLCYINSTVNPVCYALCNKTFRTT
500 510 520 530 540 550
370 380 390
pF1KB6 FLKIF---CIKKQPLPSQHSRSVSS
: .. : ::. .:... :
XP_016 FKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
560 570 580 590
>>XP_005273089 (OMIM: 100100,118494) PREDICTED: muscarin (590 aa)
initn: 449 init1: 162 opt: 417 Z-score: 369.2 bits: 77.7 E(85289): 8e-14
Smith-Waterman score: 417; 30.6% identity (65.5% similar) in 278 aa overlap (16-284:69-336)
10 20 30 40
pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKN
: .::. ...:.. ..:: :::..: :.:.
XP_005 SYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQ
40 50 60 70 80 90
50 60 70 80 90 100
pF1KB6 LRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYN
:. ..::.:.:: .:...::::. :. . ... : .:. : .::. ::. .:::.:
XP_005 LKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMN
100 110 120 130 140 150
110 120 130 140 150 160
pF1KB6 IVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAV-WVLAFLVNGPMILVSESWKDEGS-
...::.:::.:.. ..::...: : . .:... ::..:.. .: :: . . . .
XP_005 LLVISFDRYFSITRPLTYRAKRT--TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTV
160 170 180 190 200 210
170 180 190 200 210
pF1KB6 ---ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAV
:: :.:: : :.. : .:: ... .:: ..:. . .: . :: :
XP_005 PPGECFIQFLSEPTITFGTAIAAFYMPVTIMTI----LYWRIYKETE-KRTKELAGLQAS
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB6 SSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSS---LMFSSRTKMNSNTIASKM
... ..: .: :: : : :. . .. .::: . . :.... :. ..
XP_005 GTEAETENFVHPTGSSRSCS-SYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQ-
280 290 300 310 320
280 290 300 310 320 330
pF1KB6 GSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPK
. :.:::
XP_005 -DHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDN
330 340 350 360 370 380
>--
initn: 153 init1: 105 opt: 224 Z-score: 206.1 bits: 47.5 E(85289): 9.7e-05
Smith-Waterman score: 224; 26.4% identity (62.6% similar) in 174 aa overlap (231-389:407-578)
210 220 230 240 250 260
pF1KB6 LWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLM
.:....:.. . : :: . . .:..
XP_005 ILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVD
380 390 400 410 420 430
270 280 290 300
pF1KB6 FSSRTKMNSN---TIASKMGSFSQSD---SVALH------QREHVELLRARRLAKSLAIL
.. . .::. . :. ::... ::. .:... :.. .. :..:. .
XP_005 TAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAI
440 450 460 470 480 490
310 320 330 340 350 360
pF1KB6 LGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKA
: .: . :.::.....: .: .: ::. : ...:: ..:: :::. : ::.: :. .
XP_005 LLAFIITWTPYNIMVLVNTFCDSCI-PKTFW-NLGYWLCYINSTVNPVCYALCNKTFRTT
500 510 520 530 540 550
370 380 390
pF1KB6 FLKIF---CIKKQPLPSQHSRSVSS
: .. : ::. .:... :
XP_005 FKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
560 570 580 590
390 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:00:57 2016 done: Mon Nov 7 16:00:58 2016
Total Scan time: 8.190 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]