Result of FASTA (omim) for
pFN21AB6231
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6231, 743 aa
1>>>pF1KB6231 743 - 743 aa - 743 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3512+/-0.000408; mu= 6.6318+/- 0.025
mean_var=180.1294+/-37.802, 0's: 0 Z-trim(117.7): 98 B-trim: 1503 in 2/56
Lambda= 0.095561
statistics sampled from 29870 (29977) to 29870 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.691), E-opt: 0.2 (0.351), width: 16
Scan time: 13.850
The best scores are: opt bits E(85289)
NP_057653 (OMIM: 181450,601621) T-box transcriptio ( 743) 4919 691.1 4.4e-198
NP_005987 (OMIM: 181450,601621) T-box transcriptio ( 723) 3254 461.5 5.5e-129
NP_005985 (OMIM: 600747) T-box transcription facto ( 712) 1083 162.2 6.8e-39
XP_011523461 (OMIM: 600747) PREDICTED: T-box trans ( 486) 802 123.3 2.3e-27
XP_011523797 (OMIM: 147891,601719) PREDICTED: T-bo ( 417) 551 88.7 5.3e-17
NP_060958 (OMIM: 147891,601719) T-box transcriptio ( 545) 551 88.8 6.6e-17
NP_001308049 (OMIM: 147891,601719) T-box transcrip ( 546) 551 88.8 6.6e-17
XP_011523793 (OMIM: 147891,601719) PREDICTED: T-bo ( 608) 551 88.8 7.2e-17
XP_011523792 (OMIM: 147891,601719) PREDICTED: T-bo ( 609) 551 88.8 7.2e-17
NP_001159692 (OMIM: 606061,611363) T-box transcrip ( 297) 529 85.6 3.3e-16
NP_001071121 (OMIM: 606061,611363) T-box transcrip ( 447) 529 85.7 4.6e-16
NP_852259 (OMIM: 142900,601620) T-box transcriptio ( 518) 528 85.6 5.7e-16
NP_000183 (OMIM: 142900,601620) T-box transcriptio ( 518) 528 85.6 5.7e-16
XP_016875401 (OMIM: 142900,601620) PREDICTED: T-bo ( 534) 528 85.6 5.8e-16
NP_542448 (OMIM: 142900,601620) T-box transcriptio ( 468) 526 85.3 6.3e-16
NP_005983 (OMIM: 187500,188400,192430,217095,60205 ( 372) 520 84.4 9.4e-16
NP_542377 (OMIM: 187500,188400,192430,217095,60205 ( 398) 520 84.4 9.9e-16
XP_016884417 (OMIM: 187500,188400,192430,217095,60 ( 448) 520 84.4 1.1e-15
XP_006724375 (OMIM: 187500,188400,192430,217095,60 ( 495) 520 84.5 1.2e-15
XP_016884415 (OMIM: 187500,188400,192430,217095,60 ( 495) 520 84.5 1.2e-15
NP_542378 (OMIM: 187500,188400,192430,217095,60205 ( 495) 520 84.5 1.2e-15
XP_016884414 (OMIM: 187500,188400,192430,217095,60 ( 545) 520 84.5 1.3e-15
NP_005986 (OMIM: 604648) T-box transcription facto ( 385) 516 83.8 1.4e-15
XP_011543294 (OMIM: 604648) PREDICTED: T-box trans ( 430) 516 83.9 1.5e-15
XP_011544228 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 510 83.0 2.8e-15
XP_016879103 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 510 83.0 2.8e-15
NP_004599 (OMIM: 122600,602427) T-box transcriptio ( 436) 510 83.0 2.8e-15
XP_005255580 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 510 83.0 2.8e-15
XP_006715665 (OMIM: 143100,143400,604613) PREDICTE ( 364) 503 82.0 4.7e-15
XP_011534551 (OMIM: 143100,143400,604613) PREDICTE ( 372) 503 82.0 4.8e-15
XP_016866962 (OMIM: 143100,143400,604613) PREDICTE ( 376) 503 82.0 4.8e-15
XP_011534550 (OMIM: 143100,143400,604613) PREDICTE ( 377) 503 82.0 4.8e-15
XP_011534549 (OMIM: 143100,143400,604613) PREDICTE ( 379) 503 82.0 4.8e-15
NP_001073977 (OMIM: 143100,143400,604613) T-box tr ( 607) 503 82.2 7e-15
NP_689593 (OMIM: 260660,604127) T-box transcriptio ( 496) 474 78.1 9.6e-14
NP_001317606 (OMIM: 260660,604127) T-box transcrip ( 602) 474 78.2 1.1e-13
XP_005271218 (OMIM: 260660,604127) PREDICTED: T-bo ( 635) 456 75.7 6.5e-13
XP_006724720 (OMIM: 300307,302905,303400) PREDICTE ( 350) 420 70.6 1.3e-11
NP_001103348 (OMIM: 300307,302905,303400) T-box tr ( 520) 420 70.7 1.7e-11
NP_058650 (OMIM: 300307,302905,303400) T-box trans ( 520) 420 70.7 1.7e-11
XP_005262193 (OMIM: 300307,302905,303400) PREDICTE ( 521) 420 70.7 1.7e-11
XP_016866961 (OMIM: 143100,143400,604613) PREDICTE ( 449) 409 69.1 4.4e-11
NP_001257413 (OMIM: 182940,601397,615709) brachyur ( 377) 402 68.1 7.5e-11
NP_003172 (OMIM: 182940,601397,615709) brachyury p ( 435) 402 68.2 8.4e-11
XP_011534382 (OMIM: 182940,601397,615709) PREDICTE ( 436) 402 68.2 8.4e-11
NP_006584 (OMIM: 604616) T-box brain protein 1 [Ho ( 682) 404 68.6 9.9e-11
NP_037483 (OMIM: 208550,604895) T-box transcriptio ( 535) 398 67.7 1.4e-10
XP_016877522 (OMIM: 616061) PREDICTED: MAX gene-as (1439) 405 68.9 1.6e-10
XP_011519703 (OMIM: 616061) PREDICTED: MAX gene-as (1549) 405 68.9 1.7e-10
XP_016877519 (OMIM: 616061) PREDICTED: MAX gene-as (2207) 405 69.0 2.3e-10
>>NP_057653 (OMIM: 181450,601621) T-box transcription fa (743 aa)
initn: 4919 init1: 4919 opt: 4919 Z-score: 3677.2 bits: 691.1 E(85289): 4.4e-198
Smith-Waterman score: 4919; 100.0% identity (100.0% similar) in 743 aa overlap (1-743:1-743)
10 20 30 40 50 60
pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE
670 680 690 700 710 720
730 740
pF1KB6 LQSIQRLVSGLEAKPDRSRSASP
:::::::::::::::::::::::
NP_057 LQSIQRLVSGLEAKPDRSRSASP
730 740
>>NP_005987 (OMIM: 181450,601621) T-box transcription fa (723 aa)
initn: 3254 init1: 3254 opt: 3254 Z-score: 2436.8 bits: 461.5 E(85289): 5.5e-129
Smith-Waterman score: 4725; 97.3% identity (97.3% similar) in 743 aa overlap (1-743:1-723)
10 20 30 40 50 60
pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQT
::::::::::::::::::::::::::::::::::::::::
NP_005 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFT--------------------
190 200 210 220
250 260 270 280 290 300
pF1KB6 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB6 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTV
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB6 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB6 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEARALPGKEAFA
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB6 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPSQFAMGGAFSSMAAAGMG
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB6 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLASQGLAMSPFGSL
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB6 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FPYPYTYMAAAAAASSAAASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTAL
590 600 610 620 630 640
670 680 690 700 710 720
pF1KB6 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PSMAAAAGPLDGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSE
650 660 670 680 690 700
730 740
pF1KB6 LQSIQRLVSGLEAKPDRSRSASP
:::::::::::::::::::::::
NP_005 LQSIQRLVSGLEAKPDRSRSASP
710 720
>>NP_005985 (OMIM: 600747) T-box transcription factor TB (712 aa)
initn: 1467 init1: 884 opt: 1083 Z-score: 819.3 bits: 162.2 E(85289): 6.8e-39
Smith-Waterman score: 2309; 56.0% identity (70.5% similar) in 770 aa overlap (5-743:1-706)
10 20 30 40 50
pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGH-QPPFFPALTLPPNGAAALSLPG-
::.:.. ...:::::: : :: ::: :. :: :::::.::: :: : ::
NP_005 MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALPP-GALAKPLPDP
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 --ALAKPIMDQLVGAAETGIPFSSLGPQ---AHLRPLKTMEPEEEVEDDPKVHLEAKELW
: : ..:::.:. :.:::. :::: ::..:::.:::::::: :::::::
NP_005 GLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVEDDPKVTLEAKELW
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 DQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVA
::::: :::::::::::::::::::: :::::::::::::::.:::::::::::::::::
NP_005 DQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 GKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGN
:::::::::::::::::::::::::.: :.:::::::::::::::::
NP_005 GKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFT-------------
180 190 200 210 220
240 250 260 270 280 290
pF1KB6 YSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLK
:::::::::::::::::::::::::::::::.::::.::::::::::::::::
NP_005 -------ILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLK
230 240 250 260 270
300 310 320 330 340 350
pF1KB6 IDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKE-NGT-SDESSSEQAAFNCFAQ
:::::::::::::::::::::::::: :.:...:. : : .:. :: :: .
NP_005 IDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPPAR--EP
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB6 ASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDAAKISTTTSEEPCRDKGSPA
.::.:. : :. :.. :.: : :: . . .. .. : :..::
NP_005 PTSPGAA---PSPLRLHRARAEEKSCAADSDPE--PERLSEERAGAPLGRSPAPDSASP-
340 350 360 370 380
420 430 440 450 460 470
pF1KB6 VKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAEERRSPVREGTAPAKVEEAR
..: :: :. . ::. . :: . : : :: .: . . .:.:
NP_005 --TRLTEPERARE-----RRSPERGKEPAE----SGGDGPFGLRSLEKERAEARRKDEGR
390 400 410 420 430
480 490 500 510 520
pF1KB6 --ALPGKE-AFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAGQQFFN----GHPLFLHPSQ
: ::: ..:::.::::.:. :. : ::::.:. : :::::. :.::::::.:
NP_005 KEAAEGKEQGLAPLVVQTDSASP-LGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQ
440 450 460 470 480 490
530 540 550 560 570 580
pF1KB6 FAMG-GAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQG--LSGAS-AATLPF
:.:: ::::.: ::: :::.:.:...: .: .:: . :.. : :.:: :: .::
NP_005 FTMGPGAFSAM---GMGHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPF
500 510 520 530 540 550
590 600 610 620
pF1KB6 HLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSA-----------AASSSVHRHPFL
::.::.:::::. : ::.:::::::::::::::.:: ::..:. : :::
NP_005 HLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFL
560 570 580 590 600 610
630 640 650 660 670 680
pF1KB6 NLNTMRPRLRYSPYSIPVPVPDGSSLLTTALPSMAAAAGPLDGKVAALAASPASVAVDSG
. . :::::.:::.::: .: ..:::::.: : .. :. ... ::
NP_005 G--SARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGGNSR----EPSPLP------
620 630 640 650 660
690 700 710 720 730 740
pF1KB6 SELNSRSSTLSSSSMSLSPKLCAEKEAATSELQSIQRLVSGLEAKPDRSRSASP
:: :. . : .:::. : :::: .:::::::::::::.. :. ::
NP_005 -ELALRKVG-APSRGALSPSGSA-KEAA-NELQSIQRLVSGLESQ----RALSPGRESPK
670 680 690 700 710
>>XP_011523461 (OMIM: 600747) PREDICTED: T-box transcrip (486 aa)
initn: 1016 init1: 534 opt: 802 Z-score: 612.3 bits: 123.3 E(85289): 2.3e-27
Smith-Waterman score: 1256; 49.9% identity (67.5% similar) in 523 aa overlap (245-743:1-480)
220 230 240 250 260 270
pF1KB6 DKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFP
:::::::::::::::::::::::::::.::
XP_011 MHKYQPRFHIVRANDILKLPYSTFRTYVFP
10 20 30
280 290 300 310 320 330
pF1KB6 ETEFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKE-N
::.:::::::::::::::::::::::::::::::::::::::::: :.:...:. : : .
XP_011 ETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPERD
40 50 60 70 80 90
340 350 360 370 380 390
pF1KB6 GT-SDESSSEQAAFNCFAQASSPAASTVGTSNLKDLCPSEGESDAEAESKEEHGPEACDA
:. :: :: . .::.:. : :. :.. :.: : :: .
XP_011 GAESDASSCDPPP--AREPPTSPGAAP---SPLRLHRARAEEKSCAADSDPE--PERLSE
100 110 120 130 140
400 410 420 430 440 450
pF1KB6 AKISTTTSEEPCRDKGSPAVKAHLFAAERPRDSGRLDKASPDSRHSPATISSSTRGLGAE
. .. .. : :..::. .: :: :. . ::. . :: . : :
XP_011 ERAGAPLGRSPAPDSASPT---RLTEPERARE-----RRSPERGKEPAE----SGGDGPF
150 160 170 180 190
460 470 480 490 500
pF1KB6 ERRSPVREGTAPAKVEEAR--ALPGKE-AFAPLTVQTDAAAAHLAQGPLPGLGFAPGLAG
:: .: . . .:.: : ::: ..:::.::::.:. :. : ::::.:. : :
XP_011 GLRSLEKERAEARRKDEGRKEAAEGKEQGLAPLVVQTDSASP-LGAGHLPGLAFSSHLHG
200 210 220 230 240 250
510 520 530 540 550 560
pF1KB6 QQFFN----GHPLFLHPSQFAMG-GAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASA
::::. :.::::::.::.:: ::::.: ::: :::.:.:...: .: .:: .
XP_011 QQFFGPLGAGQPLFLHPGQFTMGPGAFSAM---GMGHLLASVAGGGNGGGGGPGTAAGLD
260 270 280 290 300
570 580 590 600 610
pF1KB6 AAAQG--LSGAS-AATLPFHLQQHVLASQGLAMSPFGSLFPYPYTYMAAAAAASSA----
:.. : :.:: :: .::::.::.:::::. : ::.:::::::::::::::.::
XP_011 AGGLGPAASAASTAAPFPFHLSQHMLASQGIPMPTFGGLFPYPYTYMAAAAAAASALPAT
310 320 330 340 350 360
620 630 640 650 660 670
pF1KB6 -------AASSSVHRHPFLNLNTMRPRLRYSPYSIPVPVPDGSSLLTTALPSMAAAAGPL
::..:. : ::: .. :::::.:::.::: .: ..:::::.: : .. :.
XP_011 SAAAAAAAAAGSLSRSPFL--GSARPRLRFSPYQIPVTIPPSTSLLTTGLASEGSKAAGG
370 380 390 400 410 420
680 690 700 710 720 730
pF1KB6 DGKVAALAASPASVAVDSGSELNSRSSTLSSSSMSLSPKLCAEKEAATSELQSIQRLVSG
... :: :: :. : . .:::. : :::: .:::::::::::
XP_011 NSR----EPSPLP-------ELALRKVGAPSRG-ALSPSGSA-KEAA-NELQSIQRLVSG
430 440 450 460 470
740
pF1KB6 LEAKPDRSRSASP
::.. :. ::
XP_011 LESQ----RALSPGRESPK
480
>>XP_011523797 (OMIM: 147891,601719) PREDICTED: T-box tr (417 aa)
initn: 832 init1: 543 opt: 551 Z-score: 426.2 bits: 88.7 E(85289): 5.3e-17
Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:80-341)
20 30 40 50 60 70
pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA
:. .: .:: : ::: : : ::
XP_011 GDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA
50 60 70 80 90 100
80 90 100 110 120 130
pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR
: . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.:::
XP_011 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR
110 120 130 140 150
140 150 160 170 180 190
pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP
::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.:::::
XP_011 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP
160 170 180 190 200 210
200 210 220 230 240 250
pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR
::: .:: ..:.:.::::::: : : . :::::::::::
XP_011 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR
220 230 240 250
260 270 280 290 300
pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG
.:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : .
XP_011 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS
260 270 280 290 300 310
310 320 330 340 350 360
pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL
. : : . :. . : .. .:
XP_011 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE
320 330 340 350 360 370
>>NP_060958 (OMIM: 147891,601719) T-box transcription fa (545 aa)
initn: 853 init1: 543 opt: 551 Z-score: 424.5 bits: 88.8 E(85289): 6.6e-17
Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:17-278)
20 30 40 50 60 70
pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA
:. .: .:: : ::: : : ::
NP_060 MLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA
10 20 30 40
80 90 100 110 120 130
pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR
: . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.:::
NP_060 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR
50 60 70 80 90
140 150 160 170 180 190
pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP
::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.:::::
NP_060 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR
::: .:: ..:.:.::::::: : : . :::::::::::
NP_060 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR
160 170 180 190
260 270 280 290 300
pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG
.:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : .
NP_060 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL
. : : . :. . : .. .:
NP_060 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE
260 270 280 290 300 310
>>NP_001308049 (OMIM: 147891,601719) T-box transcription (546 aa)
initn: 839 init1: 543 opt: 551 Z-score: 424.5 bits: 88.8 E(85289): 6.6e-17
Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:17-278)
20 30 40 50 60 70
pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA
:. .: .:: : ::: : : ::
NP_001 MLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA
10 20 30 40
80 90 100 110 120 130
pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR
: . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.:::
NP_001 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR
50 60 70 80 90
140 150 160 170 180 190
pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP
::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.:::::
NP_001 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR
::: .:: ..:.:.::::::: : : . :::::::::::
NP_001 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR
160 170 180 190
260 270 280 290 300
pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG
.:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : .
NP_001 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL
. : : . :. . : .. .:
NP_001 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE
260 270 280 290 300 310
>>XP_011523793 (OMIM: 147891,601719) PREDICTED: T-box tr (608 aa)
initn: 853 init1: 543 opt: 551 Z-score: 423.9 bits: 88.8 E(85289): 7.2e-17
Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:80-341)
20 30 40 50 60 70
pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA
:. .: .:: : ::: : : ::
XP_011 GDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA
50 60 70 80 90 100
80 90 100 110 120 130
pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR
: . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.:::
XP_011 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR
110 120 130 140 150
140 150 160 170 180 190
pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP
::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.:::::
XP_011 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP
160 170 180 190 200 210
200 210 220 230 240 250
pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR
::: .:: ..:.:.::::::: : : . :::::::::::
XP_011 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR
220 230 240 250
260 270 280 290 300
pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG
.:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : .
XP_011 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS
260 270 280 290 300 310
310 320 330 340 350 360
pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL
. : : . :. . : .. .:
XP_011 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE
320 330 340 350 360 370
>>XP_011523792 (OMIM: 147891,601719) PREDICTED: T-box tr (609 aa)
initn: 839 init1: 543 opt: 551 Z-score: 423.9 bits: 88.8 E(85289): 7.2e-17
Smith-Waterman score: 809; 48.8% identity (67.2% similar) in 293 aa overlap (42-328:80-341)
20 30 40 50 60 70
pF1KB6 GTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPALTLPPNGAAALSLPGALAKPIMDQLVGA
:. .: .:: : ::: : : ::
XP_011 GDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAPEP-ALAAP---GLSGA
50 60 70 80 90 100
80 90 100 110 120 130
pF1KB6 AETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVHLEAKELWDQFHKRGTEMVITKSGRR
: . : :: : . . . :. .:. :: :. :::: .::. ::::.:::.:::
XP_011 ALGSPP----GPGADV--VAAAAAEQTIEN-IKVGLHEKELWKKFHEAGTEMIITKAGRR
110 120 130 140 150
140 150 160 170 180 190
pF1KB6 MFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSP
::: .::. .:.. :.:::::.::. ::: :::: ...:::::::.: :: :.:.:::::
XP_011 MFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP
160 170 180 190 200 210
200 210 220 230 240 250
pF1KB6 ATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPR
::: .:: ..:.:.::::::: : : . :::::::::::
XP_011 ATGAHWMRQLVSFQKLKLTNNHLDPFG--------------------HIILNSMHKYQPR
220 230 240 250
260 270 280 290 300
pF1KB6 FHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR--DTG
.:::.: :. . ..: :..:::: ::.::.::: :::::::.::::::::: : .
XP_011 LHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDS
260 270 280 290 300 310
310 320 330 340 350 360
pF1KB6 NGR--REKRKQLTLQSMRVFDERHKKENGTSDESSSEQAAFNCFAQASSPAASTVGTSNL
. : : . :. . : .. .:
XP_011 DLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAE
320 330 340 350 360 370
>>NP_001159692 (OMIM: 606061,611363) T-box transcription (297 aa)
initn: 581 init1: 275 opt: 529 Z-score: 411.9 bits: 85.6 E(85289): 3.3e-16
Smith-Waterman score: 777; 45.5% identity (65.3% similar) in 303 aa overlap (19-306:9-289)
10 20 30 40 50
pF1KB6 MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVL---GHQPPFFPALTLPPNGAAALSLP
: : :: :...:.. : . :. : .
NP_001 MEFTASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKP--LEQFVEK
10 20 30 40
60 70 80 90 100 110
pF1KB6 GALAKPI--MDQLVGAAETGIPFSSLGPQAHL--RPLKTMEPEEEVEDDPKV--HLEAKE
.. :.:. . .: . .: : .: .. : .:: : :. :. ::.::
NP_001 SSCAQPLGELTSLDAHGEFGGGSGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKE
50 60 70 80 90 100
120 130 140 150 160
pF1KB6 LWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKF--HNSR
:::.::. ::::.:::::::::: ..: ::.: .::::.::::. .:. ::.. : :
NP_001 LWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSS
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB6 WMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHAT
:.::::::: .: :.:.::::: :::: ....:.:.:.::::: :.::
NP_001 WLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHG-----------
170 180 190 200 210
230 240 250 260 270 280
pF1KB6 WQGNYSFGTQTILNSMHKYQPRFHIVRAND----ILKLPYSTFRTYLFPETEFIAVTAYQ
. ::::::::::: ::.. .: .:.: :::..:::: : ::::::
NP_001 ---------HIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQ
220 230 240 250 260
290 300 310 320 330 340
pF1KB6 NDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLQSMRVFDERHKKENGTSDESSSEQAA
:. ::.::::.:::::::::.
NP_001 NQLITKLKIDSNPFAKGFRDSSRLTDIER
270 280 290
743 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:10:52 2016 done: Sun Nov 6 06:10:54 2016
Total Scan time: 13.850 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]