Result of FASTA (omim) for
pFN21AB5838
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5838, 481 aa
1>>>pF1KB5838 481 - 481 aa - 481 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1520+/-0.000533; mu= 18.8379+/- 0.034
mean_var=124.3923+/-35.275, 0's: 0 Z-trim(109.2): 596 B-trim: 1857 in 2/47
Lambda= 0.114995
statistics sampled from 16566 (17353) to 16566 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.543), E-opt: 0.2 (0.203), width: 16
Scan time: 9.130
The best scores are: opt bits E(85289)
NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 3109 528.3 1.8e-149
XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 2888 491.6 1.9e-138
NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 2843 484.2 3.2e-136
XP_005246577 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 362) 2373 406.1 8.6e-113
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 790 143.6 1.1e-33
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 790 143.6 1.1e-33
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 782 142.3 2.9e-33
XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 571 107.1 8.5e-23
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 571 107.1 8.5e-23
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 571 107.1 8.5e-23
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 571 107.1 8.5e-23
XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 571 107.1 8.5e-23
NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 571 107.1 8.5e-23
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 566 106.3 1.5e-22
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 566 106.3 1.6e-22
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367) 562 105.6 2.4e-22
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 553 104.1 6.8e-22
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 553 104.1 6.8e-22
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 512 97.5 8.8e-20
NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 510 97.0 9.8e-20
NP_001243690 (OMIM: 312861) 5-hydroxytryptamine re ( 248) 486 92.8 1.2e-18
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 415 81.3 5.7e-15
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 415 81.3 5.9e-15
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 415 81.3 5.9e-15
NP_000788 (OMIM: 126452,143465,601696) D(4) dopami ( 419) 407 80.0 1.4e-14
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 406 79.8 1.6e-14
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 397 78.2 3.9e-14
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 397 78.2 3.9e-14
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 397 78.2 4.2e-14
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 397 78.3 4.3e-14
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 397 78.3 4.4e-14
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 397 78.5 5.2e-14
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 396 78.2 5.2e-14
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 396 78.2 5.3e-14
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 397 78.5 5.4e-14
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 396 78.2 5.5e-14
NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 388 76.8 1.3e-13
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 375 74.7 5.6e-13
XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400) 373 74.3 7e-13
NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400) 373 74.3 7e-13
NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400) 373 74.3 7e-13
NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400) 373 74.3 7e-13
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 371 74.1 9.4e-13
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 371 74.2 1.1e-12
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 370 73.9 1.1e-12
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 369 73.7 1.1e-12
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 369 73.7 1.2e-12
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 356 71.3 4.2e-12
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 356 71.4 4.3e-12
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 356 71.4 4.3e-12
>>NP_000858 (OMIM: 601122) 5-hydroxytryptamine receptor (481 aa)
initn: 3109 init1: 3109 opt: 3109 Z-score: 2804.6 bits: 528.3 E(85289): 1.8e-149
Smith-Waterman score: 3109; 100.0% identity (100.0% similar) in 481 aa overlap (1-481:1-481)
10 20 30 40 50 60
pF1KB5 MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
430 440 450 460 470 480
pF1KB5 V
:
NP_000 V
>>XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytrypta (456 aa)
initn: 2888 init1: 2888 opt: 2888 Z-score: 2606.7 bits: 491.6 E(85289): 1.9e-138
Smith-Waterman score: 2888; 99.8% identity (100.0% similar) in 447 aa overlap (35-481:10-456)
10 20 30 40 50 60
pF1KB5 YRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMV
.:::::::::::::::::::::::::::::
XP_006 MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMV
10 20 30
70 80 90 100 110 120
pF1KB5 IIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB5 LVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISI
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB5 GIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHAL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB5 QKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB5 TSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEI
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB5 FVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAEN
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB5 SKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
400 410 420 430 440 450
>>NP_001307687 (OMIM: 601122) 5-hydroxytryptamine recept (439 aa)
initn: 2843 init1: 2843 opt: 2843 Z-score: 2566.5 bits: 484.2 E(85289): 3.2e-136
Smith-Waterman score: 2843; 100.0% identity (100.0% similar) in 439 aa overlap (43-481:1-439)
20 30 40 50 60 70
pF1KB5 TIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGN
::::::::::::::::::::::::::::::
NP_001 MKQIVEEQGNKLHWAALLILMVIIPTIGGN
10 20 30
80 90 100 110 120 130
pF1KB5 TLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWL
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB5 FLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPI
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB5 KGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVK
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB5 NKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKS
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB5 VQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVS
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB5 SGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHG
340 350 360 370 380 390
440 450 460 470 480
pF1KB5 IRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
400 410 420 430
>>XP_005246577 (OMIM: 601122) PREDICTED: 5-hydroxytrypta (362 aa)
initn: 2373 init1: 2373 opt: 2373 Z-score: 2146.0 bits: 406.1 E(85289): 8.6e-113
Smith-Waterman score: 2373; 100.0% identity (100.0% similar) in 362 aa overlap (120-481:1-362)
90 100 110 120 130 140
pF1KB5 NYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAI
::::::::::::::::::::::::::::::
XP_005 MWPLPLVLCPAWLFLDVLFSTASIMHLCAI
10 20 30
150 160 170 180 190 200
pF1KB5 SVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVL
40 50 60 70 80 90
210 220 230 240 250 260
pF1KB5 TKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQ
100 110 120 130 140 150
270 280 290 300 310 320
pF1KB5 RDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIV
160 170 180 190 200 210
330 340 350 360 370 380
pF1KB5 FFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRD
220 230 240 250 260 270
390 400 410 420 430 440
pF1KB5 AFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLR
280 290 300 310 320 330
450 460 470 480
pF1KB5 SSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
::::::::::::::::::::::::::::::::
XP_005 SSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
340 350 360
>>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor (458 aa)
initn: 1204 init1: 640 opt: 790 Z-score: 725.5 bits: 143.6 E(85289): 1.1e-33
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (55-403:54-391)
30 40 50 60 70 80
pF1KB5 HVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
.: :: :...:: ::::: :::.:::.:::
NP_000 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
30 40 50 60 70 80
90 100 110 120 130 140
pF1KB5 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
:. ::::::::::.::.::::.:::..::.:... .:::: :::.:. :::::::::::
NP_000 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
90 100 110 120 130 140
150 160 170 180 190 200
pF1KB5 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. . :
NP_000 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
150 160 170 180 190 200
210 220 230 240 250 260
pF1KB5 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
: ::::. .:.:.::..::: ::.::..:: :::..:...: .. . .. :.
NP_000 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
210 220 230 240 250 260
270 280 290 300 310 320
pF1KB5 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKK--SVQTISNEQR
. : : . . . ....: ::. :.. :: . . ..:.:.::..
NP_000 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
270 280 290 300
330 340 350 360 370 380
pF1KB5 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
::::::::::.::.:::::::::: :::. :::: .. ::..::::::: ::.:::::
NP_000 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
310 320 330 340 350 360
390 400 410 420 430 440
pF1KB5 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
::::: .: ::. :. :::.. :
NP_000 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
370 380 390 400 410 420
>>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept (458 aa)
initn: 1204 init1: 640 opt: 790 Z-score: 725.5 bits: 143.6 E(85289): 1.1e-33
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (55-403:54-391)
30 40 50 60 70 80
pF1KB5 HVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
.: :: :...:: ::::: :::.:::.:::
NP_001 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
30 40 50 60 70 80
90 100 110 120 130 140
pF1KB5 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
:. ::::::::::.::.::::.:::..::.:... .:::: :::.:. :::::::::::
NP_001 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
90 100 110 120 130 140
150 160 170 180 190 200
pF1KB5 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. . :
NP_001 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
150 160 170 180 190 200
210 220 230 240 250 260
pF1KB5 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
: ::::. .:.:.::..::: ::.::..:: :::..:...: .. . .. :.
NP_001 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
210 220 230 240 250 260
270 280 290 300 310 320
pF1KB5 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKK--SVQTISNEQR
. : : . . . ....: ::. :.. :: . . ..:.:.::..
NP_001 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
270 280 290 300
330 340 350 360 370 380
pF1KB5 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
::::::::::.::.:::::::::: :::. :::: .. ::..::::::: ::.:::::
NP_001 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
310 320 330 340 350 360
390 400 410 420 430 440
pF1KB5 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
::::: .: ::. :. :::.. :
NP_001 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
370 380 390 400 410 420
>>NP_000612 (OMIM: 103780,164230,181500,182135,606788,60 (471 aa)
initn: 1182 init1: 628 opt: 782 Z-score: 718.2 bits: 142.3 E(85289): 2.9e-33
Smith-Waterman score: 1200; 53.4% identity (78.0% similar) in 350 aa overlap (55-403:75-403)
30 40 50 60 70 80
pF1KB5 HVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
.:.::: .::: ::.:: :::.:::::::
NP_000 WTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKK
50 60 70 80 90 100
90 100 110 120 130 140
pF1KB5 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
:: ::::::::::.::.:.:..:::...:::.. :::: :: .:..:::::::::::
NP_000 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIM
110 120 130 140 150 160
150 160 170 180 190 200
pF1KB5 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNN
::::::.:::.::..::. ...:::. ::.:: .:: ::.::..:.:. :.. : ..
NP_000 HLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKE
170 180 190 200 210 220
210 220 230 240 250 260
pF1KB5 ITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTV
.:.:. . .:.:.::...:: ::.::..::::::..:::.: : . : .
NP_000 GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASF
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB5 STVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASK
: . : . : ::. . . :. :.: :....:.:::::.: :
NP_000 SFLPQSSL----SSEKLFQRSIHRE----PGS----------YTGRRTMQSISNEQKACK
290 300 310 320
330 340 350 360 370 380
pF1KB5 VLGIVFFLFLLMWCPFFITNITLVLC-DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF
:::::::::..:::::::::: :.: .:::. .. ::..::::::.::.:::::::::
NP_000 VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLF
330 340 350 360 370 380
390 400 410 420 430 440
pF1KB5 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ
:::.:.::.::: :.:. .:
NP_000 NKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDC
390 400 410 420 430 440
>>XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytrypta (366 aa)
initn: 539 init1: 160 opt: 571 Z-score: 530.2 bits: 107.1 E(85289): 8.5e-23
Smith-Waterman score: 571; 30.3% identity (65.0% similar) in 346 aa overlap (62-397:33-364)
40 50 60 70 80 90
pF1KB5 SGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNY
: .. :: :.::: :. . .::.. .::
XP_005 FLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTI--NSLVIAAIIVTRKLHHPANY
10 20 30 40 50 60
100 110 120 130 140 150
pF1KB5 FLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISV
.. ::::.:.::...:::.... :. :. : . :.: :: .:. : ::.:: ::..
XP_005 LICSLAVTDFLVAVLVMPFSIVYIVRES-WIMGQVVCDIWLSVDITCCTCSILHLSAIAL
70 80 90 100 110
160 170 180 190 200
pF1KB5 DRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPI--KGIETDVDNPNNITCVL
::: :: .. . . : : ::.::.::. :..: :. . :. :. :..
XP_005 DRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMP-PLFWRHQGTSRDDE----CII
120 130 140 150 160 170
210 220 230 240 250 260
pF1KB5 TKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVS--TV
.... . ......::. :::.... :. .: . : ... .:.. :. ..
XP_005 KHDHIVS-TIYSTFGAFYIPLALILILYYKIYRAAKT---LYHKRQASRIAKEEVNGQVL
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB5 FQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMR--RTSTIGKKSV--QTISN--EQR
.. : .: .:. : .: . . .. .: :. .:: : ::. :..
XP_005 LESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERK
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB5 ASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYT
:. .::... :.. : :::. .... .::.:. . . . ....:.::..: .:::.::
XP_005 AATTLGLILGAFVICWLPFFVKELVVNVCDKCKIS--EEMSNFLAWLGYLNSLINPLIYT
300 310 320 330 340
390 400 410 420 430 440
pF1KB5 LFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAM
.::. :. :: . . :
XP_005 IFNEDFKKAFQKLVRCRC
350 360
>>NP_001309139 (OMIM: 182134) 5-hydroxytryptamine recept (366 aa)
initn: 539 init1: 160 opt: 571 Z-score: 530.2 bits: 107.1 E(85289): 8.5e-23
Smith-Waterman score: 571; 30.3% identity (65.0% similar) in 346 aa overlap (62-397:33-364)
40 50 60 70 80 90
pF1KB5 SGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNY
: .. :: :.::: :. . .::.. .::
NP_001 FLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTI--NSLVIAAIIVTRKLHHPANY
10 20 30 40 50 60
100 110 120 130 140 150
pF1KB5 FLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISV
.. ::::.:.::...:::.... :. :. : . :.: :: .:. : ::.:: ::..
NP_001 LICSLAVTDFLVAVLVMPFSIVYIVRES-WIMGQVVCDIWLSVDITCCTCSILHLSAIAL
70 80 90 100 110
160 170 180 190 200
pF1KB5 DRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPI--KGIETDVDNPNNITCVL
::: :: .. . . : : ::.::.::. :..: :. . :. :. :..
NP_001 DRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMP-PLFWRHQGTSRDDE----CII
120 130 140 150 160 170
210 220 230 240 250 260
pF1KB5 TKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVS--TV
.... . ......::. :::.... :. .: . : ... .:.. :. ..
NP_001 KHDHIVS-TIYSTFGAFYIPLALILILYYKIYRAAKT---LYHKRQASRIAKEEVNGQVL
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB5 FQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMR--RTSTIGKKSV--QTISN--EQR
.. : .: .:. : .: . . .. .: :. .:: : ::. :..
NP_001 LESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERK
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB5 ASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYT
:. .::... :.. : :::. .... .::.:. . . . ....:.::..: .:::.::
NP_001 AATTLGLILGAFVICWLPFFVKELVVNVCDKCKIS--EEMSNFLAWLGYLNSLINPLIYT
300 310 320 330 340
390 400 410 420 430 440
pF1KB5 LFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAM
.::. :. :: . . :
NP_001 IFNEDFKKAFQKLVRCRC
350 360
>>NP_001309138 (OMIM: 182134) 5-hydroxytryptamine recept (366 aa)
initn: 539 init1: 160 opt: 571 Z-score: 530.2 bits: 107.1 E(85289): 8.5e-23
Smith-Waterman score: 571; 30.3% identity (65.0% similar) in 346 aa overlap (62-397:33-364)
40 50 60 70 80 90
pF1KB5 SGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNY
: .. :: :.::: :. . .::.. .::
NP_001 FLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTI--NSLVIAAIIVTRKLHHPANY
10 20 30 40 50 60
100 110 120 130 140 150
pF1KB5 FLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISV
.. ::::.:.::...:::.... :. :. : . :.: :: .:. : ::.:: ::..
NP_001 LICSLAVTDFLVAVLVMPFSIVYIVRES-WIMGQVVCDIWLSVDITCCTCSILHLSAIAL
70 80 90 100 110
160 170 180 190 200
pF1KB5 DRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPI--KGIETDVDNPNNITCVL
::: :: .. . . : : ::.::.::. :..: :. . :. :. :..
NP_001 DRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMP-PLFWRHQGTSRDDE----CII
120 130 140 150 160 170
210 220 230 240 250 260
pF1KB5 TKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVS--TV
.... . ......::. :::.... :. .: . : ... .:.. :. ..
NP_001 KHDHIVS-TIYSTFGAFYIPLALILILYYKIYRAAKT---LYHKRQASRIAKEEVNGQVL
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB5 FQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMR--RTSTIGKKSV--QTISN--EQR
.. : .: .:. : .: . . .. .: :. .:: : ::. :..
NP_001 LESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERK
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB5 ASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYT
:. .::... :.. : :::. .... .::.:. . . . ....:.::..: .:::.::
NP_001 AATTLGLILGAFVICWLPFFVKELVVNVCDKCKIS--EEMSNFLAWLGYLNSLINPLIYT
300 310 320 330 340
390 400 410 420 430 440
pF1KB5 LFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAM
.::. :. :: . . :
NP_001 IFNEDFKKAFQKLVRCRC
350 360
481 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:00:30 2016 done: Sun Nov 6 08:00:31 2016
Total Scan time: 9.130 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]