Result of FASTA (omim) for
pFN21AB5805
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5805, 471 aa
1>>>pF1KB5805 471 - 471 aa - 471 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.1014+/-0.000404; mu= -4.4846+/- 0.026
mean_var=440.8448+/-88.926, 0's: 0 Z-trim(124.6): 24 B-trim: 38 in 1/56
Lambda= 0.061085
statistics sampled from 46597 (46630) to 46597 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.547), width: 16
Scan time: 9.910
The best scores are: opt bits E(85289)
XP_011512281 (OMIM: 606198) PREDICTED: iroquois-cl ( 471) 3219 297.5 5.2e-80
NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 3219 297.5 5.2e-80
NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 3219 297.5 5.2e-80
NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 1138 114.1 8.5e-25
NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 1134 113.8 1.1e-24
XP_011521111 (OMIM: 606195,611174) PREDICTED: iroq ( 413) 784 82.9 1.9e-15
NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 729 78.1 6.2e-14
XP_005256196 (OMIM: 612985) PREDICTED: iroquois-cl ( 529) 729 78.1 6.4e-14
XP_016865334 (OMIM: 606197) PREDICTED: iroquois-cl ( 449) 607 67.3 9.9e-11
NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 607 67.3 1e-10
NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 568 63.9 1.2e-09
NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 568 63.9 1.2e-09
NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 568 63.9 1.2e-09
XP_005256194 (OMIM: 606196) PREDICTED: iroquois-cl ( 445) 552 62.5 2.8e-09
NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 552 62.5 2.8e-09
NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 486 56.7 1.8e-07
NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 486 56.7 1.8e-07
>>XP_011512281 (OMIM: 606198) PREDICTED: iroquois-class (471 aa)
initn: 3219 init1: 3219 opt: 3219 Z-score: 1557.4 bits: 297.5 E(85289): 5.2e-80
Smith-Waterman score: 3219; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
430 440 450 460 470
>>NP_001127694 (OMIM: 606198) iroquois-class homeodomain (471 aa)
initn: 3219 init1: 3219 opt: 3219 Z-score: 1557.4 bits: 297.5 E(85289): 5.2e-80
Smith-Waterman score: 3219; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
430 440 450 460 470
>>NP_150366 (OMIM: 606198) iroquois-class homeodomain pr (471 aa)
initn: 3219 init1: 3219 opt: 3219 Z-score: 1557.4 bits: 297.5 E(85289): 5.2e-80
Smith-Waterman score: 3219; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471)
10 20 30 40 50 60
pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
430 440 450 460 470
>>NP_001239126 (OMIM: 606195,611174) iroquois-class home (482 aa)
initn: 932 init1: 655 opt: 1138 Z-score: 566.2 bits: 114.1 E(85289): 8.5e-25
Smith-Waterman score: 1247; 51.8% identity (69.8% similar) in 440 aa overlap (1-405:1-423)
10 20 30 40 50 60
pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
:::::::::: .::::::::::..:....::..::.::.:::::::: ::.:::: .
NP_001 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSP-
10 20 30 40 50
70 80 90 100 110
pF1KB5 GFGSPLQYSAD-AAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRK
:..: :::.:: ::::::.: ::.:.::: :: ::.:...::::.. : .::::::
NP_001 GYNSHLQYGADPAAAAAAAFSSYVGSPYD-HTPGMAGSLGYHPYAAPLGSYPYGDPAYRK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 WAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGE
:.:::.::::.:.:. ...:: :. :. : ... :: ... . .: :
NP_001 WTPRNRSEDEEEEENIDLEKNDE--DEPQK-PEDKGDPEGPEAGAEQKAASGC------E
180 190 200 210 220
240 250 260 270 280 290
pF1KB5 KLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPVTSSPLTGLEAPLLSP
.: : : .:.: . . .: . : .: .: .::. :: : :
NP_001 RLQ---GPPT-PAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAED
230 240 250 260 270 280
300 310 320 330 340
pF1KB5 P----PEAAPRGGR-----KTPQGS------RTSPGAPPPA--SKPKLWSLAEIATSDLK
: : .:: : ..: : .. : :::: .:::::::::::::. :
NP_001 PAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDK
290 300 310 320 330 340
350 360 370 380
pF1KB5 QPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGSPYPASPLLGRPLYYT
. : : : : :: : :. ::: . .: . :.:.. .:.::::::
NP_001 VKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYT
350 360 370 380 390 400
390 400 410 420 430 440
pF1KB5 SPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRS
.::: .:::::... :.:.
NP_001 APFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQS
410 420 430 440 450 460
>>NP_005844 (OMIM: 606195,611174) iroquois-class homeodo (483 aa)
initn: 932 init1: 655 opt: 1134 Z-score: 564.3 bits: 113.8 E(85289): 1.1e-24
Smith-Waterman score: 1246; 51.8% identity (69.3% similar) in 440 aa overlap (1-405:1-424)
10 20 30 40 50 60
pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT
:::::::::: .::::::::::..:....::..::.::.:::::::: ::.:::: .
NP_005 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSP-
10 20 30 40 50
70 80 90 100 110
pF1KB5 GFGSPLQYSAD-AAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRK
:..: :::.:: ::::::.: ::.:.::: :: ::.:...::::.. : .::::::
NP_005 GYNSHLQYGADPAAAAAAAFSSYVGSPYD-HTPGMAGSLGYHPYAAPLGSYPYGDPAYRK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 WAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGE
:.:::.::::.:.:. ...:: :. :. ::.: : .. .::. .
NP_005 WTPRNRSEDEEEEENIDLEKNDE--DEPQK-----PEDKG-----DPEGPEAGGAEQKAA
180 190 200 210 220
240 250 260 270 280 290
pF1KB5 KLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPVTSSPLTGLEAPLLSP
. : : .:.: . . .: . : .: .: .::. :: : :
NP_005 SGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAED
230 240 250 260 270 280
300 310 320 330 340
pF1KB5 P----PEAAPRGGR-----KTPQGS------RTSPGAPPPA--SKPKLWSLAEIATSDLK
: : .:: : ..: : .. : :::: .:::::::::::::. :
NP_005 PAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDK
290 300 310 320 330 340
350 360 370 380
pF1KB5 QPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGSPYPASPLLGRPLYYT
. : : : : :: : :. ::: . .: . :.:.. .:.::::::
NP_005 VKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYT
350 360 370 380 390 400
390 400 410 420 430 440
pF1KB5 SPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRS
.::: .:::::... :.:.
NP_005 APFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQS
410 420 430 440 450 460
>>XP_011521111 (OMIM: 606195,611174) PREDICTED: iroquois (413 aa)
initn: 916 init1: 601 opt: 784 Z-score: 398.4 bits: 82.9 E(85289): 1.9e-15
Smith-Waterman score: 896; 47.4% identity (64.7% similar) in 365 aa overlap (75-405:5-354)
50 60 70 80 90 100
pF1KB5 FSPYPGSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYG
::.. .. :.::: :: ::.:...::::.
XP_011 MEGRAAVARSAHGGSPYD-HTPGMAGSLGYHPYA
10 20 30
110 120 130 140 150 160
pF1KB5 SAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTW
. : .:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTW
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB5 FANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHV
::::::::::::::::.:::.::::.:.:. ...:: :. :. ::.:
XP_011 FANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDE--DEPQK-----PEDKG-----
100 110 120 130 140
230 240 250 260 270 280
pF1KB5 DSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPV
: .. .::. . . : : .:.: . . .: . : .: .: .::.
XP_011 DPEGPEAGGAEQKAASGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTG
150 160 170 180 190 200
290 300 310 320
pF1KB5 TSSPLTGLEAPLLSPP----PEAAPRGGR-----KTPQGS------RTSPGAPPPA--SK
:: : : : : .:: : ..: : .. : :::: .:
XP_011 GPSPAGPAAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAK
210 220 230 240 250 260
330 340 350 360 370
pF1KB5 PKLWSLAEIATSDLKQPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGS
::::::::::::. : . : : : : :: : :. ::: . .: .
XP_011 PKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQC
270 280 290 300 310 320
380 390 400 410 420 430
pF1KB5 PYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASD
:.:.. .:.::::::.::: .:::::... :.:.
XP_011 PFPGGTVLSRPLYYTAPFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNR
330 340 350 360 370
440 450 460 470
pF1KB5 AGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
XP_011 ADALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI
380 390 400 410
>>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa)
initn: 650 init1: 513 opt: 729 Z-score: 371.2 bits: 78.1 E(85289): 6.2e-14
Smith-Waterman score: 780; 37.9% identity (59.5% similar) in 496 aa overlap (1-452:1-480)
10 20 30 40
pF1KB5 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P
::.:: :: : . ::. . . : . ..:.: :: : .. ....: :
NP_077 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTT-GM---TGAISY-HPYG
.:: .: :: :.:. : :.:. ::. .:: :. . . :. ..: .. ::.
NP_077 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH-
70 80 90 100 110
110 120 130 140 150 160
pF1KB5 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
: ::: :..::. :::::..:.::::::::::::::::::::::::::::::::::
NP_077 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
::::::::::::::::::::::.....: . :. . .:: :. . : :.: ..
NP_077 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG
180 190 200 210 220 230
230 240 250 260 270
pF1KB5 LHVDS-----LTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E
. .. :.: . . : : :.: : .: : .:. .: . :....: :
NP_077 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 EGERGLAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----SK
.. .:: .:. :. .: :: .::: :. . .: : .: :: :: .:
NP_077 DSSEGLED-RPL---PVLSL-AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQK
300 310 320 330 340
330 340 350 360 370 380
pF1KB5 PKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPLLGRPL--
::.::::: ::: . :: : ::: ::.::.. :... : :.. ::
NP_077 PKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLGK
350 360 370 380 390 400
390 400 410 420 430
pF1KB5 ---YYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAGA
. . :: : . .: :.. :: .::. :. : : : ..:
NP_077 FPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRC
410 420 430 440 450 460
440 450 460 470
pF1KB5 HPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
:: . . ...:
NP_077 SALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
470 480 490 500
>>XP_005256196 (OMIM: 612985) PREDICTED: iroquois-class (529 aa)
initn: 650 init1: 513 opt: 729 Z-score: 370.9 bits: 78.1 E(85289): 6.4e-14
Smith-Waterman score: 780; 37.9% identity (59.5% similar) in 496 aa overlap (1-452:1-480)
10 20 30 40
pF1KB5 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P
::.:: :: : . ::. . . : . ..:.: :: : .. ....: :
XP_005 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTT-GM---TGAISY-HPYG
.:: .: :: :.:. : :.:. ::. .:: :. . . :. ..: .. ::.
XP_005 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH-
70 80 90 100 110
110 120 130 140 150 160
pF1KB5 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
: ::: :..::. :::::..:.::::::::::::::::::::::::::::::::::
XP_005 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS
::::::::::::::::::::::.....: . :. . .:: :. . : :.: ..
XP_005 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG
180 190 200 210 220 230
230 240 250 260 270
pF1KB5 LHVDS-----LTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E
. .. :.: . . : : :.: : .: : .:. .: . :....: :
XP_005 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE
240 250 260 270 280 290
280 290 300 310 320
pF1KB5 EGERGLAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----SK
.. .:: .:. :. .: :: .::: :. . .: : .: :: :: .:
XP_005 DSSEGLED-RPL---PVLSL-AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQK
300 310 320 330 340
330 340 350 360 370 380
pF1KB5 PKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPLLGRPL--
::.::::: ::: . :: : ::: ::.::.. :... : :.. ::
XP_005 PKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLGK
350 360 370 380 390 400
390 400 410 420 430
pF1KB5 ---YYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAGA
. . :: : . .: :.. :: .::. :. : : : ..:
XP_005 FPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRC
410 420 430 440 450 460
440 450 460 470
pF1KB5 HPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
:: . . ...:
XP_005 SALEVEKKLLKTAFQPVPRRPRPRVLTPRAHPTVKPQHTHLQLDIILHCDTFLTIGPNPS
470 480 490 500 510 520
>>XP_016865334 (OMIM: 606197) PREDICTED: iroquois-class (449 aa)
initn: 551 init1: 448 opt: 607 Z-score: 313.7 bits: 67.3 E(85289): 9.9e-11
Smith-Waterman score: 692; 37.6% identity (60.0% similar) in 447 aa overlap (4-422:17-402)
10 20 30 40
pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSP
: .: . :: :: . : .::. . : . ::. .:...: .
XP_016 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASS-GRPGAAELGGGAGAAAVTS
10 20 30 40 50
50 60 70 80 90
pF1KB5 YPG--SAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD------AH--TTGMTGA
: .:: .: .... : :.:: . . : ::. :. .: : . :
XP_016 VLGMYAAAGPYAGAPNYSAFLPYAADLS-----LFSQMGSQYELKDNPGVHPATFAAHTA
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB5 ISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT
.:.:::. .: .::. :::::..:.::::::::::::::::::::::::::::::
XP_016 PAYYPYGQ----FQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAED
::::::::::::::::::::.::. :.:.... :. :.. .:.::.. : . :
XP_016 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG---DPEKAEDDEEIDLE-
180 190 200 210 220
220 230 240 250 260 270
pF1KB5 EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL
:. .:.. .: ::.. ..:::....:
XP_016 ---SIDIDKIDEH------DGDQ------------------------SNEDDEDKAEAPH
230 240 250
280 290 300 310 320
pF1KB5 APPKPVT-----SSPLTGLEAPLLSPPPEAAPRG-GRKTPQGSRT---SPGAPP------
:: : . .:::.. : .:. :. .: : ....:. . : ::::
XP_016 APAAPSALARDQGSPLAA--ADVLK--PQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGA
260 270 280 290 300
330 340 350 360 370 380
pF1KB5 PASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPL
: .:::.::::: ::: :. .: .:: : :. :.. : : .:.: .:
XP_016 PHGKPKIWSLAETATS----PDGAPKASPP--PPAGHPGAHG-PSAGAPLQHPAFLPSHG
310 320 330 340 350 360
390 400 410 420 430
pF1KB5 YYTSPFYGNYTNYGNLNAALQGQG-LLRYNS--AAAAPGEALHTAPKAASDAGKAGAHPL
:: . :...:. :.:. .:: :: . : ...:: : :
XP_016 LYTCHI-GKFSNW--TNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIA
370 380 390 400 410
440 450 460 470
pF1KB5 ESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
XP_016 PGALNGDKASVRSSPTLPALWPRRRERRGS
420 430 440
>>NP_077313 (OMIM: 606197) iroquois-class homeodomain pr (480 aa)
initn: 551 init1: 448 opt: 607 Z-score: 313.3 bits: 67.3 E(85289): 1e-10
Smith-Waterman score: 692; 37.6% identity (60.0% similar) in 447 aa overlap (4-422:17-402)
10 20 30 40
pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSP
: .: . :: :: . : .::. . : . ::. .:...: .
NP_077 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASS-GRPGAAELGGGAGAAAVTS
10 20 30 40 50
50 60 70 80 90
pF1KB5 YPG--SAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD------AH--TTGMTGA
: .:: .: .... : :.:: . . : ::. :. .: : . :
NP_077 VLGMYAAAGPYAGAPNYSAFLPYAADLS-----LFSQMGSQYELKDNPGVHPATFAAHTA
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB5 ISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT
.:.:::. .: .::. :::::..:.::::::::::::::::::::::::::::::
NP_077 PAYYPYGQ----FQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAED
::::::::::::::::::::.::. :.:.... :. :.. .:.::.. : . :
NP_077 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG---DPEKAEDDEEIDLE-
180 190 200 210 220
220 230 240 250 260 270
pF1KB5 EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL
:. .:.. .: ::.. ..:::....:
NP_077 ---SIDIDKIDEH------DGDQ------------------------SNEDDEDKAEAPH
230 240 250
280 290 300 310 320
pF1KB5 APPKPVT-----SSPLTGLEAPLLSPPPEAAPRG-GRKTPQGSRT---SPGAPP------
:: : . .:::.. : .:. :. .: : ....:. . : ::::
NP_077 APAAPSALARDQGSPLAA--ADVLK--PQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGA
260 270 280 290 300
330 340 350 360 370 380
pF1KB5 PASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPL
: .:::.::::: ::: :. .: .:: : :. :.. : : .:.: .:
NP_077 PHGKPKIWSLAETATS----PDGAPKASPP--PPAGHPGAHG-PSAGAPLQHPAFLPSHG
310 320 330 340 350 360
390 400 410 420 430
pF1KB5 YYTSPFYGNYTNYGNLNAALQGQG-LLRYNS--AAAAPGEALHTAPKAASDAGKAGAHPL
:: . :...:. :.:. .:: :: . : ...:: : :
NP_077 LYTCHI-GKFSNW--TNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIA
370 380 390 400 410
440 450 460 470
pF1KB5 ESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL
NP_077 PGALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPS
420 430 440 450 460 470
471 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 22:26:58 2016 done: Wed Nov 2 22:27:00 2016
Total Scan time: 9.910 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]