Result of FASTA (omim) for
pFN21AB5790
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5790, 777 aa
1>>>pF1KB5790 777 - 777 aa - 777 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9980+/-0.000527; mu= 2.6478+/- 0.032
mean_var=301.3151+/-65.297, 0's: 0 Z-trim(116.9): 507 B-trim: 327 in 1/53
Lambda= 0.073886
statistics sampled from 27656 (28394) to 27656 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.333), width: 16
Scan time: 13.780
The best scores are: opt bits E(85289)
NP_000456 (OMIM: 114480,601593) BRCA1-associated R ( 777) 5244 573.9 8.7e-163
NP_001269472 (OMIM: 114480,601593) BRCA1-associate ( 758) 4731 519.2 2.5e-146
XP_016860102 (OMIM: 114480,601593) PREDICTED: BRCA ( 810) 4728 519.0 3.2e-146
XP_016860103 (OMIM: 114480,601593) PREDICTED: BRCA ( 675) 3705 409.8 1.9e-113
NP_001269477 (OMIM: 114480,601593) BRCA1-associate ( 307) 1747 200.7 7.6e-51
NP_001269474 (OMIM: 114480,601593) BRCA1-associate ( 326) 1747 200.8 7.9e-51
NP_001269478 (OMIM: 114480,601593) BRCA1-associate ( 264) 1011 122.2 2.9e-27
XP_011523940 (OMIM: 610616) PREDICTED: ankyrin rep (1923) 439 62.2 2.4e-08
NP_001190985 (OMIM: 610616) ankyrin repeat domain- (2039) 439 62.2 2.5e-08
XP_016881152 (OMIM: 610616) PREDICTED: ankyrin rep (2039) 439 62.2 2.5e-08
NP_001077094 (OMIM: 610616) ankyrin repeat domain- (2039) 439 62.2 2.5e-08
XP_005258150 (OMIM: 610616) PREDICTED: ankyrin rep (2062) 439 62.2 2.5e-08
NP_056023 (OMIM: 610616) ankyrin repeat domain-con (2062) 439 62.2 2.5e-08
XP_005258149 (OMIM: 610616) PREDICTED: ankyrin rep (2062) 439 62.2 2.5e-08
XP_016881155 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08
XP_005258153 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08
XP_016881154 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08
XP_016881153 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08
XP_005258152 (OMIM: 610616) PREDICTED: ankyrin rep (2060) 434 61.7 3.7e-08
XP_016881150 (OMIM: 610616) PREDICTED: ankyrin rep (2060) 434 61.7 3.7e-08
XP_016881151 (OMIM: 610616) PREDICTED: ankyrin rep (2060) 434 61.7 3.7e-08
XP_006721247 (OMIM: 148050,611192) PREDICTED: anky (2564) 424 60.7 8.9e-08
XP_011521359 (OMIM: 148050,611192) PREDICTED: anky (2613) 424 60.7 9e-08
XP_011521358 (OMIM: 148050,611192) PREDICTED: anky (2620) 424 60.7 9e-08
XP_011521356 (OMIM: 148050,611192) PREDICTED: anky (2629) 424 60.7 9e-08
XP_011521357 (OMIM: 148050,611192) PREDICTED: anky (2629) 424 60.7 9e-08
XP_006721244 (OMIM: 148050,611192) PREDICTED: anky (2629) 424 60.7 9e-08
NP_001243111 (OMIM: 148050,611192) ankyrin repeat (2663) 424 60.7 9.1e-08
NP_001243112 (OMIM: 148050,611192) ankyrin repeat (2663) 424 60.7 9.1e-08
XP_011521353 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
XP_016878675 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
XP_016878671 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
XP_016878674 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
XP_016878676 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
NP_037407 (OMIM: 148050,611192) ankyrin repeat dom (2663) 424 60.7 9.1e-08
XP_011521355 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
XP_016878672 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
XP_016878673 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08
XP_011515352 (OMIM: 604546) PREDICTED: tonsoku-lik ( 953) 332 50.4 4.1e-05
XP_011515351 (OMIM: 604546) PREDICTED: tonsoku-lik (1042) 332 50.5 4.4e-05
XP_011515350 (OMIM: 604546) PREDICTED: tonsoku-lik (1054) 332 50.5 4.4e-05
NP_038460 (OMIM: 604546) tonsoku-like protein [Hom (1378) 332 50.6 5.3e-05
XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 ( 695) 303 47.2 0.00028
XP_016872189 (OMIM: 607128) PREDICTED: tankyrase-2 ( 977) 303 47.4 0.00036
XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 (1059) 303 47.4 0.00038
XP_016872187 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 303 47.4 0.00038
XP_016872186 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 303 47.4 0.00038
NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166) 303 47.5 0.0004
XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169) 303 47.5 0.0004
XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 (1187) 303 47.5 0.00041
>>NP_000456 (OMIM: 114480,601593) BRCA1-associated RING (777 aa)
initn: 5244 init1: 5244 opt: 5244 Z-score: 3043.6 bits: 573.9 E(85289): 8.7e-163
Smith-Waterman score: 5244; 99.7% identity (99.7% similar) in 777 aa overlap (1-777:1-777)
10 20 30 40 50 60
pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
NP_000 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_000 ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV
670 680 690 700 710 720
730 740 750 760 770
pF1KB5 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
730 740 750 760 770
>>NP_001269472 (OMIM: 114480,601593) BRCA1-associated RI (758 aa)
initn: 4727 init1: 4727 opt: 4731 Z-score: 2748.2 bits: 519.2 E(85289): 2.5e-146
Smith-Waterman score: 5052; 97.3% identity (97.3% similar) in 777 aa overlap (1-777:1-758)
10 20 30 40 50 60
pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRC-------
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------NCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
60 70 80 90 100
130 140 150 160 170 180
pF1KB5 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB5 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB5 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB5 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_001 ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB5 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS
590 600 610 620 630 640
670 680 690 700 710 720
pF1KB5 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV
650 660 670 680 690 700
730 740 750 760 770
pF1KB5 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
710 720 730 740 750
>>XP_016860102 (OMIM: 114480,601593) PREDICTED: BRCA1-as (810 aa)
initn: 5225 init1: 4727 opt: 4728 Z-score: 2746.1 bits: 519.0 E(85289): 3.2e-146
Smith-Waterman score: 5155; 95.6% identity (95.6% similar) in 809 aa overlap (2-777:2-810)
10 20 30 40 50 60
pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
:::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_016 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
10 20 30 40 50 60
70 80
pF1KB5 VCLGGCEHIFCS---------------------------------NCVSDCIGTGCPVCY
::::::::::: :::::::::::::::
XP_016 VCLGGCEHIFCRGLGPVTRNVLWCLGKMWLFNCYITYSVLLEPICNCVSDCIGTGCPVCY
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB5 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB5 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB5 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB5 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB5 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGSKNSNMSDEF
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
XP_016 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEF
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB5 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL
430 440 450 460 470 480
450 460 470 480 490 500
pF1KB5 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB5 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD
550 560 570 580 590 600
570 580 590 600 610 620
pF1KB5 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG
610 620 630 640 650 660
630 640 650 660 670 680
pF1KB5 CWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHP
670 680 690 700 710 720
690 700 710 720 730 740
pF1KB5 KDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHP
730 740 750 760 770 780
750 760 770
pF1KB5 ERVRQGKVWKAPSSWFIDCVMSFELLPLDS
::::::::::::::::::::::::::::::
XP_016 ERVRQGKVWKAPSSWFIDCVMSFELLPLDS
790 800 810
>>XP_016860103 (OMIM: 114480,601593) PREDICTED: BRCA1-as (675 aa)
initn: 4199 init1: 3701 opt: 3705 Z-score: 2157.7 bits: 409.8 E(85289): 1.9e-113
Smith-Waterman score: 4132; 94.5% identity (94.5% similar) in 668 aa overlap (2-635:2-669)
10 20 30 40 50 60
pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
:::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_016 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
10 20 30 40 50 60
70 80
pF1KB5 VCLGGCEHIFCS---------------------------------NCVSDCIGTGCPVCY
::::::::::: :::::::::::::::
XP_016 VCLGGCEHIFCRGLGPVTRNVLWCLGKMWLFNCYITYSVLLEPICNCVSDCIGTGCPVCY
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB5 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB5 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB5 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB5 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB5 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGSKNSNMSDEF
:::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
XP_016 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEF
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB5 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL
430 440 450 460 470 480
450 460 470 480 490 500
pF1KB5 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB5 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD
550 560 570 580 590 600
570 580 590 600 610 620
pF1KB5 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG
610 620 630 640 650 660
630 640 650 660 670 680
pF1KB5 CWILKFE-WVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHH
::::::: :
XP_016 CWILKFECWTAVVQS
670
>>NP_001269477 (OMIM: 114480,601593) BRCA1-associated RI (307 aa)
initn: 1747 init1: 1747 opt: 1747 Z-score: 1033.8 bits: 200.7 E(85289): 7.6e-51
Smith-Waterman score: 1747; 100.0% identity (100.0% similar) in 254 aa overlap (524-777:54-307)
500 510 520 530 540 550
pF1KB5 NDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSS
::::::::::::::::::::::::::::::
NP_001 PAMEPDGRGAWAHSRAALDRLEKLLRCSRCNIFGLRPVDYTDDESMKSLLLLPEKNESSS
30 40 50 60 70 80
560 570 580 590 600 610
pF1KB5 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA
90 100 110 120 130 140
620 630 640 650 660 670
pF1KB5 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD
150 160 170 180 190 200
680 690 700 710 720 730
pF1KB5 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC
210 220 230 240 250 260
740 750 760 770
pF1KB5 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
270 280 290 300
>--
initn: 373 init1: 373 opt: 373 Z-score: 242.2 bits: 54.3 E(85289): 9.4e-07
Smith-Waterman score: 373; 98.1% identity (98.1% similar) in 53 aa overlap (1-53:1-53)
10 20 30 40 50 60
pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCNIFGLRP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
NP_001 VDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAV
70 80 90 100 110 120
>>NP_001269474 (OMIM: 114480,601593) BRCA1-associated RI (326 aa)
initn: 1747 init1: 1747 opt: 1747 Z-score: 1033.5 bits: 200.8 E(85289): 7.9e-51
Smith-Waterman score: 1747; 100.0% identity (100.0% similar) in 254 aa overlap (524-777:73-326)
500 510 520 530 540 550
pF1KB5 NDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSS
::::::::::::::::::::::::::::::
NP_001 RLEKLLRCSRCTNILREPVCLGGCEHIFCSNIFGLRPVDYTDDESMKSLLLLPEKNESSS
50 60 70 80 90 100
560 570 580 590 600 610
pF1KB5 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA
110 120 130 140 150 160
620 630 640 650 660 670
pF1KB5 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD
170 180 190 200 210 220
680 690 700 710 720 730
pF1KB5 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC
230 240 250 260 270 280
740 750 760 770
pF1KB5 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
290 300 310 320
>--
initn: 517 init1: 517 opt: 517 Z-score: 324.9 bits: 69.6 E(85289): 2.3e-11
Smith-Waterman score: 517; 98.6% identity (98.6% similar) in 72 aa overlap (1-72:1-72)
10 20 30 40 50 60
pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
::::::::::::
NP_001 VCLGGCEHIFCSNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLV
70 80 90 100 110 120
>>NP_001269478 (OMIM: 114480,601593) BRCA1-associated RI (264 aa)
initn: 1011 init1: 1011 opt: 1011 Z-score: 610.6 bits: 122.2 E(85289): 2.9e-27
Smith-Waterman score: 1011; 100.0% identity (100.0% similar) in 142 aa overlap (636-777:123-264)
610 620 630 640 650 660
pF1KB5 HVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNRE
::::::::::::::::::::::::::::::
NP_001 QDLKINRQLDSMIQLCSKLRNLLHDNELSGVKACLRRKVCEQEEKYEIPEGPRRSRLNRE
100 110 120 130 140 150
670 680 690 700 710 720
pF1KB5 QLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHAR
160 170 180 190 200 210
730 740 750 760 770
pF1KB5 PDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
220 230 240 250 260
>--
initn: 871 init1: 871 opt: 871 Z-score: 529.9 bits: 107.3 E(85289): 8.9e-23
Smith-Waterman score: 871; 99.2% identity (99.2% similar) in 121 aa overlap (1-121:1-121)
10 20 30 40 50 60
pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY
:
NP_001 SGVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIK
130 140 150 160 170 180
>>XP_011523940 (OMIM: 610616) PREDICTED: ankyrin repeat (1923 aa)
initn: 464 init1: 428 opt: 439 Z-score: 270.8 bits: 62.2 E(85289): 2.4e-08
Smith-Waterman score: 439; 45.8% identity (73.2% similar) in 153 aa overlap (391-543:149-300)
370 380 390 400 410 420
pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
:: . :. :... . ..::. . .
XP_011 KSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQ-KKTPSSSSRQKDK
120 130 140 150 160 170
430 440 450 460 470 480
pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
. :::.:::: ::.:.:.::. .:. :.. :.. :::: ::::::::::: :. :...:
XP_011 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL
180 190 200 210 220 230
490 500 510 520 530 540
pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
. : ::: : ..:.::::.:..:: ::::::: .:.. .: : :::: .. : ..
XP_011 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE
240 250 260 270 280 290
550 560 570 580 590 600
pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
::
XP_011 LLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSA
300 310 320 330 340 350
>>NP_001190985 (OMIM: 610616) ankyrin repeat domain-cont (2039 aa)
initn: 464 init1: 428 opt: 439 Z-score: 270.5 bits: 62.2 E(85289): 2.5e-08
Smith-Waterman score: 439; 45.8% identity (73.2% similar) in 153 aa overlap (391-543:126-277)
370 380 390 400 410 420
pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
:: . :. :... . ..::. . .
NP_001 KSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQ-KKTPSSSSRQKDK
100 110 120 130 140 150
430 440 450 460 470 480
pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
. :::.:::: ::.:.:.::. .:. :.. :.. :::: ::::::::::: :. :...:
NP_001 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL
160 170 180 190 200 210
490 500 510 520 530 540
pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
. : ::: : ..:.::::.:..:: ::::::: .:.. .: : :::: .. : ..
NP_001 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE
220 230 240 250 260 270
550 560 570 580 590 600
pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
::
NP_001 LLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSA
280 290 300 310 320 330
>>XP_016881152 (OMIM: 610616) PREDICTED: ankyrin repeat (2039 aa)
initn: 464 init1: 428 opt: 439 Z-score: 270.5 bits: 62.2 E(85289): 2.5e-08
Smith-Waterman score: 439; 45.8% identity (73.2% similar) in 153 aa overlap (391-543:126-277)
370 380 390 400 410 420
pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM
:: . :. :... . ..::. . .
XP_016 KSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQ-KKTPSSSSRQKDK
100 110 120 130 140 150
430 440 450 460 470 480
pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL
. :::.:::: ::.:.:.::. .:. :.. :.. :::: ::::::::::: :. :...:
XP_016 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL
160 170 180 190 200 210
490 500 510 520 530 540
pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK
. : ::: : ..:.::::.:..:: ::::::: .:.. .: : :::: .. : ..
XP_016 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE
220 230 240 250 260 270
550 560 570 580 590 600
pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF
::
XP_016 LLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSA
280 290 300 310 320 330
777 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:02:23 2016 done: Sun Nov 6 18:02:25 2016
Total Scan time: 13.780 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]