Result of FASTA (omim) for
pFN21AB5347
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5347, 435 aa
1>>>pF1KB5347 435 - 435 aa - 435 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5566+/-0.000446; mu= 15.5854+/- 0.028
mean_var=62.2545+/-12.411, 0's: 0 Z-trim(109.8): 59 B-trim: 233 in 1/49
Lambda= 0.162551
statistics sampled from 17955 (18014) to 17955 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.211), width: 16
Scan time: 8.520
The best scores are: opt bits E(85289)
NP_001123996 (OMIM: 603535) AP-1 complex subunit m ( 435) 2880 684.4 1.5e-196
XP_016882909 (OMIM: 603535) PREDICTED: AP-1 comple ( 409) 2711 644.8 1.2e-184
XP_016882910 (OMIM: 603535) PREDICTED: AP-1 comple ( 397) 1600 384.2 3.2e-106
NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 ( 423) 1600 384.2 3.4e-106
NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 ( 423) 1351 325.9 1.3e-88
NP_001287816 (OMIM: 607309) AP-1 complex subunit m ( 425) 1327 320.2 6.3e-87
NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 1078 261.8 2.4e-69
NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 1072 260.4 6.5e-69
NP_001298127 (OMIM: 601024) AP-2 complex subunit m ( 460) 1014 246.8 8.5e-65
NP_004713 (OMIM: 602296,612936) AP-4 complex subun ( 453) 409 105.0 4.3e-22
XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 ( 419) 394 101.4 4.6e-21
XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 394 101.4 5e-21
XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 394 101.4 5e-21
NP_001307194 (OMIM: 610366) AP-3 complex subunit m ( 364) 316 83.1 1.3e-15
XP_016868468 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 282 75.1 2.7e-13
XP_016868467 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 282 75.1 2.7e-13
XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 ( 385) 279 74.4 5.6e-13
NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 273 73.1 1.6e-12
NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 273 73.1 1.6e-12
NP_001307192 (OMIM: 610366) AP-3 complex subunit m ( 418) 273 73.1 1.6e-12
NP_001307193 (OMIM: 610366) AP-3 complex subunit m ( 418) 273 73.1 1.6e-12
XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 ( 284) 269 72.1 2.1e-12
NP_006794 (OMIM: 610469) AP-3 complex subunit mu-2 ( 418) 262 70.5 9.5e-12
NP_001127768 (OMIM: 610469) AP-3 complex subunit m ( 418) 262 70.5 9.5e-12
XP_016868466 (OMIM: 610469) PREDICTED: AP-3 comple ( 418) 262 70.5 9.5e-12
XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 ( 228) 205 57.0 5.8e-08
NP_006864 (OMIM: 605357) stonin-1 [Homo sapiens] ( 735) 180 51.3 9.7e-06
NP_001185524 (OMIM: 605357) stonin-1 [Homo sapiens ( 735) 180 51.3 9.7e-06
XP_006720342 (OMIM: 608467) PREDICTED: stonin-2 is ( 898) 145 43.1 0.0034
NP_149095 (OMIM: 608467) stonin-2 isoform 1 [Homo ( 905) 145 43.1 0.0035
NP_001243359 (OMIM: 608467) stonin-2 isoform 2 [Ho ( 920) 145 43.1 0.0035
XP_011535544 (OMIM: 608467) PREDICTED: stonin-2 is ( 955) 145 43.1 0.0036
XP_011535543 (OMIM: 608467) PREDICTED: stonin-2 is ( 962) 145 43.1 0.0037
XP_011535542 (OMIM: 608467) PREDICTED: stonin-2 is ( 977) 145 43.2 0.0037
XP_005271599 (OMIM: 600820,617164) PREDICTED: coat ( 417) 136 40.9 0.0074
NP_001646 (OMIM: 600820,617164) coatomer subunit d ( 511) 136 41.0 0.0089
>>NP_001123996 (OMIM: 603535) AP-1 complex subunit mu-1 (435 aa)
initn: 2880 init1: 2880 opt: 2880 Z-score: 3649.7 bits: 684.4 E(85289): 1.5e-196
Smith-Waterman score: 2880; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
370 380 390 400 410 420
430
pF1KB5 VRYITQNGDYQLRTQ
:::::::::::::::
NP_001 VRYITQNGDYQLRTQ
430
>>XP_016882909 (OMIM: 603535) PREDICTED: AP-1 complex su (409 aa)
initn: 2711 init1: 2711 opt: 2711 Z-score: 3435.9 bits: 644.8 E(85289): 1.2e-184
Smith-Waterman score: 2711; 100.0% identity (100.0% similar) in 409 aa overlap (27-435:1-409)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
::::::::::::::::::::::::::::::::::
XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
340 350 360 370 380 390
430
pF1KB5 VRYITQNGDYQLRTQ
:::::::::::::::
XP_016 VRYITQNGDYQLRTQ
400
>>XP_016882910 (OMIM: 603535) PREDICTED: AP-1 complex su (397 aa)
initn: 2601 init1: 1600 opt: 1600 Z-score: 2028.1 bits: 384.2 E(85289): 3.2e-106
Smith-Waterman score: 2581; 97.1% identity (97.1% similar) in 409 aa overlap (27-435:1-397)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
::::::::::::::::::::::::::::::::::
XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
:: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LL------------VSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
160 170 180 190 200
250 260 270 280 290 300
pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
210 220 230 240 250 260
310 320 330 340 350 360
pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
330 340 350 360 370 380
430
pF1KB5 VRYITQNGDYQLRTQ
:::::::::::::::
XP_016 VRYITQNGDYQLRTQ
390
>>NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 iso (423 aa)
initn: 2770 init1: 1600 opt: 1600 Z-score: 2027.6 bits: 384.2 E(85289): 3.4e-106
Smith-Waterman score: 2750; 97.2% identity (97.2% similar) in 435 aa overlap (1-435:1-423)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
:: ::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LL------------VSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
190 200 210 220
250 260 270 280 290 300
pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
350 360 370 380 390 400
430
pF1KB5 VRYITQNGDYQLRTQ
:::::::::::::::
NP_115 VRYITQNGDYQLRTQ
410 420
>>NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 iso (423 aa)
initn: 1351 init1: 1351 opt: 1351 Z-score: 1712.0 bits: 325.9 E(85289): 1.3e-88
Smith-Waterman score: 2269; 77.6% identity (92.6% similar) in 434 aa overlap (1-434:1-422)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.::
NP_005 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
::.:::::::..::: .:::.:::::...:: :::::::::::::::::.::::::::::
NP_005 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
:.:::::::::::::::...::::: : : :::::::::::::::.:::::.:::::::
NP_005 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS
:: :.:::.:: :::::.::..:::::::::::::::.:::. :::.:.
NP_005 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRSKN
190 200 210 220
250 260 270 280 290 300
pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH
:::::::::::::::::::.::::::::::::.::::::::.:.::::::::::::: ::
NP_005 KSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSH
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF
::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..::::::
NP_005 SRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSF
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
:::::::::::::::::: :. ::.:::.:::::::::.:::::::.:::::::::::::
NP_005 PGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPW
350 360 370 380 390 400
430
pF1KB5 VRYITQNGDYQLRTQ
::::::.:::::::
NP_005 VRYITQSGDYQLRTS
410 420
>>NP_001287816 (OMIM: 607309) AP-1 complex subunit mu-2 (425 aa)
initn: 2070 init1: 1131 opt: 1327 Z-score: 1681.6 bits: 320.2 E(85289): 6.3e-87
Smith-Waterman score: 2245; 77.1% identity (92.0% similar) in 436 aa overlap (1-434:1-424)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.::
NP_001 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
::.:::::::..::: .:::.:::::...:: :::::::::::::::::.::::::::::
NP_001 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN
:.:::::::::::::::...::::: : : :::::::::::::::.:::::.:::::::
NP_001 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
130 140 150 160 170 180
190 200 210 220 230
pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG--
:: :.:::.:: :::::.::..:::::::::::::::.:::. :: .
NP_001 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGS
190 200 210 220
240 250 260 270 280 290
pF1KB5 KSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKH
:.:::::::::::::::::::.::::::::::::.::::::::.:.:::::::::::::
NP_001 KNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKF
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB5 SHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIK
::::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..::::
NP_001 SHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIK
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB5 SFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQAL
:::::::::::::::::::: :. ::.:::.:::::::::.:::::::.:::::::::::
NP_001 SFPGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQAL
350 360 370 380 390 400
420 430
pF1KB5 PWVRYITQNGDYQLRTQ
::::::::.:::::::
NP_001 PWVRYITQSGDYQLRTS
410 420
>>NP_001020376 (OMIM: 601024) AP-2 complex subunit mu is (433 aa)
initn: 1063 init1: 365 opt: 1078 Z-score: 1365.9 bits: 261.8 E(85289): 2.4e-69
Smith-Waterman score: 1078; 39.1% identity (71.3% similar) in 442 aa overlap (6-433:5-432)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
... . ::.::: : :: :. . :. : ... ... . ::. . . :. .
NP_001 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
:..:..:.:..:.:. ...:: ::::. .:.. :: .. ::.:..:::.:::::::..::
NP_001 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF
60 70 80 90 100 110
130 140 150 160 170
pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPAT--VTNAVSWRSEGIKYRKNEVFLDVIES
::::.... :. .:::.: : .: . : ::. ..:: ::::::.::.::::.::
NP_001 GYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 VNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG
:::: .: .:.:: ... : . :. .:::::: ..:.:::..... :.:
NP_001 VNLL------------MSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKG
180 190 200 210 220
240 250 260 270 280 290
pF1KB5 ------KS--KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIW
:: .:. ..: ::::::::.:...:.::::::::::::: :: . . .
NP_001 TADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFR
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB5 IESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPEN
. .... .....: . ::.:: :...:..::.: .... . :..:. .
NP_001 VIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASE
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB5 SEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKII
. :::.:: . : :: . :.. : .. . : ..::::..::.: :. ::..:::::..
NP_001 NAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVF
350 360 370 380 390 400
420 430
pF1KB5 EK----SGYQALPWVRYITQNGDYQLRTQ
: : .... ::::: ..: :. :
NP_001 EPKLNYSDHDVIKWVRYIGRSGIYETRC
410 420 430
>>NP_004059 (OMIM: 601024) AP-2 complex subunit mu isofo (435 aa)
initn: 953 init1: 545 opt: 1072 Z-score: 1358.2 bits: 260.4 E(85289): 6.5e-69
Smith-Waterman score: 1072; 38.5% identity (70.9% similar) in 444 aa overlap (6-433:5-434)
10 20 30 40 50 60
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI
... . ::.::: : :: :. . :. : ... ... . ::. . . :. .
NP_004 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF
:..:..:.:..:.:. ...:: ::::. .:.. :: .. ::.:..:::.:::::::..::
NP_004 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF
60 70 80 90 100 110
130 140 150 160 170
pF1KB5 GYPQTTDSKILQEYITQEG----HKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVI
::::.... :. .:::.: :. . . . ::. ..:: ::::::.::.::::.
NP_004 GYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 ESVNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTG
:::::: .: .:.:: ... : . :. .:::::: ..:.:::..... :
NP_004 ESVNLL------------MSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQG
180 190 200 210 220
240 250 260 270 280
pF1KB5 RG------KS--KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPL
.: :: .:. ..: ::::::::.:...:.::::::::::::: :: . .
NP_004 KGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILP
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 IWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVP
. . .... .....: . ::.:: :...:..::.: .... . :..:.
NP_004 FRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKA
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 ENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLK
.. :::.:: . : :: . :.. : .. . : ..::::..::.: :. ::..:::::
NP_004 SENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLK
350 360 370 380 390 400
410 420 430
pF1KB5 IIEK----SGYQALPWVRYITQNGDYQLRTQ
..: : .... ::::: ..: :. :
NP_004 VFEPKLNYSDHDVIKWVRYIGRSGIYETRC
410 420 430
>>NP_001298127 (OMIM: 601024) AP-2 complex subunit mu is (460 aa)
initn: 936 init1: 545 opt: 1014 Z-score: 1284.3 bits: 246.8 E(85289): 8.5e-65
Smith-Waterman score: 1014; 38.4% identity (70.5% similar) in 430 aa overlap (20-433:49-459)
10 20 30 40
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPI
: :. :: .:. .. ... . ::.
NP_001 VYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVN----VIHARQQ--VRSPV
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB5 LAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVI
. . :. .:..:..:.:..:.:. ...:: ::::. .:.. :: .. ::.:..:::.
NP_001 TNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVL
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB5 IYELLDELMDFGYPQTTDSKILQEYITQEG----HKLETGAPRPPATVTNAVSWRSEGIK
:::::::..::::::.... :. .:::.: :. . . . ::. ..:: ::::
NP_001 IYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIK
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB5 YRKNEVFLDVIESVNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLG
::.::.::::.:::::: .: .:.:: ... : . :. .:::::: ..:
NP_001 YRRNELFLDVLESVNLL------------MSPQGQVLSAHVSGRVVMKSYLSGMPECKFG
200 210 220 230 240
230 240 250 260 270
pF1KB5 LNDKVLFDNTGRG------KS--KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELM
.:::..... :.: :: .:. ..: ::::::::.:...:.:::::::::::::
NP_001 MNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB5 SYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKF
:: . . . . .... .....: . ::.:: :...:..::.: .... .
NP_001 RYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQV
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB5 KTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYF
:..:. .. :::.:: . : :: . :.. : .. . : ..::::..::.: :
NP_001 ICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVP-F
370 380 390 400 410
400 410 420 430
pF1KB5 TTSGIQVRYLKIIEK----SGYQALPWVRYITQNGDYQLRTQ
. ::..:::::..: : .... ::::: ..: :. :
NP_001 APSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC
420 430 440 450 460
>>NP_004713 (OMIM: 602296,612936) AP-4 complex subunit m (453 aa)
initn: 586 init1: 251 opt: 409 Z-score: 517.7 bits: 105.0 E(85289): 4.3e-22
Smith-Waterman score: 618; 28.1% identity (59.9% similar) in 466 aa overlap (4-433:3-452)
10 20 30 40 50
pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEV-EHFMPILMEKEEEGMLSPI-LAHGGVRFM
: ..:. :: :: ...::: .: : :. : : ::. . : : .:.
NP_004 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGL--PGDESPVVMHHHGRHFI
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 WIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELM
:.:..::::.:...:. .. .: ... ....: : : .: : ...::::::..
NP_004 HIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVL
60 70 80 90 100 110
120 130 140 150
pF1KB5 DFGYPQTTDSKILQEYITQE------------------GHKLETGAPRPPATVTNAV-SW
:.:: :::....:...: : : . . . : .... : :
NP_004 DYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSS
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 RSEGIKYRKNEVFLDVIESVNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGM
::. . .::::::::.: ...: ...::..:. .. : :... :: .
NP_004 RSD--QSQKNEVFLDVVERLSVL------------IASNGSLLKVDVQGEIRLKSFLPSG
180 190 200 210 220
220 230 240 250 260 270
pF1KB5 PELRLGLNDKVLFDNTG-RGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMS
:.:.::... .. :: . ......:.::. : :..::. : . . ::.::. .:
NP_004 SEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMR
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB5 YRLNTHVK---PLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSP
:.:. . :. . :: .. .:.. ..: . .. .: : ::..:.:.: . :
NP_004 YQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSL
290 300 310 320 330 340
340 350 360 370 380
pF1KB5 KFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEG-----KP----
. . . : .. . :.. ::.. .. .:. . ..: .:
NP_004 SQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLG
350 360 370 380 390 400
390 400 410 420 430
pF1KB5 PISVKFEIPYFTTSGIQVRYLKIIEKSGYQALP--WVRYITQNGDYQLRTQ
: :..::.: : ::.:::.:.. . .: : :::..... : .:
NP_004 PASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
410 420 430 440 450
435 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 04:38:32 2016 done: Mon Nov 7 04:38:33 2016
Total Scan time: 8.520 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]