Result of FASTA (omim) for
pFN21AB3993
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3993, 418 aa
1>>>pF1KB3993 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
63617473 residues in 89429 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6736+/-0.000323; mu= 21.2526+/- 0.020
mean_var=72.4482+/-15.032, 0's: 0 Z-trim(116.0): 16 B-trim: 0 in 0/51
Lambda= 0.150682
statistics sampled from 27458 (27473) to 27458 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.307), width: 16
Scan time: 4.360
The best scores are: opt bits E(89429)
NP_003264 (OMIM: 603414) delta(14)-sterol reductas ( 418) 2854 629.6 4.6e-180
NP_001264162 (OMIM: 603414) delta(14)-sterol reduc ( 391) 2002 444.4 2.5e-124
NP_919424 (OMIM: 169400,215140,600024,613471) lami ( 615) 1676 373.7 7.3e-103
XP_011542487 (OMIM: 169400,215140,600024,613471) P ( 615) 1676 373.7 7.3e-103
NP_002287 (OMIM: 169400,215140,600024,613471) lami ( 615) 1676 373.7 7.3e-103
XP_005273182 (OMIM: 169400,215140,600024,613471) P ( 573) 965 219.1 2.4e-56
NP_001351 (OMIM: 270400,602858) 7-dehydrocholester ( 475) 546 127.9 5.4e-29
NP_001157289 (OMIM: 270400,602858) 7-dehydrocholes ( 475) 546 127.9 5.4e-29
XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-de ( 456) 417 99.9 1.5e-20
>>NP_003264 (OMIM: 603414) delta(14)-sterol reductase is (418 aa)
initn: 2854 init1: 2854 opt: 2854 Z-score: 3354.1 bits: 629.6 E(89429): 4.6e-180
Smith-Waterman score: 2854; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418)
10 20 30 40 50 60
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 YYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA
310 320 330 340 350 360
370 380 390 400 410
pF1KB3 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
370 380 390 400 410
>>NP_001264162 (OMIM: 603414) delta(14)-sterol reductase (391 aa)
initn: 2002 init1: 2002 opt: 2002 Z-score: 2353.5 bits: 444.4 E(89429): 2.5e-124
Smith-Waterman score: 2608; 93.5% identity (93.5% similar) in 418 aa overlap (1-418:1-391)
10 20 30 40 50 60
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLIN---
250 260 270 280 290
310 320 330 340 350 360
pF1KB3 YYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA
::::::::::::::::::::::::::::::::::::
NP_001 ------------------------GLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALA
300 310 320 330
370 380 390 400 410
pF1KB3 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
340 350 360 370 380 390
>>NP_919424 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa)
initn: 1419 init1: 1081 opt: 1676 Z-score: 1968.0 bits: 373.7 E(89429): 7.3e-103
Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (11-418:207-615)
10 20 30 40
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
::::: :. ... ::. .: ::: ..
NP_919 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
180 190 200 210 220 230
50 60 70 80 90 100
pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: .
NP_919 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
240 250 260 270 280 290
110 120 130 140 150 160
pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . :
NP_919 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
300 310 320 330 340 350
170 180 190 200 210
pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS
.:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :.
NP_919 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV
360 370 380 390 400 410
220 230 240 250 260 270
pF1KB3 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL
::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .:
NP_919 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL
420 430 440 450 460 470
280 290 300 310 320 330
pF1KB3 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL
. ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..::
NP_919 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL
480 490 500 510 520 530
340 350 360 370 380 390
pF1KB3 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY
::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .::
NP_919 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY
540 550 560 570 580 590
400 410
pF1KB3 GLAWQEYCRRVPYRIMPYIY
:.::..::.::::::.::::
NP_919 GVAWEKYCQRVPYRIFPYIY
600 610
>>XP_011542487 (OMIM: 169400,215140,600024,613471) PREDI (615 aa)
initn: 1419 init1: 1081 opt: 1676 Z-score: 1968.0 bits: 373.7 E(89429): 7.3e-103
Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (11-418:207-615)
10 20 30 40
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
::::: :. ... ::. .: ::: ..
XP_011 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
180 190 200 210 220 230
50 60 70 80 90 100
pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: .
XP_011 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
240 250 260 270 280 290
110 120 130 140 150 160
pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . :
XP_011 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
300 310 320 330 340 350
170 180 190 200 210
pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS
.:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :.
XP_011 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV
360 370 380 390 400 410
220 230 240 250 260 270
pF1KB3 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL
::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .:
XP_011 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL
420 430 440 450 460 470
280 290 300 310 320 330
pF1KB3 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL
. ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..::
XP_011 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL
480 490 500 510 520 530
340 350 360 370 380 390
pF1KB3 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY
::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .::
XP_011 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY
540 550 560 570 580 590
400 410
pF1KB3 GLAWQEYCRRVPYRIMPYIY
:.::..::.::::::.::::
XP_011 GVAWEKYCQRVPYRIFPYIY
600 610
>>NP_002287 (OMIM: 169400,215140,600024,613471) lamin-B (615 aa)
initn: 1419 init1: 1081 opt: 1676 Z-score: 1968.0 bits: 373.7 E(89429): 7.3e-103
Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (11-418:207-615)
10 20 30 40
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
::::: :. ... ::. .: ::: ..
NP_002 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
180 190 200 210 220 230
50 60 70 80 90 100
pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: .
NP_002 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
240 250 260 270 280 290
110 120 130 140 150 160
pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . :
NP_002 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
300 310 320 330 340 350
170 180 190 200 210
pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS
.:. .::: .::::.:::::::: ::.::::::::::::::.:::..:. : .. :.
NP_002 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV
360 370 380 390 400 410
220 230 240 250 260 270
pF1KB3 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL
::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .:
NP_002 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL
420 430 440 450 460 470
280 290 300 310 320 330
pF1KB3 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL
. ::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..::
NP_002 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL
480 490 500 510 520 530
340 350 360 370 380 390
pF1KB3 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY
::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .::
NP_002 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY
540 550 560 570 580 590
400 410
pF1KB3 GLAWQEYCRRVPYRIMPYIY
:.::..::.::::::.::::
NP_002 GVAWEKYCQRVPYRIFPYIY
600 610
>>XP_005273182 (OMIM: 169400,215140,600024,613471) PREDI (573 aa)
initn: 1294 init1: 956 opt: 965 Z-score: 1133.1 bits: 219.1 E(89429): 2.4e-56
Smith-Waterman score: 1434; 52.9% identity (72.8% similar) in 408 aa overlap (11-418:207-573)
10 20 30 40
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
::::: :. ... ::. .: ::: ..
XP_005 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
180 190 200 210 220 230
50 60 70 80 90 100
pF1KB3 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
::. : ::.: :: :.. ..: :. .:. .:::: ::.:: : : ::.: .
XP_005 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
240 250 260 270 280 290
110 120 130 140 150 160
pF1KB3 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
::: :..::. ..: .. :. . . .: .:..::. ..:..:::.. :: . :
XP_005 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
300 310 320 330 340 350
170 180 190 200 210 220
pF1KB3 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPS
.:. .::: .::::.:::::::: ::.:::::::::::::
XP_005 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGW-------------------
360 370 380 390
230 240 250 260 270 280
pF1KB3 LAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLH
::.:::::: ::::::::::::..:::: ::.:: .:.
XP_005 ---------------------EALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVS
400 410 420 430
290 300 310 320 330 340
pF1KB3 HPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVS
::. .. ::::.: ... :: ::::::::::.::::::::..: :.:: :.::..::::
XP_005 HPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVS
440 450 460 470 480 490
350 360 370 380 390 400
pF1KB3 GWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGL
::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .:::.
XP_005 GWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGV
500 510 520 530 540 550
410
pF1KB3 AWQEYCRRVPYRIMPYIY
::..::.::::::.::::
XP_005 AWEKYCQRVPYRIFPYIY
560 570
>>NP_001351 (OMIM: 270400,602858) 7-dehydrocholesterol r (475 aa)
initn: 864 init1: 427 opt: 546 Z-score: 641.9 bits: 127.9 E(89429): 5.4e-29
Smith-Waterman score: 901; 37.6% identity (63.8% similar) in 431 aa overlap (22-418:46-475)
10 20 30 40 50
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL
:::. : ......: . : :: ...
NP_001 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI
20 30 40 50 60 70
60 70 80 90
pF1KB3 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL
: : .: .: .: :. :. .:. :: .::. . ::
NP_001 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT
80 90 100 110 120 130
100 110 120 130 140
pF1KB3 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL
.: :::.:: .:: :: .. . . . . . .:: . :.. .. : :
NP_001 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA
140 150 160 170 180 190
150 160 170 180 190 200
pF1KB3 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA
..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::.
NP_001 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS
200 210 220 230 240 250
210 220 230 240 250 260
pF1KB3 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV
. :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:.
NP_001 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL
260 270 280 290 300 310
270 280 290 300 310 320
pF1KB3 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE
:. :.::. .:..:: :. : : . :.. .:::::: :: ::. ::.. . . : .
NP_001 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK
320 330 340 350 360 370
330 340 350 360 370
pF1KB3 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL
. ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::..
NP_001 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII
380 390 400 410 420 430
380 390 400 410
pF1KB3 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
:.. ::.:: :::..: .::: :..: ::::..: :.
NP_001 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
440 450 460 470
>>NP_001157289 (OMIM: 270400,602858) 7-dehydrocholestero (475 aa)
initn: 864 init1: 427 opt: 546 Z-score: 641.9 bits: 127.9 E(89429): 5.4e-29
Smith-Waterman score: 901; 37.6% identity (63.8% similar) in 431 aa overlap (22-418:46-475)
10 20 30 40 50
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL
:::. : ......: . : :: ...
NP_001 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI
20 30 40 50 60 70
60 70 80 90
pF1KB3 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL
: : .: .: .: :. :. .:. :: .::. . ::
NP_001 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT
80 90 100 110 120 130
100 110 120 130 140
pF1KB3 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL
.: :::.:: .:: :: .. . . . . . .:: . :.. .. : :
NP_001 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA
140 150 160 170 180 190
150 160 170 180 190 200
pF1KB3 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA
..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::.
NP_001 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS
200 210 220 230 240 250
210 220 230 240 250 260
pF1KB3 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV
. :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:.
NP_001 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL
260 270 280 290 300 310
270 280 290 300 310 320
pF1KB3 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE
:. :.::. .:..:: :. : : . :.. .:::::: :: ::. ::.. . . : .
NP_001 PYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRK
320 330 340 350 360 370
330 340 350 360 370
pF1KB3 ------TISTATGR----KLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLL
. ..: :. ::::::.::..:: ::.:::. .::. : :: .:::::::..
NP_001 PKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYII
380 390 400 410 420 430
380 390 400 410
pF1KB3 YFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
:.. ::.:: :::..: .::: :..: ::::..: :.
NP_001 YMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
440 450 460 470
>>XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-dehydr (456 aa)
initn: 429 init1: 299 opt: 417 Z-score: 490.5 bits: 99.9 E(89429): 1.5e-20
Smith-Waterman score: 449; 33.6% identity (59.9% similar) in 277 aa overlap (22-274:46-321)
10 20 30 40 50
pF1KB3 MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASL
:::. : ......: . : :: ...
XP_011 DGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDI
20 30 40 50 60 70
60 70 80 90
pF1KB3 -PG---LEVLW--SP----RALLLWLAWLGLQAALY---------LLPAR--KVAEGQEL
: : .: .: .: :. :. .:. :: .::. . ::
XP_011 VTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVT
80 90 100 110 120 130
100 110 120 130 140
pF1KB3 KDKSRLRYPINGFQALVLTALL--VGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFL
.: :::.:: .:: :: .. . . . . . .:: . :.. .. : :
XP_011 PAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFA
140 150 160 170 180 190
150 160 170 180 190 200
pF1KB3 YMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRIC-FFDFKYFCELRPGLIGWVLINLA
..:. :.:: .:: .:....: :.:::: .:::: : . :::...:.::::.
XP_011 MVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLS
200 210 220 230 240 250
210 220 230 240 250 260
pF1KB3 LLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWV
. :. ::.. . :: ::: .: .:: : .:.: : :.:: :: ::..:..:: .:.
XP_011 FAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWL
260 270 280 290 300 310
270 280 290 300 310 320
pF1KB3 PFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLE
:. :.::
XP_011 PYLYTLQKRTRRQGVCQRQSWGLTPGRWAPEPTLLSSPWAKHRLTPSPSPPRVCTWCTTP
320 330 340 350 360 370
418 residues in 1 query sequences
63617473 residues in 89429 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 16 14:50:25 2017 done: Thu Nov 16 14:50:26 2017
Total Scan time: 4.360 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]