Result of FASTA (omim) for
pFN21AB0120
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0120, 1529 aa
1>>>pF1KB0120 1529 - 1529 aa - 1529 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4525+/-0.00082; mu= 7.8404+/- 0.050
mean_var=354.5331+/-72.853, 0's: 0 Z-trim(111.9): 732 B-trim: 822 in 1/48
Lambda= 0.068115
statistics sampled from 19703 (20594) to 19703 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.241), width: 16
Scan time: 12.660
The best scores are: opt bits E(85289)
NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 10738 1072.4 0
XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 10720 1070.6 0
NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 10657 1064.4 0
NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 10639 1062.7 0
XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 10329 1032.2 0
XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 10311 1030.4 0
XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 8040 807.1 0
NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 7467 751.0 1.7e-215
NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534) 7433 747.6 1.8e-214
NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 6287 635.0 1.4e-180
XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 6074 614.0 2.7e-174
XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 5716 578.9 1.1e-163
XP_016883196 (OMIM: 118450,187500,601920) PREDICTE (1059) 940 109.3 1.7e-22
NP_000205 (OMIM: 118450,187500,601920) protein jag (1218) 940 109.4 1.8e-22
NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 868 102.6 3.3e-20
XP_005259981 (OMIM: 125310,130720,600276,615293) P (2269) 767 92.8 3.4e-17
NP_000426 (OMIM: 125310,130720,600276,615293) neur (2321) 767 92.8 3.5e-17
NP_005609 (OMIM: 606582) delta-like protein 1 prec ( 723) 740 89.4 1.1e-16
NP_001186930 (OMIM: 102500,600275,610205) neurogen (1235) 741 89.9 1.4e-16
XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432) 741 90.3 2.1e-16
XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432) 741 90.3 2.1e-16
XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432) 741 90.3 2.1e-16
XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455) 741 90.3 2.1e-16
XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467) 741 90.3 2.1e-16
NP_077719 (OMIM: 102500,600275,610205) neurogenic (2471) 741 90.3 2.1e-16
NP_060087 (OMIM: 109730,190198,616028) neurogenic (2555) 731 89.3 4.3e-16
NP_001244895 (OMIM: 172870,600105,604210,613835) p ( 870) 712 86.8 8.4e-16
NP_061947 (OMIM: 605185,616589) delta-like protein ( 685) 699 85.4 1.8e-15
XP_005266991 (OMIM: 606582) PREDICTED: delta-like ( 524) 642 79.6 7.4e-14
NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 634 80.0 3.8e-13
XP_011516858 (OMIM: 219730,609720,616220) PREDICTE (1276) 620 78.0 5.5e-13
NP_775960 (OMIM: 219730,609720,616220) protein cru (1285) 620 78.0 5.5e-13
XP_011516859 (OMIM: 219730,609720,616220) PREDICTE (1220) 599 75.9 2.3e-12
XP_011516860 (OMIM: 219730,609720,616220) PREDICTE (1220) 599 75.9 2.3e-12
NP_982353 (OMIM: 277300,602768) delta-like protein ( 587) 561 71.7 2e-11
NP_058637 (OMIM: 277300,602768) delta-like protein ( 618) 561 71.8 2e-11
NP_660142 (OMIM: 602570) protein jagged-2 isoform (1200) 566 72.7 2.1e-11
NP_002217 (OMIM: 602570) protein jagged-2 isoform (1238) 566 72.7 2.1e-11
XP_016859269 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11
XP_016859268 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11
XP_016859270 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11
XP_016859267 (OMIM: 616634) PREDICTED: sushi, nido (1309) 556 71.7 4.4e-11
XP_011509236 (OMIM: 616634) PREDICTED: sushi, nido (1315) 556 71.7 4.4e-11
XP_011509235 (OMIM: 616634) PREDICTED: sushi, nido (1351) 556 71.7 4.5e-11
XP_011509234 (OMIM: 616634) PREDICTED: sushi, nido (1404) 556 71.8 4.6e-11
NP_001073906 (OMIM: 616634) sushi, nidogen and EGF (1413) 556 71.8 4.6e-11
XP_016859265 (OMIM: 616634) PREDICTED: sushi, nido (1420) 556 71.8 4.6e-11
XP_016859264 (OMIM: 616634) PREDICTED: sushi, nido (1425) 556 71.8 4.6e-11
XP_016859263 (OMIM: 616634) PREDICTED: sushi, nido (1434) 556 71.8 4.6e-11
XP_011509233 (OMIM: 616634) PREDICTED: sushi, nido (1437) 556 71.8 4.6e-11
>>NP_004778 (OMIM: 603746) slit homolog 2 protein isofor (1529 aa)
initn: 10738 init1: 10738 opt: 10738 Z-score: 5726.9 bits: 1072.4 E(85289): 0
Smith-Waterman score: 10738; 100.0% identity (100.0% similar) in 1529 aa overlap (1-1529:1-1529)
10 20 30 40 50 60
pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB0 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB0 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB0 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB0 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB0 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB0 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB0 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB0 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB0 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB0 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB0 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB0 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB0 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB0 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB0 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB0 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB0 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
1450 1460 1470 1480 1490 1500
1510 1520
pF1KB0 KYSFECTDGSSFVDEVEKVVKCGCTRCVS
:::::::::::::::::::::::::::::
NP_004 KYSFECTDGSSFVDEVEKVVKCGCTRCVS
1510 1520
>>XP_005248268 (OMIM: 603746) PREDICTED: slit homolog 2 (1533 aa)
initn: 9001 init1: 9001 opt: 10720 Z-score: 5717.3 bits: 1070.6 E(85289): 0
Smith-Waterman score: 10720; 99.7% identity (99.7% similar) in 1533 aa overlap (1-1529:1-1533)
10 20 30 40 50 60
pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
190 200 210 220 230 240
250 260 270 280 290
pF1KB0 HLRGHNVAEVQKREFVCS----GHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT
:::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_005 HLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB0 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB0 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB0 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB0 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB0 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB0 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB0 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB0 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB0 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND
790 800 810 820 830 840
840 850 860 870 880 890
pF1KB0 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KB0 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KB0 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KB0 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KB0 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KB0 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB0 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB0 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KB0 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KB0 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KB0 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR
1450 1460 1470 1480 1490 1500
1500 1510 1520
pF1KB0 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
:::::::::::::::::::::::::::::::::
XP_005 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
1510 1520 1530
>>NP_001276065 (OMIM: 603746) slit homolog 2 protein iso (1521 aa)
initn: 7459 init1: 7459 opt: 10657 Z-score: 5683.9 bits: 1064.4 E(85289): 0
Smith-Waterman score: 10657; 99.5% identity (99.5% similar) in 1529 aa overlap (1-1529:1-1521)
10 20 30 40 50 60
pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCS-
430 440 450 460 470
490 500 510 520 530 540
pF1KB0 KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------GTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB0 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB0 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB0 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
660 670 680 690 700 710
730 740 750 760 770 780
pF1KB0 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
720 730 740 750 760 770
790 800 810 820 830 840
pF1KB0 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
780 790 800 810 820 830
850 860 870 880 890 900
pF1KB0 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
840 850 860 870 880 890
910 920 930 940 950 960
pF1KB0 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KB0 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KB0 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KB0 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KB0 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KB0 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KB0 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KB0 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KB0 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KB0 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
1440 1450 1460 1470 1480 1490
1510 1520
pF1KB0 KYSFECTDGSSFVDEVEKVVKCGCTRCVS
:::::::::::::::::::::::::::::
NP_001 KYSFECTDGSSFVDEVEKVVKCGCTRCVS
1500 1510 1520
>>NP_001276064 (OMIM: 603746) slit homolog 2 protein iso (1525 aa)
initn: 9183 init1: 7459 opt: 10639 Z-score: 5674.3 bits: 1062.7 E(85289): 0
Smith-Waterman score: 10639; 99.2% identity (99.2% similar) in 1533 aa overlap (1-1529:1-1525)
10 20 30 40 50 60
pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
190 200 210 220 230 240
250 260 270 280 290
pF1KB0 HLRGHNVAEVQKREFVCS----GHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT
:::::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_001 HLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB0 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB0 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB0 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKF
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB0 RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA
::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCS--------GTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTA
490 500 510 520 530
540 550 560 570 580 590
pF1KB0 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLEN
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB0 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL
600 610 620 630 640 650
660 670 680 690 700 710
pF1KB0 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN
660 670 680 690 700 710
720 730 740 750 760 770
pF1KB0 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY
720 730 740 750 760 770
780 790 800 810 820 830
pF1KB0 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGND
780 790 800 810 820 830
840 850 860 870 880 890
pF1KB0 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKL
840 850 860 870 880 890
900 910 920 930 940 950
pF1KB0 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDV
900 910 920 930 940 950
960 970 980 990 1000 1010
pF1KB0 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDG
960 970 980 990 1000 1010
1020 1030 1040 1050 1060 1070
pF1KB0 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDID
1020 1030 1040 1050 1060 1070
1080 1090 1100 1110 1120 1130
pF1KB0 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQC
1080 1090 1100 1110 1120 1130
1140 1150 1160 1170 1180 1190
pF1KB0 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGI
1140 1150 1160 1170 1180 1190
1200 1210 1220 1230 1240 1250
pF1KB0 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSV
1200 1210 1220 1230 1240 1250
1260 1270 1280 1290 1300 1310
pF1KB0 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSE
1260 1270 1280 1290 1300 1310
1320 1330 1340 1350 1360 1370
pF1KB0 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCL
1320 1330 1340 1350 1360 1370
1380 1390 1400 1410 1420 1430
pF1KB0 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYC
1380 1390 1400 1410 1420 1430
1440 1450 1460 1470 1480 1490
pF1KB0 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLR
1440 1450 1460 1470 1480 1490
1500 1510 1520
pF1KB0 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
:::::::::::::::::::::::::::::::::
NP_001 SKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
1500 1510 1520
>>XP_016864334 (OMIM: 603746) PREDICTED: slit homolog 2 (1495 aa)
initn: 10325 init1: 10325 opt: 10329 Z-score: 5509.8 bits: 1032.2 E(85289): 0
Smith-Waterman score: 10329; 99.3% identity (99.5% similar) in 1484 aa overlap (50-1529:12-1495)
20 30 40 50 60 70
pF1KB0 LNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL----DLNGNNITRITKTDF
:..: : :: :::::::::::::::
XP_016 MPGASETPLCSPESINGVTLRLPASRDLNGNNITRITKTDF
10 20 30 40
80 90 100 110 120 130
pF1KB0 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB0 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB0 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB0 VCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVI
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB0 PPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQ
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB0 LLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICD
350 360 370 380 390 400
440 450 460 470 480 490
pF1KB0 CHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSK
410 420 430 440 450 460
500 510 520 530 540 550
pF1KB0 LSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFK
470 480 490 500 510 520
560 570 580 590 600 610
pF1KB0 KLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRS
530 540 550 560 570 580
620 630 640 650 660 670
pF1KB0 NRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWL
590 600 610 620 630 640
680 690 700 710 720 730
pF1KB0 GEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLD
650 660 670 680 690 700
740 750 760 770 780 790
pF1KB0 TVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQ
710 720 730 740 750 760
800 810 820 830 840 850
pF1KB0 SFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLA
770 780 790 800 810 820
860 870 880 890 900 910
pF1KB0 IGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNI
830 840 850 860 870 880
920 930 940 950 960 970
pF1KB0 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLK
890 900 910 920 930 940
980 990 1000 1010 1020 1030
pF1KB0 EGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEE
950 960 970 980 990 1000
1040 1050 1060 1070 1080 1090
pF1KB0 KLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAV
1010 1020 1030 1040 1050 1060
1100 1110 1120 1130 1140 1150
pF1KB0 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEK
1070 1080 1090 1100 1110 1120
1160 1170 1180 1190 1200 1210
pF1KB0 CEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRV
1130 1140 1150 1160 1170 1180
1220 1230 1240 1250 1260 1270
pF1KB0 RASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNF
1190 1200 1210 1220 1230 1240
1280 1290 1300 1310 1320 1330
pF1KB0 DSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEP
1250 1260 1270 1280 1290 1300
1340 1350 1360 1370 1380 1390
pF1KB0 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC
1310 1320 1330 1340 1350 1360
1400 1410 1420 1430 1440 1450
pF1KB0 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRG
1370 1380 1390 1400 1410 1420
1460 1470 1480 1490 1500 1510
pF1KB0 ERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDE
1430 1440 1450 1460 1470 1480
1520
pF1KB0 VEKVVKCGCTRCVS
::::::::::::::
XP_016 VEKVVKCGCTRCVS
1490
>>XP_011512211 (OMIM: 603746) PREDICTED: slit homolog 2 (1499 aa)
initn: 9001 init1: 9001 opt: 10311 Z-score: 5500.2 bits: 1030.4 E(85289): 0
Smith-Waterman score: 10311; 99.1% identity (99.2% similar) in 1488 aa overlap (50-1529:12-1499)
20 30 40 50 60 70
pF1KB0 LNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL----DLNGNNITRITKTDF
:..: : :: :::::::::::::::
XP_011 MPGASETPLCSPESINGVTLRLPASRDLNGNNITRITKTDF
10 20 30 40
80 90 100 110 120 130
pF1KB0 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLS
50 60 70 80 90 100
140 150 160 170 180 190
pF1KB0 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASF
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB0 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREF
170 180 190 200 210 220
260 270 280 290 300 310
pF1KB0 VCS----GHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNT
::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNT
230 240 250 260 270 280
320 330 340 350 360 370
pF1KB0 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGL
290 300 310 320 330 340
380 390 400 410 420 430
pF1KB0 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNP
350 360 370 380 390 400
440 450 460 470 480 490
pF1KB0 FICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTED
410 420 430 440 450 460
500 510 520 530 540 550
pF1KB0 YRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEAT
470 480 490 500 510 520
560 570 580 590 600 610
pF1KB0 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL
530 540 550 560 570 580
620 630 640 650 660 670
pF1KB0 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCY
590 600 610 620 630 640
680 690 700 710 720 730
pF1KB0 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC
650 660 670 680 690 700
740 750 760 770 780 790
pF1KB0 TCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRIST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRIST
710 720 730 740 750 760
800 810 820 830 840 850
pF1KB0 LSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSAL
770 780 790 800 810 820
860 870 880 890 900 910
pF1KB0 SHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPV
830 840 850 860 870 880
920 930 940 950 960 970
pF1KB0 DVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGT
890 900 910 920 930 940
980 990 1000 1010 1020 1030
pF1KB0 CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGE
950 960 970 980 990 1000
1040 1050 1060 1070 1080 1090
pF1KB0 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC
1010 1020 1030 1040 1050 1060
1100 1110 1120 1130 1140 1150
pF1KB0 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGY
1070 1080 1090 1100 1110 1120
1160 1170 1180 1190 1200 1210
pF1KB0 QGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELY
1130 1140 1150 1160 1170 1180
1220 1230 1240 1250 1260 1270
pF1KB0 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQS
1190 1200 1210 1220 1230 1240
1280 1290 1300 1310 1320 1330
pF1KB0 TLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILP
1250 1260 1270 1280 1290 1300
1340 1350 1360 1370 1380 1390
pF1KB0 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF
1310 1320 1330 1340 1350 1360
1400 1410 1420 1430 1440 1450
pF1KB0 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREI
1370 1380 1390 1400 1410 1420
1460 1470 1480 1490 1500 1510
pF1KB0 SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSS
1430 1440 1450 1460 1470 1480
1520
pF1KB0 FVDEVEKVVKCGCTRCVS
::::::::::::::::::
XP_011 FVDEVEKVVKCGCTRCVS
1490
>>XP_011512212 (OMIM: 603746) PREDICTED: slit homolog 2 (1159 aa)
initn: 8040 init1: 8040 opt: 8040 Z-score: 4295.2 bits: 807.1 E(85289): 0
Smith-Waterman score: 8040; 99.6% identity (99.9% similar) in 1130 aa overlap (400-1529:30-1159)
370 380 390 400 410 420
pF1KB0 GLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQ
.::::.: ::::.:::::::::::::::::
XP_011 MLYPSIAYSFSLLRREFKKISPFLWRKIFFLSLYNNTLQTITKGTFSPLRAIQTMHLAQ
10 20 30 40 50
430 440 450 460 470 480
pF1KB0 NPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGT
60 70 80 90 100 110
490 500 510 520 530 540
pF1KB0 EDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE
120 130 140 150 160 170
550 560 570 580 590 600
pF1KB0 ATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLK
180 190 200 210 220 230
610 620 630 640 650 660
pF1KB0 TLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCN
240 250 260 270 280 290
670 680 690 700 710 720
pF1KB0 CYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPT
300 310 320 330 340 350
730 740 750 760 770 780
pF1KB0 ECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRI
360 370 380 390 400 410
790 800 810 820 830 840
pF1KB0 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLS
420 430 440 450 460 470
850 860 870 880 890 900
pF1KB0 ALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQG
480 490 500 510 520 530
910 920 930 940 950 960
pF1KB0 PVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHG
540 550 560 570 580 590
970 980 990 1000 1010 1020
pF1KB0 GTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYT
600 610 620 630 640 650
1030 1040 1050 1060 1070 1080
pF1KB0 GELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGA
660 670 680 690 700 710
1090 1100 1110 1120 1130 1140
pF1KB0 HCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLP
720 730 740 750 760 770
1150 1160 1170 1180 1190 1200
pF1KB0 GYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVE
780 790 800 810 820 830
1210 1220 1230 1240 1250 1260
pF1KB0 LYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSK
840 850 860 870 880 890
1270 1280 1290 1300 1310 1320
pF1KB0 QSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGI
900 910 920 930 940 950
1330 1340 1350 1360 1370 1380
pF1KB0 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPIN
960 970 980 990 1000 1010
1390 1400 1410 1420 1430 1440
pF1KB0 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR
1020 1030 1040 1050 1060 1070
1450 1460 1470 1480 1490 1500
pF1KB0 EISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDG
1080 1090 1100 1110 1120 1130
1510 1520
pF1KB0 SSFVDEVEKVVKCGCTRCVS
::::::::::::::::::::
XP_011 SSFVDEVEKVVKCGCTRCVS
1140 1150
>>NP_001258875 (OMIM: 603745) slit homolog 3 protein iso (1530 aa)
initn: 5297 init1: 2055 opt: 7467 Z-score: 3989.7 bits: 751.0 E(85289): 1.7e-215
Smith-Waterman score: 7467; 66.3% identity (87.6% similar) in 1537 aa overlap (3-1527:7-1529)
10 20 30 40 50
pF1KB0 MRGVGWQMLS-LSLGLVLA-ILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIP
::: . . :.:.:.:: .:. :::..:.::...::::::.::.:::.::
NP_001 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH
::.:::::. :::::::: :::::..::::.: .:..:.::::::::::.:::::::.:.
NP_001 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL
::..::::: .: :: ::::::::::.:::::::: .:.:::::: :.::::::::::::
NP_001 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT
::::.::::::::.:. :.:::::::.::.:::::.::::::::::::::::: :: .:
NP_001 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 QCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV--LHCPAACTCSNNIVDCRGKGLT
::.: :::: :::.:::.:.:: . .: :::.. . ::. :::::::::::::::
NP_001 LCMAPVHLRGFNVADVQKKEYVCPAPHS-EPPSCNANSISCPSPCTCSNNIVDCRGKGLM
250 260 270 280 290
300 310 320 330 340 350
pF1KB0 EIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS
:::.:::: :.:::::::.::.:: :::. ::::.:::.:.::::..::::::::.::.:
NP_001 EIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB0 LVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIA
::::::::::. :.::.:: :::::::::::::::::..::::.:::::::::::::::.
NP_001 LVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTIS
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB0 KGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIK
:: :.::..:::.:::::::.::::::::::::. ::::::::::.::::::::::.:::
NP_001 KGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIK
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB0 SKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIP
::::::: :.:::::..:..:: ::.:::::::::: :::::::: .:: :.:
NP_001 SKKFRCS--------GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLP
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB0 QYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSN
.:...::::.:: .::::::::::::.:::::.::::: ...::::.::..:.:..::.:
NP_001 EYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB0 RLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDT
.::.:. ..:.:: .::::::::: : ::.::.: :::::::::::::.:::..:::: :
NP_001 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT
600 610 620 630 640 650
660 670 680 690 700 710
pF1KB0 LHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTC
: ::::.:::.:::::::.:::::.::::.:::.::::::::.:::::::::::::::::
NP_001 LVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTC
660 670 680 690 700 710
720 730 740 750 760 770
pF1KB0 DDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE
: ::...::. ::: .:::..::::::::::..::.:.:.:::::::.::..: ::.:
NP_001 D-GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE
720 730 740 750 760 770
780 790 800 810 820 830
pF1KB0 LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSL
:: .:::::::::: :: :.: .::::..: ::::::::::::: ..:.::.:::.:.:
NP_001 LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTL
780 790 800 810 820 830
840 850 860 870 880 890
pF1KB0 HGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEM
:::::: ::::.::::..:::::.:.:::.:::...:::.:::. :::::::::..: :
NP_001 HGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPM
840 850 860 870 880 890
900 910 920 930 940
pF1KB0 ADKLLLTTPSKKFTCQ-------GPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTC
::.::::::...: :. ::::.::.:::: :::.::::.:::..:::..:::.:
NP_001 ADRLLLTTPTHRFQCKVLWFCCPGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCAC
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KB0 PYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDN
::..::.:: :::..::.:::.:::::::.....::: : : ::::. ::.: ::::::
NP_001 PYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDN
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KB0 DCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCT
:::::.:::::::::.:.:::.::::::.: .: :. .:: :::..::: :::.:.:.
NP_001 DCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECV
1020 1030 1040 1050 1060 1070
1070 1080 1090 1100 1110 1120
pF1KB0 PGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPC
::: :. :. : ::: .::..::.:.:..::::: ::.:.:: ::: ::::: .::::
NP_001 PGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPC
1080 1090 1100 1110 1120 1130
1130 1140 1150 1160 1170 1180
pF1KB0 DNFDCQNGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNIT
:...::::::::: .:: :.: ::. : .::::..:::..:.::... :::::::.::.
NP_001 DQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANIS
1140 1150 1160 1170 1180 1190
1190 1200 1210 1220 1230 1240
pF1KB0 LQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVEL
::.:::.:.::::::::.: .:.:::.:.:: ::. : : ...:::::.:::.:: :::
NP_001 LQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVEL
1200 1210 1220 1230 1240 1250
1250 1260 1270 1280 1290 1300
pF1KB0 LALDQSLSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFH
..:.:.:.: :: :.:: . .:.:: .....::::.::.: ......:::. . .::
NP_001 VTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFH
1260 1270 1280 1290 1300 1310
1310 1320 1330 1340 1350 1360
pF1KB0 GCIRNLYINSELQDFQKVPMQT-GILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMG
:::... ::.:::::. .: :. :. :::. : :: :: :. . . .:::. :: :
NP_001 GCIHEVRINNELQDFKALPPQSLGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTG
1320 1330 1340 1350 1360
1370 1380 1390 1400 1410 1420
pF1KB0 PLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHG
:::::.. :::::..: :: :. .. :: ::: ::.:: :::...: : :.:.::.::
NP_001 PLCDQEARDPCLGHRCHHGKCVATGT-SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHG
1370 1380 1390 1400 1410 1420
1430 1440 1450 1460 1470 1480
pF1KB0 KCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRG
.:..: :.::: :. :..:. :..: : :. .:. ..:.:::.: :..:: .::::
NP_001 QCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRG
1430 1440 1450 1460 1470 1480
1490 1500 1510 1520
pF1KB0 GCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
:: : ::: : ::::::: :.::::::::.:::. ..::: :
NP_001 GC-GPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS
1490 1500 1510 1520 1530
>>NP_003052 (OMIM: 603742) slit homolog 1 protein precur (1534 aa)
initn: 6576 init1: 3063 opt: 7433 Z-score: 3971.6 bits: 747.6 E(85289): 1.8e-214
Smith-Waterman score: 7433; 66.1% identity (87.5% similar) in 1516 aa overlap (15-1527:21-1533)
10 20 30 40 50
pF1KB0 MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIP
:. : ... .:::: :.:.:.:::::: .:...:.:::
NP_003 MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH
::::::.::::::::: :.:::::..:::::::::.:...:::::.:.:::::::::::.
NP_003 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL
:...::::: .. : ::::::: ::::::::::::.:.:::::: :::::::.::::::
NP_003 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT
: :::::::::::: . :.::::::::::::::::.:.:::::::::.:::::: .::.:
NP_003 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 QCMGPSHLRGHNVAEVQKREFVCSGH-QSFMAPSCSVLH--CPAACTCSNNIVDCRGKGL
:: ::. ::: ::::::: :: :::. .. .:.:.. ::: :::::.:::::::::
NP_003 QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB0 TEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLN
: ::.:::::.:::::: : :: :::::::::.::::::::::::.:.::::::::::::
NP_003 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB0 SLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTI
::::::::::.::...: ::..:::::::::::::.: ::::::.::.::::::::.:..
NP_003 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB0 AKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQI
:::::. ::::::.:::::::::::.::::::.:.:::::::::::.:::::::::::::
NP_003 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB0 KSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHI
::::::::::::::::::::: .:...: .:..::.:::::...:.::. ::.::::.:
NP_003 KSKKFRCSAKEQYFIPGTEDY--QLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERI
490 500 510 520 530
540 550 560 570 580 590
pF1KB0 PQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTS
:: ::::::::::...:::::.:::: .:.:::.::::...::.::::::..:.:. ::.
NP_003 PQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTA
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB0 NRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFD
:.::... ::.::..:.:::::.:::.:. :::: :: .::::::::::::::.:::::
NP_003 NQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFD
600 610 620 630 640 650
660 670 680 690 700 710
pF1KB0 TLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFT
::.:::::::::::::::: ::::: ::::..:::::::::.: ::..::.::::. ::
NP_003 TLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFR
660 670 680 690 700 710
720 730 740 750 760 770
pF1KB0 CDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPK
:..:.....: : .:: ::.::::::::::: :..::::::..:::::::::::::::
NP_003 CEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPG
720 730 740 750 760 770
780 790 800 810 820 830
pF1KB0 ELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLS
.::..:.: :.:::::.::.:::.::.::.:: ::::::: :.:::: .:.::.::::::
NP_003 QLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLS
780 790 800 810 820 830
840 850 860 870 880 890
pF1KB0 LHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGE
:::::::.. :: : :...:::::::::::::::...:::.:::. :::::::::::: .
NP_003 LHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQD
840 850 860 870 880 890
900 910 920 930 940 950
pF1KB0 MADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKG
: :::::::.::: :::: . . :::. :::.::.:.:::..::.. :::.:: :.::
NP_003 MEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKG
900 910 920 930 940 950
960 970 980 990 1000 1010
pF1KB0 QDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNS
.::.: . .: :.::..::::: .:::. : : : :::: .: ::.::: :. : :..
NP_003 RDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGG
960 970 980 990 1000 1010
1020 1030 1040 1050 1060 1070
pF1KB0 TCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGE
.::::..:::: :: .: :. ::. .:.:. :::::::...:. :: : .:.: :::.:.
NP_003 VCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGD
1020 1030 1040 1050 1060 1070
1080 1090 1100 1110 1120 1130
pF1KB0 HCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQ
.:. . :::.:..:.:::.: : ::.:.:.: ::::: .::. : . :. :::.. .::
NP_003 NCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPK-SPCEGTECQ
1080 1090 1100 1110 1120 1130
1140 1150 1160 1170 1180 1190
pF1KB0 NGAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATD
:::.:. . :.:.::::::. : .::::.::::.....:::. . . :..:::::..:
NP_003 NGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTA
1140 1150 1160 1170 1180 1190
1200 1210 1220 1230 1240 1250
pF1KB0 EDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQS
::.:::::.::.::::::::.:.::.::: ::.:.:::::.::::::.:: :::.:.::
NP_003 EDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQM
1200 1210 1220 1230 1240 1250
1260 1270 1280 1290 1300 1310
pF1KB0 LSLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNL
..::.:::.: . :..:. ::: ..:::::::: : :..: :::.::::::::
NP_003 VNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNL
1260 1270 1280 1290 1300 1310
1320 1330 1340 1350 1360 1370
pF1KB0 YINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRT
:::.::::: :. :. :..::::::.: : :: :::.. : :.:. ::.: ::: .
NP_003 YINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA
1320 1330 1340 1350 1360 1370
1380 1390 1400 1410 1420 1430
pF1KB0 NDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL
. :: :.::::: :.:..:.::::.: .:..:.::.. : .::....: ::.:. ::
NP_003 DGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGT
1380 1390 1400 1410 1420 1430
1440 1450 1460 1470 1480 1490
pF1KB0 GQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC
.: :. :..:. :..: :::. .::..: :.::: ::::. .: .::::.: : :
NP_003 KGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGC
1440 1450 1460 1470 1480 1490
1500 1510 1520
pF1KB0 CGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
: :: ::::..:::.::.::..:::: .::::. :
NP_003 CQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA
1500 1510 1520 1530
>>NP_003053 (OMIM: 603745) slit homolog 3 protein isofor (1523 aa)
initn: 6255 init1: 3023 opt: 6287 Z-score: 3363.0 bits: 635.0 E(85289): 1.4e-180
Smith-Waterman score: 7491; 66.6% identity (88.0% similar) in 1530 aa overlap (3-1527:7-1522)
10 20 30 40 50
pF1KB0 MRGVGWQMLS-LSLGLVLA-ILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIP
::: . . :.:.:.:: .:. :::..:.::...::::::.::.:::.::
NP_003 MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH
::.:::::. :::::::: :::::..::::.: .:..:.::::::::::.:::::::.:.
NP_003 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRAL
::..::::: .: :: ::::::::::.:::::::: .:.:::::: :.::::::::::::
NP_003 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 RDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT
::::.::::::::.:. :.:::::::.::.:::::.::::::::::::::::: :: .:
NP_003 RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 QCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV--LHCPAACTCSNNIVDCRGKGLT
::.: :::: :::.:::.:.:: . .: :::.. . ::. :::::::::::::::
NP_003 LCMAPVHLRGFNVADVQKKEYVCPAPHS-EPPSCNANSISCPSPCTCSNNIVDCRGKGLM
250 260 270 280 290
300 310 320 330 340 350
pF1KB0 EIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNS
:::.:::: :.:::::::.::.:: :::. ::::.:::.:.::::..::::::::.::.:
NP_003 EIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB0 LVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIA
::::::::::. :.::.:: :::::::::::::::::..::::.:::::::::::::::.
NP_003 LVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTIS
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB0 KGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIK
:: :.::..:::.:::::::.::::::::::::. ::::::::::.::::::::::.:::
NP_003 KGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIK
420 430 440 450 460 470
480 490 500 510 520 530
pF1KB0 SKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIP
::::::: :.:::::..:..:: ::.:::::::::: :::::::: .:: :.:
NP_003 SKKFRCS--------GSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLP
480 490 500 510 520 530
540 550 560 570 580 590
pF1KB0 QYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSN
.:...::::.:: .::::::::::::.:::::.::::: ...::::.::..:.:..::.:
NP_003 EYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN
540 550 560 570 580 590
600 610 620 630 640 650
pF1KB0 RLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDT
.::.:. ..:.:: .::::::::: : ::.::.: :::::::::::::.:::..:::: :
NP_003 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT
600 610 620 630 640 650
660 670 680 690 700 710
pF1KB0 LHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTC
: ::::.:::.:::::::.:::::.::::.:::.::::::::.:::::::::::::::::
NP_003 LVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTC
660 670 680 690 700 710
720 730 740 750 760 770
pF1KB0 DDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKE
: ::...::. ::: .:::..::::::::::..::.:.:.:::::::.::..: ::.:
NP_003 D-GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE
720 730 740 750 760 770
780 790 800 810 820 830
pF1KB0 LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSL
:: .:::::::::: :: :.: .::::..: ::::::::::::: ..:.::.:::.:.:
NP_003 LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTL
780 790 800 810 820 830
840 850 860 870 880 890
pF1KB0 HGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEM
:::::: ::::.::::..:::::.:.:::.:::...:::.:::. :::::::::..: :
NP_003 HGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPM
840 850 860 870 880 890
900 910 920 930 940 950
pF1KB0 ADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQ
::.::::::...: :.::::.::.:::: :::.::::.:::..:::..:::.:::..::.
NP_003 ADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGK
900 910 920 930 940 950
960 970 980 990 1000 1010
pF1KB0 DCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNST
:: :::..::.:::.:::::::.....::: : : ::::. ::.: :::::::::::.:
NP_003 DCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNAT
960 970 980 990 1000 1010
1020 1030 1040 1050 1060 1070
pF1KB0 CVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEH
::::::::.:.:::.::::::.: .: :. .:: :::..::: :::.:.:.::: :.
NP_003 CVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKL
1020 1030 1040 1050 1060 1070
1080 1090 1100 1110 1120 1130
pF1KB0 CDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQN
:. : ::: .::..::.:.:..::::: ::.:.:: ::: ::::: .:::::...:::
NP_003 CETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQN
1080 1090 1100 1110 1120 1130
1140 1150 1160 1170 1180 1190
pF1KB0 GAQCIVRINEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDE
:::::: .:: :.: ::. : .::::..:::..:.::... :::::::.::.::.:::.
NP_003 GAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDK
1140 1150 1160 1170 1180 1190
1200 1210 1220 1230 1240 1250
pF1KB0 DSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSL
:.::::::::.: .:.:::.:.:: ::. : : ...:::::.:::.:: :::..:.:.:
NP_003 DNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTL
1200 1210 1220 1230 1240 1250
1260 1270 1280 1290 1300 1310
pF1KB0 SLSVDGGNPKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLY
.: :: :.:: . .:.:: .....::::.::.: ......:::. . .:::::...
NP_003 NLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVR
1260 1270 1280 1290 1300 1310
1320 1330 1340 1350 1360 1370
pF1KB0 INSELQDFQKVPMQT-GILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRT
::.:::::. .: :. :. :::. : :: :: :. . . .:::. :: ::::::..
NP_003 INNELQDFKALPPQSLGVSPGCKSC--TVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEA
1320 1330 1340 1350 1360
1380 1390 1400 1410 1420 1430
pF1KB0 NDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL
:::::..: :: :. .. :: ::: ::.:: :::...: : :.:.::.::.:..:
NP_003 RDPCLGHRCHHGKCVATGT-SYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQ
1370 1380 1390 1400 1410 1420
1440 1450 1460 1470 1480 1490
pF1KB0 GQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC
:.::: :. :..:. :..: : :. .:. ..:.:::.: :..:: .:::::: : ::
NP_003 GEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGC-GPQC
1430 1440 1450 1460 1470 1480
1500 1510 1520
pF1KB0 CGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCVS
: : ::::::: :.::::::::.:::. ..::: :
NP_003 CQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS
1490 1500 1510 1520
1529 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:38:03 2016 done: Mon Nov 7 16:38:05 2016
Total Scan time: 12.660 Total Display time: 0.880
Function used was FASTA [36.3.4 Apr, 2011]