Result of FASTA (omim) for
pFN21AA1354
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1354, 617 aa
1>>>pF1KA1354 617 - 617 aa - 617 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4142+/-0.000391; mu= 18.4952+/- 0.024
mean_var=77.4564+/-16.174, 0's: 0 Z-trim(110.7): 412 B-trim: 12 in 1/57
Lambda= 0.145729
statistics sampled from 18719 (19167) to 18719 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.225), width: 16
Scan time: 9.740
The best scores are: opt bits E(85289)
NP_061335 (OMIM: 611201) kelch-like protein 9 [Hom ( 617) 4192 891.7 0
NP_001161775 (OMIM: 300655) kelch-like protein 13 ( 613) 3911 832.6 0
NP_001161774 (OMIM: 300655) kelch-like protein 13 ( 639) 3911 832.6 0
XP_016885439 (OMIM: 300655) PREDICTED: kelch-like ( 639) 3911 832.6 0
NP_001161773 (OMIM: 300655) kelch-like protein 13 ( 639) 3911 832.6 0
NP_001161772 (OMIM: 300655) kelch-like protein 13 ( 649) 3911 832.6 0
NP_277030 (OMIM: 300655) kelch-like protein 13 iso ( 655) 3911 832.6 0
XP_011529713 (OMIM: 300655) PREDICTED: kelch-like ( 655) 3911 832.6 0
NP_001161771 (OMIM: 300655) kelch-like protein 13 ( 658) 3911 832.6 0
XP_011529711 (OMIM: 300655) PREDICTED: kelch-like ( 661) 3911 832.6 0
XP_011529712 (OMIM: 300655) PREDICTED: kelch-like ( 661) 3911 832.6 0
XP_005249164 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1324 288.7 4.2e-77
NP_001003760 (OMIM: 610749) kelch-like protein 31 ( 634) 1324 288.7 4.2e-77
XP_016866347 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1324 288.7 4.2e-77
NP_065856 (OMIM: 613772) kelch-like protein 14 [Ho ( 628) 1180 258.4 5.4e-68
XP_016863762 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1058 232.8 3.4e-60
XP_016863763 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1058 232.8 3.4e-60
XP_011512001 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1058 232.8 3.4e-60
NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 1051 231.3 8.6e-60
NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 1051 231.3 9e-60
XP_016863764 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1051 231.4 9.3e-60
XP_005262712 (OMIM: 608064) PREDICTED: kelch-like ( 789) 1051 231.4 9.4e-60
NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 1049 230.8 9.7e-60
XP_011512002 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1050 231.2 1.1e-59
XP_011512003 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1050 231.2 1.1e-59
XP_016863765 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1050 231.2 1.1e-59
NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 968 213.9 1.5e-54
NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 933 206.5 2.6e-52
NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 933 206.5 2.6e-52
XP_016876167 (OMIM: 605332) PREDICTED: kelch-like ( 575) 926 205.0 5.9e-52
NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 926 205.1 7.3e-52
NP_009177 (OMIM: 605774) kelch-like protein 2 isof ( 593) 909 201.4 7.3e-51
NP_001154993 (OMIM: 605774) kelch-like protein 2 i ( 597) 909 201.4 7.3e-51
XP_016863163 (OMIM: 605774) PREDICTED: kelch-like ( 555) 905 200.6 1.2e-50
XP_006724581 (OMIM: 300980,300982) PREDICTED: kelc ( 604) 898 199.1 3.7e-50
NP_085127 (OMIM: 300980,300982) kelch-like protein ( 604) 898 199.1 3.7e-50
NP_059111 (OMIM: 605775,614495) kelch-like protein ( 587) 894 198.3 6.4e-50
XP_011529874 (OMIM: 605774) PREDICTED: kelch-like ( 633) 892 197.9 9.1e-50
NP_067646 (OMIM: 614522) kelch-like protein 12 iso ( 568) 891 197.6 9.7e-50
NP_001289980 (OMIM: 614522) kelch-like protein 12 ( 606) 891 197.6 1e-49
XP_011508137 (OMIM: 614522) PREDICTED: kelch-like ( 623) 891 197.7 1e-49
NP_001244123 (OMIM: 605775,614495) kelch-like prot ( 555) 887 196.8 1.7e-49
NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 878 194.9 7.5e-49
XP_016876168 (OMIM: 605332) PREDICTED: kelch-like ( 525) 869 193.0 2.2e-48
NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 868 192.8 2.9e-48
NP_689680 (OMIM: 608778,615081) kelch-like protein ( 608) 868 192.8 2.9e-48
NP_569713 (OMIM: 614214) kelch-like protein 6 [Hom ( 621) 796 177.7 1.1e-43
NP_001290038 (OMIM: 614522) kelch-like protein 12 ( 467) 781 174.4 7.6e-43
XP_011508139 (OMIM: 614522) PREDICTED: kelch-like ( 522) 781 174.5 8.3e-43
NP_001244124 (OMIM: 605775,614495) kelch-like prot ( 505) 771 172.4 3.5e-42
>>NP_061335 (OMIM: 611201) kelch-like protein 9 [Homo sa (617 aa)
initn: 4192 init1: 4192 opt: 4192 Z-score: 4764.2 bits: 891.7 E(85289): 0
Smith-Waterman score: 4192; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617)
10 20 30 40 50 60
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN
550 560 570 580 590 600
610
pF1KA1 PGSPSRESPLSAPSDHS
:::::::::::::::::
NP_061 PGSPSRESPLSAPSDHS
610
>>NP_001161775 (OMIM: 300655) kelch-like protein 13 isof (613 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4445.0 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:1-613)
10 20 30 40 50 60
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD
::.:::..:::.:.::: ::: ::.::::::::::::::::::.:::::::::.::: :
NP_001 MKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD
. :::::.::::::::::::::::::::::::::::::.::::.::::::::::::::::
NP_001 DAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN
:::::::::::::::::::::::::::::.:::::::::::::::: :::::::.:.:::
NP_001 NLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI
::::::::::::::::::::::::::::::::::::::.:::::::.::::.::::::::
NP_001 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_001 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT
::::::::::::::::::::::.:.::.::::::::::::::::::::::::::::::::
NP_001 VTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN
:::::::::::::::::::::::::::::::::::::::.:::::::.::::: ::::::
NP_001 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT
:: :::.:::::::::::::::::::.:::::::::::::.::::::::::::.::::::
NP_001 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV
::::::::::::..:::::::::::::::::::::::::: :::::::::::::::::::
NP_001 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN
:::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::.
NP_001 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET
550 560 570 580 590 600
610
pF1KA1 PGSPSRESPLSAPSDHS
:::::::::::
NP_001 TPSPSRESPLSAP
610
>>NP_001161774 (OMIM: 300655) kelch-like protein 13 isof (639 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.7 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:27-639)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSS
::.:::..:::.:.::: ::: ::.::::::::
NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSS
10 20 30 40 50 60
40 50 60 70 80 90
pF1KA1 VVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIK
::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::::::
NP_001 VVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 LHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNC
::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.::::
NP_001 LHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 VEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE
:::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::::::
NP_001 VEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 LFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEAS
::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::::::
NP_001 LFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEAS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 NYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMD
::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::::::
NP_001 NYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 SALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGI
:::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::::::
NP_001 SALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 THDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS
::::::.::::::::::::.::::::::::::::::::..::::::::::::::::::::
NP_001 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW
:::::: ::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_001 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW
550 560 570 580 590 600
580 590 600 610
pF1KA1 HKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::. :::::::::::
NP_001 HKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630
>>XP_016885439 (OMIM: 300655) PREDICTED: kelch-like prot (639 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.7 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:27-639)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSS
::.:::..:::.:.::: ::: ::.::::::::
XP_016 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSS
10 20 30 40 50 60
40 50 60 70 80 90
pF1KA1 VVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIK
::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::::::
XP_016 VVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 LHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNC
::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.::::
XP_016 LHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 VEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE
:::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::::::
XP_016 VEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 LFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEAS
::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::::::
XP_016 LFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEAS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 NYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMD
::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::::::
XP_016 NYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 SALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGI
:::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::::::
XP_016 SALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 THDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS
::::::.::::::::::::.::::::::::::::::::..::::::::::::::::::::
XP_016 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW
:::::: ::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_016 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW
550 560 570 580 590 600
580 590 600 610
pF1KA1 HKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::. :::::::::::
XP_016 HKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630
>>NP_001161773 (OMIM: 300655) kelch-like protein 13 isof (639 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.7 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:27-639)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSS
::.:::..:::.:.::: ::: ::.::::::::
NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSS
10 20 30 40 50 60
40 50 60 70 80 90
pF1KA1 VVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIK
::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::::::
NP_001 VVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 LHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNC
::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.::::
NP_001 LHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 VEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE
:::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::::::
NP_001 VEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 LFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEAS
::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::::::
NP_001 LFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEAS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 NYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMD
::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::::::
NP_001 NYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 SALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGI
:::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::::::
NP_001 SALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 THDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS
::::::.::::::::::::.::::::::::::::::::..::::::::::::::::::::
NP_001 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW
:::::: ::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_001 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW
550 560 570 580 590 600
580 590 600 610
pF1KA1 HKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::. :::::::::::
NP_001 HKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630
>>NP_001161772 (OMIM: 300655) kelch-like protein 13 isof (649 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:37-649)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN
::.:::..:::.:.::: ::: ::.::::
NP_001 HLYCCSSKEDCSEDDKCILSRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN
10 20 30 40 50 60
40 50 60 70 80 90
pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL
::::::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::
NP_001 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS
::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.
NP_001 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
:::::::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::
NP_001 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
190 200 210 220 230 240
220 230 240 250 260 270
pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL
::::::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::
NP_001 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL
250 260 270 280 290 300
280 290 300 310 320 330
pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL
::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::
NP_001 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
370 380 390 400 410 420
400 410 420 430 440 450
pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI
:::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::
NP_001 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI
430 440 450 460 470 480
460 470 480 490 500 510
pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD
::::::::::.::::::::::::.::::::::::::::::::..::::::::::::::::
NP_001 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD
490 500 510 520 530 540
520 530 540 550 560 570
pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD
550 560 570 580 590 600
580 590 600 610
pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::::::. :::::::::::
NP_001 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630 640
>>NP_277030 (OMIM: 300655) kelch-like protein 13 isoform (655 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:43-655)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN
::.:::..:::.:.::: ::: ::.::::
NP_277 WKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN
20 30 40 50 60 70
40 50 60 70 80 90
pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL
::::::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::
NP_277 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS
::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.
NP_277 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
:::::::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::
NP_277 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL
::::::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::
NP_277 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL
::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::
NP_277 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_277 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
380 390 400 410 420 430
400 410 420 430 440 450
pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI
:::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::
NP_277 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD
::::::::::.::::::::::::.::::::::::::::::::..::::::::::::::::
NP_277 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::.
NP_277 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD
560 570 580 590 600 610
580 590 600 610
pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::::::. :::::::::::
NP_277 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
620 630 640 650
>>XP_011529713 (OMIM: 300655) PREDICTED: kelch-like prot (655 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:43-655)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN
::.:::..:::.:.::: ::: ::.::::
XP_011 WKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN
20 30 40 50 60 70
40 50 60 70 80 90
pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL
::::::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::
XP_011 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS
::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.
XP_011 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
:::::::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::
XP_011 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL
::::::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::
XP_011 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL
::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::
XP_011 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
380 390 400 410 420 430
400 410 420 430 440 450
pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI
:::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::
XP_011 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD
::::::::::.::::::::::::.::::::::::::::::::..::::::::::::::::
XP_011 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD
560 570 580 590 600 610
580 590 600 610
pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::::::. :::::::::::
XP_011 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
620 630 640 650
>>NP_001161771 (OMIM: 300655) kelch-like protein 13 isof (658 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:46-658)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN
::.:::..:::.:.::: ::: ::.::::
NP_001 RRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN
20 30 40 50 60 70
40 50 60 70 80 90
pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL
::::::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::
NP_001 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS
::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.
NP_001 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
:::::::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::
NP_001 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL
::::::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::
NP_001 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL
::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::
NP_001 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
380 390 400 410 420 430
400 410 420 430 440 450
pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI
:::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::
NP_001 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD
::::::::::.::::::::::::.::::::::::::::::::..::::::::::::::::
NP_001 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD
560 570 580 590 600 610
580 590 600 610
pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::::::. :::::::::::
NP_001 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
620 630 640 650
>>XP_011529711 (OMIM: 300655) PREDICTED: kelch-like prot (661 aa)
initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.5 bits: 832.6 E(85289): 0
Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:49-661)
10 20 30
pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN
::.:::..:::.:.::: ::: ::.::::
XP_011 RRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN
20 30 40 50 60 70
40 50 60 70 80 90
pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL
::::::::::::::.:::::::::.::: :. :::::.::::::::::::::::::::::
XP_011 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS
::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.
XP_011 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
:::::::::::::::: :::::::.:.:::::::::::::::::::::::::::::::::
XP_011 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL
::::::::.:::::::.::::.::::::::::::::::.:::::::::::::::::::::
XP_011 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL
::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.::
XP_011 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT
380 390 400 410 420 430
400 410 420 430 440 450
pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI
:::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.:::
XP_011 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI
440 450 460 470 480 490
460 470 480 490 500 510
pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD
::::::::::.::::::::::::.::::::::::::::::::..::::::::::::::::
XP_011 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD
500 510 520 530 540 550
520 530 540 550 560 570
pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD
560 570 580 590 600 610
580 590 600 610
pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS
:::::::::::::::::::::::::::::. :::::::::::
XP_011 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
620 630 640 650 660
617 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:50:31 2016 done: Sun Nov 6 06:50:33 2016
Total Scan time: 9.740 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]