Result of FASTA (omim) for
pF1KSDB0064
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDB0064, 832 aa
1>>>pF1KSDB0064 832 - 832 aa - 832 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.0261+/-0.000475; mu= -28.0758+/- 0.030
mean_var=741.3529+/-151.195, 0's: 0 Z-trim(124.7): 147 B-trim: 0 in 0/61
Lambda= 0.047104
statistics sampled from 46711 (46894) to 46711 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.55), width: 16
Scan time: 17.150
The best scores are: opt bits E(85289)
XP_005271321 (OMIM: 611540) PREDICTED: SH3-contain ( 832) 5641 399.0 4.5e-110
XP_006711024 (OMIM: 611540) PREDICTED: SH3-contain ( 834) 5484 388.4 7.3e-107
XP_016858000 (OMIM: 611540) PREDICTED: SH3-contain ( 828) 5432 384.8 8.4e-106
XP_016858001 (OMIM: 611540) PREDICTED: SH3-contain ( 828) 5432 384.8 8.4e-106
NP_115667 (OMIM: 611540) SH3-containing GRB2-like ( 828) 5432 384.8 8.4e-106
XP_016858002 (OMIM: 611540) PREDICTED: SH3-contain ( 827) 5429 384.6 9.7e-106
XP_006711032 (OMIM: 611540) PREDICTED: SH3-contain ( 804) 5246 372.2 5.3e-102
XP_016858008 (OMIM: 611540) PREDICTED: SH3-contain ( 804) 5246 372.2 5.3e-102
XP_016858007 (OMIM: 611540) PREDICTED: SH3-contain ( 804) 5246 372.2 5.3e-102
XP_016858009 (OMIM: 611540) PREDICTED: SH3-contain ( 800) 5200 369.0 4.6e-101
XP_006711029 (OMIM: 611540) PREDICTED: SH3-contain ( 812) 3602 260.5 2.3e-68
XP_016857995 (OMIM: 611540) PREDICTED: SH3-contain ( 850) 3405 247.1 2.5e-64
XP_016857994 (OMIM: 611540) PREDICTED: SH3-contain ( 850) 3405 247.1 2.5e-64
XP_016857997 (OMIM: 611540) PREDICTED: SH3-contain ( 849) 3402 246.9 2.9e-64
XP_016857996 (OMIM: 611540) PREDICTED: SH3-contain ( 849) 3402 246.9 2.9e-64
XP_006711030 (OMIM: 611540) PREDICTED: SH3-contain ( 808) 3393 246.3 4.3e-64
XP_016858006 (OMIM: 611540) PREDICTED: SH3-contain ( 808) 3393 246.3 4.3e-64
XP_016858003 (OMIM: 611540) PREDICTED: SH3-contain ( 826) 3219 234.4 1.6e-60
XP_016858012 (OMIM: 611540) PREDICTED: SH3-contain ( 784) 3207 233.6 2.7e-60
XP_016858010 (OMIM: 611540) PREDICTED: SH3-contain ( 784) 3207 233.6 2.7e-60
XP_016858011 (OMIM: 611540) PREDICTED: SH3-contain ( 784) 3207 233.6 2.7e-60
XP_016858004 (OMIM: 611540) PREDICTED: SH3-contain ( 818) 3136 228.8 7.8e-59
XP_016858005 (OMIM: 611540) PREDICTED: SH3-contain ( 818) 3136 228.8 7.8e-59
XP_016857998 (OMIM: 611540) PREDICTED: SH3-contain ( 842) 3136 228.8 8e-59
XP_016857999 (OMIM: 611540) PREDICTED: SH3-contain ( 842) 3136 228.8 8e-59
XP_005271325 (OMIM: 611540) PREDICTED: SH3-contain ( 637) 2701 199.1 5.1e-50
XP_011540593 (OMIM: 611540) PREDICTED: SH3-contain ( 660) 2701 199.2 5.2e-50
XP_006711035 (OMIM: 611540) PREDICTED: SH3-contain ( 665) 2701 199.2 5.3e-50
XP_005271327 (OMIM: 611540) PREDICTED: SH3-contain ( 629) 2694 198.7 7e-50
XP_016858024 (OMIM: 611540) PREDICTED: SH3-contain ( 629) 2694 198.7 7e-50
XP_016858023 (OMIM: 611540) PREDICTED: SH3-contain ( 629) 2694 198.7 7e-50
XP_016858016 (OMIM: 611540) PREDICTED: SH3-contain ( 653) 2694 198.7 7.2e-50
XP_016858015 (OMIM: 611540) PREDICTED: SH3-contain ( 653) 2694 198.7 7.2e-50
XP_016858021 (OMIM: 611540) PREDICTED: SH3-contain ( 635) 2546 188.6 7.5e-47
XP_006711034 (OMIM: 611540) PREDICTED: SH3-contain ( 667) 2544 188.5 8.6e-47
NP_001295132 (OMIM: 611540) SH3-containing GRB2-li ( 631) 2537 188.0 1.1e-46
XP_006711037 (OMIM: 611540) PREDICTED: SH3-contain ( 631) 2537 188.0 1.1e-46
XP_016858014 (OMIM: 611540) PREDICTED: SH3-contain ( 655) 2537 188.0 1.2e-46
XP_006711036 (OMIM: 611540) PREDICTED: SH3-contain ( 659) 2537 188.0 1.2e-46
XP_016858017 (OMIM: 611540) PREDICTED: SH3-contain ( 651) 2119 159.6 4.2e-38
XP_016858013 (OMIM: 611540) PREDICTED: SH3-contain ( 675) 2119 159.6 4.3e-38
XP_011540595 (OMIM: 611540) PREDICTED: SH3-contain ( 609) 2001 151.6 1e-35
XP_016858026 (OMIM: 611540) PREDICTED: SH3-contain ( 609) 2001 151.6 1e-35
XP_016858025 (OMIM: 611540) PREDICTED: SH3-contain ( 617) 2001 151.6 1e-35
XP_016858022 (OMIM: 611540) PREDICTED: SH3-contain ( 633) 2001 151.6 1.1e-35
XP_016858019 (OMIM: 611540) PREDICTED: SH3-contain ( 637) 2001 151.6 1.1e-35
XP_016858020 (OMIM: 611540) PREDICTED: SH3-contain ( 637) 2001 151.6 1.1e-35
XP_011540594 (OMIM: 611540) PREDICTED: SH3-contain ( 640) 2001 151.6 1.1e-35
XP_016858018 (OMIM: 611540) PREDICTED: SH3-contain ( 645) 2001 151.6 1.1e-35
XP_016864505 (OMIM: 613438) PREDICTED: F-BAR domai ( 775) 1347 107.2 3e-22
>>XP_005271321 (OMIM: 611540) PREDICTED: SH3-containing (832 aa)
initn: 5641 init1: 5641 opt: 5641 Z-score: 2097.2 bits: 399.0 E(85289): 4.5e-110
Smith-Waterman score: 5641; 99.9% identity (100.0% similar) in 832 aa overlap (1-832:1-832)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_005 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
730 740 750 760 770 780
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
790 800 810 820 830
>>XP_006711024 (OMIM: 611540) PREDICTED: SH3-containing (834 aa)
initn: 3908 init1: 3605 opt: 5484 Z-score: 2039.5 bits: 388.4 E(85289): 7.3e-107
Smith-Waterman score: 5484; 97.6% identity (98.4% similar) in 836 aa overlap (1-832:1-834)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
430 440 450 460 470 480
490 500 510 520 530
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDR-
::::::::::::::::::::::::::::::::::::::::::::::: .:. :..:.
XP_006 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVVSEDD--VFYDKL
490 500 510 520 530
540 550 560 570 580 590
pF1KSD GKFYLTFE---GSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVL
.: : :::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSFERRCETPAGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVL
540 550 560 570 580 590
600 610 620 630 640 650
pF1KSD SFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNL
600 610 620 630 640 650
660 670 680 690 700 710
pF1KSD MTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTD
660 670 680 690 700 710
720 730 740 750 760 770
pF1KSD AMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLL
720 730 740 750 760 770
780 790 800 810 820 830
pF1KSD ARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
780 790 800 810 820 830
>>XP_016858000 (OMIM: 611540) PREDICTED: SH3-containing (828 aa)
initn: 5456 init1: 5246 opt: 5432 Z-score: 2020.4 bits: 384.8 E(85289): 8.4e-106
Smith-Waterman score: 5432; 97.0% identity (97.8% similar) in 832 aa overlap (1-832:1-828)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
:::::::::::::::::::::::::::::::::: . . . . : : . .:
XP_016 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQPSPH-EPPYNSKAEC--AREGGKKVS
10 20 30 40 50
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
480 490 500 510 520 530
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
540 550 560 570 580 590
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
600 610 620 630 640 650
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
660 670 680 690 700 710
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
720 730 740 750 760 770
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
780 790 800 810 820
>>XP_016858001 (OMIM: 611540) PREDICTED: SH3-containing (828 aa)
initn: 5456 init1: 5246 opt: 5432 Z-score: 2020.4 bits: 384.8 E(85289): 8.4e-106
Smith-Waterman score: 5432; 97.0% identity (97.8% similar) in 832 aa overlap (1-832:1-828)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
:::::::::::::::::::::::::::::::::: . . . . : : . .:
XP_016 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQPSPH-EPPYNSKAEC--AREGGKKVS
10 20 30 40 50
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
480 490 500 510 520 530
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
540 550 560 570 580 590
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
600 610 620 630 640 650
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
660 670 680 690 700 710
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
720 730 740 750 760 770
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
780 790 800 810 820
>>NP_115667 (OMIM: 611540) SH3-containing GRB2-like prot (828 aa)
initn: 5456 init1: 5246 opt: 5432 Z-score: 2020.4 bits: 384.8 E(85289): 8.4e-106
Smith-Waterman score: 5432; 97.0% identity (97.8% similar) in 832 aa overlap (1-832:1-828)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
:::::::::::::::::::::::::::::::::: . . . . : : . .:
NP_115 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQPSPH-EPPYNSKAEC--AREGGKKVS
10 20 30 40 50
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
NP_115 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
480 490 500 510 520 530
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
540 550 560 570 580 590
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
600 610 620 630 640 650
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
660 670 680 690 700 710
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
720 730 740 750 760 770
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
780 790 800 810 820
>>XP_016858002 (OMIM: 611540) PREDICTED: SH3-containing (827 aa)
initn: 5449 init1: 5246 opt: 5429 Z-score: 2019.4 bits: 384.6 E(85289): 9.7e-106
Smith-Waterman score: 5429; 96.9% identity (98.0% similar) in 832 aa overlap (1-832:1-827)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
::::::::::::::::::::::::::::::::: . .. .. . : : . .:
XP_016 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIPSPHEPPYNS--KAEC--AREGGKKVS
10 20 30 40 50
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
480 490 500 510 520 530
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
540 550 560 570 580 590
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
600 610 620 630 640 650
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
660 670 680 690 700 710
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
720 730 740 750 760 770
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
780 790 800 810 820
>>XP_006711032 (OMIM: 611540) PREDICTED: SH3-containing (804 aa)
initn: 5246 init1: 5246 opt: 5246 Z-score: 1952.3 bits: 372.2 E(85289): 5.3e-102
Smith-Waterman score: 5397; 96.5% identity (96.6% similar) in 832 aa overlap (1-832:1-804)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
:::::::::::::::::::::::::::::::::
XP_006 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGI---------------------------
10 20 30
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
160 170 180 190 200 210
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
400 410 420 430 440 450
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
460 470 480 490 500 510
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
580 590 600 610 620 630
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
700 710 720 730 740 750
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
760 770 780 790 800
>>XP_016858008 (OMIM: 611540) PREDICTED: SH3-containing (804 aa)
initn: 5246 init1: 5246 opt: 5246 Z-score: 1952.3 bits: 372.2 E(85289): 5.3e-102
Smith-Waterman score: 5397; 96.5% identity (96.6% similar) in 832 aa overlap (1-832:1-804)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
:::::::::::::::::::::::::::::::::
XP_016 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGI---------------------------
10 20 30
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
160 170 180 190 200 210
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
400 410 420 430 440 450
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
460 470 480 490 500 510
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
580 590 600 610 620 630
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
700 710 720 730 740 750
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
760 770 780 790 800
>>XP_016858007 (OMIM: 611540) PREDICTED: SH3-containing (804 aa)
initn: 5246 init1: 5246 opt: 5246 Z-score: 1952.3 bits: 372.2 E(85289): 5.3e-102
Smith-Waterman score: 5397; 96.5% identity (96.6% similar) in 832 aa overlap (1-832:1-804)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
:::::::::::::::::::::::::::::::::
XP_016 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGI---------------------------
10 20 30
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
100 110 120 130 140 150
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
160 170 180 190 200 210
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
400 410 420 430 440 450
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
460 470 480 490 500 510
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
580 590 600 610 620 630
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
700 710 720 730 740 750
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
760 770 780 790 800
>>XP_016858009 (OMIM: 611540) PREDICTED: SH3-containing (800 aa)
initn: 4797 init1: 4592 opt: 5200 Z-score: 1935.4 bits: 369.0 E(85289): 4.6e-101
Smith-Waterman score: 5351; 96.0% identity (96.2% similar) in 832 aa overlap (1-832:1-800)
10 20 30 40 50 60
pF1KSD MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGIQGKKKTQKTQLLLTSCFWLRALSLTLS
:::::::::::::::::::::::::::::::::
XP_016 MMEGLKKRTRKAFGIRKKEKDTDSTGSPDRDGI---------------------------
10 20 30
70 80 90 100 110 120
pF1KSD QKKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -KKSNGAPNGFYAEIDWERYNSPELDEEGYSIRPEEPGSTKGKHFYSSSESEEEEESHKK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD FNIKIKPLQSKDILRNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARP
::::::::::::::.::::::::::::::::::::::: ::::::::::::::::::
XP_016 FNIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVR----RSPGAIKRNLSSEEVARP
100 110 120 130 140
190 200 210 220 230 240
pF1KSD RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMES
150 160 170 180 190 200
250 260 270 280 290 300
pF1KSD PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFG
210 220 230 240 250 260
310 320 330 340 350 360
pF1KSD PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPG
270 280 290 300 310 320
370 380 390 400 410 420
pF1KSD PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGPPGPPGPPRNVLSPLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPP
330 340 350 360 370 380
430 440 450 460 470 480
pF1KSD PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTYRTVVSSPGPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRPPSRPKLPPGKP
390 400 410 420 430 440
490 500 510 520 530 540
pF1KSD GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGDVSRPFSPPIHSSSPPPIAPLARAESTSSISSTNSLSAATTPTVENEQPSLVWFDRG
450 460 470 480 490 500
550 560 570 580 590 600
pF1KSD KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCIVKITGEMVLSFPA
510 520 530 540 550 560
610 620 630 640 650 660
pF1KSD GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLMTHL
570 580 590 600 610 620
670 680 690 700 710 720
pF1KSD KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYNTDAMTT
630 640 650 660 670 680
730 740 750 760 770 780
pF1KSD AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQ
690 700 710 720 730 740
790 800 810 820 830
pF1KSD LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGKYLADN
750 760 770 780 790 800
832 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 08:28:23 2016 done: Thu Nov 3 08:28:26 2016
Total Scan time: 17.150 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]