Result of FASTA (omim) for
pF1KSDA1479
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1479, 1011 aa
1>>>pF1KSDA1479 1011 - 1011 aa - 1011 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7114+/-0.000452; mu= 0.1109+/- 0.028
mean_var=216.7380+/-45.851, 0's: 0 Z-trim(117.2): 157 B-trim: 1776 in 3/53
Lambda= 0.087118
statistics sampled from 28906 (29080) to 28906 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.341), width: 16
Scan time: 11.560
The best scores are: opt bits E(85289)
NP_065909 (OMIM: 609295) semaphorin-6D isoform 1 p (1011) 6882 878.8 0
XP_011520382 (OMIM: 609295) PREDICTED: semaphorin- (1011) 6882 878.8 0
NP_001185928 (OMIM: 609295) semaphorin-6D isoform (1011) 6882 878.8 0
XP_016878109 (OMIM: 609295) PREDICTED: semaphorin- (1017) 6617 845.5 0
XP_011520381 (OMIM: 609295) PREDICTED: semaphorin- (1017) 6617 845.5 0
NP_705870 (OMIM: 609295) semaphorin-6D isoform 3 p (1017) 6617 845.5 0
XP_016878107 (OMIM: 609295) PREDICTED: semaphorin- (1067) 3984 514.6 1.1e-144
XP_011520378 (OMIM: 609295) PREDICTED: semaphorin- (1067) 3984 514.6 1.1e-144
XP_016878108 (OMIM: 609295) PREDICTED: semaphorin- (1030) 3979 514.0 1.7e-144
XP_011520380 (OMIM: 609295) PREDICTED: semaphorin- (1030) 3979 514.0 1.7e-144
XP_016878106 (OMIM: 609295) PREDICTED: semaphorin- (1086) 3979 514.0 1.7e-144
XP_011520377 (OMIM: 609295) PREDICTED: semaphorin- (1086) 3979 514.0 1.7e-144
XP_005254742 (OMIM: 609295) PREDICTED: semaphorin- (1086) 3979 514.0 1.7e-144
XP_005254743 (OMIM: 609295) PREDICTED: semaphorin- (1086) 3979 514.0 1.7e-144
NP_705872 (OMIM: 609295) semaphorin-6D isoform 5 p ( 597) 3747 484.7 6.3e-136
XP_005254746 (OMIM: 609295) PREDICTED: semaphorin- (1054) 3747 484.8 1e-135
XP_011520379 (OMIM: 609295) PREDICTED: semaphorin- (1054) 3747 484.8 1e-135
NP_705869 (OMIM: 609295) semaphorin-6D isoform 2 p ( 998) 3746 484.7 1.1e-135
XP_011520383 (OMIM: 609295) PREDICTED: semaphorin- ( 998) 3746 484.7 1.1e-135
XP_016878110 (OMIM: 609295) PREDICTED: semaphorin- ( 998) 3746 484.7 1.1e-135
XP_005254744 (OMIM: 609295) PREDICTED: semaphorin- (1073) 3742 484.2 1.6e-135
NP_705871 (OMIM: 609295) semaphorin-6D isoform 4 p (1073) 3742 484.2 1.6e-135
NP_079242 (OMIM: 609295) semaphorin-6D isoform 6 p ( 476) 3220 418.4 4.5e-116
XP_016878111 (OMIM: 609295) PREDICTED: semaphorin- ( 620) 2904 378.8 5.1e-104
XP_005272099 (OMIM: 605885) PREDICTED: semaphorin- ( 975) 2724 356.2 4.8e-97
NP_065847 (OMIM: 605885) semaphorin-6A isoform 2 p (1030) 2434 319.8 4.7e-86
NP_001287709 (OMIM: 605885) semaphorin-6A isoform (1047) 2434 319.8 4.8e-86
XP_016865164 (OMIM: 605885) PREDICTED: semaphorin- (1052) 2434 319.8 4.8e-86
XP_006714726 (OMIM: 605885) PREDICTED: semaphorin- (1052) 2434 319.8 4.8e-86
XP_016855568 (OMIM: 609294) PREDICTED: semaphorin- ( 930) 2147 283.7 3.1e-75
NP_112175 (OMIM: 609294) semaphorin-6C isoform 2 p ( 930) 2147 283.7 3.1e-75
XP_016855567 (OMIM: 609294) PREDICTED: semaphorin- ( 930) 2147 283.7 3.1e-75
XP_011525942 (OMIM: 608873) PREDICTED: semaphorin- ( 894) 2079 275.2 1.1e-72
XP_011525941 (OMIM: 608873) PREDICTED: semaphorin- ( 894) 2079 275.2 1.1e-72
NP_115484 (OMIM: 608873) semaphorin-6B precursor [ ( 888) 2014 267.0 3.3e-70
NP_001171532 (OMIM: 609294) semaphorin-6C isoform ( 962) 2001 265.4 1.1e-69
XP_016855564 (OMIM: 609294) PREDICTED: semaphorin- ( 962) 2001 265.4 1.1e-69
XP_005244892 (OMIM: 609294) PREDICTED: semaphorin- ( 962) 2001 265.4 1.1e-69
XP_016855566 (OMIM: 609294) PREDICTED: semaphorin- ( 962) 2001 265.4 1.1e-69
XP_016855565 (OMIM: 609294) PREDICTED: semaphorin- ( 962) 2001 265.4 1.1e-69
XP_011525943 (OMIM: 608873) PREDICTED: semaphorin- ( 578) 1902 252.8 3.9e-66
XP_016865165 (OMIM: 605885) PREDICTED: semaphorin- ( 904) 1899 252.5 7.4e-66
NP_001171533 (OMIM: 609294) semaphorin-6C isoform ( 922) 1308 178.3 1.7e-43
XP_016855569 (OMIM: 609294) PREDICTED: semaphorin- ( 922) 1308 178.3 1.7e-43
XP_016855570 (OMIM: 609294) PREDICTED: semaphorin- ( 922) 1308 178.3 1.7e-43
XP_016855571 (OMIM: 609294) PREDICTED: semaphorin- ( 697) 1106 152.8 6e-36
XP_005250168 (OMIM: 603961,614897) PREDICTED: sema ( 771) 923 129.8 5.5e-29
XP_006715902 (OMIM: 603961,614897) PREDICTED: sema ( 771) 923 129.8 5.5e-29
XP_016867162 (OMIM: 603961,614897) PREDICTED: sema ( 771) 923 129.8 5.5e-29
XP_005250167 (OMIM: 603961,614897) PREDICTED: sema ( 771) 923 129.8 5.5e-29
>>NP_065909 (OMIM: 609295) semaphorin-6D isoform 1 precu (1011 aa)
initn: 6882 init1: 6882 opt: 6882 Z-score: 4687.3 bits: 878.8 E(85289): 0
Smith-Waterman score: 6882; 100.0% identity (100.0% similar) in 1011 aa overlap (1-1011:1-1011)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHGVRWEVQSGESNQMVHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHGVRWEVQSGESNQMVHMN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD KTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD NSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD AHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD GYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 GYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQ
910 920 930 940 950 960
970 980 990 1000 1010
pF1KSD PSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
970 980 990 1000 1010
>>XP_011520382 (OMIM: 609295) PREDICTED: semaphorin-6D i (1011 aa)
initn: 6882 init1: 6882 opt: 6882 Z-score: 4687.3 bits: 878.8 E(85289): 0
Smith-Waterman score: 6882; 100.0% identity (100.0% similar) in 1011 aa overlap (1-1011:1-1011)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHGVRWEVQSGESNQMVHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHGVRWEVQSGESNQMVHMN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD KTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD NSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD AHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD GYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQ
910 920 930 940 950 960
970 980 990 1000 1010
pF1KSD PSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
970 980 990 1000 1010
>>NP_001185928 (OMIM: 609295) semaphorin-6D isoform 1 pr (1011 aa)
initn: 6882 init1: 6882 opt: 6882 Z-score: 4687.3 bits: 878.8 E(85289): 0
Smith-Waterman score: 6882; 100.0% identity (100.0% similar) in 1011 aa overlap (1-1011:1-1011)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHGVRWEVQSGESNQMVHMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHGVRWEVQSGESNQMVHMN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD KTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD NSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQM
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD AHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQR
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD GYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQ
910 920 930 940 950 960
970 980 990 1000 1010
pF1KSD PSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
970 980 990 1000 1010
>>XP_016878109 (OMIM: 609295) PREDICTED: semaphorin-6D i (1017 aa)
initn: 6637 init1: 3742 opt: 6617 Z-score: 4507.3 bits: 845.5 E(85289): 0
Smith-Waterman score: 6708; 96.9% identity (96.9% similar) in 1030 aa overlap (1-1011:1-1017)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCH------------------
::::::::: ::::::::::::::::::::
XP_016 CGRVTPGML-------------AEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPT
550 560 570 580
590 600 610 620 630 640
pF1KSD -GVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
590 600 610 620 630 640
650 660 670 680 690 700
pF1KSD AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
650 660 670 680 690 700
710 720 730 740 750 760
pF1KSD QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
710 720 730 740 750 760
770 780 790 800 810 820
pF1KSD IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
770 780 790 800 810 820
830 840 850 860 870 880
pF1KSD KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
830 840 850 860 870 880
890 900 910 920 930 940
pF1KSD RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
890 900 910 920 930 940
950 960 970 980 990 1000
pF1KSD PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
950 960 970 980 990 1000
1010
pF1KSD SVRPLNKYTY
::::::::::
XP_016 SVRPLNKYTY
1010
>>XP_011520381 (OMIM: 609295) PREDICTED: semaphorin-6D i (1017 aa)
initn: 6637 init1: 3742 opt: 6617 Z-score: 4507.3 bits: 845.5 E(85289): 0
Smith-Waterman score: 6708; 96.9% identity (96.9% similar) in 1030 aa overlap (1-1011:1-1017)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCH------------------
::::::::: ::::::::::::::::::::
XP_011 CGRVTPGML-------------AEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPT
550 560 570 580
590 600 610 620 630 640
pF1KSD -GVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
590 600 610 620 630 640
650 660 670 680 690 700
pF1KSD AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
650 660 670 680 690 700
710 720 730 740 750 760
pF1KSD QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
710 720 730 740 750 760
770 780 790 800 810 820
pF1KSD IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
770 780 790 800 810 820
830 840 850 860 870 880
pF1KSD KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
830 840 850 860 870 880
890 900 910 920 930 940
pF1KSD RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
890 900 910 920 930 940
950 960 970 980 990 1000
pF1KSD PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
950 960 970 980 990 1000
1010
pF1KSD SVRPLNKYTY
::::::::::
XP_011 SVRPLNKYTY
1010
>>NP_705870 (OMIM: 609295) semaphorin-6D isoform 3 precu (1017 aa)
initn: 6637 init1: 3742 opt: 6617 Z-score: 4507.3 bits: 845.5 E(85289): 0
Smith-Waterman score: 6708; 96.9% identity (96.9% similar) in 1030 aa overlap (1-1011:1-1017)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCH------------------
::::::::: ::::::::::::::::::::
NP_705 CGRVTPGML-------------AEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPT
550 560 570 580
590 600 610 620 630 640
pF1KSD -GVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 SGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
590 600 610 620 630 640
650 660 670 680 690 700
pF1KSD AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
650 660 670 680 690 700
710 720 730 740 750 760
pF1KSD QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
710 720 730 740 750 760
770 780 790 800 810 820
pF1KSD IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
770 780 790 800 810 820
830 840 850 860 870 880
pF1KSD KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
830 840 850 860 870 880
890 900 910 920 930 940
pF1KSD RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
890 900 910 920 930 940
950 960 970 980 990 1000
pF1KSD PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_705 PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
950 960 970 980 990 1000
1010
pF1KSD SVRPLNKYTY
::::::::::
NP_705 SVRPLNKYTY
1010
>>XP_016878107 (OMIM: 609295) PREDICTED: semaphorin-6D i (1067 aa)
initn: 6868 init1: 3978 opt: 3984 Z-score: 2718.5 bits: 514.6 E(85289): 1.1e-144
Smith-Waterman score: 6585; 94.6% identity (94.6% similar) in 1043 aa overlap (1-987:1-1043)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCH------------------
::::::::::::::::::::::::::::::::::::::::::
XP_016 CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHDMEVSSSSVTTMASIPEI
550 560 570 580 590 600
590 600
pF1KSD --------------------------------------GVRWEVQSGESNQMVHMNVLIT
::::::::::::::::::::::
XP_016 TPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLIT
610 620 630 640 650 660
610 620 630 640 650 660
pF1KSD CVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVK
670 680 690 700 710 720
670 680 690 700 710 720
pF1KSD EYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQ
730 740 750 760 770 780
730 740 750 760 770 780
pF1KSD AMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNA
790 800 810 820 830 840
790 800 810 820 830 840
pF1KSD HKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQN
850 860 870 880 890 900
850 860 870 880 890 900
pF1KSD LMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHK
910 920 930 940 950 960
910 920 930 940 950 960
pF1KSD NSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLS
970 980 990 1000 1010 1020
970 980 990 1000 1010
pF1KSD RQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
:::::::::::::::::::::::
XP_016 RQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
1030 1040 1050 1060
>>XP_011520378 (OMIM: 609295) PREDICTED: semaphorin-6D i (1067 aa)
initn: 6868 init1: 3978 opt: 3984 Z-score: 2718.5 bits: 514.6 E(85289): 1.1e-144
Smith-Waterman score: 6585; 94.6% identity (94.6% similar) in 1043 aa overlap (1-987:1-1043)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCH------------------
::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHDMEVSSSSVTTMASIPEI
550 560 570 580 590 600
590 600
pF1KSD --------------------------------------GVRWEVQSGESNQMVHMNVLIT
::::::::::::::::::::::
XP_011 TPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLIT
610 620 630 640 650 660
610 620 630 640 650 660
pF1KSD CVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVK
670 680 690 700 710 720
670 680 690 700 710 720
pF1KSD EYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQ
730 740 750 760 770 780
730 740 750 760 770 780
pF1KSD AMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNA
790 800 810 820 830 840
790 800 810 820 830 840
pF1KSD HKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQN
850 860 870 880 890 900
850 860 870 880 890 900
pF1KSD LMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHK
910 920 930 940 950 960
910 920 930 940 950 960
pF1KSD NSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLS
970 980 990 1000 1010 1020
970 980 990 1000 1010
pF1KSD RQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
:::::::::::::::::::::::
XP_011 RQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
1030 1040 1050 1060
>>XP_016878108 (OMIM: 609295) PREDICTED: semaphorin-6D i (1030 aa)
initn: 3979 init1: 3979 opt: 3979 Z-score: 2715.3 bits: 514.0 E(85289): 1.7e-144
Smith-Waterman score: 6834; 98.2% identity (98.2% similar) in 1030 aa overlap (1-1011:1-1030)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCH------------------
::::::::::::::::::::::::::::::::::::::::::
XP_016 CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPT
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD -GVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
730 740 750 760 770 780
770 780 790 800 810 820
pF1KSD IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
790 800 810 820 830 840
830 840 850 860 870 880
pF1KSD KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
850 860 870 880 890 900
890 900 910 920 930 940
pF1KSD RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KSD PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
970 980 990 1000 1010 1020
1010
pF1KSD SVRPLNKYTY
::::::::::
XP_016 SVRPLNKYTY
1030
>>XP_011520380 (OMIM: 609295) PREDICTED: semaphorin-6D i (1030 aa)
initn: 3979 init1: 3979 opt: 3979 Z-score: 2715.3 bits: 514.0 E(85289): 1.7e-144
Smith-Waterman score: 6834; 98.2% identity (98.2% similar) in 1030 aa overlap (1-1011:1-1030)
10 20 30 40 50 60
pF1KSD MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPED
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGS
490 500 510 520 530 540
550 560 570 580
pF1KSD CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCH------------------
::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRVTPGMLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPT
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD -GVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAES
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRG
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGH
730 740 750 760 770 780
770 780 790 800 810 820
pF1KSD IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL
790 800 810 820 830 840
830 840 850 860 870 880
pF1KSD KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTK
850 860 870 880 890 900
890 900 910 920 930 940
pF1KSD RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPT
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KSD PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTP
970 980 990 1000 1010 1020
1010
pF1KSD SVRPLNKYTY
::::::::::
XP_011 SVRPLNKYTY
1030
1011 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 06:26:26 2016 done: Thu Nov 3 06:26:28 2016
Total Scan time: 11.560 Total Display time: 0.490
Function used was FASTA [36.3.4 Apr, 2011]