Result of FASTA (omim) for
pF1KSDA1322
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1322, 693 aa
1>>>pF1KSDA1322 693 - 693 aa - 693 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4148+/-0.000392; mu= 10.6619+/- 0.025
mean_var=139.7450+/-29.181, 0's: 0 Z-trim(116.7): 229 B-trim: 811 in 1/51
Lambda= 0.108494
statistics sampled from 27853 (28085) to 27853 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.329), width: 16
Scan time: 11.830
The best scores are: opt bits E(85289)
XP_006713958 (OMIM: 614855) PREDICTED: TBC1 domain ( 693) 4615 734.4 3.4e-211
NP_065824 (OMIM: 614855) TBC1 domain family member ( 693) 4615 734.4 3.4e-211
NP_001106832 (OMIM: 614855) TBC1 domain family mem ( 693) 4615 734.4 3.4e-211
XP_005248043 (OMIM: 614855) PREDICTED: TBC1 domain ( 669) 3192 511.7 3.7e-144
XP_016863966 (OMIM: 614855) PREDICTED: TBC1 domain ( 669) 3192 511.7 3.7e-144
XP_011511809 (OMIM: 614855) PREDICTED: TBC1 domain ( 727) 3192 511.7 4e-144
XP_011511810 (OMIM: 614855) PREDICTED: TBC1 domain ( 727) 3192 511.7 4e-144
NP_001317567 (OMIM: 614855) TBC1 domain family mem ( 465) 3069 492.3 1.7e-138
NP_001106834 (OMIM: 614855) TBC1 domain family mem ( 413) 2788 448.3 2.7e-125
NP_001273734 (OMIM: 614855) TBC1 domain family mem ( 353) 2391 386.1 1.2e-106
XP_016863969 (OMIM: 614855) PREDICTED: TBC1 domain ( 387) 1423 234.6 5.4e-61
XP_011511815 (OMIM: 614855) PREDICTED: TBC1 domain ( 447) 1423 234.7 6.1e-61
XP_016863968 (OMIM: 614855) PREDICTED: TBC1 domain ( 389) 1365 225.5 2.9e-58
XP_016857777 (OMIM: 602942) PREDICTED: ecotropic v ( 722) 366 69.3 5.7e-11
XP_016857775 (OMIM: 602942) PREDICTED: ecotropic v ( 722) 366 69.3 5.7e-11
XP_016857776 (OMIM: 602942) PREDICTED: ecotropic v ( 722) 366 69.3 5.7e-11
XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 366 69.4 5.8e-11
XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 366 69.4 6e-11
XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 366 69.4 6.1e-11
NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 366 69.4 6.2e-11
XP_016857771 (OMIM: 602942) PREDICTED: ecotropic v ( 812) 366 69.4 6.2e-11
XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 366 69.4 6.3e-11
NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 366 69.4 6.3e-11
XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 366 69.4 6.3e-11
XP_016857768 (OMIM: 602942) PREDICTED: ecotropic v ( 841) 366 69.4 6.4e-11
XP_016857767 (OMIM: 602942) PREDICTED: ecotropic v ( 848) 366 69.4 6.5e-11
XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 366 69.4 6.5e-11
XP_016857765 (OMIM: 602942) PREDICTED: ecotropic v ( 859) 366 69.4 6.5e-11
XP_016857762 (OMIM: 602942) PREDICTED: ecotropic v ( 886) 366 69.4 6.7e-11
XP_016857763 (OMIM: 602942) PREDICTED: ecotropic v ( 886) 366 69.4 6.7e-11
XP_016857764 (OMIM: 602942) PREDICTED: ecotropic v ( 886) 366 69.4 6.7e-11
XP_016857761 (OMIM: 602942) PREDICTED: ecotropic v ( 897) 366 69.4 6.8e-11
XP_016857760 (OMIM: 602942) PREDICTED: ecotropic v ( 903) 366 69.4 6.8e-11
XP_016857759 (OMIM: 602942) PREDICTED: ecotropic v ( 927) 366 69.4 6.9e-11
XP_016857758 (OMIM: 602942) PREDICTED: ecotropic v ( 930) 366 69.4 7e-11
XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 351 67.0 3.1e-10
NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 351 67.0 3.2e-10
XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 351 67.1 3.7e-10
XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 351 67.1 3.8e-10
XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 351 67.1 3.9e-10
XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 351 67.1 3.9e-10
XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 338 65.0 1.4e-09
XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 338 65.0 1.4e-09
XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 338 65.1 1.6e-09
XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 338 65.1 1.6e-09
NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 338 65.1 1.6e-09
XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 338 65.1 1.6e-09
XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 338 65.1 1.6e-09
XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 338 65.1 1.6e-09
NP_055503 (OMIM: 605405) USP6 N-terminal-like prot ( 828) 328 63.4 3.9e-09
>>XP_006713958 (OMIM: 614855) PREDICTED: TBC1 domain fam (693 aa)
initn: 4615 init1: 4615 opt: 4615 Z-score: 3912.6 bits: 734.4 E(85289): 3.4e-211
Smith-Waterman score: 4615; 99.9% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLVSAPEYGPKLKLRALEDRHS
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_006 MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
610 620 630 640 650 660
670 680 690
pF1KSD IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
:::::::::::::::::::::::::::::::::
XP_006 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
670 680 690
>>NP_065824 (OMIM: 614855) TBC1 domain family member 14 (693 aa)
initn: 4615 init1: 4615 opt: 4615 Z-score: 3912.6 bits: 734.4 E(85289): 3.4e-211
Smith-Waterman score: 4615; 99.9% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLVSAPEYGPKLKLRALEDRHS
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
NP_065 MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
610 620 630 640 650 660
670 680 690
pF1KSD IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
:::::::::::::::::::::::::::::::::
NP_065 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
670 680 690
>>NP_001106832 (OMIM: 614855) TBC1 domain family member (693 aa)
initn: 4615 init1: 4615 opt: 4615 Z-score: 3912.6 bits: 734.4 E(85289): 3.4e-211
Smith-Waterman score: 4615; 99.9% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLVSAPEYGPKLKLRALEDRHS
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
NP_001 MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
610 620 630 640 650 660
670 680 690
pF1KSD IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
:::::::::::::::::::::::::::::::::
NP_001 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
670 680 690
>>XP_005248043 (OMIM: 614855) PREDICTED: TBC1 domain fam (669 aa)
initn: 4419 init1: 3192 opt: 3192 Z-score: 2709.0 bits: 511.7 E(85289): 3.7e-144
Smith-Waterman score: 4375; 96.4% identity (96.5% similar) in 693 aa overlap (1-693:1-669)
10 20 30 40 50 60
pF1KSD MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLVSAPEYGPKLKLRALEDRHS
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_005 MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
:: ::::::::::::::::::::::::::::::::::
XP_005 QQ------------------------VQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
490 500 510
550 560 570 580 590 600
pF1KSD AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
580 590 600 610 620 630
670 680 690
pF1KSD IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
:::::::::::::::::::::::::::::::::
XP_005 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
640 650 660
>>XP_016863966 (OMIM: 614855) PREDICTED: TBC1 domain fam (669 aa)
initn: 4419 init1: 3192 opt: 3192 Z-score: 2709.0 bits: 511.7 E(85289): 3.7e-144
Smith-Waterman score: 4375; 96.4% identity (96.5% similar) in 693 aa overlap (1-693:1-669)
10 20 30 40 50 60
pF1KSD MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLVSAPEYGPKLKLRALEDRHS
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_016 MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD QQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
:: ::::::::::::::::::::::::::::::::::
XP_016 QQ------------------------VQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQM
490 500 510
550 560 570 580 590 600
pF1KSD AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLA
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIAT
580 590 600 610 620 630
670 680 690
pF1KSD IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
:::::::::::::::::::::::::::::::::
XP_016 IQMQSRNKKWAQVLTALQKDSREMEKGSPSLRH
640 650 660
>>XP_011511809 (OMIM: 614855) PREDICTED: TBC1 domain fam (727 aa)
initn: 4601 init1: 3192 opt: 3192 Z-score: 2708.5 bits: 511.7 E(85289): 4e-144
Smith-Waterman score: 4520; 95.2% identity (95.3% similar) in 725 aa overlap (1-691:1-725)
10 20 30 40 50 60
pF1KSD MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLVSAPEYGPKLKLRALEDRHS
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_011 MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
430 440 450 460 470 480
490 500
pF1KSD QQ----------------------------------GGPYHDMLHSILGAYTCYRPDVGY
:: ::::::::::::::::::::::::
XP_011 QQVLIFVDFRVGLQKSFQKRKERESTKLQQLWSWCLGGPYHDMLHSILGAYTCYRPDVGY
490 500 510 520 530 540
510 520 530 540 550 560
pF1KSD VQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KSD KLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLF
610 620 630 640 650 660
630 640 650 660 670 680
pF1KSD EDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK
670 680 690 700 710 720
690
pF1KSD GSPSLRH
:::::
XP_011 GSPSLRH
>>XP_011511810 (OMIM: 614855) PREDICTED: TBC1 domain fam (727 aa)
initn: 4601 init1: 3192 opt: 3192 Z-score: 2708.5 bits: 511.7 E(85289): 4e-144
Smith-Waterman score: 4520; 95.2% identity (95.3% similar) in 725 aa overlap (1-691:1-725)
10 20 30 40 50 60
pF1KSD MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLVSAPEYGPKLKLRALEDRHS
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_011 MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQSVDSGIPTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERCRVEESIGNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIF
430 440 450 460 470 480
490 500
pF1KSD QQ----------------------------------GGPYHDMLHSILGAYTCYRPDVGY
:: ::::::::::::::::::::::::
XP_011 QQVLIFVDFRVGLQKSFQKRKERESTKLQQLWSWCLGGPYHDMLHSILGAYTCYRPDVGY
490 500 510 520 530 540
510 520 530 540 550 560
pF1KSD VQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KSD KLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLF
610 620 630 640 650 660
630 640 650 660 670 680
pF1KSD EDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK
670 680 690 700 710 720
690
pF1KSD GSPSLRH
:::::
XP_011 GSPSLRH
>>NP_001317567 (OMIM: 614855) TBC1 domain family member (465 aa)
initn: 3067 init1: 3067 opt: 3069 Z-score: 2607.3 bits: 492.3 E(85289): 1.7e-138
Smith-Waterman score: 3069; 98.5% identity (99.1% similar) in 462 aa overlap (232-693:4-465)
210 220 230 240 250 260
pF1KSD NVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQSARLDKHNDLGWK
..: :. :::::::::::::::::::::
NP_001 MMAISPALLFMDRNLLARKQSARLDKHNDLGWK
10 20 30
270 280 290 300 310 320
pF1KSD LFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPA
40 50 60 70 80 90
330 340 350 360 370 380
pF1KSD NLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIGNAVLTWNNEI
100 110 120 130 140 150
390 400 410 420 430 440
pF1KSD LPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLS
160 170 180 190 200 210
450 460 470 480 490 500
pF1KSD TGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYR
220 230 240 250 260 270
510 520 530 540 550 560
pF1KSD PDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFF
280 290 300 310 320 330
570 580 590 600 610 620
pF1KSD EENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALG
340 350 360 370 380 390
630 640 650 660 670 680
pF1KSD ILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWAQVLTALQKDS
400 410 420 430 440 450
690
pF1KSD REMEKGSPSLRH
::::::::::::
NP_001 REMEKGSPSLRH
460
>>NP_001106834 (OMIM: 614855) TBC1 domain family member (413 aa)
initn: 2788 init1: 2788 opt: 2788 Z-score: 2370.3 bits: 448.3 E(85289): 2.7e-125
Smith-Waterman score: 2788; 100.0% identity (100.0% similar) in 412 aa overlap (282-693:2-413)
260 270 280 290 300 310
pF1KSD LDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLST
::::::::::::::::::::::::::::::
NP_001 MEYEDKAGRPSKPPSPKQNVRKNLDFEPLST
10 20 30
320 330 340 350 360 370
pF1KSD TALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESIG
40 50 60 70 80 90
380 390 400 410 420 430
pF1KSD NAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLA
100 110 120 130 140 150
440 450 460 470 480 490
pF1KSD RAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLH
160 170 180 190 200 210
500 510 520 530 540 550
pF1KSD SILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLML
220 230 240 250 260 270
560 570 580 590 600 610
pF1KSD TYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDG
280 290 300 310 320 330
620 630 640 650 660 670
pF1KSD EEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKWA
340 350 360 370 380 390
680 690
pF1KSD QVLTALQKDSREMEKGSPSLRH
::::::::::::::::::::::
NP_001 QVLTALQKDSREMEKGSPSLRH
400 410
>>NP_001273734 (OMIM: 614855) TBC1 domain family member (353 aa)
initn: 2391 init1: 2391 opt: 2391 Z-score: 2035.5 bits: 386.1 E(85289): 1.2e-106
Smith-Waterman score: 2391; 100.0% identity (100.0% similar) in 353 aa overlap (341-693:1-353)
320 330 340 350 360 370
pF1KSD TTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKRELKEAQRRKKQLEERCRVEESI
::::::::::::::::::::::::::::::
NP_001 MVVQAKKRELKEAQRRKKQLEERCRVEESI
10 20 30
380 390 400 410 420 430
pF1KSD GNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNAVLTWNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICL
40 50 60 70 80 90
440 450 460 470 480 490
pF1KSD ARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARAKERWRSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDML
100 110 120 130 140 150
500 510 520 530 540 550
pF1KSD HSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLM
160 170 180 190 200 210
560 570 580 590 600 610
pF1KSD LTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRD
220 230 240 250 260 270
620 630 640 650 660 670
pF1KSD GEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEEFLFRTALGILKLFEDILTKMDFIHMAQFLTRLPEDLPAEELFASIATIQMQSRNKKW
280 290 300 310 320 330
680 690
pF1KSD AQVLTALQKDSREMEKGSPSLRH
:::::::::::::::::::::::
NP_001 AQVLTALQKDSREMEKGSPSLRH
340 350
693 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 05:49:22 2016 done: Thu Nov 3 05:49:24 2016
Total Scan time: 11.830 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]