Result of FASTA (omim) for
pF1KSDA1202
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1202, 1498 aa
1>>>pF1KSDA1202 1498 - 1498 aa - 1498 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4385+/-0.000436; mu= -9.3941+/- 0.027
mean_var=429.0861+/-87.144, 0's: 0 Z-trim(123.1): 42 B-trim: 0 in 0/58
Lambda= 0.061916
statistics sampled from 42274 (42320) to 42274 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.496), width: 16
Scan time: 17.340
The best scores are: opt bits E(85289)
NP_065768 (OMIM: 300434,300579) protein Shroom4 [H (1493) 10193 926.2 0
XP_016885176 (OMIM: 300434,300579) PREDICTED: prot ( 999) 6893 631.2 1.2e-179
XP_016885174 (OMIM: 300434,300579) PREDICTED: prot (1398) 6893 631.4 1.6e-179
XP_016885171 (OMIM: 300434,300579) PREDICTED: prot (1531) 6893 631.4 1.7e-179
XP_016885173 (OMIM: 300434,300579) PREDICTED: prot (1415) 6109 561.3 1.9e-158
XP_016885172 (OMIM: 300434,300579) PREDICTED: prot (1486) 5972 549.1 9.6e-155
XP_016885175 (OMIM: 300434,300579) PREDICTED: prot (1373) 5796 533.4 4.9e-150
XP_011543808 (OMIM: 300103) PREDICTED: protein Shr ( 451) 812 87.8 2.2e-16
XP_016884982 (OMIM: 300103) PREDICTED: protein Shr ( 451) 812 87.8 2.2e-16
NP_001307592 (OMIM: 300103) protein Shroom2 isofor ( 451) 812 87.8 2.2e-16
XP_016884983 (OMIM: 300103) PREDICTED: protein Shr ( 450) 803 87.0 3.8e-16
XP_016884981 (OMIM: 300103) PREDICTED: protein Shr ( 450) 803 87.0 3.8e-16
NP_001307593 (OMIM: 300103) protein Shroom2 isofor ( 450) 803 87.0 3.8e-16
NP_001640 (OMIM: 300103) protein Shroom2 isoform 1 (1616) 812 88.2 5.8e-16
XP_005274557 (OMIM: 300103) PREDICTED: protein Shr (1615) 803 87.4 1e-15
XP_005263222 (OMIM: 604570) PREDICTED: protein Shr (1820) 801 87.3 1.2e-15
XP_005263220 (OMIM: 604570) PREDICTED: protein Shr (1820) 801 87.3 1.2e-15
XP_005263221 (OMIM: 604570) PREDICTED: protein Shr (1820) 801 87.3 1.2e-15
XP_011530463 (OMIM: 604570) PREDICTED: protein Shr (1820) 801 87.3 1.2e-15
XP_011530462 (OMIM: 604570) PREDICTED: protein Shr (1871) 801 87.3 1.3e-15
XP_016863978 (OMIM: 604570) PREDICTED: protein Shr (1961) 801 87.3 1.3e-15
XP_006714345 (OMIM: 604570) PREDICTED: protein Shr (1961) 801 87.3 1.3e-15
XP_016863977 (OMIM: 604570) PREDICTED: protein Shr (1962) 801 87.3 1.3e-15
NP_065910 (OMIM: 604570) protein Shroom3 [Homo sap (1996) 801 87.3 1.3e-15
XP_011530461 (OMIM: 604570) PREDICTED: protein Shr (1997) 801 87.3 1.3e-15
XP_011530460 (OMIM: 604570) PREDICTED: protein Shr (1997) 801 87.3 1.3e-15
XP_011530459 (OMIM: 604570) PREDICTED: protein Shr (2002) 801 87.3 1.3e-15
XP_005271943 (OMIM: 611179) PREDICTED: protein Shr ( 852) 367 48.3 0.00032
NP_001166171 (OMIM: 611179) protein Shroom1 isofor ( 852) 367 48.3 0.00032
XP_005271942 (OMIM: 611179) PREDICTED: protein Shr ( 852) 367 48.3 0.00032
XP_011541469 (OMIM: 611179) PREDICTED: protein Shr ( 852) 367 48.3 0.00032
NP_597713 (OMIM: 611179) protein Shroom1 isoform 2 ( 847) 362 47.8 0.00044
>>NP_065768 (OMIM: 300434,300579) protein Shroom4 [Homo (1493 aa)
initn: 8007 init1: 8007 opt: 10193 Z-score: 4936.8 bits: 926.2 E(85289): 0
Smith-Waterman score: 10193; 99.6% identity (99.7% similar) in 1498 aa overlap (1-1498:1-1493)
10 20 30 40 50 60
pF1KSD MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD KLTVQEFPGDKWNPITGNRKTSQSGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KLTVQEFPGDKWNPITGNRKTSQSGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD LDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRREL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRREL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD FSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQQQQQKQQEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::.:: ::::
NP_065 FSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQKQQ-----EEEE
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KSD EEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSR
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KSD QGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQ
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KSD EFQHFSPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EFQHFSPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKI
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KSD QLIESISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QLIESISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKV
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KSD VNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLV
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490
pF1KSD FGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
1440 1450 1460 1470 1480 1490
>>XP_016885176 (OMIM: 300434,300579) PREDICTED: protein (999 aa)
initn: 6892 init1: 6892 opt: 6893 Z-score: 3346.2 bits: 631.2 E(85289): 1.2e-179
Smith-Waterman score: 6893; 99.1% identity (99.5% similar) in 999 aa overlap (1-996:1-999)
10 20 30 40 50 60
pF1KSD MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
910 920 930 940 950 960
970 980 990 1000 1010
pF1KSD KLTVQEFPGDKWNPITGNRKTSQSGRE--MAHSKT-SFSWATPFHPCLENPALDLSSYRA
::::::::::::::::::::::::::: . :.. ::.
XP_016 KLTVQEFPGDKWNPITGNRKTSQSGREKKLRHTEIHSFA
970 980 990
1020 1030 1040 1050 1060 1070
pF1KSD ISSLDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHR
>>XP_016885174 (OMIM: 300434,300579) PREDICTED: protein (1398 aa)
initn: 8172 init1: 6884 opt: 6893 Z-score: 3344.1 bits: 631.4 E(85289): 1.6e-179
Smith-Waterman score: 8995; 96.8% identity (96.8% similar) in 1357 aa overlap (1-1319:1-1352)
10 20 30 40 50 60
pF1KSD MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
910 920 930 940 950 960
970 980
pF1KSD KLTVQEFPGDKWNPITGNRKTSQSG-----------------------------------
:::::::::::::::::::::::::
XP_016 KLTVQEFPGDKWNPITGNRKTSQSGSEALKPSWTPEDECSTSTFCCTPGVPASLRLSLRD
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KSD ---REMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEE
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KSD GSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPP
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KSD RPPPPNWEKYRLFRAAQQQKQQQQQQQQQQKQQEEEEEEEEEEEEEEEEEEEEEAEEEEE
::::::::::::::::::::::::::.:: ::::::::::::::::::::::::::
XP_016 RPPPPNWEKYRLFRAAQQQKQQQQQQKQQ-----EEEEEEEEEEEEEEEEEEEEAEEEEE
1150 1160 1170 1180 1190
1170 1180 1190 1200 1210 1220
pF1KSD ELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLP
1200 1210 1220 1230 1240 1250
1230 1240 1250 1260 1270 1280
pF1KSD PIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYY
1260 1270 1280 1290 1300 1310
1290 1300 1310 1320 1330 1340
pF1KSD NISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLE
:::::::::::::::::::::::::::::::::::::
XP_016 NISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKDTAYRKHQQKTFCLAGGPARAAR
1320 1330 1340 1350 1360 1370
1350 1360 1370 1380 1390 1400
pF1KSD DINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSID
XP_016 GHQCQFCPWGGGGGQLKSRLQIQ
1380 1390
>>XP_016885171 (OMIM: 300434,300579) PREDICTED: protein (1531 aa)
initn: 9284 init1: 6884 opt: 6893 Z-score: 3343.6 bits: 631.4 E(85289): 1.7e-179
Smith-Waterman score: 10107; 97.1% identity (97.2% similar) in 1536 aa overlap (1-1498:1-1531)
10 20 30 40 50 60
pF1KSD MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
910 920 930 940 950 960
970 980
pF1KSD KLTVQEFPGDKWNPITGNRKTSQSG-----------------------------------
:::::::::::::::::::::::::
XP_016 KLTVQEFPGDKWNPITGNRKTSQSGSEALKPSWTPEDECSTSTFCCTPGVPASLRLSLRD
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KSD ---REMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEE
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KSD GSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPP
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KSD RPPPPNWEKYRLFRAAQQQKQQQQQQQQQQKQQEEEEEEEEEEEEEEEEEEEEEAEEEEE
::::::::::::::::::::::::::.:: ::::::::::::::::::::::::::
XP_016 RPPPPNWEKYRLFRAAQQQKQQQQQQKQQ-----EEEEEEEEEEEEEEEEEEEEAEEEEE
1150 1160 1170 1180 1190
1170 1180 1190 1200 1210 1220
pF1KSD ELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLP
1200 1210 1220 1230 1240 1250
1230 1240 1250 1260 1270 1280
pF1KSD PIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYY
1260 1270 1280 1290 1300 1310
1290 1300 1310 1320 1330 1340
pF1KSD NISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLE
1320 1330 1340 1350 1360 1370
1350 1360 1370 1380 1390 1400
pF1KSD DINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSID
1380 1390 1400 1410 1420 1430
1410 1420 1430 1440 1450 1460
pF1KSD SEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKM
1440 1450 1460 1470 1480 1490
1470 1480 1490
pF1KSD KSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
::::::::::::::::::::::::::::::::::::
XP_016 KSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
1500 1510 1520 1530
>>XP_016885173 (OMIM: 300434,300579) PREDICTED: protein (1415 aa)
initn: 8500 init1: 6100 opt: 6109 Z-score: 2965.6 bits: 561.3 E(85289): 1.9e-158
Smith-Waterman score: 9323; 96.9% identity (97.0% similar) in 1420 aa overlap (117-1498:1-1415)
90 100 110 120 130 140
pF1KSD IVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFPSEAFSLSWHSGCNTSDVCVQWCPLSR
::::::::::::::::::::::::::::::
XP_016 MHFPSEAFSLSWHSGCNTSDVCVQWCPLSR
10 20 30
150 160 170 180 190 200
pF1KSD HCSTEKSSSIGSMESLEQPGQATYESHLLPIDQNMYPNQRDSAYSSFSASSNASDCALSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCSTEKSSSIGSMESLEQPGQATYESHLLPIDQNMYPNQRDSAYSSFSASSNASDCALSL
40 50 60 70 80 90
210 220 230 240 250 260
pF1KSD RPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGSRRTNGGHLTPSSQMSSRPQEGYQSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGSRRTNGGHLTPSSQMSSRPQEGYQSGP
100 110 120 130 140 150
270 280 290 300 310 320
pF1KSD AKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASEPVVPLPQKEKLSLEPVLPARNPNRFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASEPVVPLPQKEKLSLEPVLPARNPNRFC
160 170 180 190 200 210
330 340 350 360 370 380
pF1KSD CLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLMQASTKAVGSPKACDRASSVDSNPLNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLMQASTKAVGSPKACDRASSVDSNPLNE
220 230 240 250 260 270
390 400 410 420 430 440
pF1KSD ASAELAKASFGRPPHLIGPTGHRHSAPEQLLASHLQHVHLDTRGSKGMELPPVQDGHQWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASAELAKASFGRPPHLIGPTGHRHSAPEQLLASHLQHVHLDTRGSKGMELPPVQDGHQWT
280 290 300 310 320 330
450 460 470 480 490 500
pF1KSD LSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRSLVLGHQSQSSPPHGEADGHPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRSLVLGHQSQSSPPHGEADGHPSE
340 350 360 370 380 390
510 520 530 540 550 560
pF1KSD KGFLDPNRTSRAASELANQQPSASGSLVQQATDCSSTTKAASGTEAGEEGDSEPKECSRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGFLDPNRTSRAASELANQQPSASGSLVQQATDCSSTTKAASGTEAGEEGDSEPKECSRM
400 410 420 430 440 450
570 580 590 600 610 620
pF1KSD GGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKGPLSQLCDTKEPVEETQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKGPLSQLCDTKEPVEETQEP
460 470 480 490 500 510
630 640 650 660 670 680
pF1KSD PESPPLTASNTSLLSSCKKPPSPRDKLFNKSMMLRARSSECLSQAPESHESRTGLEGRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PESPPLTASNTSLLSSCKKPPSPRDKLFNKSMMLRARSSECLSQAPESHESRTGLEGRIS
520 530 540 550 560 570
690 700 710 720 730 740
pF1KSD PGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCGVRGGHWRWSPEHNSQPLVAAAMEGPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCGVRGGHWRWSPEHNSQPLVAAAMEGPS
580 590 600 610 620 630
750 760 770 780 790 800
pF1KSD NPGDNKELKASTAQAGEDAILLPFADRRKFFEESSKSLSTSHLPGLTTHSNKTFTQRPKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPGDNKELKASTAQAGEDAILLPFADRRKFFEESSKSLSTSHLPGLTTHSNKTFTQRPKP
640 650 660 670 680 690
810 820 830 840 850 860
pF1KSD IDQNFQPMSSSCRELRRHPMDQSYHSADQPYHATDQSYHSMSPLQSETPTYSECFASKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDQNFQPMSSSCRELRRHPMDQSYHSADQPYHATDQSYHSMSPLQSETPTYSECFASKGL
700 710 720 730 740 750
870 880 890 900 910 920
pF1KSD ENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEICPALLKRNMMPNCYNCRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEICPALLKRNMMPNCYNCRC
760 770 780 790 800 810
930 940 950 960 970 980
pF1KSD HHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFPGDKWNPITGNRKTSQSG-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFPGDKWNPITGNRKTSQSGS
820 830 840 850 860 870
990 1000
pF1KSD -------------------------------------REMAHSKTSFSWATPFHPCLENP
:::::::::::::::::::::::
XP_016 EALKPSWTPEDECSTSTFCCTPGVPASLRLSLRDRQGREMAHSKTSFSWATPFHPCLENP
880 890 900 910 920 930
1010 1020 1030 1040 1050 1060
pF1KSD ALDLSSYRAISSLDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALDLSSYRAISSLDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQ
940 950 960 970 980 990
1070 1080 1090 1100 1110 1120
pF1KSD STRAWGQHRRELFSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STRAWGQHRRELFSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQ
1000 1010 1020 1030 1040 1050
1130 1140 1150 1160 1170 1180
pF1KSD QQQQKQQEEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQP
.:: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQQ-----EEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQP
1060 1070 1080 1090 1100
1190 1200 1210 1220 1230 1240
pF1KSD QPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWR
1110 1120 1130 1140 1150 1160
1250 1260 1270 1280 1290 1300
pF1KSD TSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGE
1170 1180 1190 1200 1210 1220
1310 1320 1330 1340 1350 1360
pF1KSD EEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFE
1230 1240 1250 1260 1270 1280
1370 1380 1390 1400 1410 1420
pF1KSD KYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKE
1290 1300 1310 1320 1330 1340
1430 1440 1450 1460 1470 1480
pF1KSD LKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLR
1350 1360 1370 1380 1390 1400
1490
pF1KSD ESLLLGPSNF
::::::::::
XP_016 ESLLLGPSNF
1410
>>XP_016885172 (OMIM: 300434,300579) PREDICTED: protein (1486 aa)
initn: 8941 init1: 5963 opt: 5972 Z-score: 2899.2 bits: 549.1 E(85289): 9.6e-155
Smith-Waterman score: 9678; 94.2% identity (94.3% similar) in 1536 aa overlap (1-1498:1-1486)
10 20 30 40 50 60
pF1KSD MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
:::::::::::::::::::::::::::::
XP_016 INGTPLYGSRQEALILIKGSFRILKLIVR-------------------------------
70 80
130 140 150 160 170 180
pF1KSD SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --------------SDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
90 100 110 120 130
190 200 210 220 230 240
pF1KSD MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
140 150 160 170 180 190
250 260 270 280 290 300
pF1KSD RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
200 210 220 230 240 250
310 320 330 340 350 360
pF1KSD PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
260 270 280 290 300 310
370 380 390 400 410 420
pF1KSD QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
320 330 340 350 360 370
430 440 450 460 470 480
pF1KSD LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
380 390 400 410 420 430
490 500 510 520 530 540
pF1KSD DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
440 450 460 470 480 490
550 560 570 580 590 600
pF1KSD SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
500 510 520 530 540 550
610 620 630 640 650 660
pF1KSD AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
560 570 580 590 600 610
670 680 690 700 710 720
pF1KSD RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
620 630 640 650 660 670
730 740 750 760 770 780
pF1KSD VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
680 690 700 710 720 730
790 800 810 820 830 840
pF1KSD SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
740 750 760 770 780 790
850 860 870 880 890 900
pF1KSD DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
800 810 820 830 840 850
910 920 930 940 950 960
pF1KSD CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
860 870 880 890 900 910
970 980
pF1KSD KLTVQEFPGDKWNPITGNRKTSQSG-----------------------------------
:::::::::::::::::::::::::
XP_016 KLTVQEFPGDKWNPITGNRKTSQSGSEALKPSWTPEDECSTSTFCCTPGVPASLRLSLRD
920 930 940 950 960 970
990 1000 1010 1020 1030 1040
pF1KSD ---REMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEE
980 990 1000 1010 1020 1030
1050 1060 1070 1080 1090 1100
pF1KSD GSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPP
1040 1050 1060 1070 1080 1090
1110 1120 1130 1140 1150 1160
pF1KSD RPPPPNWEKYRLFRAAQQQKQQQQQQQQQQKQQEEEEEEEEEEEEEEEEEEEEEAEEEEE
::::::::::::::::::::::::::.:: ::::::::::::::::::::::::::
XP_016 RPPPPNWEKYRLFRAAQQQKQQQQQQKQQ-----EEEEEEEEEEEEEEEEEEEEAEEEEE
1100 1110 1120 1130 1140 1150
1170 1180 1190 1200 1210 1220
pF1KSD ELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLP
1160 1170 1180 1190 1200 1210
1230 1240 1250 1260 1270 1280
pF1KSD PIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYY
1220 1230 1240 1250 1260 1270
1290 1300 1310 1320 1330 1340
pF1KSD NISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLE
1280 1290 1300 1310 1320 1330
1350 1360 1370 1380 1390 1400
pF1KSD DINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSID
1340 1350 1360 1370 1380 1390
1410 1420 1430 1440 1450 1460
pF1KSD SEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKM
1400 1410 1420 1430 1440 1450
1470 1480 1490
pF1KSD KSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
::::::::::::::::::::::::::::::::::::
XP_016 KSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
1460 1470 1480
>>XP_016885175 (OMIM: 300434,300579) PREDICTED: protein (1373 aa)
initn: 8187 init1: 5787 opt: 5796 Z-score: 2814.7 bits: 533.4 E(85289): 4.9e-150
Smith-Waterman score: 9010; 96.8% identity (96.9% similar) in 1378 aa overlap (159-1498:1-1373)
130 140 150 160 170 180
pF1KSD HSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQNMYPNQRDS
::::::::::::::::::::::::::::::
XP_016 MESLEQPGQATYESHLLPIDQNMYPNQRDS
10 20 30
190 200 210 220 230 240
pF1KSD AYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGSRRTNGGHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGSRRTNGGHL
40 50 60 70 80 90
250 260 270 280 290 300
pF1KSD TPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASEPVVPLPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASEPVVPLPQK
100 110 120 130 140 150
310 320 330 340 350 360
pF1KSD EKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLMQASTKAVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLMQASTKAVG
160 170 180 190 200 210
370 380 390 400 410 420
pF1KSD SPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASHLQHVHLDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASHLQHVHLDT
220 230 240 250 260 270
430 440 450 460 470 480
pF1KSD RGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRSLVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQVDDRSLVLG
280 290 300 310 320 330
490 500 510 520 530 540
pF1KSD HQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDCSSTTKAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDCSSTTKAAS
340 350 360 370 380 390
550 560 570 580 590 600
pF1KSD GTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRKAQLQKSKG
400 410 420 430 440 450
610 620 630 640 650 660
pF1KSD PLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMMLRARSSECL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMMLRARSSECL
460 470 480 490 500 510
670 680 690 700 710 720
pF1KSD SQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCGVRGGHWRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCGVRGGHWRW
520 530 540 550 560 570
730 740 750 760 770 780
pF1KSD SPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEESSKSLSTSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEESSKSLSTSH
580 590 600 610 620 630
790 800 810 820 830 840
pF1KSD LPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHATDQSYHSMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHATDQSYHSMS
640 650 660 670 680 690
850 860 870 880 890 900
pF1KSD PLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDPCIYCSGEI
700 710 720 730 740 750
910 920 930 940 950 960
pF1KSD CPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPRKLTVQEFP
760 770 780 790 800 810
970 980 990
pF1KSD GDKWNPITGNRKTSQSG--------------------------------------REMAH
::::::::::::::::: :::::
XP_016 GDKWNPITGNRKTSQSGSEALKPSWTPEDECSTSTFCCTPGVPASLRLSLRDRQGREMAH
820 830 840 850 860 870
1000 1010 1020 1030 1040 1050
pF1KSD SKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEEGSSLASMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKTSFSWATPFHPCLENPALDLSSYRAISSLDLLGDFKHALKKSEETSVYEEGSSLASMP
880 890 900 910 920 930
1060 1070 1080 1090 1100 1110
pF1KSD HPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPPRPPPPNWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLRSRAFSESHISLAPQSTRAWGQHRRELFSKGDETQSDLLGARKKAFPPPRPPPPNWE
940 950 960 970 980 990
1120 1130 1140 1150 1160 1170
pF1KSD KYRLFRAAQQQKQQQQQQQQQQKQQEEEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFS
::::::::::::::::::.:: ::::::::::::::::::::::::::::::::::
XP_016 KYRLFRAAQQQKQQQQQQKQQ-----EEEEEEEEEEEEEEEEEEEEAEEEEEELPPQYFS
1000 1010 1020 1030 1040
1180 1190 1200 1210 1220 1230
pF1KSD SETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQSVPAEQESFALHSSDFLPPIRGHLGS
1050 1060 1070 1080 1090 1100
1240 1250 1260 1270 1280 1290
pF1KSD QPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYYNISVAKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYSAYYNISVAKAE
1110 1120 1130 1140 1150 1160
1300 1310 1320 1330 1340 1350
pF1KSD LLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSAL
1170 1180 1190 1200 1210 1220
1360 1370 1380 1390 1400 1410
pF1KSD GEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQEKL
1230 1240 1250 1260 1270 1280
1420 1430 1440 1450 1460 1470
pF1KSD VLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQ
1290 1300 1310 1320 1330 1340
1480 1490
pF1KSD RELEEKIKLGEEQLKCLRESLLLGPSNF
::::::::::::::::::::::::::::
XP_016 RELEEKIKLGEEQLKCLRESLLLGPSNF
1350 1360 1370
>>XP_011543808 (OMIM: 300103) PREDICTED: protein Shroom2 (451 aa)
initn: 484 init1: 423 opt: 812 Z-score: 415.3 bits: 87.8 E(85289): 2.2e-16
Smith-Waterman score: 812; 59.6% identity (82.6% similar) in 230 aa overlap (1272-1491:219-445)
1250 1260 1270 1280 1290
pF1KSD GIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYS-----AYYNISVAKAELLNKLK
:..:.. : .::. :. ::::: :.:
XP_011 DEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMK
190 200 210 220 230 240
1300 1310 1320 1330 1340 1350
pF1KSD DQPEMAEIGLGEEE----VDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGE
: :. : ::. .::.:. :: .:::::::::.:::::...::::..::..::
XP_011 DLQEQQE---HEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGA
250 260 270 280 290 300
1360 1370 1380 1390 1400 1410
pF1KSD EVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQ-EKLV
:::: .:.::: .::.:...:.:::::::::::::::::::::::::..:. :. ..
XP_011 EVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQS
310 320 330 340 350 360
1420 1430 1440 1450 1460 1470
pF1KSD LIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQR
:.::.. : : :::::::..::::..:: ... :: ...: ::.::::::::::::::
XP_011 LLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQR
370 380 390 400 410 420
1480 1490
pF1KSD ELEEKIKLGEEQLKCLRESLLLGPSNF
:::.::.::::::::: .::
XP_011 ELEDKIHLGEEQLKCLLDSLQPERGK
430 440 450
>>XP_016884982 (OMIM: 300103) PREDICTED: protein Shroom2 (451 aa)
initn: 484 init1: 423 opt: 812 Z-score: 415.3 bits: 87.8 E(85289): 2.2e-16
Smith-Waterman score: 812; 59.6% identity (82.6% similar) in 230 aa overlap (1272-1491:219-445)
1250 1260 1270 1280 1290
pF1KSD GIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYS-----AYYNISVAKAELLNKLK
:..:.. : .::. :. ::::: :.:
XP_016 DEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMK
190 200 210 220 230 240
1300 1310 1320 1330 1340 1350
pF1KSD DQPEMAEIGLGEEE----VDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGE
: :. : ::. .::.:. :: .:::::::::.:::::...::::..::..::
XP_016 DLQEQQE---HEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGA
250 260 270 280 290 300
1360 1370 1380 1390 1400 1410
pF1KSD EVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQ-EKLV
:::: .:.::: .::.:...:.:::::::::::::::::::::::::..:. :. ..
XP_016 EVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQS
310 320 330 340 350 360
1420 1430 1440 1450 1460 1470
pF1KSD LIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQR
:.::.. : : :::::::..::::..:: ... :: ...: ::.::::::::::::::
XP_016 LLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQR
370 380 390 400 410 420
1480 1490
pF1KSD ELEEKIKLGEEQLKCLRESLLLGPSNF
:::.::.::::::::: .::
XP_016 ELEDKIHLGEEQLKCLLDSLQPERGK
430 440 450
>>NP_001307592 (OMIM: 300103) protein Shroom2 isoform 2 (451 aa)
initn: 484 init1: 423 opt: 812 Z-score: 415.3 bits: 87.8 E(85289): 2.2e-16
Smith-Waterman score: 812; 59.6% identity (82.6% similar) in 230 aa overlap (1272-1491:219-445)
1250 1260 1270 1280 1290
pF1KSD GIGGLWRTSGQEATESAKQEFQHFSPPSGAPGIPTSYS-----AYYNISVAKAELLNKLK
:..:.. : .::. :. ::::: :.:
NP_001 DEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMK
190 200 210 220 230 240
1300 1310 1320 1330 1340 1350
pF1KSD DQPEMAEIGLGEEE----VDHELAQKKIQLIESISRKLSVLREAQRGLLEDINANSALGE
: :. : ::. .::.:. :: .:::::::::.:::::...::::..::..::
NP_001 DLQEQQE---HEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGA
250 260 270 280 290 300
1360 1370 1380 1390 1400 1410
pF1KSD EVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLLSLSGRLARVENALNSIDSEANQ-EKLV
:::: .:.::: .::.:...:.:::::::::::::::::::::::::..:. :. ..
NP_001 EVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQS
310 320 330 340 350 360
1420 1430 1440 1450 1460 1470
pF1KSD LIEKKQQLTGQLADAKELKEHVDRREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQR
:.::.. : : :::::::..::::..:: ... :: ...: ::.::::::::::::::
NP_001 LLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQR
370 380 390 400 410 420
1480 1490
pF1KSD ELEEKIKLGEEQLKCLRESLLLGPSNF
:::.::.::::::::: .::
NP_001 ELEDKIHLGEEQLKCLLDSLQPERGK
430 440 450
1498 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 05:21:51 2016 done: Thu Nov 3 05:21:53 2016
Total Scan time: 17.340 Total Display time: 0.620
Function used was FASTA [36.3.4 Apr, 2011]