Result of FASTA (omim) for
pF1KSDA1133
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1133, 836 aa
1>>>pF1KSDA1133 836 - 836 aa - 836 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.5675+/-0.000344; mu= 6.8386+/- 0.021
mean_var=222.4794+/-44.946, 0's: 0 Z-trim(122.1): 122 B-trim: 283 in 1/55
Lambda= 0.085986
statistics sampled from 39645 (39787) to 39645 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.466), width: 16
Scan time: 14.470
The best scores are: opt bits E(85289)
NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 5876 742.3 2.1e-213
XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 5876 742.3 2.1e-213
NP_001193927 (OMIM: 612062) E3 ubiquitin-protein l ( 936) 5876 742.3 2.3e-213
XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 686 98.5 1.4e-19
XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 686 98.5 1.4e-19
NP_060233 (OMIM: 612482,617108) E3 ubiquitin-prote ( 783) 662 95.4 1e-18
NP_001292473 (OMIM: 612482,617108) E3 ubiquitin-pr ( 783) 662 95.4 1e-18
XP_011523258 (OMIM: 612482,617108) PREDICTED: E3 u ( 742) 531 79.2 7.8e-14
NP_001292474 (OMIM: 612482,617108) E3 ubiquitin-pr ( 656) 507 76.2 5.6e-13
NP_919445 (OMIM: 300439) E3 ubiquitin-protein liga ( 428) 263 45.7 0.00053
NP_078815 (OMIM: 300439) E3 ubiquitin-protein liga ( 402) 255 44.7 0.001
XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 227) 247 43.5 0.0013
NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 247 43.6 0.0017
NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 247 43.6 0.0017
NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 247 43.6 0.0017
NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 247 43.6 0.0017
NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 247 43.7 0.0018
NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350) 247 43.7 0.0018
NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 247 43.7 0.0018
NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 247 43.7 0.0018
NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 247 43.7 0.0018
NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 247 43.7 0.0018
NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 247 43.7 0.0018
XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 247 43.7 0.0018
XP_016861150 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 193) 239 42.4 0.0023
XP_016861149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 250) 239 42.5 0.0028
XP_016861148 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 239 42.6 0.0029
XP_011510678 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 239 42.6 0.0029
XP_005247149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 239 42.6 0.0029
XP_016861147 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 239 42.6 0.0029
XP_016861145 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 239 42.6 0.0029
XP_016861146 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 239 42.6 0.0029
XP_011510675 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 239 42.7 0.0038
XP_016861143 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 239 42.7 0.0038
XP_011510676 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 239 42.7 0.0038
NP_899237 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 239 42.7 0.0038
XP_016861144 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 239 42.7 0.0038
NP_009213 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 239 42.7 0.0038
>>NP_115549 (OMIM: 612062) E3 ubiquitin-protein ligase Z (836 aa)
initn: 5876 init1: 5876 opt: 5876 Z-score: 3952.2 bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:1-836)
10 20 30 40 50 60
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 NPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD IFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 IFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD KGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 KGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 RHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD CFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD GSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD AGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 AGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD WKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 WKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 LHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD GARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERAL
730 740 750 760 770 780
790 800 810 820 830
pF1KSD CCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 CCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA
790 800 810 820 830
>>XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 5876 init1: 5876 opt: 5876 Z-score: 3952.1 bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)
10 20 30 40 50
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
790 800 810 820 830 840
pF1KSD A
:
XP_011 A
>>XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 5876 init1: 5876 opt: 5876 Z-score: 3952.1 bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)
10 20 30 40 50
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
790 800 810 820 830 840
pF1KSD A
:
XP_011 A
>>XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 5876 init1: 5876 opt: 5876 Z-score: 3952.1 bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)
10 20 30 40 50
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
790 800 810 820 830 840
pF1KSD A
:
XP_011 A
>>XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 5876 init1: 5876 opt: 5876 Z-score: 3952.1 bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)
10 20 30 40 50
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
790 800 810 820 830 840
pF1KSD A
:
XP_011 A
>>XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquitin-pr (841 aa)
initn: 5876 init1: 5876 opt: 5876 Z-score: 3952.1 bits: 742.3 E(85289): 2.1e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:6-841)
10 20 30 40 50
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MITLKMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRH
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHV
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATRE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADSSSPG
790 800 810 820 830 840
pF1KSD A
:
XP_016 A
>>NP_001193927 (OMIM: 612062) E3 ubiquitin-protein ligas (936 aa)
initn: 5876 init1: 5876 opt: 5876 Z-score: 3951.5 bits: 742.3 E(85289): 2.3e-213
Smith-Waterman score: 5876; 100.0% identity (100.0% similar) in 836 aa overlap (1-836:101-936)
10 20 30
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPE
::::::::::::::::::::::::::::::
NP_001 SGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPE
80 90 100 110 120 130
40 50 60 70 80 90
pF1KSD LDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIK
140 150 160 170 180 190
100 110 120 130 140 150
pF1KSD LMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNS
200 210 220 230 240 250
160 170 180 190 200 210
pF1KSD MNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIP
260 270 280 290 300 310
220 230 240 250 260 270
pF1KSD CTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPG
320 330 340 350 360 370
280 290 300 310 320 330
pF1KSD RVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAA
380 390 400 410 420 430
340 350 360 370 380 390
pF1KSD HRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSL
440 450 460 470 480 490
400 410 420 430 440 450
pF1KSD APRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSGYLADCPGSD
500 510 520 530 540 550
460 470 480 490 500 510
pF1KSD SSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEA
560 570 580 590 600 610
520 530 540 550 560 570
pF1KSD GGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSN
620 630 640 650 660 670
580 590 600 610 620 630
pF1KSD SSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAGPSAGAAGS
680 690 700 710 720 730
640 650 660 670 680 690
pF1KSD STLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARG
740 750 760 770 780 790
700 710 720 730 740 750
pF1KSD GGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTH
800 810 820 830 840 850
760 770 780 790 800 810
pF1KSD SLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQD
860 870 880 890 900 910
820 830
pF1KSD TQESSTTATEAAGPRSHSADSSSPGA
::::::::::::::::::::::::::
NP_001 TQESSTTATEAAGPRSHSADSSSPGA
920 930
>>XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 ubiqu (869 aa)
initn: 845 init1: 266 opt: 686 Z-score: 472.4 bits: 98.5 E(85289): 1.4e-19
Smith-Waterman score: 906; 32.2% identity (53.5% similar) in 763 aa overlap (2-720:86-744)
10 20 30
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPEL
::: ::: .:...: : :....::::.:.
XP_016 DPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRR
60 70 80 90 100 110
40 50 60 70 80 90
pF1KSD DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKL
:.:::.. .::. : .:::.::.::..:. : .::.: : ::: . : :: ::
XP_016 APRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDAEKL
120 130 140 150 160 170
100 110 120 130 140
pF1KSD MNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQ-N
:..: :.. :..::. . :: : .:. :... .. .. : ...:. . :.:. .
XP_016 MEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHSRPD
180 190 200 210 220 230
150 160 170 180 190 200
pF1KSD SMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGEELR
... .. :. .. ::..... . : : :. :: :.. ::::::.. .:.:::
XP_016 PLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQELR
240 250 260 270 280
210 220 230 240 250 260
pF1KSD VIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVH
:: : :.:::.:::::: ::.::: : :: : . ... : :: :. : .
XP_016 VISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHLIRQ
290 300 310 320 330 340
270 280 290 300 310 320
pF1KSD YPGRVHRTNAIPAY----PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLH
.::..: .:: :.:... : .: :. .. : :
XP_016 HPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMGPRH
350 360 370 380
330 340 350 360 370 380
pF1KSD LDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LSYPE
:: :: : : .. .:.: :: : :: ::. .
XP_016 -------HRF---PRAAHPRAPGEQQRLAGA---------------QHPYAQGWGLSHLQ
390 400 410 420
390 400 410 420 430 440
pF1KSD QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSG
. .: : . : :: ::..::: : . : .: ::
XP_016 STSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTER---SG
430 440 450
450 460 470 480 490 500
pF1KSD YLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS
:::: :.::: ::: :: :::::::.::..: :::.:: ::: ::::::.::..: :
XP_016 YLADGPASDS----SSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCS
460 470 480 490 500 510
510 520 530 540 550
pF1KSD RS--PCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--PAS
. : :.. . : :. :. . : . : : : . : : :.
XP_016 PKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRKPGP
520 530 540 550 560 570
560 570 580 590 600 610
pF1KSD PSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCAC
.: : . .. . : .:...... : .:::. : . :.:
XP_016 ETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQCPR
580 590 600 610
620 630 640 650 660
pF1KSD CC-EPQPSPAGPSAGAAGSSTLF------LG---PHLYEGSGPAGGEPQSGSSQGLYGLH
:: :.:. :. ..:.:: :. :. . .::. :: :: .:
XP_016 ALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDATVH
620 630 640 650 660 670
670 680 690 700 710
pF1KSD P--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQYTL
: . .:. : .: : : : . . : : . ::... : . :
XP_016 PACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTP
680 690 700 710 720 730
720 730 740 750 760
pF1KSD TE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPH
. :: ::: :
XP_016 RQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSEGSGCGRERRLQLNISGQ
740 750 760 770 780 790
>>XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 ubiqu (869 aa)
initn: 845 init1: 266 opt: 686 Z-score: 472.4 bits: 98.5 E(85289): 1.4e-19
Smith-Waterman score: 906; 32.2% identity (53.5% similar) in 763 aa overlap (2-720:86-744)
10 20 30
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPEL
::: ::: .:...: : :....::::.:.
XP_011 DPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRR
60 70 80 90 100 110
40 50 60 70 80 90
pF1KSD DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKL
:.:::.. .::. : .:::.::.::..:. : .::.: : ::: . : :: ::
XP_011 APRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPL--GLTWPVVLIWGNDAEKL
120 130 140 150 160 170
100 110 120 130 140
pF1KSD MNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQ-N
:..: :.. :..::. . :: : .:. :... .. .. : ...:. . :.:. .
XP_011 MEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHSRPD
180 190 200 210 220 230
150 160 170 180 190 200
pF1KSD SMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGEELR
... .. :. .. ::..... . : : :. :: :.. ::::::.. .:.:::
XP_011 PLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQELR
240 250 260 270 280
210 220 230 240 250 260
pF1KSD VIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVH
:: : :.:::.:::::: ::.::: : :: : . ... : :: :. : .
XP_011 VISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHLIRQ
290 300 310 320 330 340
270 280 290 300 310 320
pF1KSD YPGRVHRTNAIPAY----PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLH
.::..: .:: :.:... : .: :. .. : :
XP_011 HPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMGPRH
350 360 370 380
330 340 350 360 370 380
pF1KSD LDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LSYPE
:: :: : : .. .:.: :: : :: ::. .
XP_011 -------HRF---PRAAHPRAPGEQQRLAGA---------------QHPYAQGWGLSHLQ
390 400 410 420
390 400 410 420 430 440
pF1KSD QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSG
. .: : . : :: ::..::: : . : .: ::
XP_011 STSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTER---SG
430 440 450
450 460 470 480 490 500
pF1KSD YLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS
:::: :.::: ::: :: :::::::.::..: :::.:: ::: ::::::.::..: :
XP_011 YLADGPASDS----SSGPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCS
460 470 480 490 500 510
510 520 530 540 550
pF1KSD RS--PCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--PAS
. : :.. . : :. :. . : . : : : . : : :.
XP_011 PKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRKPGP
520 530 540 550 560 570
560 570 580 590 600 610
pF1KSD PSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCAC
.: : . .. . : .:...... : .:::. : . :.:
XP_011 ETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQCPR
580 590 600 610
620 630 640 650 660
pF1KSD CC-EPQPSPAGPSAGAAGSSTLF------LG---PHLYEGSGPAGGEPQSGSSQGLYGLH
:: :.:. :. ..:.:: :. :. . .::. :: :: .:
XP_011 ALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDATVH
620 630 640 650 660 670
670 680 690 700 710
pF1KSD P--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGG---------GSGCYTEDYSVSVQYTL
: . .:. : .: : : : . . : : . ::... : . :
XP_011 PACQIFPHYTPSVAYPWSP----EAHPLICGPPGLDKRLLPETPGPCYSNSQPVWLCLTP
680 690 700 710 720 730
720 730 740 750 760
pF1KSD TE--EP-PPGCYPGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPH
. :: ::: :
XP_011 RQPLEPHPPGEGPSEWSSDTAEGRPCPYPHCQVLSAQPGEFSEGSGCGRERRLQLNISGQ
740 750 760 770 780 790
>>NP_060233 (OMIM: 612482,617108) E3 ubiquitin-protein l (783 aa)
initn: 845 init1: 266 opt: 662 Z-score: 456.9 bits: 95.4 E(85289): 1e-18
Smith-Waterman score: 919; 31.7% identity (52.9% similar) in 823 aa overlap (2-784:86-782)
10 20 30
pF1KSD MHPLGLCNNNDEEDLYEYGWVGVVKLEQPEL
::: ::: .:...: : :....::::.:.
NP_060 DPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNL-EPGFISIVKLESPRR
60 70 80 90 100 110
40 50 60 70 80 90
pF1KSD DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKL
:.:::.. .::. : .:::.::.::..:. : .::.: : ::: . : :: ::
NP_060 APRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQ--PLGLTWPVVLIWGNDAEKL
120 130 140 150 160 170
100 110 120 130 140
pF1KSD MNIVNKQKVARARIQHR-PPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQ-N
:..: :.. :..::. . :: : .:. :... .. .. : ...:. . :.:. .
NP_060 MEFVYKNQKAHVRIELKEPPAWPD--YDVWILMTVVGTIFVIILASVLRIRCRPRHSRPD
180 190 200 210 220 230
150 160 170 180 190 200
pF1KSD SMNRLAVQALEKMETRKFNSKSKGRREGSCGAL-DTLSSSSTSD-CAICLEKYIDGEELR
... .. :. .. ::..... . : : :. :: :.. ::::::.. .:.:::
NP_060 PLQQRTAWAISQLATRRYQASCRQAR----GEWPDSGSSCSSAPVCAICLEEFSEGQELR
240 250 260 270 280
210 220 230 240 250 260
pF1KSD VIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVH
:: : :.:::.:::::: ::.::: : :: : . ... : :: :. : .
NP_060 VISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDSFSQSLGPSRSYQEPGR--RLHLIRQ
290 300 310 320 330 340
270 280 290 300 310 320
pF1KSD YPGRVHRTNAIPAY----PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLH
.::..: .:: :.:... : .: :. .. : :
NP_060 HPGHAHYH--LPAAYLLGPSRSAVARPPRP---------------GPFLPSQEPGMGPRH
350 360 370 380
330 340 350 360 370 380
pF1KSD LDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQG--LSYPE
:: :: : : .. .:.: :: : :: ::. .
NP_060 -------HRFP---RAAHPRAPGEQQRLAGA---------------QHPYAQGWGLSHLQ
390 400 410 420
390 400 410 420 430 440
pF1KSD QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCSG
. .: : . : :: ::..::: : . : .:: :
NP_060 STSQHPAA-CPVPLRRARPPDSSGS-----------------GES-----YCTERS---G
430 440 450
450 460 470 480 490 500
pF1KSD YLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRS
:::: :.::::: : :: :::::::.::..: :::.:: ::: ::::::.::..: :
NP_060 YLADGPASDSSS----GPCHGSSSDSVVNCTDISLQGVHGSSSTFCSSLSSDFDPLVYCS
460 470 480 490 500 510
510 520 530 540 550
pF1KSD RS--PCRASEAGGSGSSGRG-----PALCFEGSPPPEELPAVHSHGAGRGEPWPG--PAS
. : :.. . : :. :. . : . : : : . : : :.
NP_060 PKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVSSHVHYHRHRHHHYKKRFQ-WHGRKPGP
520 530 540 550 560 570
560 570 580 590 600 610
pF1KSD PSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCAC
.: : . .. . : .:...... : .:::. : . :.:
NP_060 ETGVPQSRPPIP---RTQPQPEPPSPDQQVTR-----SNSAAPSGRLSN------PQCPR
580 590 600 610
620 630 640 650 660
pF1KSD CC-EPQPSPAGPSAGAAGSSTLF------LG---PHLYEGSGPAGGEPQSGSSQGLYGLH
:: :.:. :. ..:.:: :. :. . .::. :: :: .:
NP_060 ALPEPAPGPVDASSICPSTSSLFNLQKSSLSARHPQRKRRGGPS--EPTPGSRPQDATVH
620 630 640 650 660 670
670 680 690 700 710
pF1KSD P--DHLPR-TDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCY
: . .:. : .: : : : . . : : . . : : : : ::
NP_060 PACQIFPHYTPSVAYPWSP----EAHPLICGPPGLD-----------KRLLPETPGP-CY
680 690 700 710
720 730 740 750 760 770
pF1KSD PGARD----LSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPH-RGLGA--
... :. : :. :. :.. : .: ..: : :: . :.:
NP_060 SNSQPVWLCLTPRQPLEPHP-------PGE--GPSEWSS-DTAEGRPCPYPHCQVLSAQP
720 730 740 750 760
780 790 800 810 820 830
pF1KSD -TREEERALCCQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAGPRSHSADS
..:: . :: ::
NP_060 GSEEELEELCEQAV
770 780
836 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 05:06:51 2016 done: Thu Nov 3 05:06:53 2016
Total Scan time: 14.470 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]