Result of FASTA (omim) for
pF1KSDA1089
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1089, 1016 aa
1>>>pF1KSDA1089 1016 - 1016 aa - 1016 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.8996+/-0.000379; mu= 10.3109+/- 0.024
mean_var=156.6909+/-30.733, 0's: 0 Z-trim(118.1): 48 B-trim: 107 in 1/59
Lambda= 0.102460
statistics sampled from 30603 (30653) to 30603 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.359), width: 16
Scan time: 17.040
The best scores are: opt bits E(85289)
NP_056142 (OMIM: 610962) protein SMG5 isoform 1 [H (1016) 6778 1014.6 0
NP_001310545 (OMIM: 610962) protein SMG5 isoform 4 ( 950) 6349 951.2 0
NP_001310546 (OMIM: 610962) protein SMG5 isoform 4 ( 950) 6349 951.2 0
XP_016856331 (OMIM: 610962) PREDICTED: protein SMG ( 804) 5338 801.7 0
NP_001310543 (OMIM: 610962) protein SMG5 isoform 2 ( 963) 5101 766.7 0
XP_016856332 (OMIM: 610962) PREDICTED: protein SMG ( 755) 5008 752.9 1.5e-216
NP_001310544 (OMIM: 610962) protein SMG5 isoform 3 ( 970) 3977 600.5 1.4e-170
NP_963862 (OMIM: 610964) protein SMG7 isoform 2 [H (1091) 278 53.8 6.1e-06
XP_011508511 (OMIM: 610964) PREDICTED: protein SMG (1120) 278 53.8 6.2e-06
XP_016858456 (OMIM: 610964) PREDICTED: protein SMG (1120) 278 53.8 6.2e-06
NP_775179 (OMIM: 610964) protein SMG7 isoform 1 [H (1137) 278 53.8 6.3e-06
XP_006711741 (OMIM: 610964) PREDICTED: protein SMG (1141) 278 53.8 6.3e-06
XP_011508510 (OMIM: 610964) PREDICTED: protein SMG (1166) 278 53.8 6.4e-06
XP_005245710 (OMIM: 610964) PREDICTED: protein SMG (1169) 278 53.8 6.4e-06
XP_011508509 (OMIM: 610964) PREDICTED: protein SMG (1169) 278 53.8 6.4e-06
XP_016858455 (OMIM: 610964) PREDICTED: protein SMG (1170) 278 53.8 6.4e-06
NP_001317936 (OMIM: 610964) protein SMG7 isoform 6 (1170) 278 53.8 6.4e-06
XP_011508508 (OMIM: 610964) PREDICTED: protein SMG (1170) 278 53.8 6.4e-06
NP_963863 (OMIM: 610964) protein SMG7 isoform 4 [H (1178) 278 53.8 6.5e-06
XP_005245709 (OMIM: 610964) PREDICTED: protein SMG (1187) 278 53.8 6.5e-06
XP_005245705 (OMIM: 610964) PREDICTED: protein SMG (1216) 278 53.8 6.6e-06
XP_005245706 (OMIM: 610964) PREDICTED: protein SMG (1216) 278 53.8 6.6e-06
XP_011508507 (OMIM: 610964) PREDICTED: protein SMG (1216) 278 53.8 6.6e-06
XP_016858457 (OMIM: 610964) PREDICTED: protein SMG (1049) 271 52.7 1.2e-05
XP_011508512 (OMIM: 610964) PREDICTED: protein SMG (1099) 271 52.8 1.3e-05
NP_001167532 (OMIM: 610964) protein SMG7 isoform 5 (1145) 271 52.8 1.3e-05
XP_011522076 (OMIM: 610963) PREDICTED: telomerase- ( 897) 242 48.4 0.00021
XP_005256627 (OMIM: 610963) PREDICTED: telomerase- ( 899) 242 48.4 0.00021
XP_011522075 (OMIM: 610963) PREDICTED: telomerase- ( 904) 242 48.4 0.00021
XP_016879887 (OMIM: 610963) PREDICTED: telomerase- ( 944) 242 48.4 0.00022
XP_011522074 (OMIM: 610963) PREDICTED: telomerase- ( 961) 242 48.4 0.00022
XP_005256626 (OMIM: 610963) PREDICTED: telomerase- (1388) 242 48.5 0.00029
XP_011522071 (OMIM: 610963) PREDICTED: telomerase- (1388) 242 48.5 0.00029
NP_060045 (OMIM: 610963) telomerase-binding protei (1419) 242 48.5 0.0003
>>NP_056142 (OMIM: 610962) protein SMG5 isoform 1 [Homo (1016 aa)
initn: 6778 init1: 6778 opt: 6778 Z-score: 5420.8 bits: 1014.6 E(85289): 0
Smith-Waterman score: 6778; 100.0% identity (100.0% similar) in 1016 aa overlap (1-1016:1-1016)
10 20 30 40 50 60
pF1KSD MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
910 920 930 940 950 960
970 980 990 1000 1010
pF1KSD AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
970 980 990 1000 1010
>>NP_001310545 (OMIM: 610962) protein SMG5 isoform 4 [Ho (950 aa)
initn: 6349 init1: 6349 opt: 6349 Z-score: 5078.5 bits: 951.2 E(85289): 0
Smith-Waterman score: 6349; 100.0% identity (100.0% similar) in 950 aa overlap (67-1016:1-950)
40 50 60 70 80 90
pF1KSD ILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKT
::::::::::::::::::::::::::::::
NP_001 MFLHPVDYGRKAEELLWRKVYYEVIQLIKT
10 20 30
100 110 120 130 140 150
pF1KSD NKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKP
40 50 60 70 80 90
160 170 180 190 200 210
pF1KSD VSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFN
100 110 120 130 140 150
220 230 240 250 260 270
pF1KSD QLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSP
160 170 180 190 200 210
280 290 300 310 320 330
pF1KSD GKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLA
220 230 240 250 260 270
340 350 360 370 380 390
pF1KSD SEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVN
280 290 300 310 320 330
400 410 420 430 440 450
pF1KSD IRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRL
340 350 360 370 380 390
460 470 480 490 500 510
pF1KSD SCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEM
400 410 420 430 440 450
520 530 540 550 560 570
pF1KSD NSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQ
460 470 480 490 500 510
580 590 600 610 620 630
pF1KSD TKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSC
520 530 540 550 560 570
640 650 660 670 680 690
pF1KSD RNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAA
580 590 600 610 620 630
700 710 720 730 740 750
pF1KSD GELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLL
640 650 660 670 680 690
760 770 780 790 800 810
pF1KSD STLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQ
700 710 720 730 740 750
820 830 840 850 860 870
pF1KSD EEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLAT
760 770 780 790 800 810
880 890 900 910 920 930
pF1KSD SGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLK
820 830 840 850 860 870
940 950 960 970 980 990
pF1KSD RQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAA
880 890 900 910 920 930
1000 1010
pF1KSD HASVDIKNVLDFYKQWKEIG
::::::::::::::::::::
NP_001 HASVDIKNVLDFYKQWKEIG
940 950
>>NP_001310546 (OMIM: 610962) protein SMG5 isoform 4 [Ho (950 aa)
initn: 6349 init1: 6349 opt: 6349 Z-score: 5078.5 bits: 951.2 E(85289): 0
Smith-Waterman score: 6349; 100.0% identity (100.0% similar) in 950 aa overlap (67-1016:1-950)
40 50 60 70 80 90
pF1KSD ILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKT
::::::::::::::::::::::::::::::
NP_001 MFLHPVDYGRKAEELLWRKVYYEVIQLIKT
10 20 30
100 110 120 130 140 150
pF1KSD NKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKP
40 50 60 70 80 90
160 170 180 190 200 210
pF1KSD VSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFN
100 110 120 130 140 150
220 230 240 250 260 270
pF1KSD QLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSP
160 170 180 190 200 210
280 290 300 310 320 330
pF1KSD GKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLA
220 230 240 250 260 270
340 350 360 370 380 390
pF1KSD SEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVN
280 290 300 310 320 330
400 410 420 430 440 450
pF1KSD IRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRL
340 350 360 370 380 390
460 470 480 490 500 510
pF1KSD SCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEM
400 410 420 430 440 450
520 530 540 550 560 570
pF1KSD NSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQ
460 470 480 490 500 510
580 590 600 610 620 630
pF1KSD TKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSC
520 530 540 550 560 570
640 650 660 670 680 690
pF1KSD RNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNERSIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAA
580 590 600 610 620 630
700 710 720 730 740 750
pF1KSD GELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLL
640 650 660 670 680 690
760 770 780 790 800 810
pF1KSD STLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STLEESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQ
700 710 720 730 740 750
820 830 840 850 860 870
pF1KSD EEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLAT
760 770 780 790 800 810
880 890 900 910 920 930
pF1KSD SGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRFIVIIPRTVIDGLDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLK
820 830 840 850 860 870
940 950 960 970 980 990
pF1KSD RQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQDADAWTLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAA
880 890 900 910 920 930
1000 1010
pF1KSD HASVDIKNVLDFYKQWKEIG
::::::::::::::::::::
NP_001 HASVDIKNVLDFYKQWKEIG
940 950
>>XP_016856331 (OMIM: 610962) PREDICTED: protein SMG5 is (804 aa)
initn: 5338 init1: 5338 opt: 5338 Z-score: 4271.9 bits: 801.7 E(85289): 0
Smith-Waterman score: 5338; 100.0% identity (100.0% similar) in 804 aa overlap (213-1016:1-804)
190 200 210 220 230 240
pF1KSD RYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSE
::::::::::::::::::::::::::::::
XP_016 MPFNQLGTLAGSKYYNVEAMYCYLRCIQSE
10 20 30
250 260 270 280 290 300
pF1KSD VSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQPKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQPKS
40 50 60 70 80 90
310 320 330 340 350 360
pF1KSD SSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIIC
100 110 120 130 140 150
370 380 390 400 410 420
pF1KSD LMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPE
160 170 180 190 200 210
430 440 450 460 470 480
pF1KSD SKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDS
220 230 240 250 260 270
490 500 510 520 530 540
pF1KSD SHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPP
280 290 300 310 320 330
550 560 570 580 590 600
pF1KSD RGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSA
340 350 360 370 380 390
610 620 630 640 650 660
pF1KSD SHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKVFL
400 410 420 430 440 450
670 680 690 700 710 720
pF1KSD DWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELPDL
460 470 480 490 500 510
730 740 750 760 770 780
pF1KSD PSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQGS
520 530 540 550 560 570
790 800 810 820 830 840
pF1KSD ILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQLEG
580 590 600 610 620 630
850 860 870 880 890 900
pF1KSD SLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHPGA
640 650 660 670 680 690
910 920 930 940 950 960
pF1KSD RDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQGAG
700 710 720 730 740 750
970 980 990 1000 1010
pF1KSD EEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
760 770 780 790 800
>>NP_001310543 (OMIM: 610962) protein SMG5 isoform 2 [Ho (963 aa)
initn: 5098 init1: 5098 opt: 5101 Z-score: 4081.4 bits: 766.7 E(85289): 0
Smith-Waterman score: 6316; 94.8% identity (94.8% similar) in 1016 aa overlap (1-1016:1-963)
10 20 30 40 50 60
pF1KSD MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ
:::::::::::::::::::::::::::::::::::::::::
NP_001 DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEE-------------------
730 740 750 760
790 800 810 820 830 840
pF1KSD GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL
::::::::::::::::::::::::::
NP_001 ----------------------------------AQEEARRNRLMRDMAQLRLQLEVSQL
770 780
850 860 870 880 890 900
pF1KSD EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
790 800 810 820 830 840
910 920 930 940 950 960
pF1KSD GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
850 860 870 880 890 900
970 980 990 1000 1010
pF1KSD AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
910 920 930 940 950 960
>>XP_016856332 (OMIM: 610962) PREDICTED: protein SMG5 is (755 aa)
initn: 5008 init1: 5008 opt: 5008 Z-score: 4008.7 bits: 752.9 E(85289): 1.5e-216
Smith-Waterman score: 5008; 100.0% identity (100.0% similar) in 755 aa overlap (262-1016:1-755)
240 250 260 270 280 290
pF1KSD MYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNF
::::::::::::::::::::::::::::::
XP_016 MYHQLKKCETRKLSPGKKRCKDIKRLLVNF
10 20 30
300 310 320 330 340 350
pF1KSD MYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLP
40 50 60 70 80 90
360 370 380 390 400 410
pF1KSD DLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVP
100 110 120 130 140 150
420 430 440 450 460 470
pF1KSD AFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDD
160 170 180 190 200 210
480 490 500 510 520 530
pF1KSD SDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEE
220 230 240 250 260 270
540 550 560 570 580 590
pF1KSD EGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLL
280 290 300 310 320 330
600 610 620 630 640 650
pF1KSD LQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMA
340 350 360 370 380 390
660 670 680 690 700 710
pF1KSD EGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQ
400 410 420 430 440 450
720 730 740 750 760 770
pF1KSD DLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRS
460 470 480 490 500 510
780 790 800 810 820 830
pF1KSD FGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQL
520 530 540 550 560 570
840 850 860 870 880 890
pF1KSD RLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQLEVSQLEGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDG
580 590 600 610 620 630
900 910 920 930 940 950
pF1KSD LDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDLLKKEHPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDS
640 650 660 670 680 690
960 970 980 990 1000 1010
pF1KSD CKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKQLTLAQGAGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQ
700 710 720 730 740 750
pF1KSD WKEIG
:::::
XP_016 WKEIG
>>NP_001310544 (OMIM: 610962) protein SMG5 isoform 3 [Ho (970 aa)
initn: 6471 init1: 3977 opt: 3977 Z-score: 3183.5 bits: 600.5 E(85289): 1.4e-170
Smith-Waterman score: 6383; 95.5% identity (95.5% similar) in 1016 aa overlap (1-1016:1-970)
10 20 30 40 50 60
pF1KSD MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE
:::::::::::: ::
NP_001 ICLMCVHSLERA----------------------------------------------DE
370
430 440 450 460 470 480
pF1KSD PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
380 390 400 410 420 430
490 500 510 520 530 540
pF1KSD DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
440 450 460 470 480 490
550 560 570 580 590 600
pF1KSD PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
500 510 520 530 540 550
610 620 630 640 650 660
pF1KSD SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
560 570 580 590 600 610
670 680 690 700 710 720
pF1KSD FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
620 630 640 650 660 670
730 740 750 760 770 780
pF1KSD DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ
680 690 700 710 720 730
790 800 810 820 830 840
pF1KSD GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL
740 750 760 770 780 790
850 860 870 880 890 900
pF1KSD EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
800 810 820 830 840 850
910 920 930 940 950 960
pF1KSD GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
860 870 880 890 900 910
970 980 990 1000 1010
pF1KSD AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
920 930 940 950 960 970
>>NP_963862 (OMIM: 610964) protein SMG7 isoform 2 [Homo (1091 aa)
initn: 203 init1: 138 opt: 278 Z-score: 227.7 bits: 53.8 E(85289): 6.1e-06
Smith-Waterman score: 281; 25.0% identity (57.0% similar) in 344 aa overlap (56-379:33-358)
30 40 50 60 70 80
pF1KSD AVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYG--RKAEELLW
:. :..: : :.. ..:. .:.:. ::
NP_963 LQSAQYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQK-MLVTDLEYALDKKVEQDLW
10 20 30 40 50 60
90 100 110 120 130 140
pF1KSD RKVYYEVIQLIKTNKKH--IHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCI
... . : .. . :. .:: .. : :. ::: .:: . . ....: : .
NP_963 NHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRV
70 80 90 100 110 120
150 160 170 180 190
pF1KSD DWTHVTDPLIGCKKP-VSASGKEMDWA-QMACHRCLVYLGDLSRYQNELAGVDTELLAER
... .:. :. .:: : .. . .. :..:::.:::..::.:. . ::
NP_963 KSSQL--GIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQ------AES
130 140 150 160 170
200 210 220 230 240 250
pF1KSD FYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKA
.: .: ...:. :.:.:::. ::.:: .. ... : : : . : .: ::.. .::
NP_963 YYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKA
180 190 200 210 220 230
260 270 280 290 300 310
pF1KSD AKMYHQLKKCETRKLSPGKKRCKDIKRLLVNF---MYL-QSL--LQPKSSSVDSELTSL-
:.: : .:. . ...: .:: .:: :.: ... .. :
NP_963 L---------ESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLL
240 250 260 270 280
320 330 340 350 360
pF1KSD ------CQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCV
:.... . :: : ..: .:.. .. .:: . : .. ..:
NP_963 FQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCK
290 300 310 320 330 340
370 380 390 400 410 420
pF1KSD HSLERAGSKQ-YSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKE
:. .... :.:
NP_963 CPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHE
350 360 370 380 390 400
>>XP_011508511 (OMIM: 610964) PREDICTED: protein SMG7 is (1120 aa)
initn: 203 init1: 138 opt: 278 Z-score: 227.5 bits: 53.8 E(85289): 6.2e-06
Smith-Waterman score: 281; 25.0% identity (57.0% similar) in 344 aa overlap (56-379:62-387)
30 40 50 60 70 80
pF1KSD AVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYG--RKAEELLW
:. :..: : :.. ..:. .:.:. ::
XP_011 HLKSSNIRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQK-MLVTDLEYALDKKVEQDLW
40 50 60 70 80 90
90 100 110 120 130 140
pF1KSD RKVYYEVIQLIKTNKKH--IHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCI
... . : .. . :. .:: .. : :. ::: .:: . . ....: : .
XP_011 NHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRV
100 110 120 130 140 150
150 160 170 180 190
pF1KSD DWTHVTDPLIGCKKP-VSASGKEMDWA-QMACHRCLVYLGDLSRYQNELAGVDTELLAER
... .:. :. .:: : .. . .. :..:::.:::..::.:. . ::
XP_011 KSSQL--GIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQ------AES
160 170 180 190 200
200 210 220 230 240 250
pF1KSD FYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKA
.: .: ...:. :.:.:::. ::.:: .. ... : : : . : .: ::.. .::
XP_011 YYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKA
210 220 230 240 250 260
260 270 280 290 300 310
pF1KSD AKMYHQLKKCETRKLSPGKKRCKDIKRLLVNF---MYL-QSL--LQPKSSSVDSELTSL-
:.: : .:. . ...: .:: .:: :.: ... .. :
XP_011 L---------ESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLL
270 280 290 300 310
320 330 340 350 360
pF1KSD ------CQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCV
:.... . :: : ..: .:.. .. .:: . : .. ..:
XP_011 FQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCK
320 330 340 350 360 370
370 380 390 400 410 420
pF1KSD HSLERAGSKQ-YSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKE
:. .... :.:
XP_011 CPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHE
380 390 400 410 420 430
>>XP_016858456 (OMIM: 610964) PREDICTED: protein SMG7 is (1120 aa)
initn: 203 init1: 138 opt: 278 Z-score: 227.5 bits: 53.8 E(85289): 6.2e-06
Smith-Waterman score: 281; 25.0% identity (57.0% similar) in 344 aa overlap (56-379:62-387)
30 40 50 60 70 80
pF1KSD AVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLMFLHPVDYG--RKAEELLW
:. :..: : :.. ..:. .:.:. ::
XP_016 HLKSSNIRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQK-MLVTDLEYALDKKVEQDLW
40 50 60 70 80 90
90 100 110 120 130 140
pF1KSD RKVYYEVIQLIKTNKKH--IHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCI
... . : .. . :. .:: .. : :. ::: .:: . . ....: : .
XP_016 NHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRV
100 110 120 130 140 150
150 160 170 180 190
pF1KSD DWTHVTDPLIGCKKP-VSASGKEMDWA-QMACHRCLVYLGDLSRYQNELAGVDTELLAER
... .:. :. .:: : .. . .. :..:::.:::..::.:. . ::
XP_016 KSSQL--GIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQ------AES
160 170 180 190 200
200 210 220 230 240 250
pF1KSD FYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKA
.: .: ...:. :.:.:::. ::.:: .. ... : : : . : .: ::.. .::
XP_016 YYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKA
210 220 230 240 250 260
260 270 280 290 300 310
pF1KSD AKMYHQLKKCETRKLSPGKKRCKDIKRLLVNF---MYL-QSL--LQPKSSSVDSELTSL-
:.: : .:. . ...: .:: .:: :.: ... .. :
XP_016 L---------ESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLL
270 280 290 300 310
320 330 340 350 360
pF1KSD ------CQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCV
:.... . :: : ..: .:.. .. .:: . : .. ..:
XP_016 FQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCK
320 330 340 350 360 370
370 380 390 400 410 420
pF1KSD HSLERAGSKQ-YSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKE
:. .... :.:
XP_016 CPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHE
380 390 400 410 420 430
1016 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:57:13 2016 done: Thu Nov 3 04:57:15 2016
Total Scan time: 17.040 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]