Result of FASTA (omim) for
pF1KSDA0738
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0738, 921 aa
1>>>pF1KSDA0738 921 - 921 aa - 921 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5738+/-0.00041; mu= 19.1571+/- 0.025
mean_var=66.9908+/-13.541, 0's: 0 Z-trim(111.3): 24 B-trim: 36 in 1/54
Lambda= 0.156699
statistics sampled from 19887 (19908) to 19887 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.233), width: 16
Scan time: 11.590
The best scores are: opt bits E(85289)
NP_055534 (OMIM: 616251) TRPM8 channel-associated ( 921) 6285 1430.5 0
XP_005250134 (OMIM: 616251) PREDICTED: TRPM8 chann ( 921) 6284 1430.3 0
XP_006716254 (OMIM: 616251) PREDICTED: TRPM8 chann ( 921) 6284 1430.3 0
XP_005250132 (OMIM: 616251) PREDICTED: TRPM8 chann ( 921) 6284 1430.3 0
XP_005250133 (OMIM: 616251) PREDICTED: TRPM8 chann ( 921) 6284 1430.3 0
XP_005250131 (OMIM: 616251) PREDICTED: TRPM8 chann ( 921) 6284 1430.3 0
NP_001193867 (OMIM: 616251) TRPM8 channel-associat ( 919) 6265 1426.0 0
XP_016868323 (OMIM: 616251) PREDICTED: TRPM8 chann ( 919) 6264 1425.8 0
XP_016868325 (OMIM: 616251) PREDICTED: TRPM8 chann ( 919) 6264 1425.8 0
XP_006716255 (OMIM: 616251) PREDICTED: TRPM8 chann ( 919) 6264 1425.8 0
XP_016868324 (OMIM: 616251) PREDICTED: TRPM8 chann ( 919) 6264 1425.8 0
XP_016868322 (OMIM: 616251) PREDICTED: TRPM8 chann ( 919) 6264 1425.8 0
XP_006715990 (OMIM: 616252) PREDICTED: TRPM8 chann ( 919) 4108 938.4 0
NP_001123497 (OMIM: 616252) TRPM8 channel-associat ( 845) 3700 846.1 0
NP_775949 (OMIM: 616252) TRPM8 channel-associated ( 845) 3700 846.1 0
XP_006715991 (OMIM: 616252) PREDICTED: TRPM8 chann ( 845) 3700 846.1 0
NP_001193870 (OMIM: 616251) TRPM8 channel-associat ( 497) 3436 786.4 0
XP_011514361 (OMIM: 616252) PREDICTED: TRPM8 chann ( 755) 3150 721.8 3.1e-207
NP_001123498 (OMIM: 616252) TRPM8 channel-associat ( 815) 1934 446.9 1.9e-124
>>NP_055534 (OMIM: 616251) TRPM8 channel-associated fact (921 aa)
initn: 6285 init1: 6285 opt: 6285 Z-score: 7670.3 bits: 1430.5 E(85289): 0
Smith-Waterman score: 6285; 100.0% identity (100.0% similar) in 921 aa overlap (1-921:1-921)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::::
NP_055 AYLPEWKENIMKLYLLTQMPH
910 920
>>XP_005250134 (OMIM: 616251) PREDICTED: TRPM8 channel-a (921 aa)
initn: 6284 init1: 6284 opt: 6284 Z-score: 7669.1 bits: 1430.3 E(85289): 0
Smith-Waterman score: 6284; 99.9% identity (100.0% similar) in 921 aa overlap (1-921:1-921)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::::
XP_005 AYLPEWKENIMKLYLLTQMPH
910 920
>>XP_006716254 (OMIM: 616251) PREDICTED: TRPM8 channel-a (921 aa)
initn: 6284 init1: 6284 opt: 6284 Z-score: 7669.1 bits: 1430.3 E(85289): 0
Smith-Waterman score: 6284; 99.9% identity (100.0% similar) in 921 aa overlap (1-921:1-921)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::::
XP_006 AYLPEWKENIMKLYLLTQMPH
910 920
>>XP_005250132 (OMIM: 616251) PREDICTED: TRPM8 channel-a (921 aa)
initn: 6284 init1: 6284 opt: 6284 Z-score: 7669.1 bits: 1430.3 E(85289): 0
Smith-Waterman score: 6284; 99.9% identity (100.0% similar) in 921 aa overlap (1-921:1-921)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::::
XP_005 AYLPEWKENIMKLYLLTQMPH
910 920
>>XP_005250133 (OMIM: 616251) PREDICTED: TRPM8 channel-a (921 aa)
initn: 6284 init1: 6284 opt: 6284 Z-score: 7669.1 bits: 1430.3 E(85289): 0
Smith-Waterman score: 6284; 99.9% identity (100.0% similar) in 921 aa overlap (1-921:1-921)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::::
XP_005 AYLPEWKENIMKLYLLTQMPH
910 920
>>XP_005250131 (OMIM: 616251) PREDICTED: TRPM8 channel-a (921 aa)
initn: 6284 init1: 6284 opt: 6284 Z-score: 7669.1 bits: 1430.3 E(85289): 0
Smith-Waterman score: 6284; 99.9% identity (100.0% similar) in 921 aa overlap (1-921:1-921)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::::
XP_005 AYLPEWKENIMKLYLLTQMPH
910 920
>>NP_001193867 (OMIM: 616251) TRPM8 channel-associated f (919 aa)
initn: 6265 init1: 6265 opt: 6265 Z-score: 7645.9 bits: 1426.0 E(85289): 0
Smith-Waterman score: 6265; 100.0% identity (100.0% similar) in 919 aa overlap (1-919:1-919)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::
NP_001 AYLPEWKENIMKLYLLTQM
910
>>XP_016868323 (OMIM: 616251) PREDICTED: TRPM8 channel-a (919 aa)
initn: 6264 init1: 6264 opt: 6264 Z-score: 7644.7 bits: 1425.8 E(85289): 0
Smith-Waterman score: 6264; 99.9% identity (100.0% similar) in 919 aa overlap (1-919:1-919)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::
XP_016 AYLPEWKENIMKLYLLTQM
910
>>XP_016868325 (OMIM: 616251) PREDICTED: TRPM8 channel-a (919 aa)
initn: 6264 init1: 6264 opt: 6264 Z-score: 7644.7 bits: 1425.8 E(85289): 0
Smith-Waterman score: 6264; 99.9% identity (100.0% similar) in 919 aa overlap (1-919:1-919)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::
XP_016 AYLPEWKENIMKLYLLTQM
910
>>XP_006716255 (OMIM: 616251) PREDICTED: TRPM8 channel-a (919 aa)
initn: 6264 init1: 6264 opt: 6264 Z-score: 7644.7 bits: 1425.8 E(85289): 0
Smith-Waterman score: 6264; 99.9% identity (100.0% similar) in 919 aa overlap (1-919:1-919)
10 20 30 40 50 60
pF1KSD MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIAASSYGRGRLV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLGVYCIDAYNETMTEKLVKFMKCGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSDDREELLHGISELDISNSDCFPSQLLV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRRIQENPGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQI
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GWEPFIRLFTEYRNQTNLPTENVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVATSL
850 860 870 880 890 900
910 920
pF1KSD AYLPEWKENIMKLYLLTQMPH
:::::::::::::::::::
XP_006 AYLPEWKENIMKLYLLTQM
910
921 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:41:00 2016 done: Thu Nov 3 18:41:02 2016
Total Scan time: 11.590 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]