Result of FASTA (omim) for
pF1KSDA0526
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0526, 562 aa
1>>>pF1KSDA0526 562 - 562 aa - 562 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6456+/-0.000427; mu= 22.1549+/- 0.026
mean_var=62.1516+/-13.005, 0's: 0 Z-trim(110.6): 56 B-trim: 246 in 1/49
Lambda= 0.162685
statistics sampled from 18965 (19021) to 18965 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.581), E-opt: 0.2 (0.223), width: 16
Scan time: 9.810
The best scores are: opt bits E(85289)
NP_004854 (OMIM: 605713,613640) serine palmitoyltr ( 562) 3744 887.9 0
XP_011535686 (OMIM: 605713,613640) PREDICTED: seri ( 470) 2915 693.3 4.6e-199
NP_060797 (OMIM: 611120) serine palmitoyltransfera ( 552) 2580 614.7 2.4e-175
XP_011527581 (OMIM: 611120) PREDICTED: serine palm ( 523) 2466 587.9 2.6e-167
XP_011527582 (OMIM: 611120) PREDICTED: serine palm ( 361) 1829 438.3 2e-122
XP_016883411 (OMIM: 611120) PREDICTED: serine palm ( 301) 760 187.3 5.9e-47
XP_011516440 (OMIM: 162400,605712) PREDICTED: seri ( 365) 574 143.7 9.4e-34
NP_006406 (OMIM: 162400,605712) serine palmitoyltr ( 473) 573 143.6 1.4e-33
NP_001268232 (OMIM: 162400,605712) serine palmitoy ( 513) 573 143.6 1.4e-33
XP_016869690 (OMIM: 162400,605712) PREDICTED: seri ( 351) 478 121.2 5.6e-27
XP_016869689 (OMIM: 162400,605712) PREDICTED: seri ( 351) 478 121.2 5.6e-27
XP_016869691 (OMIM: 162400,605712) PREDICTED: seri ( 346) 473 120.0 1.2e-26
XP_011516441 (OMIM: 162400,605712) PREDICTED: seri ( 318) 437 111.5 4.1e-24
NP_055106 (OMIM: 607422) 2-amino-3-ketobutyrate co ( 419) 430 110.0 1.6e-23
XP_016884166 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 419) 430 110.0 1.6e-23
XP_005261467 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 445) 430 110.0 1.6e-23
NP_001165161 (OMIM: 607422) 2-amino-3-ketobutyrate ( 445) 430 110.0 1.6e-23
XP_016884164 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 507) 430 110.0 1.8e-23
XP_011528325 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 253) 413 105.8 1.7e-22
XP_005261468 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 433) 413 106.0 2.6e-22
XP_005261466 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 459) 413 106.0 2.7e-22
XP_016884165 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 495) 413 106.1 2.8e-22
XP_016884163 (OMIM: 607422) PREDICTED: 2-amino-3-k ( 521) 413 106.1 2.9e-22
NP_001291372 (OMIM: 125290) 5-aminolevulinate synt ( 640) 382 98.9 5.3e-20
NP_000679 (OMIM: 125290) 5-aminolevulinate synthas ( 640) 382 98.9 5.3e-20
NP_954635 (OMIM: 125290) 5-aminolevulinate synthas ( 640) 382 98.9 5.3e-20
NP_001291373 (OMIM: 125290) 5-aminolevulinate synt ( 657) 382 98.9 5.4e-20
NP_001033056 (OMIM: 300751,300752,301300) 5-aminol ( 550) 360 93.6 1.7e-18
NP_001033057 (OMIM: 300751,300752,301300) 5-aminol ( 574) 360 93.7 1.8e-18
XP_016884843 (OMIM: 300751,300752,301300) PREDICTE ( 582) 360 93.7 1.8e-18
NP_000023 (OMIM: 300751,300752,301300) 5-aminolevu ( 587) 360 93.7 1.8e-18
XP_005262052 (OMIM: 300751,300752,301300) PREDICTE ( 611) 360 93.7 1.8e-18
XP_011529073 (OMIM: 300751,300752,301300) PREDICTE ( 300) 330 86.4 1.4e-16
XP_016861362 (OMIM: 125290) PREDICTED: 5-aminolevu ( 585) 267 71.8 6.6e-12
XP_011531780 (OMIM: 125290) PREDICTED: 5-aminolevu ( 602) 267 71.9 6.8e-12
XP_011531779 (OMIM: 125290) PREDICTED: 5-aminolevu ( 611) 267 71.9 6.8e-12
>>NP_004854 (OMIM: 605713,613640) serine palmitoyltransf (562 aa)
initn: 3744 init1: 3744 opt: 3744 Z-score: 4745.4 bits: 887.9 E(85289): 0
Smith-Waterman score: 3744; 100.0% identity (100.0% similar) in 562 aa overlap (1-562:1-562)
10 20 30 40 50 60
pF1KSD MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
490 500 510 520 530 540
550 560
pF1KSD RHRLVPLLDRPFDETTYEETED
::::::::::::::::::::::
NP_004 RHRLVPLLDRPFDETTYEETED
550 560
>>XP_011535686 (OMIM: 605713,613640) PREDICTED: serine p (470 aa)
initn: 2942 init1: 2911 opt: 2915 Z-score: 3694.9 bits: 693.3 E(85289): 4.6e-199
Smith-Waterman score: 2915; 96.1% identity (98.0% similar) in 456 aa overlap (1-456:1-456)
10 20 30 40 50 60
pF1KSD MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
:::::::::::::::. . . . .:: .:.. .
XP_011 TSMKCIMGQDGTSLGNGITIHEVVQTRNTYHRFSPLSPVFSHQCLWIMLP
430 440 450 460 470
490 500 510 520 530 540
pF1KSD AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
>>NP_060797 (OMIM: 611120) serine palmitoyltransferase 3 (552 aa)
initn: 2518 init1: 2518 opt: 2580 Z-score: 3269.0 bits: 614.7 E(85289): 2.4e-175
Smith-Waterman score: 2580; 70.0% identity (88.4% similar) in 550 aa overlap (18-562:7-552)
10 20 30 40 50
pF1KSD MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAA-AAAAAGQIHHVTQNGG--LYKR
: : ::...: .:... . . : .... ::: .: .
NP_060 MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDK
10 20 30 40
60 70 80 90 100 110
pF1KSD PFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQD
. :.:::.:. : :.::.:::. ::::::::::: : ::::. :.::.:::::: ::::
NP_060 LIVESFEEAPLHVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQD
50 60 70 80 90 100
120 130 140 150 160 170
pF1KSD FENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYN
:::::::::::::::::::::::.:: :.::: : ::::.:..:: .:: ::::::::
NP_060 FENFYTRNLYMRIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYN
110 120 130 140 150 160
180 190 200 210 220 230
pF1KSD YLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGM
.::.: . ... ::: ::.:: :::.:.:.::::.:::.:::.::.:::::..::
NP_060 FLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGM
170 180 190 200 210 220
240 250 260 270 280 290
pF1KSD GFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIV
::::::::::::::::::::::::::.:::::::::::::::::::: :::::::.::..
NP_060 GFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVI
230 240 250 260 270 280
300 310 320 330 340 350
pF1KSD YGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGR
:::::::: ::::::::::.::::::::.::..::::::::::::.::::::::.:::::
NP_060 YGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGR
290 300 310 320 330 340
360 370 380 390 400 410
pF1KSD GVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVE
::.:.:::::..:::.:::::::::::::::.:.:.:.::::.::::::::.:.:::..:
NP_060 GVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAE
350 360 370 380 390 400
420 430 440 450 460 470
pF1KSD QIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPA
::: :.: ::: :::. : . :::::.::::::.::.::::::::::.. ::::.::::.
NP_060 QIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPG
410 420 430 440 450 460
480 490 500 510 520 530
pF1KSD KIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQL
:..::.:.::...::::::::::::. :.:::::.:::::.:.:::.:. .::.::::::
NP_060 KVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQL
470 480 490 500 510 520
540 550 560
pF1KSD KYSRHRLVPLLDRP--FDETTYEETED
:::::. :: .:::..: ::
NP_060 KYSRHKKSA---RPELYDETSFE-LED
530 540 550
>>XP_011527581 (OMIM: 611120) PREDICTED: serine palmitoy (523 aa)
initn: 2421 init1: 2421 opt: 2466 Z-score: 3124.7 bits: 587.9 E(85289): 2.6e-167
Smith-Waterman score: 2466; 71.0% identity (89.6% similar) in 511 aa overlap (18-525:7-517)
10 20 30 40 50
pF1KSD MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAA-AAAAAGQIHHVTQNGG--LYKR
: : ::...: .:... . . : .... ::: .: .
XP_011 MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDK
10 20 30 40
60 70 80 90 100 110
pF1KSD PFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQD
. :.:::.:. : :.::.:::. ::::::::::: : ::::. :.::.:::::: ::::
XP_011 LIVESFEEAPLHVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQD
50 60 70 80 90 100
120 130 140 150 160 170
pF1KSD FENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYN
:::::::::::::::::::::::.:: :.::: : ::::.:..:: .:: ::::::::
XP_011 FENFYTRNLYMRIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYN
110 120 130 140 150 160
180 190 200 210 220 230
pF1KSD YLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGM
.::.: . ... ::: ::.:: :::.:.:.::::.:::.:::.::.:::::..::
XP_011 FLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGM
170 180 190 200 210 220
240 250 260 270 280 290
pF1KSD GFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIV
::::::::::::::::::::::::::.:::::::::::::::::::: :::::::.::..
XP_011 GFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVI
230 240 250 260 270 280
300 310 320 330 340 350
pF1KSD YGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGR
:::::::: ::::::::::.::::::::.::..::::::::::::.::::::::.:::::
XP_011 YGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGR
290 300 310 320 330 340
360 370 380 390 400 410
pF1KSD GVVEYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVE
::.:.:::::..:::.:::::::::::::::.:.:.:.::::.::::::::.:.:::..:
XP_011 GVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAE
350 360 370 380 390 400
420 430 440 450 460 470
pF1KSD QIITSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPA
::: :.: ::: :::. : . :::::.::::::.::.::::::::::.. ::::.::::.
XP_011 QIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPG
410 420 430 440 450 460
480 490 500 510 520 530
pF1KSD KIGAFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQL
:..::.:.::...::::::::::::. :.:::::.:::::.:.:::..
XP_011 KVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVICCVMKI
470 480 490 500 510 520
540 550 560
pF1KSD KYSRHRLVPLLDRPFDETTYEETED
>>XP_011527582 (OMIM: 611120) PREDICTED: serine palmitoy (361 aa)
initn: 1804 init1: 1804 opt: 1829 Z-score: 2318.9 bits: 438.3 E(85289): 2e-122
Smith-Waterman score: 1829; 76.8% identity (94.1% similar) in 354 aa overlap (211-562:12-361)
190 200 210 220 230 240
pF1KSD FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
:.::::.:::.:::.::.:::::..:::::
XP_011 MENGQALFPVGGTLDKHKELEDLVAKFLNVEAAMVFGMGFA
10 20 30 40
250 260 270 280 290 300
pF1KSD TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
:::::::::::::::::::::::.:::::::::::::::::::: :::::::.::..:::
XP_011 TNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQ
50 60 70 80 90 100
310 320 330 340 350 360
pF1KSD PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
::::: ::::::::::.::::::::.::..::::::::::::.::::::::.:::::::.
XP_011 PRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVT
110 120 130 140 150 160
370 380 390 400 410 420
pF1KSD EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
:.:::::..:::.:::::::::::::::.:.:.:.::::.::::::::.:.:::..::::
XP_011 EFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQII
170 180 190 200 210 220
430 440 450 460 470 480
pF1KSD TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
:.: ::: :::. : . :::::.::::::.::.::::::::::.. ::::.::::.:..
XP_011 RSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVA
230 240 250 260 270 280
490 500 510 520 530 540
pF1KSD AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
::.:.::...::::::::::::. :.:::::.:::::.:.:::.:. .::.:::::::::
XP_011 AFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYS
290 300 310 320 330 340
550 560
pF1KSD RHRLVPLLDRP--FDETTYEETED
::. :: .:::..: ::
XP_011 RHKKSA---RPELYDETSFE-LED
350 360
>>XP_016883411 (OMIM: 611120) PREDICTED: serine palmitoy (301 aa)
initn: 715 init1: 715 opt: 760 Z-score: 964.0 bits: 187.3 E(85289): 5.9e-47
Smith-Waterman score: 760; 57.3% identity (78.4% similar) in 199 aa overlap (18-213:7-205)
10 20 30 40 50
pF1KSD MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAA-AAAAAGQIHHVTQNGG--LYKR
: : ::...: .:... . . : .... ::: .: .
XP_016 MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDK
10 20 30 40
60 70 80 90 100 110
pF1KSD PFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQD
. :.:::.:. : :.::.:::. ::::::::::: : ::::. :.::.:::::: ::::
XP_016 LIVESFEEAPLHVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQD
50 60 70 80 90 100
120 130 140 150 160 170
pF1KSD FENFYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYN
:::::::::::::::::::::::.:: :.::: : ::::.:..:: .:: ::::::::
XP_016 FENFYTRNLYMRIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYN
110 120 130 140 150 160
180 190 200 210 220 230
pF1KSD YLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGM
.::.: . ... ::: ::.:: :::.:.:..
XP_016 FLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGEFTSSWQNALCVGGVLQADSVPQGPP
170 180 190 200 210 220
240 250 260 270 280 290
pF1KSD GFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIV
XP_016 WSWKMGRHSSLLEVRQPAPNPTTCHSCLPFRLLKPDSDSSLFCPNTPGNQRKHPQKPEGK
230 240 250 260 270 280
>>XP_011516440 (OMIM: 162400,605712) PREDICTED: serine p (365 aa)
initn: 516 init1: 268 opt: 574 Z-score: 726.9 bits: 143.7 E(85289): 9.4e-34
Smith-Waterman score: 574; 35.6% identity (68.5% similar) in 270 aa overlap (168-435:98-364)
140 150 160 170 180 190
pF1KSD ICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLE
: ::..:.:.::. : . :: :.
XP_011 PLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNP-RVKAAALASLK
70 80 90 100 110 120
200 210 220 230 240 250
pF1KSD EYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLIL
.::.:.:. : :..: : .::. .:.:. .: :. :..:::: . ::: .: ...
XP_011 KYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVF
130 140 150 160 170 180
260 270 280 290 300 310
pF1KSD SDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ--PRTRRPWKKILILVE
:. .. : . : . :..::::.: .::.:::. . : :: : .. .:.::
XP_011 VDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRR-FIVVE
190 200 210 220 230 240
320 330 340 350 360 370
pF1KSD GIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMG
:.: :.: :::.. :: :::: ..:.:. :.:.:: ::::.:..:.. .:.:.. .
XP_011 GLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISA
250 260 270 280 290 300
380 390 400 410 420 430
pF1KSD TFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSLG
.. ..... ::. :.. .::. : ... ...:: : .. : ... :: .. . ::
XP_011 NMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALN-IMEENPARLG
310 320 330 340 350 360
440 450 460 470 480 490
pF1KSD KECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVVV
XP_011 S
>>NP_006406 (OMIM: 162400,605712) serine palmitoyltransf (473 aa)
initn: 527 init1: 279 opt: 573 Z-score: 724.1 bits: 143.6 E(85289): 1.4e-33
Smith-Waterman score: 575; 31.0% identity (61.3% similar) in 390 aa overlap (168-537:98-473)
140 150 160 170 180 190
pF1KSD ICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLE
: ::..:.:.::. : . :: :.
NP_006 PLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNP-RVKAAALASLK
70 80 90 100 110 120
200 210 220 230 240 250
pF1KSD EYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLIL
.::.:.:. : :..: : .::. .:.:. .: :. :..:::: . ::: .: ...
NP_006 KYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVF
130 140 150 160 170 180
260 270 280 290 300 310
pF1KSD SDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ--PRTRRPWKKILILVE
:. .. : . : . :..::::.: .::.:::. . : :: : .. .:.::
NP_006 VDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRR-FIVVE
190 200 210 220 230 240
320 330 340 350 360 370
pF1KSD GIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMG
:.: :.: :::.. :: :::: ..:.:. :.:.:: ::::.:..:.. .:.:.. .
NP_006 GLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISA
250 260 270 280 290 300
380 390 400 410 420 430
pF1KSD TFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDG--TS
.. ..... ::. :.. .::. : ... ...:: : .. : ... . . : .
NP_006 NMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAV
310 320 330 340 350 360
440 450 460 470 480 490
pF1KSD LGKECVQQLAENTRYFRRRLKEM-GFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIG
: ..: : ... :. . :. . :. ::. :.: . :. ::. : .
NP_006 LKEKCGQ--------IHKALQGISGLKVVGESLSPAFHLQL--EESTGS--REQDVRLLQ
370 380 390 400 410
500 510 520 530
pF1KSD VVVVGFPATPIIESRARF------CL---------SAAHTKEILDTALKEIDEVGDLLQL
.: : ..::. :: .. .:.: :. : . : ::.. . :
NP_006 EIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVLL
420 430 440 450 460 470
540 550 560
pF1KSD KYSRHRLVPLLDRPFDETTYEETED
>>NP_001268232 (OMIM: 162400,605712) serine palmitoyltra (513 aa)
initn: 527 init1: 279 opt: 573 Z-score: 723.6 bits: 143.6 E(85289): 1.4e-33
Smith-Waterman score: 573; 33.1% identity (65.6% similar) in 311 aa overlap (168-473:98-398)
140 150 160 170 180 190
pF1KSD ICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLE
: ::..:.:.::. : . :: :.
NP_001 PLVPPVPKDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNP-RVKAAALASLK
70 80 90 100 110 120
200 210 220 230 240 250
pF1KSD EYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGCLIL
.::.:.:. : :..: : .::. .:.:. .: :. :..:::: . ::: .: ...
NP_001 KYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSKRGDIVF
130 140 150 160 170 180
260 270 280 290 300 310
pF1KSD SDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ--PRTRRPWKKILILVE
:. .. : . : . :..::::.: .::.:::. . : :: : .. .:.::
NP_001 VDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRR-FIVVE
190 200 210 220 230 240
320 330 340 350 360 370
pF1KSD GIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMMG
:.: :.: :::.. :: :::: ..:.:. :.:.:: ::::.:..:.. .:.:.. .
NP_001 GLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISA
250 260 270 280 290 300
380 390 400 410 420 430
pF1KSD TFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDG--TS
.. ..... ::. :.. .::. : ... ...:: : .. : ... . . : .
NP_001 NMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAV
310 320 330 340 350 360
440 450 460 470 480 490
pF1KSD LGKECVQQLAENTRYFRRRLKEM-GFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIG
: ..: : ... :. . :. . :. ::. :.:
NP_001 LKEKCGQ--------IHKALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVD
370 380 390 400 410
500 510 520 530 540 550
pF1KSD VVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRPF
NP_001 QCMNRSIALTQARYLEKEEKCLPPPRGRTGESCVHHQGGSPGRPALGRVPGPWPPATQHA
420 430 440 450 460 470
>>XP_016869690 (OMIM: 162400,605712) PREDICTED: serine p (351 aa)
initn: 468 init1: 279 opt: 478 Z-score: 605.4 bits: 121.2 E(85289): 5.6e-27
Smith-Waterman score: 480; 29.9% identity (60.8% similar) in 344 aa overlap (214-537:21-351)
190 200 210 220 230 240
pF1KSD NTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNS
: : .::. .:.:. .: :. :..:::: .
XP_016 MYDFKYSEFPGSHQRRPAFYDVHLDLEDRLAKFMKTEEAIIYSYGFATIA
10 20 30 40 50
250 260 270 280 290 300
pF1KSD MNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ--P
::: .: ... :. .. : . : . :..::::.: .::.:::. . : :
XP_016 SAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNP
60 70 80 90 100 110
310 320 330 340 350 360
pF1KSD RTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVE
: : .. .:.:::.: :.: :::.. :: :::: ..:.:. :.:.:: ::::.:
XP_016 RKARVTRR-FIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTE
120 130 140 150 160
370 380 390 400 410 420
pF1KSD YFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIIT
..:.. .:.:.. ... ..... ::. :.. .::. : ... ...:: : .. :
XP_016 HYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIE
170 180 190 200 210 220
430 440 450 460 470
pF1KSD SMKCIMGQDG--TSLGKECVQQLAENTRYFRRRLKEM-GFIIYGNEDSPVVPLMLYMPAK
... . . : . : ..: : ... :. . :. . :. ::. . : . .
XP_016 ALNIMEENPGIFAVLKEKCGQ--------IHKALQGISGLKVVGESLSPA--FHLQLEES
230 240 250 260 270
480 490 500 510 520
pF1KSD IGAFGREMLKRNIGVVVVGFPATPIIESRARF------CL---------SAAHTKEILDT
:. ::. : . .: : ..::. :: .. .:.: :.
XP_016 TGS--REQDVRLLQEIVDQCMNRSIALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELER
280 290 300 310 320 330
530 540 550 560
pF1KSD ALKEIDEVGDLLQLKYSRHRLVPLLDRPFDETTYEETED
: . : ::.. . :
XP_016 AASTIKEVAQAVLL
340 350
562 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 01:57:16 2016 done: Thu Nov 3 01:57:18 2016
Total Scan time: 9.810 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]