Result of FASTA (omim) for
pF1KSDA0422
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0422, 1115 aa
1>>>pF1KSDA0422 1115 - 1115 aa - 1115 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1872+/-0.000398; mu= 18.5813+/- 0.025
mean_var=92.5879+/-18.991, 0's: 0 Z-trim(113.7): 112 B-trim: 216 in 1/51
Lambda= 0.133290
statistics sampled from 23030 (23147) to 23030 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.271), width: 16
Scan time: 10.100
The best scores are: opt bits E(85289)
XP_006719273 (OMIM: 600294,616287) PREDICTED: aden (1168) 5113 994.3 0
NP_056085 (OMIM: 600294,616287) adenylate cyclase (1168) 5113 994.3 0
XP_016874232 (OMIM: 600294,616287) PREDICTED: aden (1067) 4477 871.9 0
NP_899200 (OMIM: 600293,606703) adenylate cyclase (1261) 3066 600.7 1.8e-170
XP_005247134 (OMIM: 600293,606703) PREDICTED: aden (1286) 3066 600.7 1.9e-170
XP_016861128 (OMIM: 600293,606703) PREDICTED: aden ( 920) 2421 476.5 3.1e-133
NP_001186571 (OMIM: 600293,606703) adenylate cycla ( 911) 2416 475.6 6e-133
XP_005247135 (OMIM: 600293,606703) PREDICTED: aden ( 936) 2416 475.6 6.1e-133
XP_011510662 (OMIM: 600293,606703) PREDICTED: aden ( 923) 2409 474.2 1.5e-132
XP_011510661 (OMIM: 600293,606703) PREDICTED: aden ( 953) 2409 474.2 1.6e-132
XP_016861127 (OMIM: 600293,606703) PREDICTED: aden ( 920) 2408 474.0 1.7e-132
XP_006713546 (OMIM: 600293,606703) PREDICTED: aden ( 919) 2407 473.8 2e-132
XP_005250826 (OMIM: 103070) PREDICTED: adenylate c (1221) 1965 388.9 9.7e-107
XP_016861129 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 331.7 1.1e-89
XP_006713547 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 331.7 1.1e-89
XP_011510663 (OMIM: 600293,606703) PREDICTED: aden ( 845) 1668 331.7 1.1e-89
NP_001106 (OMIM: 103070) adenylate cyclase type 8 (1251) 1485 296.6 6e-79
XP_011512244 (OMIM: 103071) PREDICTED: adenylate c (1045) 1371 274.7 2.1e-72
XP_016868495 (OMIM: 103070) PREDICTED: adenylate c (1155) 1317 264.3 3e-69
XP_006716564 (OMIM: 103070) PREDICTED: adenylate c (1185) 1317 264.3 3.1e-69
XP_005249642 (OMIM: 103072,610154,610154) PREDICTE ( 563) 1312 263.2 3.2e-69
XP_005249641 (OMIM: 103072,610154,610154) PREDICTE ( 979) 1312 263.3 5.1e-69
NP_066939 (OMIM: 103072,610154,610154) adenylate c (1119) 1312 263.3 5.7e-69
XP_016868496 (OMIM: 103070) PREDICTED: adenylate c ( 646) 1305 261.8 9.2e-69
NP_001268697 (OMIM: 103072,610154,610154) adenylat ( 338) 1164 234.6 7.8e-61
XP_016858679 (OMIM: 600291) PREDICTED: adenylate c (1098) 1079 218.5 1.7e-55
NP_004027 (OMIM: 600291) adenylate cyclase type 3 (1144) 1068 216.4 7.7e-55
NP_001307542 (OMIM: 600291) adenylate cyclase type (1145) 1068 216.4 7.7e-55
XP_016858676 (OMIM: 600291) PREDICTED: adenylate c (1163) 1068 216.4 7.8e-55
XP_011530793 (OMIM: 600291) PREDICTED: adenylate c (1164) 1068 216.4 7.8e-55
XP_016858682 (OMIM: 600291) PREDICTED: adenylate c ( 903) 986 200.6 3.6e-50
XP_016858681 (OMIM: 600291) PREDICTED: adenylate c ( 904) 986 200.6 3.6e-50
XP_011530796 (OMIM: 600291) PREDICTED: adenylate c (1120) 910 186.0 1.1e-45
XP_016858678 (OMIM: 600291) PREDICTED: adenylate c (1139) 910 186.0 1.1e-45
XP_011530795 (OMIM: 600291) PREDICTED: adenylate c (1140) 910 186.0 1.1e-45
XP_016858677 (OMIM: 600291) PREDICTED: adenylate c (1149) 910 186.0 1.1e-45
XP_011530794 (OMIM: 600291) PREDICTED: adenylate c (1150) 910 186.0 1.1e-45
XP_016858675 (OMIM: 600291) PREDICTED: adenylate c (1166) 910 186.0 1.1e-45
XP_006711988 (OMIM: 600291) PREDICTED: adenylate c (1167) 910 186.0 1.1e-45
XP_011530792 (OMIM: 600291) PREDICTED: adenylate c (1185) 910 186.0 1.1e-45
XP_011530791 (OMIM: 600291) PREDICTED: adenylate c (1186) 910 186.0 1.1e-45
XP_016858680 (OMIM: 600291) PREDICTED: adenylate c ( 974) 886 181.4 2.3e-44
NP_065433 (OMIM: 103071) adenylate cyclase type 2 (1091) 872 178.7 1.6e-43
XP_016878388 (OMIM: 600385) PREDICTED: adenylate c ( 723) 867 177.7 2.3e-43
NP_001272986 (OMIM: 600385) adenylate cyclase type ( 734) 867 177.7 2.3e-43
XP_016878387 (OMIM: 600385) PREDICTED: adenylate c ( 734) 867 177.7 2.3e-43
XP_016878385 (OMIM: 600385) PREDICTED: adenylate c ( 886) 867 177.7 2.7e-43
XP_016878386 (OMIM: 600385) PREDICTED: adenylate c ( 886) 867 177.7 2.7e-43
NP_001105 (OMIM: 600385) adenylate cyclase type 7 (1080) 867 177.8 3.2e-43
XP_016878384 (OMIM: 600385) PREDICTED: adenylate c (1080) 867 177.8 3.2e-43
>>XP_006719273 (OMIM: 600294,616287) PREDICTED: adenylat (1168 aa)
initn: 5102 init1: 5102 opt: 5113 Z-score: 5309.2 bits: 994.3 E(85289): 0
Smith-Waterman score: 7135; 95.4% identity (95.4% similar) in 1147 aa overlap (1-1094:1-1147)
10 20 30 40 50 60
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
670 680 690 700 710 720
730 740 750 760
pF1KSD GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------
:::::::::::::::::::::::::::::::::::::::::
XP_006 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
730 740 750 760 770 780
770 780
pF1KSD ----------------------------------YFIGNMLLSLLASSVFLHISSIGKLA
::::::::::::::::::::::::::
XP_006 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
790 800 810 820 830 840
790 800 810 820 830 840
pF1KSD MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
850 860 870 880 890 900
850 860 870 880 890 900
pF1KSD ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
910 920 930 940 950 960
910 920 930 940 950 960
pF1KSD LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
970 980 990 1000 1010 1020
970 980 990 1000 1010 1020
pF1KSD EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
1030 1040 1050 1060 1070 1080
1030 1040 1050 1060 1070 1080
pF1KSD FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
1090 1100 1110 1120 1130 1140
1090 1100 1110
pF1KSD YQLECRGVVKVKGKGEMTTYFLNGGPSS
:::::::
XP_006 YQLECRGVVKVKGKGEMTTYFLNGGPSS
1150 1160
>>NP_056085 (OMIM: 600294,616287) adenylate cyclase type (1168 aa)
initn: 5102 init1: 5102 opt: 5113 Z-score: 5309.2 bits: 994.3 E(85289): 0
Smith-Waterman score: 7135; 95.4% identity (95.4% similar) in 1147 aa overlap (1-1094:1-1147)
10 20 30 40 50 60
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
670 680 690 700 710 720
730 740 750 760
pF1KSD GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------
:::::::::::::::::::::::::::::::::::::::::
NP_056 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
730 740 750 760 770 780
770 780
pF1KSD ----------------------------------YFIGNMLLSLLASSVFLHISSIGKLA
::::::::::::::::::::::::::
NP_056 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
790 800 810 820 830 840
790 800 810 820 830 840
pF1KSD MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
850 860 870 880 890 900
850 860 870 880 890 900
pF1KSD ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
910 920 930 940 950 960
910 920 930 940 950 960
pF1KSD LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
970 980 990 1000 1010 1020
970 980 990 1000 1010 1020
pF1KSD EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
1030 1040 1050 1060 1070 1080
1030 1040 1050 1060 1070 1080
pF1KSD FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
1090 1100 1110 1120 1130 1140
1090 1100 1110
pF1KSD YQLECRGVVKVKGKGEMTTYFLNGGPSS
:::::::
NP_056 YQLECRGVVKVKGKGEMTTYFLNGGPSS
1150 1160
>>XP_016874232 (OMIM: 600294,616287) PREDICTED: adenylat (1067 aa)
initn: 6732 init1: 4457 opt: 4477 Z-score: 4648.8 bits: 871.9 E(85289): 0
Smith-Waterman score: 6646; 91.7% identity (92.9% similar) in 1121 aa overlap (1-1115:1-1067)
10 20 30 40 50 60
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
610 620 630 640 650 660
670 680 690 700 710
pF1KSD YSRKVDPRFGAYVACALLVFCFI------CFIQLLIFPHSTLMLGIYASIFLLLLITVLI
.. . : .:: .. . : .: : . ::. : : :.
XP_016 FTCNHTP----IRSCAARMLNLTPADITACHLQQLNYS-----LGLDAP---LCEGTMPT
670 680 690 700
720 730 740 750 760 770
pF1KSD CAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLAS
:. ::. :::::::::::::
XP_016 CS-------FPE-----------------------------------YFIGNMLLSLLAS
710 720
780 790 800 810 820 830
pF1KSD SVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCP
730 740 750 760 770 780
840 850 860 870 880 890
pF1KSD AAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRL
790 800 810 820 830 840
900 910 920 930 940 950
pF1KSD LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL
850 860 870 880 890 900
960 970 980 990 1000 1010
pF1KSD LNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLM
910 920 930 940 950 960
1020 1030 1040 1050 1060 1070
pF1KSD EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQ
970 980 990 1000 1010 1020
1080 1090 1100 1110
pF1KSD VTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
:::::::::::::::::::::::::::::::::::::::::
XP_016 VTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
1030 1040 1050 1060
>>NP_899200 (OMIM: 600293,606703) adenylate cyclase type (1261 aa)
initn: 4783 init1: 2353 opt: 3066 Z-score: 3181.3 bits: 600.7 E(85289): 1.8e-170
Smith-Waterman score: 4638; 65.7% identity (80.2% similar) in 1146 aa overlap (16-1092:100-1237)
10 20 30 40
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
:.:: ::.:. .: .:::. .::
NP_899 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
70 80 90 100 110 120
50 60 70 80 90
pF1KSD PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
. . . . .: : . .. . ::: . :: :: : . . .
NP_899 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
130 140 150 160 170 180
100 110 120 130 140 150
pF1KSD TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
.: . . ..: :: : : :.:.:.::.: : :::::::::::..::::::.::::
NP_899 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
190 200 210 220 230 240
160 170 180 190 200 210
pF1KSD LVLLTAVLLAFHAAPARP--QPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVL
:::. :.::::: ::: : :.:.:: :..... . :.::: .:.:: : .. :...
NP_899 LVLVCLVMLAFHA--ARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALI
250 260 270 280 290 300
220 230 240 250 260 270
pF1KSD GILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW
... :::: : : .::: : :.: :::.: :::::.:::::::::. ::.::: .:
NP_899 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIAL
310 320 330 340 350 360
280 290 300 310 320 330
pF1KSD QLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENR
. : : :: ::: .:::.: :::..:.:::::::::::::::::: :::::: :.::.
NP_899 RTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQ
370 380 390 400 410 420
340 350 360 370 380 390
pF1KSD QQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
:::::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::
NP_899 QQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
430 440 450 460 470 480
400 410 420 430 440 450
pF1KSD AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_899 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIE
490 500 510 520 530 540
460 470 480 490 500 510
pF1KSD AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHI
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_899 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHI
550 560 570 580 590 600
520 530 540 550 560 570
pF1KSD TRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANS
:.:::.::::::::::: ::::::::::. ::::::: .:::::::::.::..: :.::
NP_899 TKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNS
610 620 630 640 650 660
580 590 600 610 620 630
pF1KSD MEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAI
. :.: .: : .. :: ...::..: :: ...:.. ::::::::::.:::
NP_899 IGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAI
670 680 690 700 710 720
640 650 660 670 680 690
pF1KSD DARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP
::::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :
NP_899 DARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVP
730 740 750 760 770 780
700 710 720 730 740 750
pF1KSD HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLL
:: .::..: . ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :
NP_899 HSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITL
790 800 810 820 830 840
760
pF1KSD VFTSAIANM---------------------------------------------------
:: .:..::
NP_899 VFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNC
850 860 870 880 890 900
770 780 790 800 810
pF1KSD ----YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLG
:: ..:::::: ::::.:: ::::...... ::: ::.. : .:.::: :::.
NP_899 NFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVT
910 920 930 940 950 960
820 830 840 850 860 870
pF1KSD VHGLASSNETFDGLDCPA-AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQ
.... :. . .:: : .:::: .::.:. ::.:::::::::::::::::::::::
NP_899 ANAIDFFNNGTS--QCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQ
970 980 990 1000 1010 1020
880 890 900 910 920 930
pF1KSD ATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFS
:: :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_899 ATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFS
1030 1040 1050 1060 1070 1080
940 950 960 970 980 990
pF1KSD EFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYD
::::::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::
NP_899 EFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYD
1090 1100 1110 1120 1130 1140
1000 1010 1020 1030 1040 1050
pF1KSD QVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN
.::..:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::
NP_899 KVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGN
1150 1160 1170 1180 1190 1200
1060 1070 1080 1090 1100 1110
pF1KSD TVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
::::.:::::::::::::::::.::::::. :::::
NP_899 TVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
1210 1220 1230 1240 1250 1260
>>XP_005247134 (OMIM: 600293,606703) PREDICTED: adenylat (1286 aa)
initn: 4735 init1: 2353 opt: 3066 Z-score: 3181.2 bits: 600.7 E(85289): 1.9e-170
Smith-Waterman score: 4439; 63.9% identity (78.2% similar) in 1144 aa overlap (16-1067:100-1237)
10 20 30 40
pF1KSD MSWFSGLLVPKVDERKTAWGERNGQ-----KRSRRRGTRAGGFCT
:.:: ::.:. .: .:::. .::
XP_005 ASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTR
70 80 90 100 110 120
50 60 70 80 90
pF1KSD PRYMSCLRDAEPPSPTPAGPPRCPWQDDAFI--RRGGPGKGKELGLRAVALGFEDTEVTT
. . . . .: : . .. . ::: . :: :: : . . .
XP_005 APPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGS
130 140 150 160 170 180
100 110 120 130 140 150
pF1KSD TAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAV
.: . . ..: :: : : :.:.:.::.: : :::::::::::..::::::.::::
XP_005 SADSGSGAGPGAVLSLGACCLA-LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAV
190 200 210 220 230 240
160 170 180 190 200 210
pF1KSD LVLLTAVLLAFHAAPARP--QPAYVALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVL
:::. :.:::::: :: : :.:.:: :..... . :.::: .:.:: : .. :...
XP_005 LVLVCLVMLAFHAA--RPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALI
250 260 270 280 290 300
220 230 240 250 260 270
pF1KSD GILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW
... :::: : : .::: : :.: :::.: :::::.:::::::::. ::.::: .:
XP_005 AVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIAL
310 320 330 340 350 360
280 290 300 310 320 330
pF1KSD QLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENR
. : : :: ::: .:::.: :::..:.:::::::::::::::::: :::::: :.::.
XP_005 RTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQ
370 380 390 400 410 420
340 350 360 370 380 390
pF1KSD QQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
:::::::::::.::::::: :::.:.::::::::::::::::::::::::::::::::::
XP_005 QQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT
430 440 450 460 470 480
400 410 420 430 440 450
pF1KSD AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 AQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIE
490 500 510 520 530 540
460 470 480 490 500 510
pF1KSD AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHI
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_005 AISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHI
550 560 570 580 590 600
520 530 540 550 560 570
pF1KSD TRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANS
:.:::.::::::::::: ::::::::::. ::::::: .:::::::::.::..: :.::
XP_005 TKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNS
610 620 630 640 650 660
580 590 600 610 620 630
pF1KSD MEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAI
. :.: .: : .. :: ...::..: :: ...:.. ::::::::::.:::
XP_005 IGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-KNAQESANPEDEVDEFLGRAI
670 680 690 700 710 720
640 650 660 670 680 690
pF1KSD DARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP
::::::.::..:::.:::::.. :::::::..:: ::::::::: ::: ::::.:. : :
XP_005 DARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVP
730 740 750 760 770 780
700 710 720 730 740 750
pF1KSD HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLL
:: .::..: . ::: ..:.. ..::: .:::. :: :::.::::. .:: ::.:.. :
XP_005 HSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITL
790 800 810 820 830 840
760
pF1KSD VFTSAIANM---------------------------------------------------
:: .:..::
XP_005 VFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNC
850 860 870 880 890 900
770 780 790 800 810
pF1KSD ----YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLG
:: ..:::::: ::::.:: ::::...... ::: ::.. : .:.::: :::.
XP_005 NFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-VLIVEVPGVTLFDNADLLVT
910 920 930 940 950 960
820 830 840 850
pF1KSD VHGLASSNETFD---------------GLDCPA---------AGRVALKYMTPVILLVFA
.... :. . : :. : .:::: .::.:. ::.
XP_005 ANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFV
970 980 990 1000 1010 1020
860 870 880 890 900 910
pF1KSD LALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
XP_005 LALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR
1030 1040 1050 1060 1070 1080
920 930 940 950 960 970
pF1KSD NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_005 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQ
1090 1100 1110 1120 1130 1140
980 990 1000 1010 1020 1030
pF1KSD LEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIG
:::::::::::::::::: ::::.::..:: ::::.::.::.:::.::::::::::::::
XP_005 LEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIG
1150 1160 1170 1180 1190 1200
1040 1050 1060 1070 1080 1090
pF1KSD LNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECR
::.::::::::::::::::::::::::.::::::
XP_005 LNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECR
1210 1220 1230 1240 1250 1260
1100 1110
pF1KSD GVVKVKGKGEMTTYFLNGGPSS
XP_005 GVVKVKGKGEMMTYFLNGGPPLS
1270 1280
>--
initn: 283 init1: 283 opt: 283 Z-score: 288.9 bits: 65.5 E(85289): 2.4e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:1238-1283)
1040 1050 1060 1070 1080 1090
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
:::::::::::.::::::. ::::::::::
XP_005 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
1210 1220 1230 1240 1250 1260
1100 1110
pF1KSD VKGKGEMTTYFLNGGPSS
::::::: ::::::::
XP_005 VKGKGEMMTYFLNGGPPLS
1270 1280
>>XP_016861128 (OMIM: 600293,606703) PREDICTED: adenylat (920 aa)
initn: 4158 init1: 1776 opt: 2421 Z-score: 2513.0 bits: 476.5 E(85289): 3.1e-133
Smith-Waterman score: 3794; 70.2% identity (82.2% similar) in 865 aa overlap (286-1067:10-871)
260 270 280 290 300 310
pF1KSD RMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQR
: .: .:::.: :::..:.:::::::::::
XP_016 MQTSACCPEWAKLVSNVLIFSCTNIVGVCTHYPAEVSQR
10 20 30
320 330 340 350 360 370
pF1KSD QAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKH
::::::: :::::: :.::.:::::::::::.::::::: :::.:.:::::::::::::
XP_016 QAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKH
40 50 60 70 80 90
380 390 400 410 420 430
pF1KSD DNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG
100 110 120 130 140 150
440 450 460 470 480 490
pF1KSD LPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_016 LPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW
160 170 180 190 200 210
500 510 520 530 540 550
pF1KSD SNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGA
::::::::::::::.:::::::.:::.::::::::::: ::::::::::. :::::::
XP_016 SNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRC
220 230 240 250 260 270
560 570 580 590 600 610
pF1KSD SQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDN
.:::::::::.::..: :.::. :.: .: : .. :: ...::..: ::
XP_016 TQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-
280 290 300 310 320 330
620 630 640 650 660 670
pF1KSD RGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGA
...:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..:: ::::
XP_016 KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGA
340 350 360 370 380 390
680 690 700 710 720 730
pF1KSD YVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRL
::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::: .:::. :: :
XP_016 YVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTL
400 410 420 430 440 450
740 750 760
pF1KSD SRSIVRSRAHSTAVGIFSVLLVFTSAIANM------------------------------
::.::::. .:: ::.:.. ::: .:..::
XP_016 SRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAE
460 470 480 490 500 510
770 780 790
pF1KSD -------------------------YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIY
:: ..:::::: ::::.:: ::::...... :::
XP_016 SAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY
520 530 540 550 560 570
800 810 820 830
pF1KSD LVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA------
::.. : .:.::: :::. .... :. . : :.
XP_016 -VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQS
580 590 600 610 620 630
840 850 860 870 880 890
pF1KSD ---AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNR
: .:::: .::.:. ::.::::::::::::::::::::::::: :::::::::::::
XP_016 PEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNR
640 650 660 670 680 690
900 910 920 930 940 950
pF1KSD RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KSD RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR
::::::::::::::::.:::::::::::::::::::::: ::::.::..:: ::::.::.
XP_016 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMK
760 770 780 790 800 810
1020 1030 1040 1050 1060 1070
pF1KSD LMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDR
::.:::.::::::::::::::::.::::::::::::::::::::::::.::::::
XP_016 LMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDR
820 830 840 850 860 870
1080 1090 1100 1110
pF1KSD IQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
XP_016 IQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
880 890 900 910 920
>--
initn: 283 init1: 283 opt: 283 Z-score: 291.1 bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:872-917)
1040 1050 1060 1070 1080 1090
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
:::::::::::.::::::. ::::::::::
XP_016 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
850 860 870 880 890 900
1100 1110
pF1KSD VKGKGEMTTYFLNGGPSS
::::::: ::::::::
XP_016 VKGKGEMMTYFLNGGPPLS
910 920
>>NP_001186571 (OMIM: 600293,606703) adenylate cyclase t (911 aa)
initn: 4194 init1: 1764 opt: 2416 Z-score: 2507.9 bits: 475.6 E(85289): 6e-133
Smith-Waterman score: 3988; 71.8% identity (84.3% similar) in 879 aa overlap (274-1092:14-887)
250 260 270 280 290 300
pF1KSD FFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIG
:. : . : . ..: .:::.: :::..:
NP_001 MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
10 20 30 40
310 320 330 340 350 360
pF1KSD ICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE
.:::::::::::::::::: :::::: :.::.:::::::::::.::::::: :::.:.:
NP_001 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
50 60 70 80 90 100
370 380 390 400 410 420
pF1KSD DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
110 120 130 140 150 160
430 440 450 460 470 480
pF1KSD KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
170 180 190 200 210 220
490 500 510 520 530 540
pF1KSD VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLK
::::::::::::::::::::::::::.:::::::.:::.::::::::::: :::::::::
NP_001 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
230 240 250 260 270 280
550 560 570 580 590
pF1KSD EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAF
:. ::::::: .:::::::::.::..: :.::. :.: .: : .. :: .
NP_001 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
290 300 310 320 330 340
600 610 620 630 640 650
pF1KSD RQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEK
..::..: :: ...:.. ::::::::::.:::::::::.::..:::.:::::.. ::::
NP_001 KRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEK
350 360 370 380 390 400
660 670 680 690 700 710
pF1KSD KYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYS
:::..:: ::::::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::
NP_001 KYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYS
410 420 430 440 450 460
720 730 740 750 760
pF1KSD CGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM------------------
: .:::. :: :::.::::. .:: ::.:.. ::: .:..::
NP_001 CVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI
470 480 490 500 510 520
770 780
pF1KSD -------------------------------------YFIGNMLLSLLASSVFLHISSIG
:: ..:::::: ::::.:: ::
NP_001 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIG
530 540 550 560 570 580
790 800 810 820 830 840
pF1KSD KLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA-AGRVALKY
::...... ::: ::.. : .:.::: :::. .... :. . .:: : .::::
NP_001 KLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTS--QCPEHATKVALKV
590 600 610 620 630
850 860 870 880 890 900
pF1KSD MTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDV
.::.:. ::.::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 VTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDV
640 650 660 670 680 690
910 920 930 940 950 960
pF1KSD AAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFD
700 710 720 730 740 750
970 980 990 1000 1010 1020
pF1KSD EIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEH
:::::.:::::::::::::::::::::: ::::.::..:: ::::.::.::.:::.::::
NP_001 EIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEH
760 770 780 790 800 810
1030 1040 1050 1060 1070 1080
pF1KSD SFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL
::::::::::::.::::::::::::::::::::::::.:::::::::::::::::.::::
NP_001 SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL
820 830 840 850 860 870
1090 1100 1110
pF1KSD AAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
::. :::::
NP_001 AANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
880 890 900 910
>>XP_005247135 (OMIM: 600293,606703) PREDICTED: adenylat (936 aa)
initn: 4146 init1: 1764 opt: 2416 Z-score: 2507.7 bits: 475.6 E(85289): 6.1e-133
Smith-Waterman score: 3789; 69.4% identity (81.8% similar) in 877 aa overlap (274-1067:14-887)
250 260 270 280 290 300
pF1KSD FFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIG
:. : . : . ..: .:::.: :::..:
XP_005 MKSQKEGCCSRGDLSIQTGPGGEWAPRRLVSNVLIFSCTNIVG
10 20 30 40
310 320 330 340 350 360
pF1KSD ICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE
.:::::::::::::::::: :::::: :.::.:::::::::::.::::::: :::.:.:
XP_005 VCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQE
50 60 70 80 90 100
370 380 390 400 410 420
pF1KSD DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI
110 120 130 140 150 160
430 440 450 460 470 480
pF1KSD KILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
XP_005 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCG
170 180 190 200 210 220
490 500 510 520 530 540
pF1KSD VLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLK
::::::::::::::::::::::::::.:::::::.:::.::::::::::: :::::::::
XP_005 VLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLK
230 240 250 260 270 280
550 560 570 580 590
pF1KSD EQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAF
:. ::::::: .:::::::::.::..: :.::. :.: .: : .. :: .
XP_005 EHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEM
290 300 310 320 330 340
600 610 620 630 640 650
pF1KSD RQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEK
..::..: :: ...:.. ::::::::::.:::::::::.::..:::.:::::.. ::::
XP_005 KRMGFEDP-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEK
350 360 370 380 390 400
660 670 680 690 700 710
pF1KSD KYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYS
:::..:: ::::::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::
XP_005 KYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYS
410 420 430 440 450 460
720 730 740 750 760
pF1KSD CGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM------------------
: .:::. :: :::.::::. .:: ::.:.. ::: .:..::
XP_005 CVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNI
470 480 490 500 510 520
770 780
pF1KSD -------------------------------------YFIGNMLLSLLASSVFLHISSIG
:: ..:::::: ::::.:: ::
XP_005 SASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIG
530 540 550 560 570 580
790 800 810 820
pF1KSD KLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------
::...... ::: ::.. : .:.::: :::. .... :. .
XP_005 KLVLMLAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEA
590 600 610 620 630 640
830 840 850 860 870 880
pF1KSD GLDCPA---------AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGE
: :. : .:::: .::.:. ::.::::::::::::::::::::::::: :
XP_005 GTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEE
650 660 670 680 690 700
890 900 910 920 930 940
pF1KSD KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV
710 720 730 740 750 760
950 960 970 980 990 1000
pF1KSD ELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR
::::::::::::::::::::::::::::.:::::::::::::::::::::: ::::.::.
XP_005 ELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGK
770 780 790 800 810 820
1010 1020 1030 1040 1050 1060
pF1KSD SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNV
.:: ::::.::.::.:::.::::::::::::::::.::::::::::::::::::::::::
XP_005 THIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNV
830 840 850 860 870 880
1070 1080 1090 1100 1110
pF1KSD SSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
.::::::
XP_005 ASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
890 900 910 920 930
>--
initn: 283 init1: 283 opt: 283 Z-score: 291.0 bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:888-933)
1040 1050 1060 1070 1080 1090
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
:::::::::::.::::::. ::::::::::
XP_005 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
860 870 880 890 900 910
1100 1110
pF1KSD VKGKGEMTTYFLNGGPSS
::::::: ::::::::
XP_005 VKGKGEMMTYFLNGGPPLS
920 930
>>XP_011510662 (OMIM: 600293,606703) PREDICTED: adenylat (923 aa)
initn: 4146 init1: 1764 opt: 2409 Z-score: 2500.5 bits: 474.2 E(85289): 1.5e-132
Smith-Waterman score: 3782; 70.3% identity (82.2% similar) in 864 aa overlap (287-1067:14-874)
260 270 280 290 300 310
pF1KSD MRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQ
: : .:::.: :::..:.::::::::::::
XP_011 MLLIRLRDFPSIPKLLVSNVLIFSCTNIVGVCTHYPAEVSQRQ
10 20 30 40
320 330 340 350 360 370
pF1KSD AFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHD
:::::: :::::: :.::.:::::::::::.::::::: :::.:.::::::::::::::
XP_011 AFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHD
50 60 70 80 90 100
380 390 400 410 420 430
pF1KSD NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL
110 120 130 140 150 160
440 450 460 470 480 490
pF1KSD PEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS
170 180 190 200 210 220
500 510 520 530 540 550
pF1KSD NDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGAS
:::::::::::::.:::::::.:::.::::::::::: ::::::::::. ::::::: .
XP_011 NDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCT
230 240 250 260 270 280
560 570 580 590 600 610
pF1KSD QKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDDSSKDNR
:::::::::.::..: :.::. :.: .: : .. :: ...::..: :: .
XP_011 QKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDP-KD-K
290 300 310 320 330 340
620 630 640 650 660 670
pF1KSD GTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAY
..:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..:: :::::
XP_011 NAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAY
350 360 370 380 390 400
680 690 700 710 720 730
pF1KSD VACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLS
:::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::: .:::. :: ::
XP_011 VACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLS
410 420 430 440 450 460
740 750 760
pF1KSD RSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------------------
:.::::. .:: ::.:.. ::: .:..::
XP_011 RKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAES
470 480 490 500 510 520
770 780 790
pF1KSD ------------------------YFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYL
:: ..:::::: ::::.:: ::::...... :::
XP_011 AVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIY-
530 540 550 560 570 580
800 810 820 830
pF1KSD VLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA-------
::.. : .:.::: :::. .... :. . : :.
XP_011 VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSP
590 600 610 620 630 640
840 850 860 870 880 890
pF1KSD --AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRR
: .:::: .::.:. ::.::::::::::::::::::::::::: ::::::::::::::
XP_011 EHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRR
650 660 670 680 690 700
900 910 920 930 940 950
pF1KSD LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR
710 720 730 740 750 760
960 970 980 990 1000 1010
pF1KSD LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRL
:::::::::::::::.:::::::::::::::::::::: ::::.::..:: ::::.::.:
XP_011 LLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKL
770 780 790 800 810 820
1020 1030 1040 1050 1060 1070
pF1KSD MEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRI
:.:::.::::::::::::::::.::::::::::::::::::::::::.::::::
XP_011 MDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRI
830 840 850 860 870 880
1080 1090 1100 1110
pF1KSD QVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
XP_011 QVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
890 900 910 920
>--
initn: 283 init1: 283 opt: 283 Z-score: 291.1 bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:875-920)
1040 1050 1060 1070 1080 1090
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
:::::::::::.::::::. ::::::::::
XP_011 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
850 860 870 880 890 900
1100 1110
pF1KSD VKGKGEMTTYFLNGGPSS
::::::: ::::::::
XP_011 VKGKGEMMTYFLNGGPPLS
910 920
>>XP_011510661 (OMIM: 600293,606703) PREDICTED: adenylat (953 aa)
initn: 4142 init1: 1760 opt: 2409 Z-score: 2500.3 bits: 474.2 E(85289): 1.6e-132
Smith-Waterman score: 3782; 70.0% identity (82.0% similar) in 870 aa overlap (281-1067:41-904)
260 270 280 290 300 310
pF1KSD TLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPA
: .: : : .:::.: :::..:.::::::
XP_011 THTLQTWSPLEKPVCTGQAEHGVEKEKPSGGRSF-W--LVSNVLIFSCTNIVGVCTHYPA
20 30 40 50 60
320 330 340 350 360 370
pF1KSD EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKI
:::::::::::: :::::: :.::.:::::::::::.::::::: :::.:.::::::::
XP_011 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKI
70 80 90 100 110 120
380 390 400 410 420 430
pF1KSD YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY
130 140 150 160 170 180
440 450 460 470 480 490
pF1KSD YCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_011 YCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW
190 200 210 220 230 240
500 510 520 530 540 550
pF1KSD QFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETF
:::::::::::::::::::.:::::::.:::.::::::::::: ::::::::::. ::::
XP_011 QFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETF
250 260 270 280 290 300
560 570 580 590 600
pF1KSD LILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSR----TKDSKAFRQMGIDD
::: .:::::::::.::..: :.::. :.: .: : .. :: ...::..:
XP_011 LILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFED
310 320 330 340 350 360
610 620 630 640 650 660
pF1KSD SSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVD
:: ...:.. ::::::::::.:::::::::.::..:::.:::::.. :::::::..::
XP_011 P-KD-KNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVD
370 380 390 400 410 420
670 680 690 700 710 720
pF1KSD PRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPK
::::::::: ::: ::::.:. : ::: .::..: . ::: ..:.. ..::: .:::.
XP_011 DRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPS
430 440 450 460 470 480
730 740 750 760
pF1KSD ALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-------------------------
:: :::.::::. .:: ::.:.. ::: .:..::
XP_011 PLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNA
490 500 510 520 530 540
770 780 790
pF1KSD ------------------------------YFIGNMLLSLLASSVFLHISSIGKLAMIFV
:: ..:::::: ::::.:: ::::.....
XP_011 CHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLA
550 560 570 580 590 600
800 810 820 830
pF1KSD LGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFD---------------GLDCPA-
. ::: ::.. : .:.::: :::. .... :. . : :.
XP_011 IELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSG
610 620 630 640 650 660
840 850 860 870 880
pF1KSD --------AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEEL
: .:::: .::.:. ::.::::::::::::::::::::::::: ::::::::
XP_011 VKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEEL
670 680 690 700 710 720
890 900 910 920 930 940
pF1KSD QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE
730 740 750 760 770 780
950 960 970 980 990 1000
pF1KSD GVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALA
:::::::::::::::::::::.:::::::::::::::::::::: ::::.::..:: :::
XP_011 GVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALA
790 800 810 820 830 840
1010 1020 1030 1040 1050 1060
pF1KSD DYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDST
:.::.::.:::.::::::::::::::::.::::::::::::::::::::::::.::::::
XP_011 DFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDST
850 860 870 880 890 900
1070 1080 1090 1100 1110
pF1KSD GVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
XP_011 GVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
910 920 930 940 950
>--
initn: 283 init1: 283 opt: 283 Z-score: 290.9 bits: 65.4 E(85289): 1.8e-09
Smith-Waterman score: 283; 91.3% identity (95.7% similar) in 46 aa overlap (1068-1113:905-950)
1040 1050 1060 1070 1080 1090
pF1KSD PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK
:::::::::::.::::::. ::::::::::
XP_011 PVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK
880 890 900 910 920 930
1100 1110
pF1KSD VKGKGEMTTYFLNGGPSS
::::::: ::::::::
XP_011 VKGKGEMMTYFLNGGPPLS
940 950
1115 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 01:40:39 2016 done: Thu Nov 3 01:40:40 2016
Total Scan time: 10.100 Total Display time: 0.410
Function used was FASTA [36.3.4 Apr, 2011]