FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0390, 1300 aa 1>>>pF1KSDA0390 1300 - 1300 aa - 1300 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2742+/-0.00119; mu= -4.1956+/- 0.069 mean_var=633.9435+/-166.802, 0's: 0 Z-trim(112.1): 242 B-trim: 0 in 0/54 Lambda= 0.050939 statistics sampled from 12708 (12904) to 12708 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.396), width: 16 Scan time: 6.120 The best scores are: opt bits E(32554) CCDS32984.1 ZNF536 gene_id:9745|Hs108|chr19 (1300) 8858 668.2 3.9e-191 CCDS74234.1 ZNF516 gene_id:9658|Hs108|chr18 (1163) 1000 90.6 2.5e-17 >>CCDS32984.1 ZNF536 gene_id:9745|Hs108|chr19 (1300 aa) initn: 8858 init1: 8858 opt: 8858 Z-score: 3544.9 bits: 668.2 E(32554): 3.9e-191 Smith-Waterman score: 8858; 100.0% identity (100.0% similar) in 1300 aa overlap (1-1300:1-1300) 10 20 30 40 50 60 pF1KSD MEEASLCLGVSSAEPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 MEEASLCLGVSSAEPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PASLEEKAHVPMSGQPMGSQMALLANQLGREVDTSLNGRVDLQQFLNGQNLGIMSQMSDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 PASLEEKAHVPMSGQPMGSQMALLANQLGREVDTSLNGRVDLQQFLNGQNLGIMSQMSDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 EDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KLGNLGKGRGRVREENRLLHELEERAILRDKQLKGSLLQPRPDLKPPPHAQQAPLAACTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 KLGNLGKGRGRVREENRLLHELEERAILRDKQLKGSLLQPRPDLKPPPHAQQAPLAACTL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD ALQANHSVPDVAHPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 ALQANHSVPDVAHPVPSPKPASVQEDAVAPAAGFRCTFCKGKFKKREELDRHIRILHKPY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 KCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD KGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 KGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD EAHANLYSRYLSCLQSGFMTPDKAGLSEPSQLYGKGELPMKEKEALGKLLSPISSMAHGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 EAHANLYSRYLSCLQSGFMTPDKAGLSEPSQLYGKGELPMKEKEALGKLLSPISSMAHGV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD PEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 PEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD EHPLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGSQRDLPSKLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 EHPLQRNHEDTLANAGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGSQRDLPSKLDP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LESSRDFLSHGLNQTLEYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 LESSRDFLSHGLNQTLEYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD EDGLHVGLDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 EDGLHVGLDERRGSGSDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD SSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 SSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYK 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD CPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPDILRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 CPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPDILRG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD AFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 AFKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEI 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD GRAYQSIVSNGVNFQGSLQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 GRAYQSIVSNGVNFQGSLQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 GKSSQRKSEKSQYEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD QANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 QANHLGKAKRKDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMA 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD QGQLKETLGEQKSGAWTGHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 QGQLKETLGEQKSGAWTGHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAH 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD SEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSALSKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 SEEDVPILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSALSKD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD SSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 SSSDGGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDK 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 pF1KSD PMNMLSVLRAYSSDGLAAFNGLASSTANSGCIKRPDLCGK :::::::::::::::::::::::::::::::::::::::: CCDS32 PMNMLSVLRAYSSDGLAAFNGLASSTANSGCIKRPDLCGK 1270 1280 1290 1300 >>CCDS74234.1 ZNF516 gene_id:9658|Hs108|chr18 (1163 aa) initn: 1224 init1: 377 opt: 1000 Z-score: 424.4 bits: 90.6 E(32554): 2.5e-17 Smith-Waterman score: 1254; 38.3% identity (62.2% similar) in 622 aa overlap (121-727:25-606) 100 110 120 130 140 150 pF1KSD EVDTSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMR : :. : . : .::: : :.: :: ::: CCDS74 MDRNREAEMELRRGPSPTRAGRGHEVDGDKATCHTCCICGKSFPFQSSLSQHMR 10 20 30 40 50 160 170 180 190 200 210 pF1KSD THTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRD ::::::.:::::::::.::::::::.:.:. :.: .:. : . : : .: CCDS74 KHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGH----EPEAGEAPLGE---MRA 60 70 80 90 100 220 230 240 250 260 270 pF1KSD KQLKGSLLQPRPDLKPPPHAQQAPLAACTLALQANHSVPDVAHPVPSPKPASVQEDAVAP .. . .: . . . .. : . . : : .. . . ... .: :: CCDS74 SEGLDACASPTKSASACNRLLNGASQADGARVLNGASQADSGRVLLRSSKKGAEGSACAP 110 120 130 140 150 160 280 290 300 310 320 pF1KSD A---AGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAE . :. .:.:::..:.....:. :.. :::.:: ::..:. .:: :.::.:. ::::. CCDS74 GEAKAAVQCSFCKSQFERKKDLELHVHQAHKPFKCRLCSYATLREESLLSHIERDHITAQ 170 180 190 200 210 220 330 340 350 360 370 380 pF1KSD SAQGQGP----NGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFK . :.: :: : : .:: ::::::.:::.::::.::.::. ::.: :.::::::: CCDS74 GP-GSGEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFK 230 240 250 260 270 280 390 400 410 420 430 440 pF1KSD EPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPMGGMSQEAH--ANLYSRYLSCLQSGFMTP ::::::::::.: : . ::. :. . . .... :: :.: : : : . : . CCDS74 EPWFLKNHMKAHGPKTGSKNRPKSELDPIATINNVVQEEVIVAGL-SLYEVCAKCGNLFT 290 300 310 320 330 340 450 460 470 480 490 500 pF1KSD DKAGLSEPSQLYGKGELPMKEKEALGKLLSPISSMAHGVPEGDKHSLLGCLNLVPPLKSS . .:. . .. .. :: .. .: :.: : :. .: :::: : .. CCDS74 NLDSLNAHNAIH-------RRVEA-SRTRAPAEEGAEG-PSDTKQFFLQCLNLRPSAAGD 350 360 370 380 390 510 520 530 540 550 560 pF1KSD CIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHPLQRNHEDTLANAGVLFDK ::. ..::.::::::::::: .:: . : . :. :. . : . : ::: CCDS74 SCPGTQAGRRVAELDPVNSYQAWQLATRGKVAEPA----EY-LKYGAWDEALAGDVAFDK 400 410 420 430 440 450 570 580 590 600 610 pF1KSD EKREYVLVGADGSK--QKMPADLVHSTKVGSQRDLPS---KLDPLESSRDFLSHGLNQTL ..::::::. . : : :: : .: :. .::: ..: :. CCDS74 DRREYVLVSQEKRKREQDAPAAQGPPRKRASGPGDPAPAGHLDPRSAARP------NRRA 460 470 480 490 500 620 630 640 650 660 670 pF1KSD EYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGEE-DGLHVGLDERRGSG . : : : .:: .::..::::::.:.:::::.: :. .. :: ... : : CCDS74 AATT-GQG----KSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGDRAA---RARCG 510 520 530 540 550 680 690 700 710 720 730 pF1KSD SDQESQSVSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGV : .:..:.:. ..:::. .. .: :.::.. : ::: . ..: . :. CCDS74 SLSEGDSASQPSSPGSACAAADSP-GSGLAD--EAAEDSGEEGAPEPAPGGQPRRCCFSE 560 570 580 590 600 610 740 750 760 770 780 790 pF1KSD QQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLK CCDS74 EVTSTELSSGDQSHKMGDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLK 620 630 640 650 660 670 1300 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 01:36:12 2016 done: Thu Nov 3 01:36:13 2016 Total Scan time: 6.120 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]