Result of FASTA (omim) for
pF1KSDA0221
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0221, 1129 aa
1>>>pF1KSDA0221 1129 - 1129 aa - 1129 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5994+/-0.000426; mu= 14.5831+/- 0.027
mean_var=209.0394+/-41.883, 0's: 0 Z-trim(118.8): 56 B-trim: 86 in 1/54
Lambda= 0.088707
statistics sampled from 32073 (32130) to 32073 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.377), width: 16
Scan time: 13.890
The best scores are: opt bits E(85289)
NP_001284478 (OMIM: 601430) regulator of nonsense (1129) 7595 985.8 0
XP_016882594 (OMIM: 601430) PREDICTED: regulator o (1137) 7569 982.5 0
XP_016882595 (OMIM: 601430) PREDICTED: regulator o (1126) 7461 968.7 0
NP_002902 (OMIM: 601430) regulator of nonsense tra (1118) 5115 668.4 6.6e-191
NP_002171 (OMIM: 600502,604320,616155) DNA-binding ( 993) 496 77.2 5.4e-13
XP_016873158 (OMIM: 600502,604320,616155) PREDICTE ( 656) 487 75.9 9e-13
XP_005274031 (OMIM: 600502,604320,616155) PREDICTE ( 656) 487 75.9 9e-13
XP_016873159 (OMIM: 600502,604320,616155) PREDICTE ( 656) 487 75.9 9e-13
XP_016869986 (OMIM: 602433,606002,608465) PREDICTE ( 828) 450 71.3 2.8e-11
NP_055861 (OMIM: 602433,606002,608465) probable he (2677) 450 71.8 6.2e-11
XP_016869984 (OMIM: 602433,606002,608465) PREDICTE (2677) 450 71.8 6.2e-11
XP_016869985 (OMIM: 602433,606002,608465) PREDICTE ( 857) 414 66.7 7e-10
XP_005261980 (OMIM: 605794) PREDICTED: RNA helicas (1191) 410 66.3 1.2e-09
NP_061868 (OMIM: 605794) RNA helicase Mov10l1 isof (1211) 410 66.3 1.3e-09
XP_011516707 (OMIM: 602433,606002,608465) PREDICTE (2706) 414 67.2 1.5e-09
XP_005272228 (OMIM: 602433,606002,608465) PREDICTE (2706) 414 67.2 1.5e-09
XP_011516706 (OMIM: 602433,606002,608465) PREDICTE (2706) 414 67.2 1.5e-09
XP_005272230 (OMIM: 602433,606002,608465) PREDICTE (2706) 414 67.2 1.5e-09
XP_005272229 (OMIM: 602433,606002,608465) PREDICTE (2706) 414 67.2 1.5e-09
NP_001157577 (OMIM: 605794) RNA helicase Mov10l1 i (1165) 391 63.9 6.6e-09
XP_011543296 (OMIM: 600502,604320,616155) PREDICTE ( 582) 343 57.4 2.9e-07
XP_005274032 (OMIM: 600502,604320,616155) PREDICTE ( 617) 343 57.4 3.1e-07
XP_011516708 (OMIM: 602433,606002,608465) PREDICTE (2413) 332 56.7 2e-06
NP_055506 (OMIM: 610548) intron-binding protein aq (1485) 324 55.4 3e-06
NP_001157578 (OMIM: 605794) RNA helicase Mov10l1 i ( 338) 300 51.6 9.2e-06
XP_011537719 (OMIM: 601810,615156,615807) PREDICTE ( 700) 299 51.9 1.6e-05
XP_016871288 (OMIM: 601810,615156,615807) PREDICTE ( 836) 299 51.9 1.9e-05
NP_001073918 (OMIM: 601810,615156,615807) DNA repl (1060) 299 52.1 2.2e-05
XP_006717743 (OMIM: 601810,615156,615807) PREDICTE (1090) 299 52.1 2.2e-05
XP_016873160 (OMIM: 600502,604320,616155) PREDICTE ( 546) 293 51.0 2.4e-05
XP_016856808 (OMIM: 610742) PREDICTED: putative he ( 936) 257 46.6 0.00083
>>NP_001284478 (OMIM: 601430) regulator of nonsense tran (1129 aa)
initn: 7595 init1: 7595 opt: 7595 Z-score: 5263.7 bits: 985.8 E(85289): 0
Smith-Waterman score: 7595; 99.9% identity (100.0% similar) in 1129 aa overlap (1-1129:1-1129)
10 20 30 40 50 60
pF1KSD MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GPGGAGAGSAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD QVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD ADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD VVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD AFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD AANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD NYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD SSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD TPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KSD PGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
1090 1100 1110 1120
>>XP_016882594 (OMIM: 601430) PREDICTED: regulator of no (1137 aa)
initn: 4859 init1: 4859 opt: 7569 Z-score: 5245.6 bits: 982.5 E(85289): 0
Smith-Waterman score: 7569; 99.2% identity (99.3% similar) in 1137 aa overlap (1-1129:1-1137)
10 20 30 40 50 60
pF1KSD MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GPGGAGAGSAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
310 320 330 340 350 360
370 380 390 400 410
pF1KSD WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDN--------YGDEIAIELRSSVGA
::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_016 WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNANLTQHTDYGDEIAIELRSSVGA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD PVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPK
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD RFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD PSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLK
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD DETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQA
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD TEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQ
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD YRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD TSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEV
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD EIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSK
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD QPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD IPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQA
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD NGPAAGRGTPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGPAAGRGTPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISM
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120
pF1KSD SQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
1090 1100 1110 1120 1130
>>XP_016882595 (OMIM: 601430) PREDICTED: regulator of no (1126 aa)
initn: 7261 init1: 4859 opt: 7461 Z-score: 5171.0 bits: 968.7 E(85289): 0
Smith-Waterman score: 7461; 98.2% identity (98.3% similar) in 1137 aa overlap (1-1129:1-1126)
10 20 30 40 50 60
pF1KSD MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GPGGAGAGSAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDS--------
310 320 330 340 350
370 380 390 400 410
pF1KSD WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDN--------YGDEIAIELRSSVGA
:::::::::::::::::::::::::::::::::: :::::::::::::::
XP_016 ---DMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNANLTQHTDYGDEIAIELRSSVGA
360 370 380 390 400
420 430 440 450 460 470
pF1KSD PVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPK
410 420 430 440 450 460
480 490 500 510 520 530
pF1KSD RFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCA
470 480 490 500 510 520
540 550 560 570 580 590
pF1KSD PSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLK
530 540 550 560 570 580
600 610 620 630 640 650
pF1KSD DETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQA
590 600 610 620 630 640
660 670 680 690 700 710
pF1KSD TEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQ
650 660 670 680 690 700
720 730 740 750 760 770
pF1KSD YRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSG
710 720 730 740 750 760
780 790 800 810 820 830
pF1KSD TSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEV
770 780 790 800 810 820
840 850 860 870 880 890
pF1KSD EIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSK
830 840 850 860 870 880
900 910 920 930 940 950
pF1KSD QPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAI
890 900 910 920 930 940
960 970 980 990 1000 1010
pF1KSD IPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQA
950 960 970 980 990 1000
1020 1030 1040 1050 1060 1070
pF1KSD NGPAAGRGTPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGPAAGRGTPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISM
1010 1020 1030 1040 1050 1060
1080 1090 1100 1110 1120
pF1KSD SQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
1070 1080 1090 1100 1110 1120
>>NP_002902 (OMIM: 601430) regulator of nonsense transcr (1118 aa)
initn: 7505 init1: 5103 opt: 5115 Z-score: 3548.4 bits: 668.4 E(85289): 6.6e-191
Smith-Waterman score: 7487; 98.9% identity (99.0% similar) in 1129 aa overlap (1-1129:1-1118)
10 20 30 40 50 60
pF1KSD MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSVEAYGPSSQTLTFLDTEEAELLGADTQGSEFEFTDFTLPSQTQTPPGGPGGPGGGGAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GPGGAGAGSAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GPGGAGAGAAAGQLDAQVGPEGILQNGAVDDSVAKTSQLLAELNFEEDEEDTYYTKDLPI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WLVKIPSEQEQLRARQITAQQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSGNEDLVII
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDS--------
310 320 330 340 350
370 380 390 400 410 420
pF1KSD WLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ---DMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNF
360 370 380 390 400
430 440 450 460 470 480
pF1KSD QVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLP
410 420 430 440 450 460
490 500 510 520 530 540
pF1KSD DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS
530 540 550 560 570 580
610 620 630 640 650 660
pF1KSD ADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVP
590 600 610 620 630 640
670 680 690 700 710 720
pF1KSD VVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALS
650 660 670 680 690 700
730 740 750 760 770 780
pF1KSD AFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTE
710 720 730 740 750 760
790 800 810 820 830 840
pF1KSD AANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF
770 780 790 800 810 820
850 860 870 880 890 900
pF1KSD QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLL
830 840 850 860 870 880
910 920 930 940 950 960
pF1KSD NYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NYYKEQKVLVEGPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDR
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KSD SSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SSQGRPSSMYFQTHDQIGMISAGPSHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAGRG
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KSD TPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGYISMSQPSQMSQ
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120
pF1KSD PGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PGLSQPELSQDSYLGDEFKSQIDVALSQDSTYQGERAYQHGGVTGLSQY
1070 1080 1090 1100 1110
>>NP_002171 (OMIM: 600502,604320,616155) DNA-binding pro (993 aa)
initn: 379 init1: 221 opt: 496 Z-score: 354.3 bits: 77.2 E(85289): 5.4e-13
Smith-Waterman score: 678; 31.0% identity (59.3% similar) in 565 aa overlap (389-906:86-633)
360 370 380 390 400 410
pF1KSD IIWLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPD--NYGDEIAIEL-----RSSVG
: .. . : : :...: . ..::
NP_002 RTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVGLYDAANEGSQLATGILTRVTQKSVT
60 70 80 90 100 110
420 430 440 450 460
pF1KSD APVEVTHNFQVDF----------VWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEV
. . .:.::... . ..... :...:: .. ... .. . . :.:. .
NP_002 VAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSA
120 130 140 150 160 170
470 480 490 500 510 520
pF1KSD EDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVL-QRPLSLIQGPPGTGKTVTSATIVYHL
. . . : : : . :: :: .: :. :..:.::::::::.: . :. .
NP_002 PSPASEIH-PLTFFNTCL---DTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQA
180 190 200 210 220 230
530 540 550 560 570
pF1KSD ARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSR--EAID--SPVSFLALHN--
..:: :: :::::::::.:.:.. ...:: .: :.:. : . :: .
NP_002 VKQGL-KVLCCAPSNIAVDNLVERLALCKQRILRLGHPARLLESIQQHSLDAVLARSDSA
240 250 260 270 280 290
580 590 600 610 620
pF1KSD QI-----RNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAER---ELLMNADVICC
:: ...:.. .: : : : ... . . . ::. : : : .:.:.
NP_002 QIVADIRKDIDQVFVKNKKTQDKREKSNFRNEIKLLRKELKEREEAAMLESLTSANVVLA
300 310 320 330 340 350
630 640 650 660 670 680
pF1KSD TCVGAG--DPR--LAKMQFRSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVM
: .::. : : . : ..::: .:: : : .:. : :.. ::.::: :: :...
NP_002 TNTGASADGPLKLLPESYFDVVVIDECAQALEASCWIPL-LKARKCILAGDHKQLPPTTV
360 370 380 390 400
690 700 710 720 730 740
pF1KSD CKKAAKAGLSQSLFERLVV-LGIRPIR-LQVQYRMHPALSAFPSNIFYEGSLQNGVTAAD
.::: :::: ::.:::. : : .: : :::::: :. . :. .: :.: ..:
NP_002 SHKAALAGLSLSLMERLAEEYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVAR
410 420 430 440 450 460
750 760 770 780 790
pF1KSD RVKKGFD--FQWPQPDKPMFFYVTQG-------QEEIASSGTSYLNRTEAANVEKITTKL
.. . . . :... : : .:. :.:. : . ... :
NP_002 HLLRDLPGVAATEETGVPLLLVDTAGCGLFELEEEDEQSKGNPGEVRLVSLHIQA----L
470 480 490 500 510 520
800 810 820 830 840 850
pF1KSD LKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILS
. ::. .:....::. : . : : . .: . :.:: :::.::::::. .:::
NP_002 VDAGVPARDIAVVSPYNLQVDLLRQSL-----VHR--HPELEIKSVDGFQGREKEAVILS
530 540 550 560 570
860 870 880 890 900 910
pF1KSD CVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVE
::.:.. .::: . ::.:::.:::: : .. . ...... . . :..:. ..
NP_002 FVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRT
580 590 600 610 620 630
920 930 940 950 960 970
pF1KSD GPLNNLRESLMQFSKPRKLVNTINPGARFMTTAMYDAREAIIPGSVYDRSSQGRPSSMYF
NP_002 AFEYLDDIVPENYSHENSQGSSHAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPA
640 650 660 670 680 690
>>XP_016873158 (OMIM: 600502,604320,616155) PREDICTED: D (656 aa)
initn: 281 init1: 221 opt: 487 Z-score: 350.3 bits: 75.9 E(85289): 9e-13
Smith-Waterman score: 491; 34.6% identity (61.8% similar) in 306 aa overlap (616-906:3-296)
590 600 610 620 630 640
pF1KSD QKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAG--DPR--LAKMQF
: : .:.:. : .::. : : . :
XP_016 MLESLTSANVVLATNTGASADGPLKLLPESYF
10 20 30
650 660 670 680 690 700
pF1KSD RSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVV
..::: .:: : : .:. : :.. ::.::: :: :... .::: :::: ::.:::.
XP_016 DVVVIDECAQALEASCWIPL-LKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAE
40 50 60 70 80 90
710 720 730 740 750
pF1KSD -LGIRPIR-LQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFD--FQWPQPDKPM
: : .: : :::::: :. . :. .: :.: ..: .. . . . :.
XP_016 EYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATEETGVPL
100 110 120 130 140 150
760 770 780 790 800 810
pF1KSD FFYVTQG-------QEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQ
.. : : .:. :.:. : . ... :. ::. .:....::. :
XP_016 LLVDTAGCGLFELEEEDEQSKGNPGEVRLVSLHIQA----LVDAGVPARDIAVVSPYNLQ
160 170 180 190 200
820 830 840 850 860 870
pF1KSD RSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRL
. : : . .: . :.:: :::.::::::. .::: ::.:.. .::: . ::.
XP_016 VDLLRQSL-----VHR--HPELEIKSVDGFQGREKEAVILSFVRSNRKGEVGFLAEDRRI
210 220 230 240 250 260
880 890 900 910 920 930
pF1KSD NVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKL
:::.:::: : .. . ...... . . :..:. ..
XP_016 NVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAFEYLDDIVPENYSHENSQ
270 280 290 300 310 320
940 950 960 970 980 990
pF1KSD VNTINPGARFMTTAMYDAREAIIPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAM
XP_016 GSSHAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPAGKSLASEAPSQPSLNGGSP
330 340 350 360 370 380
>>XP_005274031 (OMIM: 600502,604320,616155) PREDICTED: D (656 aa)
initn: 281 init1: 221 opt: 487 Z-score: 350.3 bits: 75.9 E(85289): 9e-13
Smith-Waterman score: 491; 34.6% identity (61.8% similar) in 306 aa overlap (616-906:3-296)
590 600 610 620 630 640
pF1KSD QKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAG--DPR--LAKMQF
: : .:.:. : .::. : : . :
XP_005 MLESLTSANVVLATNTGASADGPLKLLPESYF
10 20 30
650 660 670 680 690 700
pF1KSD RSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVV
..::: .:: : : .:. : :.. ::.::: :: :... .::: :::: ::.:::.
XP_005 DVVVIDECAQALEASCWIPL-LKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAE
40 50 60 70 80 90
710 720 730 740 750
pF1KSD -LGIRPIR-LQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFD--FQWPQPDKPM
: : .: : :::::: :. . :. .: :.: ..: .. . . . :.
XP_005 EYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATEETGVPL
100 110 120 130 140 150
760 770 780 790 800 810
pF1KSD FFYVTQG-------QEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQ
.. : : .:. :.:. : . ... :. ::. .:....::. :
XP_005 LLVDTAGCGLFELEEEDEQSKGNPGEVRLVSLHIQA----LVDAGVPARDIAVVSPYNLQ
160 170 180 190 200
820 830 840 850 860 870
pF1KSD RSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRL
. : : . .: . :.:: :::.::::::. .::: ::.:.. .::: . ::.
XP_005 VDLLRQSL-----VHR--HPELEIKSVDGFQGREKEAVILSFVRSNRKGEVGFLAEDRRI
210 220 230 240 250 260
880 890 900 910 920 930
pF1KSD NVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKL
:::.:::: : .. . ...... . . :..:. ..
XP_005 NVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAFEYLDDIVPENYSHENSQ
270 280 290 300 310 320
940 950 960 970 980 990
pF1KSD VNTINPGARFMTTAMYDAREAIIPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAM
XP_005 GSSHAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPAGKSLASEAPSQPSLNGGSP
330 340 350 360 370 380
>>XP_016873159 (OMIM: 600502,604320,616155) PREDICTED: D (656 aa)
initn: 281 init1: 221 opt: 487 Z-score: 350.3 bits: 75.9 E(85289): 9e-13
Smith-Waterman score: 491; 34.6% identity (61.8% similar) in 306 aa overlap (616-906:3-296)
590 600 610 620 630 640
pF1KSD QKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAG--DPR--LAKMQF
: : .:.:. : .::. : : . :
XP_016 MLESLTSANVVLATNTGASADGPLKLLPESYF
10 20 30
650 660 670 680 690 700
pF1KSD RSILIDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVV
..::: .:: : : .:. : :.. ::.::: :: :... .::: :::: ::.:::.
XP_016 DVVVIDECAQALEASCWIPL-LKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAE
40 50 60 70 80 90
710 720 730 740 750
pF1KSD -LGIRPIR-LQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFD--FQWPQPDKPM
: : .: : :::::: :. . :. .: :.: ..: .. . . . :.
XP_016 EYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATEETGVPL
100 110 120 130 140 150
760 770 780 790 800 810
pF1KSD FFYVTQG-------QEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQ
.. : : .:. :.:. : . ... :. ::. .:....::. :
XP_016 LLVDTAGCGLFELEEEDEQSKGNPGEVRLVSLHIQA----LVDAGVPARDIAVVSPYNLQ
160 170 180 190 200
820 830 840 850 860 870
pF1KSD RSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRL
. : : . .: . :.:: :::.::::::. .::: ::.:.. .::: . ::.
XP_016 VDLLRQSL-----VHR--HPELEIKSVDGFQGREKEAVILSFVRSNRKGEVGFLAEDRRI
210 220 230 240 250 260
880 890 900 910 920 930
pF1KSD NVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKL
:::.:::: : .. . ...... . . :..:. ..
XP_016 NVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAFEYLDDIVPENYSHENSQ
270 280 290 300 310 320
940 950 960 970 980 990
pF1KSD VNTINPGARFMTTAMYDAREAIIPGSVYDRSSQGRPSSMYFQTHDQIGMISAGPSHVAAM
XP_016 GSSHAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPAGKSLASEAPSQPSLNGGSP
330 340 350 360 370 380
>>XP_016869986 (OMIM: 602433,606002,608465) PREDICTED: p (828 aa)
initn: 614 init1: 135 opt: 450 Z-score: 323.5 bits: 71.3 E(85289): 2.8e-11
Smith-Waterman score: 626; 29.5% identity (55.2% similar) in 665 aa overlap (479-1022:82-729)
450 460 470 480 490 500
pF1KSD SGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKT----VLQRP----LSL
: :.:..: :..: : . : . :
XP_016 QLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICL
60 70 80 90 100 110
510 520 530 540
pF1KSD IQGPPGTGKTVTSATIVYHL----ARQGNGP-----------VLVCAPSNIAVDQLTEKI
:.:::::::. : . ..:.: :.:.. :::::::: :::.: .::
XP_016 IHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKI
120 130 140 150 160 170
550 560 570
pF1KSD ------------HQTG----LKVVRLCAKS-------REAIDS----------PVSFLAL
. : ...::: .. . ..:: : :.
XP_016 ILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAM
180 190 200 210 220 230
580 590 600 610
pF1KSD HNQIRNMD-SMPELQKLQQL--------KDETGE-LSSADEKRYRALKRTAERE------
:.. . .: .. ::.. . : ..: : .:.....: . .. : .
XP_016 HKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKT
240 250 260 270 280 290
620 630 640 650 660
pF1KSD ---LLMNADVICCTCVGAGDPRLAK-------MQFRSILIDESTQATEPECMVPVVLGAK
..... .:::: .: : . . : ...::. :. : : ..:.. .
XP_016 QSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCN
300 310 320 330 340 350
670 680 690 700 710
pF1KSD QLILVGDHCQLGPVVMCKKAAKAGLSQSL---FERLVVLGIR-------PI-RLQVQYRM
.:::::: :: :.:. :: . : .::. : ::. ... :: .: :::::
XP_016 KLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRM
360 370 380 390 400 410
720 730 740 750 760 770
pF1KSD HPALSAFPSNIFYEGSLQ-NGVTAADRVKKGFDFQWP-QPDKPMFFYVTQGQEEIASSGT
:: . :::: :. .:. : : : : .. .:: :: . : : .:.:. ..
XP_016 HPDICLFPSNYVYNRNLKTNRQTEAIRCSS----DWPFQPY--LVFDVGDGSER--RDND
420 430 440 450 460
780 790 800 810 820 830
pF1KSD SYLNRTEAANVEKITTKLLKAGAKP---DQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQ
::.: : : .: ::.: : .::::: :..:.. ..: ... . :
XP_016 SYINVQEIKLVMEII-KLIKDKRKDVSFRNIGIITHYKAQKT-MIQK-DLDKEFDRK--G
470 480 490 500 510
840 850 860 870 880
pF1KSD EVEIASVDAFQGREKDFIILSCVRANEHQG-IGFLNDPRRLNVALTRARYGVIIVGNPKA
.:. .:::::::.:: .:..::::: :: :::: . .::::..:::.:...:.:. ..
XP_016 PAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRT
520 530 540 550 560 570
890 900 910 920 930 940
pF1KSD LSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSK--P---RKLVN--TINP-GARF-
: .. ::.:.. ... .... .: :.. ... : : :.:.. :: : :.:
XP_016 LMENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPVLQRSLTHPPTIAPEGSRPQ
580 590 600 610 620 630
950 960 970 980
pF1KSD --MTTAMYDAREAI--IPGSVYDRSSQGRPSSMYFQT--------HDQIGMISAGPSHVA
. .. :. : . .:.: :... .. . :::. : .
XP_016 GGLPSSKLDSGFAKTSVAASLYHTPSDSKEITLTVTSKDPERPPVHDQL----QDPRLLK
640 650 660 670 680 690
990 1000 1010 1020 1030 1040
pF1KSD AMNIPIPFNLVM-PPMPPPGYFGQANGPAAGRGTPKGKTGRGGRQKNRFGLPGPSQTNLP
:.: . .. . :.: :. :.. : :
XP_016 RMGIEVKGGIFLWDPQPSSPQHPGATPPTGEPGFPVVHQDLSHIQQPAAVVAALSSHKPP
700 710 720 730 740 750
1050 1060 1070 1080 1090 1100
pF1KSD NSQASQDVASQPFSQGALTQGYISMSQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALS
XP_016 VRGEPPAASPEASTCQSKCDDPEEELCHRREARAFSEGEQEKCGSETHHTRRNSRWDKRT
760 770 780 790 800 810
>>NP_055861 (OMIM: 602433,606002,608465) probable helica (2677 aa)
initn: 581 init1: 135 opt: 450 Z-score: 317.3 bits: 71.8 E(85289): 6.2e-11
Smith-Waterman score: 626; 29.5% identity (55.2% similar) in 665 aa overlap (479-1022:1931-2578)
450 460 470 480 490 500
pF1KSD SGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKT----VLQRP----LSL
: :.:..: :..: : . : . :
NP_055 QLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICL
1910 1920 1930 1940 1950 1960
510 520 530 540
pF1KSD IQGPPGTGKTVTSATIVYHL----ARQGNGP-----------VLVCAPSNIAVDQLTEKI
:.:::::::. : . ..:.: :.:.. :::::::: :::.: .::
NP_055 IHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKI
1970 1980 1990 2000 2010 2020
550 560 570
pF1KSD ------------HQTG----LKVVRLCAKS-------REAIDS----------PVSFLAL
. : ...::: .. . ..:: : :.
NP_055 ILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAM
2030 2040 2050 2060 2070 2080
580 590 600 610
pF1KSD HNQIRNMD-SMPELQKLQQL--------KDETGE-LSSADEKRYRALKRTAERE------
:.. . .: .. ::.. . : ..: : .:.....: . .. : .
NP_055 HKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKT
2090 2100 2110 2120 2130 2140
620 630 640 650 660
pF1KSD ---LLMNADVICCTCVGAGDPRLAK-------MQFRSILIDESTQATEPECMVPVVLGAK
..... .:::: .: : . . : ...::. :. : : ..:.. .
NP_055 QSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCN
2150 2160 2170 2180 2190 2200
670 680 690 700 710
pF1KSD QLILVGDHCQLGPVVMCKKAAKAGLSQSL---FERLVVLGIR-------PI-RLQVQYRM
.:::::: :: :.:. :: . : .::. : ::. ... :: .: :::::
NP_055 KLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRM
2210 2220 2230 2240 2250 2260
720 730 740 750 760 770
pF1KSD HPALSAFPSNIFYEGSLQ-NGVTAADRVKKGFDFQWP-QPDKPMFFYVTQGQEEIASSGT
:: . :::: :. .:. : : : : .. .:: :: . : : .:.:. ..
NP_055 HPDICLFPSNYVYNRNLKTNRQTEAIRCSS----DWPFQPY--LVFDVGDGSER--RDND
2270 2280 2290 2300 2310
780 790 800 810 820 830
pF1KSD SYLNRTEAANVEKITTKLLKAGAKP---DQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQ
::.: : : .: ::.: : .::::: :..:.. ..: ... . :
NP_055 SYINVQEIKLVMEII-KLIKDKRKDVSFRNIGIITHYKAQKT-MIQK-DLDKEFDRK--G
2320 2330 2340 2350 2360
840 850 860 870 880
pF1KSD EVEIASVDAFQGREKDFIILSCVRANEHQG-IGFLNDPRRLNVALTRARYGVIIVGNPKA
.:. .:::::::.:: .:..::::: :: :::: . .::::..:::.:...:.:. ..
NP_055 PAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRT
2370 2380 2390 2400 2410 2420
890 900 910 920 930 940
pF1KSD LSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSK--P---RKLVN--TINP-GARF-
: .. ::.:.. ... .... .: :.. ... : : :.:.. :: : :.:
NP_055 LMENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPVLQRSLTHPPTIAPEGSRPQ
2430 2440 2450 2460 2470 2480
950 960 970 980
pF1KSD --MTTAMYDAREAI--IPGSVYDRSSQGRPSSMYFQT--------HDQIGMISAGPSHVA
. .. :. : . .:.: :... .. . :::. : .
NP_055 GGLPSSKLDSGFAKTSVAASLYHTPSDSKEITLTVTSKDPERPPVHDQL----QDPRLLK
2490 2500 2510 2520 2530 2540
990 1000 1010 1020 1030 1040
pF1KSD AMNIPIPFNLVM-PPMPPPGYFGQANGPAAGRGTPKGKTGRGGRQKNRFGLPGPSQTNLP
:.: . .. . :.: :. :.. : :
NP_055 RMGIEVKGGIFLWDPQPSSPQHPGATPPTGEPGFPVVHQDLSHIQQPAAVVAALSSHKPP
2550 2560 2570 2580 2590 2600
1050 1060 1070 1080 1090 1100
pF1KSD NSQASQDVASQPFSQGALTQGYISMSQPSQMSQPGLSQPELSQDSYLGDEFKSQIDVALS
NP_055 VRGEPPAASPEASTCQSKCDDPEEELCHRREARAFSEGEQEKCGSETHHTRRNSRWDKRT
2610 2620 2630 2640 2650 2660
1129 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 00:45:48 2016 done: Thu Nov 3 00:45:50 2016
Total Scan time: 13.890 Total Display time: 0.350
Function used was FASTA [36.3.4 Apr, 2011]