Result of FASTA (omim) for
pF1KSDA0157
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0157, 415 aa
1>>>pF1KSDA0157 415 - 415 aa - 415 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9692+/-0.000322; mu= 7.3324+/- 0.020
mean_var=168.3718+/-34.883, 0's: 0 Z-trim(120.5): 6 B-trim: 57 in 1/57
Lambda= 0.098842
statistics sampled from 35869 (35876) to 35869 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.75), E-opt: 0.2 (0.421), width: 16
Scan time: 8.180
The best scores are: opt bits E(85289)
NP_115558 (OMIM: 611144) BRISC complex subunit Abr ( 415) 2735 401.6 1.9e-111
XP_016871475 (OMIM: 611144) PREDICTED: BRISC compl ( 311) 2058 305.0 1.7e-82
XP_011537856 (OMIM: 611144) PREDICTED: BRISC compl ( 311) 2058 305.0 1.7e-82
NP_620775 (OMIM: 611143) BRCA1-A complex subunit A ( 409) 718 114.0 7.2e-25
XP_005263337 (OMIM: 611143) PREDICTED: BRCA1-A com ( 360) 581 94.4 4.9e-19
NP_001332891 (OMIM: 611143) BRCA1-A complex subuni ( 300) 387 66.7 9.1e-11
>>NP_115558 (OMIM: 611144) BRISC complex subunit Abro1 [ (415 aa)
initn: 2735 init1: 2735 opt: 2735 Z-score: 2121.8 bits: 401.6 E(85289): 1.9e-111
Smith-Waterman score: 2735; 99.5% identity (100.0% similar) in 415 aa overlap (1-415:1-415)
10 20 30 40 50 60
pF1KSD MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIQIYNHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:::
NP_115 MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD PCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD GVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD TSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 TSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD VNKLRRQITQRKNEKEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 VNKLRRQITQRKNEKEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ASDPPPPYSDFHPNNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 ASDPPPPYSDFHPNNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPP
310 320 330 340 350 360
370 380 390 400 410
pF1KSD PQRAAGDSGEDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 PQRAAGDSGEDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
370 380 390 400 410
>>XP_016871475 (OMIM: 611144) PREDICTED: BRISC complex s (311 aa)
initn: 2058 init1: 2058 opt: 2058 Z-score: 1601.9 bits: 305.0 E(85289): 1.7e-82
Smith-Waterman score: 2058; 100.0% identity (100.0% similar) in 311 aa overlap (105-415:1-311)
80 90 100 110 120 130
pF1KSD VNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRILGVPDLVFLLFSFIS
::::::::::::::::::::::::::::::
XP_016 MSYREQVLHKQLTRILGVPDLVFLLFSFIS
10 20 30
140 150 160 170 180 190
pF1KSD TANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGT
40 50 60 70 80 90
200 210 220 230 240 250
pF1KSD DFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNE
100 110 120 130 140 150
260 270 280 290 300 310
pF1KSD KEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPN
160 170 180 190 200 210
320 330 340 350 360 370
pF1KSD NQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDD
220 230 240 250 260 270
380 390 400 410
pF1KSD SDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
:::::::::::::::::::::::::::::::::::::::::
XP_016 SDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
280 290 300 310
>>XP_011537856 (OMIM: 611144) PREDICTED: BRISC complex s (311 aa)
initn: 2058 init1: 2058 opt: 2058 Z-score: 1601.9 bits: 305.0 E(85289): 1.7e-82
Smith-Waterman score: 2058; 100.0% identity (100.0% similar) in 311 aa overlap (105-415:1-311)
80 90 100 110 120 130
pF1KSD VNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRILGVPDLVFLLFSFIS
::::::::::::::::::::::::::::::
XP_011 MSYREQVLHKQLTRILGVPDLVFLLFSFIS
10 20 30
140 150 160 170 180 190
pF1KSD TANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGT
40 50 60 70 80 90
200 210 220 230 240 250
pF1KSD DFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNE
100 110 120 130 140 150
260 270 280 290 300 310
pF1KSD KEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPN
160 170 180 190 200 210
320 330 340 350 360 370
pF1KSD NQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDD
220 230 240 250 260 270
380 390 400 410
pF1KSD SDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
:::::::::::::::::::::::::::::::::::::::::
XP_011 SDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
280 290 300 310
>>NP_620775 (OMIM: 611143) BRCA1-A complex subunit Abrax (409 aa)
initn: 714 init1: 416 opt: 718 Z-score: 567.5 bits: 114.0 E(85289): 7.2e-25
Smith-Waterman score: 718; 32.3% identity (66.7% similar) in 378 aa overlap (2-374:7-380)
10 20 30 40 50
pF1KSD MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIQ
.: .::....:. :. :...: ::::::::. : ::.:::....: . .:.
NP_620 MEGESTSAVLSGFVLGALAFQHLNTDSDTEGFLLGEVKGEAKNSITDSQMDDVEVVYTID
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD IYNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQ
: .. :: .:::::. ...:::..: .::.. .:.:.:::.:::...: :..::..:::.
NP_620 IQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD LTRILGVPDLVFLLFS-FISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYK
: . .. ::::::.. : : . ::: ::. :..:.. .:. :.. ::: . : ::
NP_620 LQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD VSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVV
. : : ....... :.. ::..:: .:... : ..: .:::.....: :: ::..:
NP_620 TVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD ESCQAEVNKLRRQITQRKNEKEQERRLQQAVLSRQMPSES--LDPAFSPRMPSSGFAAEG
.. .::.:.:.: .:.. . : : .. .. :.:. : :. .:.: :
NP_620 DKLVKDVNRLKREIEKRRGAQIQAAREKNI---QKDPQENIFLCQALRTFFPNSEFLHSC
250 260 270 280 290
300 310 320 330 340 350
pF1KSD RSTLGDAEASDPPPPYSDFHP--NNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLK
.: . ..: :. .: . :. . .. :: . . . . . .
NP_620 VMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQII-KHKALDLDDRWQ
300 310 320 330 340 350
360 370 380 390 400 410
pF1KSD YPGSGADLPPPQRAAGDSGEDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNT
. : .:. .:.: ...:
NP_620 FKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF
360 370 380 390 400
>>XP_005263337 (OMIM: 611143) PREDICTED: BRCA1-A complex (360 aa)
initn: 577 init1: 312 opt: 581 Z-score: 462.7 bits: 94.4 E(85289): 4.9e-19
Smith-Waterman score: 581; 30.1% identity (64.8% similar) in 335 aa overlap (45-374:1-331)
20 30 40 50 60 70
pF1KSD FHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIQIYNHQPCSKLFSFYDYASK
....: . .:.: .. :: .:::::. ...
XP_005 MDDVEVVYTIDIQKYIPCYQLFSFYNSSGE
10 20 30
80 90 100 110 120 130
pF1KSD VNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRILGVPDLVFLLFS-FI
:::..: .::.. .:.:.:::.:::...: :..::..:::.: . .. ::::::.. :
XP_005 VNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSI
40 50 60 70 80 90
140 150 160 170 180 190
pF1KSD STANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHG
: . ::: ::. :..:.. .:. :.. ::: . : ::. : : ....... :.
XP_005 ITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHS
100 110 120 130 140 150
200 210 220 230 240 250
pF1KSD TDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKN
. ::..:: .:... : ..: .:::.....: :: ::..:.. .::.:.:.: .:..
XP_005 SKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRG
160 170 180 190 200 210
260 270 280 290 300 310
pF1KSD EKEQERRLQQAVLSRQMPSES--LDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDF
. : : .. .. :.:. : :. .:.: : .: . ..: :.
XP_005 AQIQAAREKNI---QKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHH
220 230 240 250 260
320 330 340 350 360
pF1KSD HP--NNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSG
.: . :. . .. :: . . . . .. : .:. .:.:
XP_005 LDVVDNLTLMVEHTDIPEASPASTPQIIKHKAL-DLDDRWQFKRSRLLDTQDKRSKADTG
270 280 290 300 310 320
370 380 390 400 410
pF1KSD EDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
...:
XP_005 SSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF
330 340 350 360
>>NP_001332891 (OMIM: 611143) BRCA1-A complex subunit Ab (300 aa)
initn: 390 init1: 312 opt: 387 Z-score: 314.3 bits: 66.7 E(85289): 9.1e-11
Smith-Waterman score: 387; 27.6% identity (60.7% similar) in 275 aa overlap (105-374:1-271)
80 90 100 110 120 130
pF1KSD VNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRILGVPDLVFLLFS-FI
:..::..:::.: . .. ::::::.. :
NP_001 MTFRERLLHKNLQEHFSNQDLVFLLLTPSI
10 20 30
140 150 160 170 180 190
pF1KSD STANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHG
: . ::: ::. :..:.. .:. :.. ::: . : ::. : : ....... :.
NP_001 ITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHS
40 50 60 70 80 90
200 210 220 230 240 250
pF1KSD TDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKN
. ::..:: .:... : ..: .:::.....: :: ::..:.. .::.:.:.: .:..
NP_001 SKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRG
100 110 120 130 140 150
260 270 280 290 300 310
pF1KSD EKEQERRLQQAVLSRQMPSES--LDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDF
. : : .. .. :.:. : :. .:.: : .: . ..: :.
NP_001 AQIQAAREKNI---QKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHH
160 170 180 190 200
320 330 340 350 360
pF1KSD HP--NNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSG
.: . :. . .. :: . . . . . .. : .:. .:.:
NP_001 LDVVDNLTLMVEHTDIPEASPASTPQII-KHKALDLDDRWQFKRSRLLDTQDKRSKADTG
210 220 230 240 250 260
370 380 390 400 410
pF1KSD EDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI
...:
NP_001 SSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF
270 280 290 300
415 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 00:20:06 2016 done: Thu Nov 3 00:20:07 2016
Total Scan time: 8.180 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]