Result of FASTA (omim) for
pF1KSDA0135
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0135, 1330 aa
1>>>pF1KSDA0135 1330 - 1330 aa - 1330 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.7353+/-0.000627; mu= -30.5968+/- 0.037
mean_var=834.9483+/-184.843, 0's: 0 Z-trim(115.9): 682 B-trim: 1390 in 1/57
Lambda= 0.044386
statistics sampled from 25875 (26665) to 25875 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.313), width: 16
Scan time: 13.950
The best scores are: opt bits E(85289)
XP_011509131 (OMIM: 607505) PREDICTED: PAS domain- (1330) 8974 592.6 6e-168
NP_001239048 (OMIM: 607505) PAS domain-containing (1330) 8974 592.6 6e-168
XP_011509132 (OMIM: 607505) PREDICTED: PAS domain- (1330) 8974 592.6 6e-168
XP_011509130 (OMIM: 607505) PREDICTED: PAS domain- (1330) 8974 592.6 6e-168
XP_011509128 (OMIM: 607505) PREDICTED: PAS domain- (1355) 8974 592.6 6.1e-168
NP_055963 (OMIM: 607505) PAS domain-containing ser (1323) 8906 588.3 1.2e-166
NP_001239049 (OMIM: 607505) PAS domain-containing (1323) 8906 588.3 1.2e-166
XP_016859124 (OMIM: 607505) PREDICTED: PAS domain- (1323) 8906 588.3 1.2e-166
XP_016859125 (OMIM: 607505) PREDICTED: PAS domain- (1323) 8906 588.3 1.2e-166
XP_016859123 (OMIM: 607505) PREDICTED: PAS domain- (1414) 8906 588.3 1.3e-166
XP_011509133 (OMIM: 607505) PREDICTED: PAS domain- (1144) 7635 506.8 3.5e-142
XP_011509134 (OMIM: 607505) PREDICTED: PAS domain- (1137) 7567 502.5 7.1e-141
NP_001239053 (OMIM: 607505) PAS domain-containing (1143) 7564 502.3 8.2e-141
XP_011509135 (OMIM: 607505) PREDICTED: PAS domain- (1114) 7530 500.1 3.6e-140
XP_005247048 (OMIM: 607505) PREDICTED: PAS domain- (1107) 7462 495.7 7.4e-139
NP_001239051 (OMIM: 607505) PAS domain-containing (1288) 7013 467.0 3.7e-130
XP_011509136 (OMIM: 607505) PREDICTED: PAS domain- ( 944) 6056 405.6 8.4e-112
XP_011509137 (OMIM: 607505) PREDICTED: PAS domain- ( 873) 5898 395.5 8.8e-109
XP_006723370 (OMIM: 606495) PREDICTED: MAP/microtu ( 685) 477 48.2 0.00024
NP_113605 (OMIM: 606495) MAP/microtubule affinity- ( 688) 477 48.2 0.00024
NP_001186796 (OMIM: 606495) MAP/microtubule affini ( 752) 477 48.3 0.00025
NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 473 48.0 0.00029
NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719) 473 48.0 0.00029
NP_004945 (OMIM: 600526) serine/threonine-protein ( 724) 473 48.0 0.00029
XP_011543100 (OMIM: 600526) PREDICTED: serine/thre ( 729) 473 48.0 0.00029
XP_016872800 (OMIM: 600526) PREDICTED: serine/thre ( 738) 473 48.0 0.0003
XP_011543099 (OMIM: 600526) PREDICTED: serine/thre ( 739) 473 48.0 0.0003
XP_011543098 (OMIM: 600526) PREDICTED: serine/thre ( 744) 473 48.0 0.0003
XP_011543097 (OMIM: 600526) PREDICTED: serine/thre ( 745) 473 48.0 0.0003
NP_059672 (OMIM: 600526) serine/threonine-protein ( 745) 473 48.0 0.0003
XP_011543096 (OMIM: 600526) PREDICTED: serine/thre ( 753) 473 48.0 0.0003
XP_016872799 (OMIM: 600526) PREDICTED: serine/thre ( 763) 473 48.0 0.0003
XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 470 47.8 0.00031
XP_011543095 (OMIM: 600526) PREDICTED: serine/thre ( 784) 473 48.0 0.00031
NP_001034558 (OMIM: 600526) serine/threonine-prote ( 788) 473 48.0 0.00031
XP_011543094 (OMIM: 600526) PREDICTED: serine/thre ( 793) 473 48.0 0.00031
XP_011543093 (OMIM: 600526) PREDICTED: serine/thre ( 798) 473 48.0 0.00031
XP_011543092 (OMIM: 600526) PREDICTED: serine/thre ( 799) 473 48.0 0.00031
XP_016876788 (OMIM: 602678) PREDICTED: MAP/microtu ( 664) 470 47.8 0.00031
XP_016876787 (OMIM: 602678) PREDICTED: MAP/microtu ( 665) 470 47.8 0.00031
XP_011543091 (OMIM: 600526) PREDICTED: serine/thre ( 808) 473 48.0 0.00031
NP_002639 (OMIM: 164960) serine/threonine-protein ( 313) 458 46.7 0.00032
XP_016876786 (OMIM: 602678) PREDICTED: MAP/microtu ( 673) 470 47.8 0.00032
XP_011535071 (OMIM: 602678) PREDICTED: MAP/microtu ( 673) 470 47.8 0.00032
XP_016876785 (OMIM: 602678) PREDICTED: MAP/microtu ( 674) 470 47.8 0.00032
XP_016876784 (OMIM: 602678) PREDICTED: MAP/microtu ( 680) 470 47.8 0.00032
XP_016876783 (OMIM: 602678) PREDICTED: MAP/microtu ( 689) 470 47.8 0.00032
XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708) 470 47.8 0.00033
NP_006866 (OMIM: 300295) serine/threonine-protein ( 311) 457 46.6 0.00033
NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713) 470 47.8 0.00033
>>XP_011509131 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa)
initn: 8974 init1: 8974 opt: 8974 Z-score: 3136.2 bits: 592.6 E(85289): 6e-168
Smith-Waterman score: 8974; 99.6% identity (99.8% similar) in 1330 aa overlap (1-1330:1-1330)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1270 1280 1290 1300 1310 1320
1330
pF1KSD HPGDPRLLTS
::::::::::
XP_011 HPGDPRLLTS
1330
>>NP_001239048 (OMIM: 607505) PAS domain-containing seri (1330 aa)
initn: 8974 init1: 8974 opt: 8974 Z-score: 3136.2 bits: 592.6 E(85289): 6e-168
Smith-Waterman score: 8974; 99.6% identity (99.8% similar) in 1330 aa overlap (1-1330:1-1330)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1270 1280 1290 1300 1310 1320
1330
pF1KSD HPGDPRLLTS
::::::::::
NP_001 HPGDPRLLTS
1330
>>XP_011509132 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa)
initn: 8974 init1: 8974 opt: 8974 Z-score: 3136.2 bits: 592.6 E(85289): 6e-168
Smith-Waterman score: 8974; 99.6% identity (99.8% similar) in 1330 aa overlap (1-1330:1-1330)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1270 1280 1290 1300 1310 1320
1330
pF1KSD HPGDPRLLTS
::::::::::
XP_011 HPGDPRLLTS
1330
>>XP_011509130 (OMIM: 607505) PREDICTED: PAS domain-cont (1330 aa)
initn: 8974 init1: 8974 opt: 8974 Z-score: 3136.2 bits: 592.6 E(85289): 6e-168
Smith-Waterman score: 8974; 99.6% identity (99.8% similar) in 1330 aa overlap (1-1330:1-1330)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_011 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1270 1280 1290 1300 1310 1320
1330
pF1KSD HPGDPRLLTS
::::::::::
XP_011 HPGDPRLLTS
1330
>>XP_011509128 (OMIM: 607505) PREDICTED: PAS domain-cont (1355 aa)
initn: 8974 init1: 8974 opt: 8974 Z-score: 3136.1 bits: 592.6 E(85289): 6.1e-168
Smith-Waterman score: 8974; 99.6% identity (99.8% similar) in 1330 aa overlap (1-1330:26-1355)
10 20 30
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTA
:::::::::::::::::::::::::::::::::::
XP_011 MRPRAAPPPEQLLELEAWQLASLLPMEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KSD EPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KSD TDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KSD GYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSV
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_011 GYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSV
190 200 210 220 230 240
220 230 240 250 260 270
pF1KSD WMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHIT
250 260 270 280 290 300
280 290 300 310 320 330
pF1KSD DLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGY
310 320 330 340 350 360
340 350 360 370 380 390
pF1KSD RASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLA
370 380 390 400 410 420
400 410 420 430 440 450
pF1KSD YNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIR
430 440 450 460 470 480
460 470 480 490 500 510
pF1KSD KLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALG
490 500 510 520 530 540
520 530 540 550 560 570
pF1KSD REEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLER
550 560 570 580 590 600
580 590 600 610 620 630
pF1KSD MGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_011 MGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAG
610 620 630 640 650 660
640 650 660 670 680 690
pF1KSD LSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_011 LSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVS
670 680 690 700 710 720
700 710 720 730 740 750
pF1KSD SCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQT
730 740 750 760 770 780
760 770 780 790 800 810
pF1KSD SSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRE
790 800 810 820 830 840
820 830 840 850 860 870
pF1KSD SCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTP
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_011 SCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTP
850 860 870 880 890 900
880 890 900 910 920 930
pF1KSD VIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHS
910 920 930 940 950 960
940 950 960 970 980 990
pF1KSD QRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEY
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KSD SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KSD LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAG
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KSD QSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEY
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KSD CAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLV
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KSD SGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSL
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 SGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSL
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330
pF1KSD SDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
:::::::::::::::::::::::::::::::::::
XP_011 SDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
1330 1340 1350
>>NP_055963 (OMIM: 607505) PAS domain-containing serine/ (1323 aa)
initn: 7517 init1: 7517 opt: 8906 Z-score: 3112.7 bits: 588.3 E(85289): 1.2e-166
Smith-Waterman score: 8906; 99.1% identity (99.2% similar) in 1330 aa overlap (1-1330:1-1323)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_055 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_055 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_055 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::: ::::::::::::::::::::::
NP_055 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1260 1270 1280 1290 1300 1310
1330
pF1KSD HPGDPRLLTS
::::::::::
NP_055 HPGDPRLLTS
1320
>>NP_001239049 (OMIM: 607505) PAS domain-containing seri (1323 aa)
initn: 7517 init1: 7517 opt: 8906 Z-score: 3112.7 bits: 588.3 E(85289): 1.2e-166
Smith-Waterman score: 8906; 99.1% identity (99.2% similar) in 1330 aa overlap (1-1330:1-1323)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_001 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_001 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::: ::::::::::::::::::::::
NP_001 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1260 1270 1280 1290 1300 1310
1330
pF1KSD HPGDPRLLTS
::::::::::
NP_001 HPGDPRLLTS
1320
>>XP_016859124 (OMIM: 607505) PREDICTED: PAS domain-cont (1323 aa)
initn: 7517 init1: 7517 opt: 8906 Z-score: 3112.7 bits: 588.3 E(85289): 1.2e-166
Smith-Waterman score: 8906; 99.1% identity (99.2% similar) in 1330 aa overlap (1-1330:1-1323)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_016 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_016 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1260 1270 1280 1290 1300 1310
1330
pF1KSD HPGDPRLLTS
::::::::::
XP_016 HPGDPRLLTS
1320
>>XP_016859125 (OMIM: 607505) PREDICTED: PAS domain-cont (1323 aa)
initn: 7517 init1: 7517 opt: 8906 Z-score: 3112.7 bits: 588.3 E(85289): 1.2e-166
Smith-Waterman score: 8906; 99.1% identity (99.2% similar) in 1330 aa overlap (1-1330:1-1323)
10 20 30 40 50 60
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ALSEEHMEADGHAAVVFGTVVDIITRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_016 ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LAGGSLLMHCPCYGSEWGLWWRRQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPMSSCDLGGRDLCGGCTGSSSACYALAT
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_016 LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RESPGHVPSMLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDEN
::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDEN
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KSD IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KSD YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KSD PVNLADYTWEEVCRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCL
1260 1270 1280 1290 1300 1310
1330
pF1KSD HPGDPRLLTS
::::::::::
XP_016 HPGDPRLLTS
1320
>>XP_016859123 (OMIM: 607505) PREDICTED: PAS domain-cont (1414 aa)
initn: 7517 init1: 7517 opt: 8906 Z-score: 3112.3 bits: 588.3 E(85289): 1.3e-166
Smith-Waterman score: 8906; 99.1% identity (99.2% similar) in 1330 aa overlap (1-1330:92-1414)
10 20 30
pF1KSD MEDGGLTAFEEDQRCLSQSLPLPVSAEGPA
::::::::::::::::::::::::::::::
XP_016 THAKCRLLLTLGAGGQLLELEAWQLASLLPMEDGGLTAFEEDQRCLSQSLPLPVSAEGPA
70 80 90 100 110 120
40 50 60 70 80 90
pF1KSD AQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCP
130 140 150 160 170 180
100 110 120 130 140 150
pF1KSD AAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDK
190 200 210 220 230 240
160 170 180 190 200 210
pF1KSD ACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIITRSGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
XP_016 ACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEK
250 260 270 280 290 300
220 230 240 250 260 270
pF1KSD IPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVA
310 320 330 340 350 360
280 290 300 310 320 330
pF1KSD GQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAA
370 380 390 400 410 420
340 350 360 370 380 390
pF1KSD PVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYS
430 440 450 460 470 480
400 410 420 430 440 450
pF1KSD YMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVP
490 500 510 520 530 540
460 470 480 490 500 510
pF1KSD RDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQ
550 560 570 580 590 600
520 530 540 550 560 570
pF1KSD ITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQK
610 620 630 640 650 660
580 590 600 610 620 630
pF1KSD AQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRRQDLAPSP
:::::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_016 AQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSP
670 680 690 700 710 720
640 650 660 670 680 690
pF1KSD SGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAV
730 740 750 760 770 780
700 710 720 730 740 750
pF1KSD TAPMSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSD
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSD
790 800 810 820 830 840
760 770 780 790 800 810
pF1KSD QTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQG
850 860 870 880 890 900
820 830 840 850 860 870
pF1KSD RRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSMLDAGPEDTCPSAEEPRLNVQ
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_016 RRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQ
910 920 930 940 950 960
880 890 900 910 920 930
pF1KSD VTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVK
970 980 990 1000 1010 1020
940 950 960 970 980 990
pF1KSD DLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAA
1030 1040 1050 1060 1070 1080
1000 1010 1020 1030 1040 1050
pF1KSD CEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVT
1090 1100 1110 1120 1130 1140
1060 1070 1080 1090 1100 1110
pF1KSD LEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR
1150 1160 1170 1180 1190 1200
1120 1130 1140 1150 1160 1170
pF1KSD QVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFC
: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 Q-------LVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFC
1210 1220 1230 1240 1250
1180 1190 1200 1210 1220 1230
pF1KSD GTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKE
1260 1270 1280 1290 1300 1310
1240 1250 1260 1270 1280 1290
pF1KSD LMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVCRVNKPESGVLSAASLEM
:::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 LMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEM
1320 1330 1340 1350 1360 1370
1300 1310 1320 1330
pF1KSD GNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
::::::::::::::::::::::::::::::::::::::::
XP_016 GNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
1380 1390 1400 1410
1330 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 00:10:11 2016 done: Thu Nov 3 00:10:14 2016
Total Scan time: 13.950 Total Display time: 0.670
Function used was FASTA [36.3.4 Apr, 2011]