Result of FASTA (omim) for
pF1KSDA0106
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0106, 224 aa
1>>>pF1KSDA0106 224 - 224 aa - 224 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7320+/-0.000333; mu= 16.8258+/- 0.021
mean_var=56.1730+/-11.340, 0's: 0 Z-trim(113.7): 27 B-trim: 94 in 1/52
Lambda= 0.171124
statistics sampled from 23104 (23127) to 23104 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.271), width: 16
Scan time: 5.470
The best scores are: opt bits E(85289)
NP_004896 (OMIM: 602316) peroxiredoxin-6 [Homo sap ( 224) 1498 377.7 8.7e-105
NP_001189360 (OMIM: 176763) peroxiredoxin-1 [Homo ( 199) 199 57.0 2.7e-08
NP_859048 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199) 199 57.0 2.7e-08
NP_002565 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199) 199 57.0 2.7e-08
NP_859047 (OMIM: 176763) peroxiredoxin-1 [Homo sap ( 199) 199 57.0 2.7e-08
NP_005800 (OMIM: 600538) peroxiredoxin-2 [Homo sap ( 198) 189 54.5 1.5e-07
NP_001289201 (OMIM: 604769) thioredoxin-dependent ( 198) 156 46.3 4.3e-05
NP_006784 (OMIM: 604769) thioredoxin-dependent per ( 256) 156 46.4 5.3e-05
XP_005274495 (OMIM: 300927) PREDICTED: peroxiredox ( 257) 155 46.2 6.3e-05
XP_016884720 (OMIM: 300927) PREDICTED: peroxiredox ( 336) 155 46.2 7.8e-05
NP_006397 (OMIM: 300927) peroxiredoxin-4 precursor ( 271) 142 43.0 0.0006
XP_016884719 (OMIM: 300927) PREDICTED: peroxiredox ( 350) 142 43.0 0.00074
>>NP_004896 (OMIM: 602316) peroxiredoxin-6 [Homo sapiens (224 aa)
initn: 1498 init1: 1498 opt: 1498 Z-score: 2002.3 bits: 377.7 E(85289): 8.7e-105
Smith-Waterman score: 1498; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224)
10 20 30 40 50 60
pF1KSD MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
130 140 150 160 170 180
190 200 210 220
pF1KSD WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
::::::::::::::::::::::::::::::::::::::::::::
NP_004 WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
190 200 210 220
>>NP_001189360 (OMIM: 176763) peroxiredoxin-1 [Homo sapi (199 aa)
initn: 245 init1: 132 opt: 199 Z-score: 269.8 bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)
10 20 30 40 50
pF1KSD MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
:. .: ::::.:.... .:.:. :.: : ..: .: ::: :: ::. .
NP_001 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
: :: : : ..:. :.:: :::: .:. . . . .:...: .: .: :
NP_001 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
70 80 90 100 110
120 130 140 150 160 170
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
.: : ..: .. : .:.. :. . .::. :: ::.: ..:.: ..
NP_001 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
120 130 140 150 160 170
180 190 200 210 220
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
. :. :: :... . : . ...:. : :
NP_001 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK
180 190
>>NP_859048 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens (199 aa)
initn: 245 init1: 132 opt: 199 Z-score: 269.8 bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)
10 20 30 40 50
pF1KSD MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
:. .: ::::.:.... .:.:. :.: : ..: .: ::: :: ::. .
NP_859 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
: :: : : ..:. :.:: :::: .:. . . . .:...: .: .: :
NP_859 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
70 80 90 100 110
120 130 140 150 160 170
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
.: : ..: .. : .:.. :. . .::. :: ::.: ..:.: ..
NP_859 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
120 130 140 150 160 170
180 190 200 210 220
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
. :. :: :... . : . ...:. : :
NP_859 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK
180 190
>>NP_002565 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens (199 aa)
initn: 245 init1: 132 opt: 199 Z-score: 269.8 bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)
10 20 30 40 50
pF1KSD MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
:. .: ::::.:.... .:.:. :.: : ..: .: ::: :: ::. .
NP_002 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
: :: : : ..:. :.:: :::: .:. . . . .:...: .: .: :
NP_002 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
70 80 90 100 110
120 130 140 150 160 170
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
.: : ..: .. : .:.. :. . .::. :: ::.: ..:.: ..
NP_002 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
120 130 140 150 160 170
180 190 200 210 220
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
. :. :: :... . : . ...:. : :
NP_002 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK
180 190
>>NP_859047 (OMIM: 176763) peroxiredoxin-1 [Homo sapiens (199 aa)
initn: 245 init1: 132 opt: 199 Z-score: 269.8 bits: 57.0 E(85289): 2.7e-08
Smith-Waterman score: 286; 30.6% identity (59.7% similar) in 206 aa overlap (3-204:4-197)
10 20 30 40 50
pF1KSD MPGGLLLGDVAPNFEANTTVGRIRFHDF-LGDSWG---ILFSHPRDFTPVCTTELGRAA
:. .: ::::.:.... .:.:. :.: : ..: .: ::: :: ::. .
NP_859 MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
: :: : : ..:. :.:: :::: .:. . . . .:...: .: .: :
NP_859 DRAEEFKKLNCQVIGASVDSHFCHLAW---VNTPKKQGGLGPMNIPLVSDPKRTIAQDYG
70 80 90 100 110
120 130 140 150 160 170
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
.: : ..: .. : .:.. :. . .::. :: ::.: ..:.: ..
NP_859 VL----KADEG--ISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGE
120 130 140 150 160 170
180 190 200 210 220
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
. :. :: :... . : . ...:. : :
NP_859 VCPAGWKPGSDT-IKPDV--QKSKEYFSKQK
180 190
>>NP_005800 (OMIM: 600538) peroxiredoxin-2 [Homo sapiens (198 aa)
initn: 206 init1: 128 opt: 189 Z-score: 256.5 bits: 54.5 E(85289): 1.5e-07
Smith-Waterman score: 280; 30.1% identity (60.2% similar) in 206 aa overlap (3-204:4-196)
10 20 30 40 50
pF1KSD MPGGLLLGDVAPNFEANTTVG----RIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAA
:. .: ::.:.:...: .... :. : .. .:: .: ::: :: ::. .
NP_005 MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKG-KYVVLFFYPLDFTFVCPTEIIAFS
10 20 30 40 50
60 70 80 90 100 110
pF1KSD KLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLG
. : .: : . .....:.:: :::: ::. : : .:.. : .:.:. :
NP_005 NRAEDFRKLGCEVLGVSVDSQFTHLAW---INTPRKEGGLGPLNIPLLADVTRRLSEDYG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD MLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRV
.: : ..: .. : .:.. :. . .::. :: ::.: ..: : :.
NP_005 VL----KTDEG--IAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGE
120 130 140 150 160 170
180 190 200 210 220
pF1KSD ATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP
. :. :: :... . :.. ...:. : :
NP_005 VCPAGWKPGSDT-IKPNV--DDSKEYFSKHN
180 190
>>NP_001289201 (OMIM: 604769) thioredoxin-dependent pero (198 aa)
initn: 137 init1: 137 opt: 156 Z-score: 212.5 bits: 46.3 E(85289): 4.3e-05
Smith-Waterman score: 156; 31.5% identity (63.1% similar) in 111 aa overlap (11-117:69-175)
10 20 30
pF1KSD MPGGLLLGDVAPNFEANTTV-GRIR---FHDFLGDSWGIL
:: :.....: :... . :: : .. .:
NP_001 SLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKG-KYLVL
40 50 60 70 80 90
40 50 60 70 80 90
pF1KSD FSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTE
: .: ::: :: ::. . : :: : ...:.:.:: .:::: ::. .
NP_001 FFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAW---INTPRKNGGLG
100 110 120 130 140 150
100 110 120 130 140 150
pF1KSD KLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRN
.. . ...: ..... :.:
NP_001 HMNIALLSDLTKQISRDYGVLLEGSGLALRSSQVQLLPKSTFRR
160 170 180 190
>>NP_006784 (OMIM: 604769) thioredoxin-dependent peroxid (256 aa)
initn: 169 init1: 137 opt: 156 Z-score: 210.9 bits: 46.4 E(85289): 5.3e-05
Smith-Waterman score: 226; 28.3% identity (58.1% similar) in 198 aa overlap (11-204:69-253)
10 20 30
pF1KSD MPGGLLLGDVAPNFEANTTV-GRIR---FHDFLGDSWGIL
:: :.....: :... . :: : .. .:
NP_006 SLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKG-KYLVL
40 50 60 70 80 90
40 50 60 70 80 90
pF1KSD FSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTE
: .: ::: :: ::. . : :: : ...:.:.:: .:::: ::. .
NP_006 FFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAW---INTPRKNGGLG
100 110 120 130 140 150
100 110 120 130 140 150
pF1KSD KLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRN
.. . ...: ..... :.: .: .. : .:.. :. .: . .::.
NP_006 HMNIALLSDLTKQISRDYGVL------LEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRS
160 170 180 190 200
160 170 180 190 200 210
pF1KSD FDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKK
.: ::.: ..: . . . :..: :: . :. : .:. : :
NP_006 VEETLRLVKAFQYVETHGEVCPANWTP-DSPTIKPS-PAA-SKEYFQKVNQ
210 220 230 240 250
220
pF1KSD YLRYTPQP
>>XP_005274495 (OMIM: 300927) PREDICTED: peroxiredoxin-4 (257 aa)
initn: 219 init1: 124 opt: 155 Z-score: 209.5 bits: 46.2 E(85289): 6.3e-05
Smith-Waterman score: 235; 26.8% identity (57.4% similar) in 209 aa overlap (1-204:61-255)
10 20
pF1KSD MPGGLLLGDVAPNFEANTTVG----RIRFH
.: ..... :: .:..... ....
XP_005 VQQEAREGEDWEREPPRQRPPIYEPPESEELPDNVMVSKPAPYWEGTAVIDGEFKELKLT
40 50 60 70 80 90
30 40 50 60 70 80
pF1KSD DFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDI
:. : .. ..: .: ::: :: ::. . :: . :....: :.:: :::: :
XP_005 DYRG-KYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAW---I
100 110 120 130 140
90 100 110 120 130 140
pF1KSD NAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLS
:. . . .:...: ..... :. ...: : : .:.. :.
XP_005 NTPRRQGGLGPIRIPLLSDLTHQISKDYGVY----LEDSGH--TLRGLFIIDDKGILRQI
150 160 170 180 190 200
150 160 170 180 190 200
pF1KSD ILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAK-KLFPKG
: .::. :: ::.: ..: : .. . :. :: :. .. ::. .: : : :
XP_005 TLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETI----IPDPAGKLKYFDKL
210 220 230 240 250
210 220
pF1KSD VFTKELPSGKKYLRYTPQP
XP_005 N
>>XP_016884720 (OMIM: 300927) PREDICTED: peroxiredoxin-4 (336 aa)
initn: 214 init1: 124 opt: 155 Z-score: 207.8 bits: 46.2 E(85289): 7.8e-05
Smith-Waterman score: 225; 26.6% identity (58.0% similar) in 188 aa overlap (1-184:61-238)
10 20
pF1KSD MPGGLLLGDVAPNFEANTTVG----RIRFH
.: ..... :: .:..... ....
XP_016 VQQEAREGEDWEREPPRQRPPIYEPPESEELPDNVMVSKPAPYWEGTAVIDGEFKELKLT
40 50 60 70 80 90
30 40 50 60 70 80
pF1KSD DFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDI
:. : .. ..: .: ::: :: ::. . :: . :....: :.:: :::: :
XP_016 DYRG-KYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAW---I
100 110 120 130 140
90 100 110 120 130 140
pF1KSD NAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLS
:. . . .:...: ..... :. ...: : : .:.. :.
XP_016 NTPRRQGGLGPIRIPLLSDLTHQISKDYGVY----LEDSGH--TLRGLFIIDDKGILRQI
150 160 170 180 190 200
150 160 170 180 190 200
pF1KSD ILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGV
: .::. :: ::.: ..: : .. . :. :: :
XP_016 TLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETVSIYICFYVELMVRVEKNA
210 220 230 240 250 260
210 220
pF1KSD FTKELPSGKKYLRYTPQP
XP_016 GRAQWLTPVIPALWEAEAGRSRGQEMETILANMVKSVSTKIQKKKISRAWWWVPVVPATR
270 280 290 300 310 320
224 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 00:00:06 2016 done: Thu Nov 3 00:00:07 2016
Total Scan time: 5.470 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]