Result of FASTA (omim) for
pF1KSDA0093
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0093, 900 aa
1>>>pF1KSDA0093 900 - 900 aa - 900 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6543+/-0.000456; mu= 4.1428+/- 0.028
mean_var=214.8469+/-45.510, 0's: 0 Z-trim(116.5): 478 B-trim: 488 in 1/52
Lambda= 0.087500
statistics sampled from 27125 (27694) to 27125 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.325), width: 16
Scan time: 12.220
The best scores are: opt bits E(85289)
NP_006145 (OMIM: 602278) E3 ubiquitin-protein liga ( 900) 6131 788.1 0
XP_011519926 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 875) 5891 757.8 5.2e-218
XP_011519927 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 5807 747.2 7.9e-215
XP_011519928 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 5807 747.2 7.9e-215
XP_011519929 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 827) 5629 724.7 4.5e-208
NP_001271267 (OMIM: 602278) E3 ubiquitin-protein l (1319) 5502 708.8 4.3e-203
NP_001271269 (OMIM: 602278) E3 ubiquitin-protein l (1302) 5383 693.8 1.4e-198
NP_001316141 (OMIM: 602278) E3 ubiquitin-protein l ( 753) 5154 664.7 4.7e-190
NP_940682 (OMIM: 602278) E3 ubiquitin-protein liga (1247) 5026 648.7 5e-185
NP_001271268 (OMIM: 602278) E3 ubiquitin-protein l (1303) 4906 633.6 1.9e-180
NP_001230889 (OMIM: 606384) E3 ubiquitin-protein l ( 911) 2951 386.7 2.8e-106
XP_016881169 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 750) 2850 373.8 1.7e-102
XP_016881166 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 838) 2850 373.9 1.8e-102
XP_016881168 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 854) 2830 371.4 1.1e-101
NP_001138438 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 2830 371.4 1.1e-101
NP_001138437 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 2830 371.4 1.1e-101
NP_001138436 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 2830 371.4 1.1e-101
XP_005266717 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 942) 2830 371.4 1.1e-101
NP_001138440 (OMIM: 606384) E3 ubiquitin-protein l ( 967) 2830 371.4 1.2e-101
NP_001138439 (OMIM: 606384) E3 ubiquitin-protein l ( 975) 2830 371.4 1.2e-101
NP_001138443 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 2827 371.0 1.4e-101
NP_001138442 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 2827 371.0 1.4e-101
XP_005266720 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 922) 2827 371.0 1.5e-101
NP_001138441 (OMIM: 606384) E3 ubiquitin-protein l ( 947) 2827 371.0 1.5e-101
NP_056092 (OMIM: 606384) E3 ubiquitin-protein liga ( 955) 2827 371.0 1.5e-101
XP_006722488 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 772) 2626 345.6 5.6e-94
XP_016881170 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 684) 2614 344.0 1.5e-93
XP_006722487 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 790) 2359 311.9 7.9e-84
XP_016881165 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 856) 2357 311.6 1e-83
XP_006722493 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 872) 2357 311.7 1e-83
XP_006722484 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 940) 2357 311.7 1.1e-83
XP_005266715 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 960) 2357 311.7 1.1e-83
XP_016881167 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 973) 2357 311.7 1.1e-83
XP_006722491 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 993) 2357 311.7 1.1e-83
XP_011524189 (OMIM: 606384) PREDICTED: E3 ubiquiti (1011) 2357 311.7 1.1e-83
XP_006722489 (OMIM: 606384) PREDICTED: E3 ubiquiti (1019) 2357 311.7 1.1e-83
XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1678 225.9 5.4e-58
XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1678 225.9 5.4e-58
NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 1678 225.9 5.8e-58
XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 u ( 752) 1678 225.9 5.8e-58
NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862) 1678 225.9 6.4e-58
NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862) 1678 225.9 6.4e-58
XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 u ( 900) 1678 226.0 6.6e-58
XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 u ( 903) 1678 226.0 6.6e-58
NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1678 226.0 6.6e-58
NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1678 226.0 6.6e-58
NP_955456 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 431) 1501 203.4 2e-51
XP_011521128 (OMIM: 602308) PREDICTED: NEDD4-like ( 754) 1501 203.5 3.1e-51
NP_001257382 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 754) 1501 203.5 3.1e-51
NP_008945 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 870) 1501 203.6 3.4e-51
>>NP_006145 (OMIM: 602278) E3 ubiquitin-protein ligase N (900 aa)
initn: 6131 init1: 6131 opt: 6131 Z-score: 4198.6 bits: 788.1 E(85289): 0
Smith-Waterman score: 6131; 99.8% identity (100.0% similar) in 900 aa overlap (1-900:1-900)
10 20 30 40 50 60
pF1KSD MATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MATCAVEVFGLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD ERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD QRAFTTRRQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEE
:::::::::::::::::::.::::::::::::::::::.:::::::::::::::::::::
NP_006 QRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD RGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD ERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
850 860 870 880 890 900
>>XP_011519926 (OMIM: 602278) PREDICTED: E3 ubiquitin-pr (875 aa)
initn: 5891 init1: 5891 opt: 5891 Z-score: 4035.0 bits: 757.8 E(85289): 5.2e-218
Smith-Waterman score: 5891; 99.8% identity (100.0% similar) in 861 aa overlap (40-900:15-875)
10 20 30 40 50 60
pF1KSD GLLEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLN
::::::::::::::::::::::::::::::
XP_011 MLRVFWCLRVWPIKSDPYVRVTLYDPMNGVLTSVQTKTIKKSLN
10 20 30 40
70 80 90 100 110 120
pF1KSD PKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KSD VLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQE
110 120 130 140 150 160
190 200 210 220 230 240
pF1KSD PSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQ
170 180 190 200 210 220
250 260 270 280 290 300
pF1KSD ISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELNARLTIFG
::::::::::.::::::::::::::::::.::::::::::::::::::::::::::::::
XP_011 ISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFG
230 240 250 260 270 280
310 320 330 340 350 360
pF1KSD NSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDH
290 300 310 320 330 340
370 380 390 400 410 420
pF1KSD NSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEV
350 360 370 380 390 400
430 440 450 460 470 480
pF1KSD RHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRI
410 420 430 440 450 460
490 500 510 520 530 540
pF1KSD FYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRR
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD ATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFE
530 540 550 560 570 580
610 620 630 640 650 660
pF1KSD YSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPI
590 600 610 620 630 640
670 680 690 700 710 720
pF1KSD TLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNK
650 660 670 680 690 700
730 740 750 760 770 780
pF1KSD KEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWR
710 720 730 740 750 760
790 800 810 820 830 840
pF1KSD EHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQS
770 780 790 800 810 820
850 860 870 880 890 900
pF1KSD FTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
830 840 850 860 870
>>XP_011519927 (OMIM: 602278) PREDICTED: E3 ubiquitin-pr (849 aa)
initn: 5807 init1: 5807 opt: 5807 Z-score: 3977.9 bits: 747.2 E(85289): 7.9e-215
Smith-Waterman score: 5807; 99.8% identity (100.0% similar) in 849 aa overlap (52-900:1-849)
30 40 50 60 70 80
pF1KSD RVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRVH
::::::::::::::::::::::::::::::
XP_011 MNGVLTSVQTKTIKKSLNPKWNEEILFRVH
10 20 30
90 100 110 120 130 140
pF1KSD PQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVK
40 50 60 70 80 90
150 160 170 180 190 200
pF1KSD GYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQ
100 110 120 130 140 150
210 220 230 240 250 260
pF1KSD DILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_011 DILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRE
160 170 180 190 200 210
270 280 290 300 310 320
pF1KSD SSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSN
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
XP_011 SSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSN
220 230 240 250 260 270
330 340 350 360 370 380
pF1KSD HSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV
280 290 300 310 320 330
390 400 410 420 430 440
pF1KSD QATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFID
340 350 360 370 380 390
450 460 470 480 490 500
pF1KSD HNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQW
400 410 420 430 440 450
510 520 530 540 550 560
pF1KSD EDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIM
460 470 480 490 500 510
570 580 590 600 610 620
pF1KSD GVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQIN
520 530 540 550 560 570
630 640 650 660 670 680
pF1KSD PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY
580 590 600 610 620 630
690 700 710 720 730 740
pF1KSD YNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRF
640 650 660 670 680 690
750 760 770 780 790 800
pF1KSD VNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSAN
700 710 720 730 740 750
810 820 830 840 850 860
pF1KSD HQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKL
760 770 780 790 800 810
870 880 890 900
pF1KSD PRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
:::::::::::::::::::::::::::::::::::::::
XP_011 PRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
820 830 840
>>XP_011519928 (OMIM: 602278) PREDICTED: E3 ubiquitin-pr (849 aa)
initn: 5807 init1: 5807 opt: 5807 Z-score: 3977.9 bits: 747.2 E(85289): 7.9e-215
Smith-Waterman score: 5807; 99.8% identity (100.0% similar) in 849 aa overlap (52-900:1-849)
30 40 50 60 70 80
pF1KSD RVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRVH
::::::::::::::::::::::::::::::
XP_011 MNGVLTSVQTKTIKKSLNPKWNEEILFRVH
10 20 30
90 100 110 120 130 140
pF1KSD PQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVK
40 50 60 70 80 90
150 160 170 180 190 200
pF1KSD GYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQ
100 110 120 130 140 150
210 220 230 240 250 260
pF1KSD DILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_011 DILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRE
160 170 180 190 200 210
270 280 290 300 310 320
pF1KSD SSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSN
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
XP_011 SSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSN
220 230 240 250 260 270
330 340 350 360 370 380
pF1KSD HSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV
280 290 300 310 320 330
390 400 410 420 430 440
pF1KSD QATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFID
340 350 360 370 380 390
450 460 470 480 490 500
pF1KSD HNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQW
400 410 420 430 440 450
510 520 530 540 550 560
pF1KSD EDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIM
460 470 480 490 500 510
570 580 590 600 610 620
pF1KSD GVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQIN
520 530 540 550 560 570
630 640 650 660 670 680
pF1KSD PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEY
580 590 600 610 620 630
690 700 710 720 730 740
pF1KSD YNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRF
640 650 660 670 680 690
750 760 770 780 790 800
pF1KSD VNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSAN
700 710 720 730 740 750
810 820 830 840 850 860
pF1KSD HQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKL
760 770 780 790 800 810
870 880 890 900
pF1KSD PRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
:::::::::::::::::::::::::::::::::::::::
XP_011 PRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
820 830 840
>>XP_011519929 (OMIM: 602278) PREDICTED: E3 ubiquitin-pr (827 aa)
initn: 5629 init1: 5629 opt: 5629 Z-score: 3856.6 bits: 724.7 E(85289): 4.5e-208
Smith-Waterman score: 5629; 99.6% identity (100.0% similar) in 822 aa overlap (79-900:6-827)
50 60 70 80 90 100
pF1KSD YDPMNGVLTSVQTKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDV
.:::::::::::::::::::::::::::::
XP_011 MDQCEQVHPQQHRLLFEVFDENRLTRDDFLGQVDV
10 20 30
110 120 130 140 150 160
pF1KSD PLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEEL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KSD EPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNL
100 110 120 130 140 150
230 240 250 260 270 280
pF1KSD TDAENGNIQLQAQRAFTTRRQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPS
:::::::::::::::::::::::::::::::.::::::::::::::::::.:::::::::
XP_011 TDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPS
160 170 180 190 200 210
290 300 310 320 330 340
pF1KSD SNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSS
220 230 240 250 260 270
350 360 370 380 390 400
pF1KSD GLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDS
280 290 300 310 320 330
410 420 430 440 450 460
pF1KSD GQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDT
340 350 360 370 380 390
470 480 490 500 510 520
pF1KSD SNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEF
400 410 420 430 440 450
530 540 550 560 570 580
pF1KSD FRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGV
460 470 480 490 500 510
590 600 610 620 630 640
pF1KSD AREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYH
520 530 540 550 560 570
650 660 670 680 690 700
pF1KSD GKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFG
580 590 600 610 620 630
710 720 730 740 750 760
pF1KSD QTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIF
640 650 660 670 680 690
770 780 790 800 810 820
pF1KSD DENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVT
700 710 720 730 740 750
830 840 850 860 870 880
pF1KSD GTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQM
760 770 780 790 800 810
890 900
pF1KSD AIENTQGFDGVD
::::::::::::
XP_011 AIENTQGFDGVD
820
>>NP_001271267 (OMIM: 602278) E3 ubiquitin-protein ligas (1319 aa)
initn: 5502 init1: 5502 opt: 5502 Z-score: 3767.2 bits: 708.8 E(85289): 4.3e-203
Smith-Waterman score: 5502; 99.8% identity (100.0% similar) in 803 aa overlap (98-900:517-1319)
70 80 90 100 110 120
pF1KSD LNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFK
::::::::::::::::::::::::::::::
NP_001 KFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLERPYTFK
490 500 510 520 530 540
130 140 150 160 170 180
pF1KSD DFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQ
550 560 570 580 590 600
190 200 210 220 230 240
pF1KSD QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR
610 620 630 640 650 660
250 260 270 280 290 300
pF1KSD RQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELNARLTI
::::::::::::.::::::::::::::::::.::::::::::::::::::::::::::::
NP_001 RQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTI
670 680 690 700 710 720
310 320 330 340 350 360
pF1KSD FGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYV
730 740 750 760 770 780
370 380 390 400 410 420
pF1KSD DHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGW
790 800 810 820 830 840
430 440 450 460 470 480
pF1KSD EVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDG
850 860 870 880 890 900
490 500 510 520 530 540
pF1KSD RIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKL
910 920 930 940 950 960
550 560 570 580 590 600
pF1KSD RRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGL
970 980 990 1000 1010 1020
610 620 630 640 650 660
pF1KSD FEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHK
1030 1040 1050 1060 1070 1080
670 680 690 700 710 720
pF1KSD PITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNK
1090 1100 1110 1120 1130 1140
730 740 750 760 770 780
pF1KSD NKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVND
1150 1160 1170 1180 1190 1200
790 800 810 820 830 840
pF1KSD WREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGP
1210 1220 1230 1240 1250 1260
850 860 870 880 890 900
pF1KSD QSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
1270 1280 1290 1300 1310
>>NP_001271269 (OMIM: 602278) E3 ubiquitin-protein ligas (1302 aa)
initn: 5380 init1: 5380 opt: 5383 Z-score: 3686.1 bits: 693.8 E(85289): 1.4e-198
Smith-Waterman score: 5383; 96.2% identity (97.6% similar) in 822 aa overlap (82-900:481-1302)
60 70 80 90 100
pF1KSD MNGVLTSVQTKTIKKSLNPKWNEEILFRVHPQQHRLLFEVFDENR---LTRDDFLGQVDV
:.: . : .:.. :.::. ..
NP_001 GILRRSISLGGAYPNISCLSSLKHNCSKGGPSQLLIKFASGNEGKVDNLSRDSNRDCTNE
460 470 480 490 500 510
110 120 130 140 150 160
pF1KSD PLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSNSCKTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEEL
520 530 540 550 560 570
170 180 190 200 210 220
pF1KSD EPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNL
580 590 600 610 620 630
230 240 250 260 270 280
pF1KSD TDAENGNIQLQAQRAFTTRRQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPS
:::::::::::::::::::::::::::::::.::::::::::::::::::.:::::::::
NP_001 TDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPS
640 650 660 670 680 690
290 300 310 320 330 340
pF1KSD SNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSS
700 710 720 730 740 750
350 360 370 380 390 400
pF1KSD GLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDS
760 770 780 790 800 810
410 420 430 440 450 460
pF1KSD GQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDT
820 830 840 850 860 870
470 480 490 500 510 520
pF1KSD SNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEF
880 890 900 910 920 930
530 540 550 560 570 580
pF1KSD FRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGV
940 950 960 970 980 990
590 600 610 620 630 640
pF1KSD AREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYH
1000 1010 1020 1030 1040 1050
650 660 670 680 690 700
pF1KSD GKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFG
1060 1070 1080 1090 1100 1110
710 720 730 740 750 760
pF1KSD QTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIF
1120 1130 1140 1150 1160 1170
770 780 790 800 810 820
pF1KSD DENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVT
1180 1190 1200 1210 1220 1230
830 840 850 860 870 880
pF1KSD GTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQM
1240 1250 1260 1270 1280 1290
890 900
pF1KSD AIENTQGFDGVD
::::::::::::
NP_001 AIENTQGFDGVD
1300
>>NP_001316141 (OMIM: 602278) E3 ubiquitin-protein ligas (753 aa)
initn: 5154 init1: 5154 opt: 5154 Z-score: 3533.1 bits: 664.7 E(85289): 4.7e-190
Smith-Waterman score: 5154; 99.7% identity (100.0% similar) in 753 aa overlap (148-900:1-753)
120 130 140 150 160 170
pF1KSD PRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQ
::::::::::::::::::::::::::::::
NP_001 MTYLPKTSGSEDDNAEQAEELEPGWVVLDQ
10 20 30
180 190 200 210 220 230
pF1KSD PDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQ
40 50 60 70 80 90
240 250 260 270 280 290
pF1KSD LQAQRAFTTRRQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHL
::::::::::::::::::::::.::::::::::::::::::.::::::::::::::::::
NP_001 LQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KSD AEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEK
160 170 180 190 200 210
360 370 380 390 400 410
pF1KSD QDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSE
220 230 240 250 260 270
420 430 440 450 460 470
pF1KSD IEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPP
280 290 300 310 320 330
480 490 500 510 520 530
pF1KSD GWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQN
340 350 360 370 380 390
540 550 560 570 580 590
pF1KSD DIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLIS
400 410 420 430 440 450
600 610 620 630 640 650
pF1KSD KEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFI
460 470 480 490 500 510
660 670 680 690 700 710
pF1KSD RPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPFYKMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKN
520 530 540 550 560 570
720 730 740 750 760 770
pF1KSD GGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLM
580 590 600 610 620 630
780 790 800 810 820 830
pF1KSD CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNG
640 650 660 670 680 690
840 850 860 870 880 890
pF1KSD FAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD
700 710 720 730 740 750
900
pF1KSD GVD
:::
NP_001 GVD
>>NP_940682 (OMIM: 602278) E3 ubiquitin-protein ligase N (1247 aa)
initn: 5018 init1: 5018 opt: 5026 Z-score: 3442.8 bits: 648.7 E(85289): 5e-185
Smith-Waterman score: 5026; 98.1% identity (99.2% similar) in 748 aa overlap (157-900:500-1247)
130 140 150 160 170 180
pF1KSD KDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEEL----EPGWVVLDQPDAAC
:.:.: . ..:: .:::::::::::::
NP_940 SSLKHNCSKGGPSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKPGWVVLDQPDAAC
470 480 490 500 510 520
190 200 210 220 230 240
pF1KSD HLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 HLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQR
530 540 550 560 570 580
250 260 270 280 290 300
pF1KSD AFTTRRQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELN
:::::::::::::::::.::::::::::::::::::.:::::::::::::::::::::::
NP_940 AFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELN
590 600 610 620 630 640
310 320 330 340 350 360
pF1KSD ARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 ARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERG
650 660 670 680 690 700
370 380 390 400 410 420
pF1KSD RSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 RSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGF
710 720 730 740 750 760
430 440 450 460 470 480
pF1KSD LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER
770 780 790 800 810 820
490 500 510 520 530 540
pF1KSD THTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 THTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNK
830 840 850 860 870 880
550 560 570 580 590 600
pF1KSD FEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 FEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFN
890 900 910 920 930 940
610 620 630 640 650 660
pF1KSD PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 PYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYK
950 960 970 980 990 1000
670 680 690 700 710 720
pF1KSD MMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 MMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEI
1010 1020 1030 1040 1050 1060
730 740 750 760 770 780
pF1KSD VVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 VVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGD
1070 1080 1090 1100 1110 1120
790 800 810 820 830 840
pF1KSD VDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 VDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELY
1130 1140 1150 1160 1170 1180
850 860 870 880 890 900
pF1KSD GSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 GSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
1190 1200 1210 1220 1230 1240
>>NP_001271268 (OMIM: 602278) E3 ubiquitin-protein ligas (1303 aa)
initn: 4906 init1: 4906 opt: 4906 Z-score: 3360.7 bits: 633.6 E(85289): 1.9e-180
Smith-Waterman score: 5334; 97.8% identity (98.0% similar) in 803 aa overlap (98-900:517-1303)
70 80 90 100 110 120
pF1KSD LNPKWNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFK
::::::::::::::::::::::::::::::
NP_001 KFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLERPYTFK
490 500 510 520 530 540
130 140 150 160 170 180
pF1KSD DFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQ
:::::::::::::::::::::::::::::::::::::::::: ::
NP_001 DFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELE----------------QQ
550 560 570 580 590
190 200 210 220 230 240
pF1KSD QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTR
600 610 620 630 640 650
250 260 270 280 290 300
pF1KSD RQISEETESVDNQESSENWEIIREDEATMYSSQAFPSPPPSSNLDVPTHLAEELNARLTI
::::::::::::.::::::::::::::::::.::::::::::::::::::::::::::::
NP_001 RQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTI
660 670 680 690 700 710
310 320 330 340 350 360
pF1KSD FGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYV
720 730 740 750 760 770
370 380 390 400 410 420
pF1KSD DHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGW
780 790 800 810 820 830
430 440 450 460 470 480
pF1KSD EVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEERTHTDG
840 850 860 870 880 890
490 500 510 520 530 540
pF1KSD RIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPNKFEMKL
900 910 920 930 940 950
550 560 570 580 590 600
pF1KSD RRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGL
960 970 980 990 1000 1010
610 620 630 640 650 660
pF1KSD FEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHK
1020 1030 1040 1050 1060 1070
670 680 690 700 710 720
pF1KSD PITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNK
1080 1090 1100 1110 1120 1130
730 740 750 760 770 780
pF1KSD NKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVND
1140 1150 1160 1170 1180 1190
790 800 810 820 830 840
pF1KSD WREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGP
1200 1210 1220 1230 1240 1250
850 860 870 880 890 900
pF1KSD QSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
1260 1270 1280 1290 1300
900 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 23:56:50 2016 done: Wed Nov 2 23:56:52 2016
Total Scan time: 12.220 Total Display time: 0.250
Function used was FASTA [36.3.4 Apr, 2011]