Result of FASTA (omim) for
pF1KSDA0067
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0067, 1291 aa
1>>>pF1KSDA0067 1291 - 1291 aa - 1291 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.3932+/-0.000439; mu= -9.5760+/- 0.027
mean_var=378.8531+/-78.839, 0's: 0 Z-trim(121.4): 52 B-trim: 1893 in 2/56
Lambda= 0.065893
statistics sampled from 37876 (37936) to 37876 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.739), E-opt: 0.2 (0.445), width: 16
Scan time: 16.390
The best scores are: opt bits E(85289)
NP_001138887 (OMIM: 604396) histone-lysine N-methy (1291) 8782 850.0 0
XP_005245698 (OMIM: 604396) PREDICTED: histone-lys (1292) 8764 848.3 0
XP_016858442 (OMIM: 604396) PREDICTED: histone-lys (1292) 8764 848.3 0
NP_036564 (OMIM: 604396) histone-lysine N-methyltr (1290) 8763 848.2 0
XP_016858443 (OMIM: 604396) PREDICTED: histone-lys ( 739) 4983 488.7 6.3e-137
XP_016858444 (OMIM: 604396) PREDICTED: histone-lys ( 397) 2495 252.0 6e-66
NP_001230420 (OMIM: 604396) histone-lysine N-methy ( 397) 2495 252.0 6e-66
NP_001153780 (OMIM: 607865) histone-lysine N-methy ( 707) 857 96.5 7.2e-19
NP_001307628 (OMIM: 607865) histone-lysine N-methy ( 707) 857 96.5 7.2e-19
NP_114121 (OMIM: 607865) histone-lysine N-methyltr ( 719) 857 96.5 7.3e-19
>>NP_001138887 (OMIM: 604396) histone-lysine N-methyltra (1291 aa)
initn: 8782 init1: 8782 opt: 8782 Z-score: 4527.5 bits: 850.0 E(85289): 0
Smith-Waterman score: 8782; 100.0% identity (100.0% similar) in 1291 aa overlap (1-1291:1-1291)
10 20 30 40 50 60
pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE
1210 1220 1230 1240 1250 1260
1270 1280 1290
pF1KSD LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
:::::::::::::::::::::::::::::::
NP_001 LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
1270 1280 1290
>>XP_005245698 (OMIM: 604396) PREDICTED: histone-lysine (1292 aa)
initn: 8762 init1: 5619 opt: 8764 Z-score: 4518.3 bits: 848.3 E(85289): 0
Smith-Waterman score: 8764; 99.8% identity (99.9% similar) in 1292 aa overlap (1-1291:1-1292)
10 20 30 40 50 60
pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
370 380 390 400 410 420
430 440 450 460 470
pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSD-LESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::. ::::
XP_005 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290
pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL
::::::::::::::::::::::::::::::::
XP_005 ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL
1270 1280 1290
>>XP_016858442 (OMIM: 604396) PREDICTED: histone-lysine (1292 aa)
initn: 8762 init1: 5619 opt: 8764 Z-score: 4518.3 bits: 848.3 E(85289): 0
Smith-Waterman score: 8764; 99.8% identity (99.9% similar) in 1292 aa overlap (1-1291:1-1292)
10 20 30 40 50 60
pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
370 380 390 400 410 420
430 440 450 460 470
pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSD-LESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::. ::::
XP_016 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPV
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRM
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290
pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL
::::::::::::::::::::::::::::::::
XP_016 ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL
1270 1280 1290
>>NP_036564 (OMIM: 604396) histone-lysine N-methyltransf (1290 aa)
initn: 8510 init1: 8510 opt: 8763 Z-score: 4517.8 bits: 848.2 E(85289): 0
Smith-Waterman score: 8763; 99.9% identity (99.9% similar) in 1291 aa overlap (1-1291:1-1290)
10 20 30 40 50 60
pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_036 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTE
1210 1220 1230 1240 1250
1270 1280 1290
pF1KSD LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
:::::::::::::::::::::::::::::::
NP_036 LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
1260 1270 1280 1290
>>XP_016858443 (OMIM: 604396) PREDICTED: histone-lysine (739 aa)
initn: 4981 init1: 3157 opt: 4983 Z-score: 2579.3 bits: 488.7 E(85289): 6.3e-137
Smith-Waterman score: 4983; 99.7% identity (99.9% similar) in 739 aa overlap (1-738:1-739)
10 20 30 40 50 60
pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
370 380 390 400 410 420
430 440 450 460 470
pF1KSD NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSD-LESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::. ::::
XP_016 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFC
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFI
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD NTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVY
:::::::::::::::::::
XP_016 NTGPEFLVGCDCKDGCRDK
730
>>XP_016858444 (OMIM: 604396) PREDICTED: histone-lysine (397 aa)
initn: 2495 init1: 2495 opt: 2495 Z-score: 1305.0 bits: 252.0 E(85289): 6e-66
Smith-Waterman score: 2495; 100.0% identity (100.0% similar) in 380 aa overlap (1-380:1-380)
10 20 30 40 50 60
pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
::::::::::::::::::::
XP_016 TWWKSRVEEVDGSLVRILFLVLFFSTILEAEVGGGGT
370 380 390
>>NP_001230420 (OMIM: 604396) histone-lysine N-methyltra (397 aa)
initn: 2495 init1: 2495 opt: 2495 Z-score: 1305.0 bits: 252.0 E(85289): 6e-66
Smith-Waterman score: 2495; 100.0% identity (100.0% similar) in 380 aa overlap (1-380:1-380)
10 20 30 40 50 60
pF1KSD MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
::::::::::::::::::::
NP_001 TWWKSRVEEVDGSLVRILFLVLFFSTILEAEVGGGGT
370 380 390
>>NP_001153780 (OMIM: 607865) histone-lysine N-methyltra (707 aa)
initn: 1181 init1: 764 opt: 857 Z-score: 459.8 bits: 96.5 E(85289): 7.2e-19
Smith-Waterman score: 1038; 31.4% identity (55.3% similar) in 722 aa overlap (571-1291:128-707)
550 560 570 580 590 600
pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
: : : :: .:: .. :. . .:.:::
NP_001 DCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKM-PL---NLKGENPL
100 110 120 130 140 150
610 620 630 640 650 660
pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
.:. :.: :. ... ..:: :::::: ::...:. :::.:: :.::: . : .
NP_001 QLPIKCHFQRRHAKTN-SHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF
160 170 180 190 200 210
670 680 690 700 710 720
pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
. :: . :.. : .::. : :.::.: ::::. :: : : : . :
NP_001 NTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTN
220 230 240 250 260 270
730 740 750 760 770 780
pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
. : .:::..:: : .:::: ::: . . .: .. . ..::.::::.. .:::.::
NP_001 FSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYE
280 290 300 310 320 330
790 800 810 820 830 840
pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
:. :::. ..: ::.:::: :::::.:::..::::.:::::: .:.:::::.:..:.
NP_001 CSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSR-
340 350 360 370 380 390
850 860 870 880 890 900
pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
:. : :: . . .... :.. . .. ::.
NP_001 -ANTEKSYGIDENGRDENTMKNI--FSKKRKLEVACSD----------------------
400 410 420
910 920 930 940 950 960
pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
:. : . :: ..:: . :
NP_001 ----------CEVEVLPL-------------------GL------ETHPRTAKTEKCP--
430 440
970 980 990 1000 1010
pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSS-FKTNEGGEGRAGGSRM
: . :: : : .. .:: . : .:... :. : :..:
NP_001 ---PKFSNNPKELTVETKYDNISRIQYHSV----IRDPESKTAIFQHN--------GKKM
450 460 470 480 490
1020 1030 1040 1050 1060 1070
pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK
: .:. .. .:. .: . : ....: .. .:: :.
NP_001 EF--VSSESVTPEDNDGFKPPR-EHLNSKTK-GAQKDSSSNH------------------
500 510 520 530
1080 1090 1100 1110 1120 1130
pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG
.. .. :. : ::. ... : :. : . ..::..:...:.
NP_001 VDEFEDNLLIES------DVIDITKYRE---ET----PPRSRCNQATTLDNQNIK-----
540 550 560 570
1140 1150 1160 1170 1180 1190
pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ
.. . . .: . : :..: . . : . .. : :. :. . .
NP_001 -KAIEVQIQKPQEG---RSTACQRQQVFC----------DEELLSETKNTSSD---SLTK
580 590 600 610
1200 1210 1220 1230 1240 1250
pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT
: : . ...:: :::.::.::::: :::.::::::.::. :: ::::... ..: :
NP_001 FNKG--NVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKART
620 630 640 650 660 670
1260 1270 1280 1290
pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL
::::::.::.:.: ::..: ::. .:: ..:
NP_001 ELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL
680 690 700
>>NP_001307628 (OMIM: 607865) histone-lysine N-methyltra (707 aa)
initn: 1181 init1: 764 opt: 857 Z-score: 459.8 bits: 96.5 E(85289): 7.2e-19
Smith-Waterman score: 1038; 31.4% identity (55.3% similar) in 722 aa overlap (571-1291:128-707)
550 560 570 580 590 600
pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
: : : :: .:: .. :. . .:.:::
NP_001 DCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKM-PL---NLKGENPL
100 110 120 130 140 150
610 620 630 640 650 660
pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
.:. :.: :. ... ..:: :::::: ::...:. :::.:: :.::: . : .
NP_001 QLPIKCHFQRRHAKTN-SHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF
160 170 180 190 200 210
670 680 690 700 710 720
pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
. :: . :.. : .::. : :.::.: ::::. :: : : : . :
NP_001 NTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTN
220 230 240 250 260 270
730 740 750 760 770 780
pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
. : .:::..:: : .:::: ::: . . .: .. . ..::.::::.. .:::.::
NP_001 FSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYE
280 290 300 310 320 330
790 800 810 820 830 840
pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
:. :::. ..: ::.:::: :::::.:::..::::.:::::: .:.:::::.:..:.
NP_001 CSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSR-
340 350 360 370 380 390
850 860 870 880 890 900
pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
:. : :: . . .... :.. . .. ::.
NP_001 -ANTEKSYGIDENGRDENTMKNI--FSKKRKLEVACSD----------------------
400 410 420
910 920 930 940 950 960
pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
:. : . :: ..:: . :
NP_001 ----------CEVEVLPL-------------------GL------ETHPRTAKTEKCP--
430 440
970 980 990 1000 1010
pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSS-FKTNEGGEGRAGGSRM
: . :: : : .. .:: . : .:... :. : :..:
NP_001 ---PKFSNNPKELTVETKYDNISRIQYHSV----IRDPESKTAIFQHN--------GKKM
450 460 470 480 490
1020 1030 1040 1050 1060 1070
pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK
: .:. .. .:. .: . : ....: .. .:: :.
NP_001 EF--VSSESVTPEDNDGFKPPR-EHLNSKTK-GAQKDSSSNH------------------
500 510 520 530
1080 1090 1100 1110 1120 1130
pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG
.. .. :. : ::. ... : :. : . ..::..:...:.
NP_001 VDEFEDNLLIES------DVIDITKYRE---ET----PPRSRCNQATTLDNQNIK-----
540 550 560 570
1140 1150 1160 1170 1180 1190
pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ
.. . . .: . : :..: . . : . .. : :. :. . .
NP_001 -KAIEVQIQKPQEG---RSTACQRQQVFC----------DEELLSETKNTSSD---SLTK
580 590 600 610
1200 1210 1220 1230 1240 1250
pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT
: : . ...:: :::.::.::::: :::.::::::.::. :: ::::... ..: :
NP_001 FNKG--NVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKART
620 630 640 650 660 670
1260 1270 1280 1290
pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL
::::::.::.:.: ::..: ::. .:: ..:
NP_001 ELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL
680 690 700
>>NP_114121 (OMIM: 607865) histone-lysine N-methyltransf (719 aa)
initn: 1181 init1: 764 opt: 857 Z-score: 459.7 bits: 96.5 E(85289): 7.3e-19
Smith-Waterman score: 1038; 31.4% identity (55.3% similar) in 722 aa overlap (571-1291:140-719)
550 560 570 580 590 600
pF1KSD ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
: : : :: .:: .. :. . .:.:::
NP_114 DCTFLTTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKM-PL---NLKGENPL
110 120 130 140 150 160
610 620 630 640 650 660
pF1KSD LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
.:. :.: :. ... ..:: :::::: ::...:. :::.:: :.::: . : .
NP_114 QLPIKCHFQRRHAKTN-SHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSF
170 180 190 200 210 220
670 680 690 700 710 720
pF1KSD DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
. :: . :.. : .::. : :.::.: ::::. :: : : : . :
NP_114 NTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTN
230 240 250 260 270 280
730 740 750 760 770 780
pF1KSD TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
. : .:::..:: : .:::: ::: . . .: .. . ..::.::::.. .:::.::
NP_114 FSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYE
290 300 310 320 330 340
790 800 810 820 830 840
pF1KSD CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
:. :::. ..: ::.:::: :::::.:::..::::.:::::: .:.:::::.:..:.
NP_114 CSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSR-
350 360 370 380 390 400
850 860 870 880 890 900
pF1KSD FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
:. : :: . . .... :.. . .. ::.
NP_114 -ANTEKSYGIDENGRDENTMKNI--FSKKRKLEVACSD----------------------
410 420 430
910 920 930 940 950 960
pF1KSD SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
:. : . :: ..:: . :
NP_114 ----------CEVEVLPL-------------------GL------ETHPRTAKTEKCP--
440 450 460
970 980 990 1000 1010
pF1KSD PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSS-FKTNEGGEGRAGGSRM
: . :: : : .. .:: . : .:... :. : :..:
NP_114 ---PKFSNNPKELTVETKYDNISRIQYHSV----IRDPESKTAIFQHN--------GKKM
470 480 490 500
1020 1030 1040 1050 1060 1070
pF1KSD EAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSK
: .:. .. .:. .: . : ....: .. .:: :.
NP_114 EF--VSSESVTPEDNDGFKPPR-EHLNSKTK-GAQKDSSSNH------------------
510 520 530 540
1080 1090 1100 1110 1120 1130
pF1KSD TSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSG
.. .. :. : ::. ... : :. : . ..::..:...:.
NP_114 VDEFEDNLLIES------DVIDITKYRE---ET----PPRSRCNQATTLDNQNIK-----
550 560 570 580
1140 1150 1160 1170 1180 1190
pF1KSD SEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQ
.. . . .: . : :..: . . : . .. : :. :. . .
NP_114 -KAIEVQIQKPQEG---RSTACQRQQVFC----------DEELLSETKNTSSD---SLTK
590 600 610 620
1200 1210 1220 1230 1240 1250
pF1KSD FYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGT
: : . ...:: :::.::.::::: :::.::::::.::. :: ::::... ..: :
NP_114 FNKG--NVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKART
630 640 650 660 670 680
1260 1270 1280 1290
pF1KSD ELTWDYNYEVGSVEGKELLCCCGAIECRGRLL
::::::.::.:.: ::..: ::. .:: ..:
NP_114 ELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL
690 700 710
1291 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 23:45:58 2016 done: Wed Nov 2 23:46:00 2016
Total Scan time: 16.390 Total Display time: 0.370
Function used was FASTA [36.3.4 Apr, 2011]