Result of FASTA (omim) for
pF1KSDA0043
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0043, 726 aa
1>>>pF1KSDA0043 726 - 726 aa - 726 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.7601+/-0.000407; mu= -23.5663+/- 0.025
mean_var=502.6431+/-103.954, 0's: 0 Z-trim(125.2): 80 B-trim: 477 in 2/60
Lambda= 0.057206
statistics sampled from 48183 (48339) to 48183 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.815), E-opt: 0.2 (0.567), width: 16
Scan time: 11.200
The best scores are: opt bits E(85289)
NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 4780 409.1 3.2e-113
XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 4780 409.1 3.2e-113
XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 4780 409.1 3.2e-113
XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 4763 407.7 8.5e-113
XP_016870655 (OMIM: 601541) PREDICTED: bromodomain ( 405) 2604 229.4 2.3e-59
NP_001186385 (OMIM: 601540) bromodomain-containing ( 754) 1971 177.3 2e-43
NP_001106653 (OMIM: 601540) bromodomain-containing ( 801) 1971 177.3 2.1e-43
NP_005095 (OMIM: 601540) bromodomain-containing pr ( 801) 1971 177.3 2.1e-43
NP_001186384 (OMIM: 601540) bromodomain-containing ( 836) 1971 177.3 2.2e-43
NP_001317313 (OMIM: 608749) bromodomain-containing ( 794) 1742 158.4 1e-37
NP_055114 (OMIM: 608749) bromodomain-containing pr ( 722) 1739 158.1 1.1e-37
XP_011526158 (OMIM: 608749) PREDICTED: bromodomain ( 722) 1739 158.1 1.1e-37
NP_490597 (OMIM: 608749) bromodomain-containing pr (1362) 1747 158.9 1.2e-37
XP_011526156 (OMIM: 608749) PREDICTED: bromodomain (1362) 1747 158.9 1.2e-37
NP_001278915 (OMIM: 601540) bromodomain-containing ( 681) 1574 144.5 1.4e-33
NP_001229739 (OMIM: 602144) bromodomain testis-spe ( 874) 953 93.3 4.5e-18
NP_001229736 (OMIM: 602144) bromodomain testis-spe ( 901) 953 93.3 4.6e-18
NP_001229737 (OMIM: 602144) bromodomain testis-spe ( 901) 953 93.3 4.6e-18
NP_001229735 (OMIM: 602144) bromodomain testis-spe ( 951) 735 75.3 1.3e-12
XP_011540335 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
XP_006710919 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
XP_011540337 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
XP_011540338 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
NP_997072 (OMIM: 602144) bromodomain testis-specif ( 947) 722 74.2 2.7e-12
NP_001717 (OMIM: 602144) bromodomain testis-specif ( 947) 722 74.2 2.7e-12
XP_006710918 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
XP_006710916 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
XP_006710920 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
NP_001229734 (OMIM: 602144) bromodomain testis-spe ( 947) 722 74.2 2.7e-12
XP_006710917 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
XP_011540336 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
XP_011540334 (OMIM: 602144) PREDICTED: bromodomain ( 947) 722 74.2 2.7e-12
>>NP_031397 (OMIM: 601541) bromodomain-containing protei (726 aa)
initn: 4780 init1: 4780 opt: 4780 Z-score: 2153.6 bits: 409.1 E(85289): 3.2e-113
Smith-Waterman score: 4780; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KSD MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_031 AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
670 680 690 700 710 720
pF1KSD DSSDSE
::::::
NP_031 DSSDSE
>>XP_006717354 (OMIM: 601541) PREDICTED: bromodomain-con (726 aa)
initn: 4780 init1: 4780 opt: 4780 Z-score: 2153.6 bits: 409.1 E(85289): 3.2e-113
Smith-Waterman score: 4780; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KSD MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
670 680 690 700 710 720
pF1KSD DSSDSE
::::::
XP_006 DSSDSE
>>XP_011517354 (OMIM: 601541) PREDICTED: bromodomain-con (726 aa)
initn: 4780 init1: 4780 opt: 4780 Z-score: 2153.6 bits: 409.1 E(85289): 3.2e-113
Smith-Waterman score: 4780; 100.0% identity (100.0% similar) in 726 aa overlap (1-726:1-726)
10 20 30 40 50 60
pF1KSD MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
670 680 690 700 710 720
pF1KSD DSSDSE
::::::
XP_011 DSSDSE
>>XP_016870654 (OMIM: 601541) PREDICTED: bromodomain-con (725 aa)
initn: 4799 init1: 4372 opt: 4763 Z-score: 2146.0 bits: 407.7 E(85289): 8.5e-113
Smith-Waterman score: 4763; 99.9% identity (99.9% similar) in 726 aa overlap (1-726:1-725)
10 20 30 40 50 60
pF1KSD MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_016 SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFS-SGKKQAAKSKEEL
610 620 630 640 650
670 680 690 700 710 720
pF1KSD AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
660 670 680 690 700 710
pF1KSD DSSDSE
::::::
XP_016 DSSDSE
720
>>XP_016870655 (OMIM: 601541) PREDICTED: bromodomain-con (405 aa)
initn: 2604 init1: 2604 opt: 2604 Z-score: 1186.9 bits: 229.4 E(85289): 2.3e-59
Smith-Waterman score: 2604; 100.0% identity (100.0% similar) in 405 aa overlap (322-726:1-405)
300 310 320 330 340 350
pF1KSD DLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDI
::::::::::::::::::::::::::::::
XP_016 MLSKKHAAYAWPFYKPVDAEALELHDYHDI
10 20 30
360 370 380 390 400 410
pF1KSD IKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMR
40 50 60 70 80 90
420 430 440 450 460 470
pF1KSD FAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLK
100 110 120 130 140 150
480 490 500 510 520 530
pF1KSD AVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQ
160 170 180 190 200 210
540 550 560 570 580 590
pF1KSD QKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEK
220 230 240 250 260 270
600 610 620 630 640 650
pF1KSD LGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKK
280 290 300 310 320 330
660 670 680 690 700 710
pF1KSD QAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESG
340 350 360 370 380 390
720
pF1KSD SSSSSGSSSDSSDSE
:::::::::::::::
XP_016 SSSSSGSSSDSSDSE
400
>>NP_001186385 (OMIM: 601540) bromodomain-containing pro (754 aa)
initn: 2642 init1: 961 opt: 1971 Z-score: 900.5 bits: 177.3 E(85289): 2e-43
Smith-Waterman score: 2903; 63.5% identity (79.2% similar) in 761 aa overlap (10-723:2-749)
10 20 30 40 50
pF1KSD MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPF
:..:: :.::::::::::.:::: ::::::...::.:.::::::::::
NP_001 MASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPF
10 20 30 40 50
60 70 80 90 100 110
pF1KSD YQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPT
:::::.::.:::::::::.::::::::.::::::::.::::::::::::::::::::::
NP_001 RQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD DDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGT----QQVAAVS
::::::::.::::::::::.::::: ::. ::.. .: : : :. .:: :::
NP_001 DDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KSD SVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPP
::: : . . :: . : . : :. : : :. . : : ..::. :
NP_001 SVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLLKSLHSAGPPLLAVTAAPPAQP
180 190 200 210 220
240 250 260 270 280 290
pF1KSD VVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQAKVVARRESGGRPIKPPKKDLE
..::::::::::::::: .:: : : . :: : .:: :.. :. .:::::::.:::
NP_001 LAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KSD DGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKH
:.. ....:::::::.:..:..::.:.:::::::::::::::::: :: ::::::::::
NP_001 DSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKH
290 300 310 320 330 340
360 370 380 390 400 410
pF1KSD PMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAK
:::::::::::..:.: ::: ::::::::::::::::::::.:::::::::::::.:.::
NP_001 PMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAK
350 360 370 380 390 400
420 430 440 450
pF1KSD MPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSGS------------------SD
:::::.: ::. .: : ..:.. : :::::::.:.: ::
NP_001 MPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESSSEEEEEEDEEDEEEEESESSD
410 420 430 440 450 460
460 470 480 490 500 510
pF1KSD SEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVK
:::::: :::::::::.:::::::::::.:..:::.:.:::::.::.: ::.. ..
NP_001 SEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRK---AEKHRGRAG
470 480 490 500 510 520
520 530 540 550 560
pF1KSD AEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT----------AGRQL-KKGGKQASAS--
:.:. :. :: : . ..::: .. ..:.. .: .: ::. : : .
NP_001 ADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALP
530 540 550 560 570 580
570 580 590 600 610
pF1KSD --YDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDF
::::::::. :::::::::::::::.::::::::::::::.::::::::::.::::::
NP_001 TGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDF
590 600 610 620 630 640
620 630 640 650 660 670
pF1KSD ETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQ
:::::.::::::::: :::.:: :::.. :: ..:.::::: :::.::::::::::::
NP_001 ETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTKEELALEKKRELEKRLQDVSGQ
650 660 670 680 690
680 690 700 710 720
pF1KSD LSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGSSSSSGSSSDSSDSE
:.:.::: .: :: .:: . . :::: :::::.:.:::::.::::.:
NP_001 LNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
700 710 720 730 740 750
>>NP_001106653 (OMIM: 601540) bromodomain-containing pro (801 aa)
initn: 2642 init1: 961 opt: 1971 Z-score: 900.1 bits: 177.3 E(85289): 2.1e-43
Smith-Waterman score: 2903; 63.5% identity (79.2% similar) in 761 aa overlap (10-723:49-796)
10 20 30
pF1KSD MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
:..:: :.::::::::::.:::: :::
NP_001 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
:::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
NP_001 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
:::::::::::::::::::::::::::::.::::::::::.::::: ::. ::.. .:
NP_001 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
: : :. .:: :::::: : . . :: . : . : :. : : :.
NP_001 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
. : : ..::. :..::::::::::::::: .:: : : . :: : .:: :
NP_001 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
.. :. .:::::::.::: :.. ....:::::::.:..:..::.:.:::::::::::
NP_001 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
NP_001 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
::.:::::::::::::.:.:::::::.: ::. .: : ..:.. : :::::::.:.
NP_001 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
440 450 460 470 480 490
460 470 480 490
pF1KSD S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
: :::::::: :::::::::.:::::::::::.:..:::.:.:
NP_001 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
500 510 520 530 540 550
500 510 520 530 540
pF1KSD KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
::::.::.: ::.. .. :.:. :. :: : . ..::: .. ..:..
NP_001 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
560 570 580 590 600
550 560 570 580 590
pF1KSD ---AGRQL-KKGGKQASAS----YDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
.: .: ::. : : . ::::::::. :::::::::::::::.:::::::::::
NP_001 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
610 620 630 640 650 660
600 610 620 630 640 650
pF1KSD IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
:::.::::::::::.:::::::::::.::::::::: :::.:: :::.. :: ..:.:
NP_001 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
670 680 690 700 710 720
660 670 680 690 700 710
pF1KSD EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
:::: :::.:::::::::::::.:.::: .: :: .:: . . :::: :::::.:.:
NP_001 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
730 740 750 760 770 780
720
pF1KSD SSSSGSSSDSSDSE
::::.::::.:
NP_001 SSSSSSSSDTSDSDSG
790 800
>>NP_005095 (OMIM: 601540) bromodomain-containing protei (801 aa)
initn: 2642 init1: 961 opt: 1971 Z-score: 900.1 bits: 177.3 E(85289): 2.1e-43
Smith-Waterman score: 2903; 63.5% identity (79.2% similar) in 761 aa overlap (10-723:49-796)
10 20 30
pF1KSD MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
:..:: :.::::::::::.:::: :::
NP_005 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
:::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
NP_005 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
:::::::::::::::::::::::::::::.::::::::::.::::: ::. ::.. .:
NP_005 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
: : :. .:: :::::: : . . :: . : . : :. : : :.
NP_005 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
. : : ..::. :..::::::::::::::: .:: : : . :: : .:: :
NP_005 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
.. :. .:::::::.::: :.. ....:::::::.:..:..::.:.:::::::::::
NP_005 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
NP_005 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
::.:::::::::::::.:.:::::::.: ::. .: : ..:.. : :::::::.:.
NP_005 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
440 450 460 470 480 490
460 470 480 490
pF1KSD S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
: :::::::: :::::::::.:::::::::::.:..:::.:.:
NP_005 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
500 510 520 530 540 550
500 510 520 530 540
pF1KSD KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
::::.::.: ::.. .. :.:. :. :: : . ..::: .. ..:..
NP_005 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
560 570 580 590 600
550 560 570 580 590
pF1KSD ---AGRQL-KKGGKQASAS----YDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
.: .: ::. : : . ::::::::. :::::::::::::::.:::::::::::
NP_005 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
610 620 630 640 650 660
600 610 620 630 640 650
pF1KSD IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
:::.::::::::::.:::::::::::.::::::::: :::.:: :::.. :: ..:.:
NP_005 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
670 680 690 700 710 720
660 670 680 690 700 710
pF1KSD EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
:::: :::.:::::::::::::.:.::: .: :: .:: . . :::: :::::.:.:
NP_005 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
730 740 750 760 770 780
720
pF1KSD SSSSGSSSDSSDSE
::::.::::.:
NP_005 SSSSSSSSDTSDSDSG
790 800
>>NP_001186384 (OMIM: 601540) bromodomain-containing pro (836 aa)
initn: 2880 init1: 940 opt: 1971 Z-score: 899.8 bits: 177.3 E(85289): 2.2e-43
Smith-Waterman score: 2760; 60.7% identity (75.4% similar) in 756 aa overlap (10-688:49-791)
10 20 30
pF1KSD MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
:..:: :.::::::::::.:::: :::
NP_001 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
:::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
NP_001 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
:::::::::::::::::::::::::::::.::::::::::.::::: ::. ::.. .:
NP_001 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
: : :. .:: :::::: : . . :: . : . : :. : : :.
NP_001 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
. : : ..::. :..::::::::::::::: .:: : : . :: : .:: :
NP_001 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
.. :. .:::::::.::: :.. ....:::::::.:..:..::.:.:::::::::::
NP_001 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
NP_001 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
::.:::::::::::::.:.:::::::.: ::. .: : ..:.. : :::::::.:.
NP_001 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSS-SESSSEESSSESS
440 450 460 470 480 490
460 470 480 490
pF1KSD S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
: :::::::: :::::::::.:::::::::::.:..:::.:.:
NP_001 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
500 510 520 530 540 550
500 510 520 530
pF1KSD KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKA----------------P
::::.::.: ::.. .. :.:. :. :: : . ..::: :
NP_001 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
560 570 580 590 600
540 550 560
pF1KSD AKKANSTTTAGRQLKKGG--------------------------KQASAS--------YD
. ... :: : . : :.:. . ::
NP_001 SGGSGTKLQAGVQWRDLGLLQPPLLGFKRFSCLSLPSSQDYRLPKKATKTAPPALPTGYD
610 620 630 640 650 660
570 580 590 600 610 620
pF1KSD SEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLK
::::::. :::::::::::::::.::::::::::::::.::::::::::.::::::::::
NP_001 SEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLK
670 680 690 700 710 720
630 640 650 660 670 680
pF1KSD PTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSS
:.::::::::: :::.:: :::.. :: ..:.::::: :::.:::::::::::::.:.
NP_001 PSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTKEELALEKKRELEKRLQDVSGQLNST
730 740 750 760 770 780
690 700 710 720
pF1KSD KKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
::: .:
NP_001 KKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
790 800 810 820 830
>>NP_001317313 (OMIM: 608749) bromodomain-containing pro (794 aa)
initn: 2726 init1: 939 opt: 1742 Z-score: 798.0 bits: 158.4 E(85289): 1e-37
Smith-Waterman score: 2526; 58.0% identity (74.8% similar) in 734 aa overlap (1-700:26-733)
10 20 30
pF1KSD MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRK
:::. . : ::. . .::::::.:::.:: :.
NP_001 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQ-PANAASTNPPPPETSNPNKPKRQ
10 20 30 40 50
40 50 60 70 80 90
pF1KSD TNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYY
::::::. ::.:::::::::::: :::::.:::::::.::::.::::::::::::::::
NP_001 TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
60 70 80 90 100 110
100 110 120 130 140 150
pF1KSD WSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGK
:.:.::.:::::::::::::::: :::::::.::::.::::. ..: ::.:.. ::.
NP_001 WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGR
120 130 140 150 160 170
160 170 180 190 200
pF1KSD GR-KPAAGAQSAGTQQVAAVSSVS--PATPF-QSVPPTVSQTP---------VIAATPVP
:: . .:. . :.. : ....: : : : :: :. :: .:. :::
NP_001 GRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVM
180 190 200 210 220 230
210 220 230 240 250
pF1KSD TITANV---TSVPVPPAAAPPP-PATPIV----PVVPPTP-PVVKKKGVKRKADTTTPTT
:.. : :::: ::: :: : :.. :: :: ::::::::::::::
NP_001 TVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPT-
240 250 260 270 280 290
260 270 280 290 300 310
pF1KSD SAITASRSESPPPLS-DPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAG--KKGKLSE
: . . :: : .:: .:. ::::. ::.::::::. :.. :: . :..:.::
NP_001 ---TIDPIHEPPSLPPEPKTTKLGQRRESS-RPVKPPKKDVPDSQ--QHPAPEKSSKVSE
300 310 320 330 340 350
320 330 340 350 360 370
pF1KSD HLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREY
.:. :..::.::..:::::::::::::::.::: :::: ::::::::.::.: :...:::
NP_001 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREY
360 370 380 390 400 410
380 390 400 410 420
pF1KSD PDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEP------VEAPA
::: :.:::::::::::::::::::::::::::::::::::::::::: : .::
NP_001 RDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPA
420 430 440 450 460 470
430 440 450 460 470 480
pF1KSD LPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAP
.: :. .. .. .: :. :.:::...::::::: :::::::::::::::::::::
NP_001 VPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQ
480 490 500 510 520 530
490 500 510 520 530 540
pF1KSD VNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTT
:::::: ::.::.: :::.:.:..:. ....::: :: : :: ....: .
NP_001 QNKPKKK----EKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKT---KKNNSSNSNVSK
540 550 560 570 580
550 560 570 580 590 600
pF1KSD TAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREP
.: .. .:.::::.. ::::.::::::::::.::::::::::::::::::
NP_001 KEPAPMK---SKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREP
590 600 610 620 630 640
610 620 630 640 650 660
pF1KSD SLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEK
::..:::::::::::::::.::::::::: :::.:: ::: :: : .. :
NP_001 SLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKP-------QAEKVDVIAGSSK
650 660 670 680 690
670 680 690 700 710 720
pF1KSD KKELEKRLQDVSGQLSSSKKPARKEK---PGSAPSGGPSRLSSSSSSESGSSSSSGSSSD
: . . .. :.. ::: . . :. : :::
NP_001 MKGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVD
700 710 720 730 740 750
pF1KSD SSDSE
NP_001 VEQTAAGQPHRQSAAGPAITWAPAIAYPSPECARCCVGCS
760 770 780 790
726 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 23:36:04 2016 done: Wed Nov 2 23:36:05 2016
Total Scan time: 11.200 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]