Result of FASTA (omim) for
pF1KF0141
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KF0141, 1319 aa
1>>>pF1KF0141 1319 - 1319 aa - 1319 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.4352+/-0.000471; mu= -30.1585+/- 0.029
mean_var=581.6718+/-120.477, 0's: 0 Z-trim(122.9): 59 B-trim: 604 in 1/57
Lambda= 0.053178
statistics sampled from 41839 (41901) to 41839 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.491), width: 16
Scan time: 21.090
The best scores are: opt bits E(85289)
NP_001138231 (OMIM: 612834) pleckstrin homology-li (1319) 8663 680.5 2.1e-194
XP_005271531 (OMIM: 612834) PREDICTED: pleckstrin (1365) 8663 680.5 2.2e-194
XP_005271530 (OMIM: 612834) PREDICTED: pleckstrin (1376) 8347 656.2 4.4e-187
XP_005271529 (OMIM: 612834) PREDICTED: pleckstrin (1391) 6514 515.6 9.6e-145
XP_016872899 (OMIM: 612834) PREDICTED: pleckstrin (1495) 6043 479.5 7.7e-134
XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin (1543) 6008 476.8 5.1e-133
NP_001138230 (OMIM: 612834) pleckstrin homology-li (1377) 5996 475.9 8.7e-133
NP_055972 (OMIM: 612834) pleckstrin homology-like (1377) 5996 475.9 8.7e-133
XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin (1412) 5996 475.9 8.9e-133
XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin (1423) 5996 475.9 9e-133
XP_005271526 (OMIM: 612834) PREDICTED: pleckstrin (1427) 5996 475.9 9e-133
XP_005271525 (OMIM: 612834) PREDICTED: pleckstrin (1438) 5996 475.9 9.1e-133
XP_016872896 (OMIM: 612834) PREDICTED: pleckstrin (1542) 5991 475.5 1.3e-132
XP_016872898 (OMIM: 612834) PREDICTED: pleckstrin (1503) 5363 427.3 3.9e-118
XP_011541012 (OMIM: 612834) PREDICTED: pleckstrin (1529) 5360 427.1 4.7e-118
XP_006718866 (OMIM: 612834) PREDICTED: pleckstrin (1408) 5321 424.1 3.5e-117
XP_006718865 (OMIM: 612834) PREDICTED: pleckstrin (1419) 5321 424.1 3.5e-117
XP_006718864 (OMIM: 612834) PREDICTED: pleckstrin (1434) 5321 424.1 3.5e-117
XP_006718863 (OMIM: 612834) PREDICTED: pleckstrin (1455) 5321 424.1 3.6e-117
XP_006718862 (OMIM: 612834) PREDICTED: pleckstrin (1466) 5321 424.1 3.6e-117
XP_006718861 (OMIM: 612834) PREDICTED: pleckstrin (1481) 5321 424.1 3.6e-117
XP_016872897 (OMIM: 612834) PREDICTED: pleckstrin (1512) 5321 424.1 3.7e-117
XP_006718860 (OMIM: 612834) PREDICTED: pleckstrin (1538) 5321 424.1 3.7e-117
XP_011541010 (OMIM: 612834) PREDICTED: pleckstrin (1540) 5321 424.1 3.7e-117
XP_011541011 (OMIM: 612834) PREDICTED: pleckstrin (1540) 5321 424.1 3.7e-117
XP_011541008 (OMIM: 612834) PREDICTED: pleckstrin (1560) 5321 424.1 3.8e-117
XP_011541007 (OMIM: 612834) PREDICTED: pleckstrin (1571) 5321 424.1 3.8e-117
XP_011541006 (OMIM: 612834) PREDICTED: pleckstrin (1575) 5321 424.1 3.8e-117
XP_011541005 (OMIM: 612834) PREDICTED: pleckstrin (1586) 5321 424.1 3.8e-117
XP_006718859 (OMIM: 612834) PREDICTED: pleckstrin (1539) 5304 422.8 9.2e-117
XP_005277737 (OMIM: 612834) PREDICTED: pleckstrin (1585) 5304 422.8 9.5e-117
XP_011541016 (OMIM: 612834) PREDICTED: pleckstrin ( 848) 5269 420.0 3.5e-116
XP_005271532 (OMIM: 612834) PREDICTED: pleckstrin ( 858) 5263 419.5 4.9e-116
XP_016872900 (OMIM: 612834) PREDICTED: pleckstrin ( 858) 5263 419.5 4.9e-116
XP_011541017 (OMIM: 612834) PREDICTED: pleckstrin ( 721) 4558 365.4 8e-100
XP_011541013 (OMIM: 612834) PREDICTED: pleckstrin (1420) 4509 361.8 2e-98
XP_011541015 (OMIM: 612834) PREDICTED: pleckstrin (1419) 4492 360.5 4.9e-98
NP_665696 (OMIM: 610298) pleckstrin homology-like (1210) 1419 124.7 4e-27
NP_001127909 (OMIM: 610298) pleckstrin homology-li (1237) 1419 124.7 4e-27
NP_001127910 (OMIM: 610298) pleckstrin homology-li (1253) 1366 120.6 6.8e-26
NP_001127911 (OMIM: 610298) pleckstrin homology-li (1253) 1366 120.6 6.8e-26
>>NP_001138231 (OMIM: 612834) pleckstrin homology-like d (1319 aa)
initn: 8663 init1: 8663 opt: 8663 Z-score: 3611.0 bits: 680.5 E(85289): 2.1e-194
Smith-Waterman score: 8663; 100.0% identity (100.0% similar) in 1319 aa overlap (1-1319:1-1319)
10 20 30 40 50 60
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPFPKTTSTLKEVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQW
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KF0 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVD
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KF0 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAI
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310
pF1KF0 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1270 1280 1290 1300 1310
>>XP_005271531 (OMIM: 612834) PREDICTED: pleckstrin homo (1365 aa)
initn: 8663 init1: 8663 opt: 8663 Z-score: 3610.8 bits: 680.5 E(85289): 2.2e-194
Smith-Waterman score: 8663; 100.0% identity (100.0% similar) in 1319 aa overlap (1-1319:47-1365)
10 20 30
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910 920 930
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
920 930 940 950 960 970
940 950 960 970 980 990
pF1KF0 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KF0 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
1040 1050 1060 1070 1080 1090
1060 1070 1080 1090 1100 1110
pF1KF0 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
1100 1110 1120 1130 1140 1150
1120 1130 1140 1150 1160 1170
pF1KF0 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
1160 1170 1180 1190 1200 1210
1180 1190 1200 1210 1220 1230
pF1KF0 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
1220 1230 1240 1250 1260 1270
1240 1250 1260 1270 1280 1290
pF1KF0 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLY
1280 1290 1300 1310 1320 1330
1300 1310
pF1KF0 YMVAPSAEAMRIWMDVIVTGAEGYTQFMN
:::::::::::::::::::::::::::::
XP_005 YMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1340 1350 1360
>>XP_005271530 (OMIM: 612834) PREDICTED: pleckstrin homo (1376 aa)
initn: 8347 init1: 8347 opt: 8347 Z-score: 3479.7 bits: 656.2 E(85289): 4.4e-187
Smith-Waterman score: 8631; 99.2% identity (99.2% similar) in 1330 aa overlap (1-1319:47-1376)
10 20 30
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910 920 930
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
920 930 940 950 960 970
940 950 960 970 980 990
pF1KF0 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
980 990 1000 1010 1020 1030
1000 1010 1020 1030 1040 1050
pF1KF0 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPA
1040 1050 1060 1070 1080 1090
1060 1070 1080 1090 1100 1110
pF1KF0 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKE
1100 1110 1120 1130 1140 1150
1120 1130 1140 1150 1160 1170
pF1KF0 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFS
1160 1170 1180 1190 1200 1210
1180 1190 1200 1210 1220 1230
pF1KF0 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRW
1220 1230 1240 1250 1260 1270
1240 1250 1260 1270
pF1KF0 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNPAL
::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_005 FVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPAL
1280 1290 1300 1310 1320 1330
1280 1290 1300 1310
pF1KF0 TFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::::::::::::::::::::::
XP_005 TFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1340 1350 1360 1370
>>XP_005271529 (OMIM: 612834) PREDICTED: pleckstrin homo (1391 aa)
initn: 6792 init1: 6489 opt: 6514 Z-score: 2719.6 bits: 515.6 E(85289): 9.6e-145
Smith-Waterman score: 8591; 98.1% identity (98.1% similar) in 1345 aa overlap (1-1319:47-1391)
10 20 30
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910 920 930
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEVYRSKMDGEATSPLPRTR
920 930 940 950 960 970
940 950 960 970 980 990
pF1KF0 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLAL
980 990 1000 1010 1020 1030
1000 1010 1020 1030
pF1KF0 QQK---------------GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSG
::: ::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKVESLPAEPLPTDDPAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSG
1040 1050 1060 1070 1080 1090
1040 1050 1060 1070 1080 1090
pF1KF0 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASG
1100 1110 1120 1130 1140 1150
1100 1110 1120 1130 1140 1150
pF1KF0 LDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQ
1160 1170 1180 1190 1200 1210
1160 1170 1180 1190 1200 1210
pF1KF0 QLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGY
1220 1230 1240 1250 1260 1270
1220 1230 1240 1250 1260 1270
pF1KF0 LVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKR
1280 1290 1300 1310 1320 1330
1280 1290 1300 1310
pF1KF0 ---------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1340 1350 1360 1370 1380 1390
>>XP_016872899 (OMIM: 612834) PREDICTED: pleckstrin homo (1495 aa)
initn: 7830 init1: 5985 opt: 6043 Z-score: 2523.8 bits: 479.5 E(85289): 7.7e-134
Smith-Waterman score: 7825; 91.2% identity (91.2% similar) in 1351 aa overlap (1-1232:47-1397)
10 20 30
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_016 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
::::::::::::::::::::::::::::::::::::::::::
XP_016 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEYVMLEQLKVMRGTSPMPP
920 930 940 950 960 970
pF1KF0 ------------------------------------------------------------
XP_016 APVPGLSPWASASRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAG
980 990 1000 1010 1020 1030
920 930 940
pF1KF0 --------------------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQ
::::::::::::::::::::::::::::::::::
XP_016 LGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQ
1040 1050 1060 1070 1080 1090
950 960 970 980 990
pF1KF0 LSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDD
1100 1110 1120 1130 1140 1150
1000 1010 1020 1030 1040 1050
pF1KF0 --GQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAG
1160 1170 1180 1190 1200 1210
1060 1070 1080 1090 1100 1110
pF1KF0 RERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEA
1220 1230 1240 1250 1260 1270
1120 1130 1140 1150 1160 1170
pF1KF0 HAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQ
1280 1290 1300 1310 1320 1330
1180 1190 1200 1210 1220 1230
pF1KF0 ARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWF
1340 1350 1360 1370 1380 1390
1240 1250 1260 1270 1280 1290
pF1KF0 VFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYY
:
XP_016 VFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALT
1400 1410 1420 1430 1440 1450
>--
initn: 317 init1: 317 opt: 548 Z-score: 245.5 bits: 57.9 E(85289): 6.2e-07
Smith-Waterman score: 548; 88.8% identity (88.8% similar) in 98 aa overlap (1233-1319:1398-1495)
1210 1220 1230 1240 1250 1260
pF1KF0 LHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEE
::::::::::::::::::::::::::::::
XP_016 LHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEE
1370 1380 1390 1400 1410 1420
1270 1280 1290 1300 1310
pF1KF0 VYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGA
::::::::::: ::::::::::::::::::::::::::::::::::::::
XP_016 VYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGA
1430 1440 1450 1460 1470 1480
pF1KF0 EGYTQFMN
::::::::
XP_016 EGYTQFMN
1490
>>XP_011541009 (OMIM: 612834) PREDICTED: pleckstrin homo (1543 aa)
initn: 7830 init1: 5985 opt: 6008 Z-score: 2509.1 bits: 476.8 E(85289): 5.1e-133
Smith-Waterman score: 7391; 87.6% identity (87.6% similar) in 1351 aa overlap (1-1184:47-1397)
10 20 30
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_011 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
::::::::::::::::::::::::::::::::::::::::::
XP_011 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLGTKAL
920 930 940 950 960 970
pF1KF0 ------------------------------------------------------------
XP_011 GLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASA
980 990 1000 1010 1020 1030
pF1KF0 ------------------------------------------------------------
XP_011 SRDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHS
1040 1050 1060 1070 1080 1090
920 930 940 950
pF1KF0 --------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSP
1100 1110 1120 1130 1140 1150
960 970 980 990 1000
pF1KF0 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQK---------------GQQVIEEQRR
::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 KSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRR
1160 1170 1180 1190 1200 1210
1010 1020 1030 1040 1050 1060
pF1KF0 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
1220 1230 1240 1250 1260 1270
1070 1080 1090 1100 1110 1120
pF1KF0 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
1280 1290 1300 1310 1320 1330
1130 1140 1150 1160 1170 1180
pF1KF0 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
1340 1350 1360 1370 1380 1390
1190 1200 1210 1220 1230 1240
pF1KF0 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
:
XP_011 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
1400 1410 1420 1430 1440 1450
>--
initn: 602 init1: 602 opt: 886 Z-score: 385.4 bits: 83.8 E(85289): 1e-14
Smith-Waterman score: 886; 92.5% identity (92.5% similar) in 146 aa overlap (1185-1319:1398-1543)
1160 1170 1180 1190 1200 1210
pF1KF0 QQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRG
::::::::::::::::::::::::::::::
XP_011 QQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRG
1370 1380 1390 1400 1410 1420
1220 1230 1240 1250 1260 1270
pF1KF0 YLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKK
1430 1440 1450 1460 1470 1480
1280 1290 1300 1310
pF1KF0 ----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1490 1500 1510 1520 1530 1540
>>NP_001138230 (OMIM: 612834) pleckstrin homology-like d (1377 aa)
initn: 6290 init1: 5987 opt: 5996 Z-score: 2504.9 bits: 475.9 E(85289): 8.7e-133
Smith-Waterman score: 8353; 95.7% identity (95.7% similar) in 1351 aa overlap (1-1293:1-1351)
10 20 30 40 50 60
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
850 860 870 880 890 900
910
pF1KF0 RPFPKTTSTLKE-----------------------------------------------V
:::::::::::: :
NP_001 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
910 920 930 940 950 960
920 930 940 950 960 970
pF1KF0 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KF0 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KF0 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KF0 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KF0 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KF0 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310
pF1KF0 -----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::
NP_001 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1330 1340 1350 1360 1370
>>NP_055972 (OMIM: 612834) pleckstrin homology-like doma (1377 aa)
initn: 6290 init1: 5987 opt: 5996 Z-score: 2504.9 bits: 475.9 E(85289): 8.7e-133
Smith-Waterman score: 8353; 95.7% identity (95.7% similar) in 1351 aa overlap (1-1293:1-1351)
10 20 30 40 50 60
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
850 860 870 880 890 900
910
pF1KF0 RPFPKTTSTLKE-----------------------------------------------V
:::::::::::: :
NP_055 RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
910 920 930 940 950 960
920 930 940 950 960 970
pF1KF0 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KF0 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KF0 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KF0 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KF0 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KF0 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310
pF1KF0 -----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
::::::::::::::::::::
NP_055 KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN
1330 1340 1350 1360 1370
>>XP_005271528 (OMIM: 612834) PREDICTED: pleckstrin homo (1412 aa)
initn: 5987 init1: 5987 opt: 5996 Z-score: 2504.7 bits: 475.9 E(85289): 8.9e-133
Smith-Waterman score: 8462; 96.5% identity (96.5% similar) in 1351 aa overlap (1-1304:47-1397)
10 20 30
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
920 930 940 950 960 970
920 930 940
pF1KF0 -----------------------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
:::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
980 990 1000 1010 1020 1030
950 960 970 980 990 1000
pF1KF0 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
1040 1050 1060 1070 1080 1090
1010 1020 1030 1040 1050 1060
pF1KF0 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
1100 1110 1120 1130 1140 1150
1070 1080 1090 1100 1110 1120
pF1KF0 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
1160 1170 1180 1190 1200 1210
1130 1140 1150 1160 1170 1180
pF1KF0 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
1220 1230 1240 1250 1260 1270
1190 1200 1210 1220 1230 1240
pF1KF0 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
1280 1290 1300 1310 1320 1330
1250 1260 1270 1280 1290 1300
pF1KF0 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKSPNPALTFCVKTHDRLYYMVAPSAEAMRIW
1340 1350 1360 1370 1380 1390
1310
pF1KF0 MDVIVTGAEGYTQFMN
:
XP_005 MDVIVTGAEGYTQFMN
1400 1410
>>XP_005271527 (OMIM: 612834) PREDICTED: pleckstrin homo (1423 aa)
initn: 6290 init1: 5987 opt: 5996 Z-score: 2504.7 bits: 475.9 E(85289): 9e-133
Smith-Waterman score: 8353; 95.7% identity (95.7% similar) in 1351 aa overlap (1-1293:47-1397)
10 20 30
pF1KF0 MDALNRNQIGPGCQTQTMVQKGPLDLIETG
::::::::::::::::::::::::::::::
XP_005 PGGPLATAMHRLGRGRGRPPGTQELWSLRTMDALNRNQIGPGCQTQTMVQKGPLDLIETG
20 30 40 50 60 70
40 50 60 70 80 90
pF1KF0 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KF0 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGTLTLYPCGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR
140 150 160 170 180 190
160 170 180 190 200 210
pF1KF0 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APGPPYSPVPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KF0 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASH
260 270 280 290 300 310
280 290 300 310 320 330
pF1KF0 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSESPRLSRKGGHERPPSPGLRGL
320 330 340 350 360 370
340 350 360 370 380 390
pF1KF0 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDSPAATVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KF0 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRNKIGTLQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGLATRTLQPPESPRLGRRG
440 450 460 470 480 490
460 470 480 490 500 510
pF1KF0 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDSMRELPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLG
500 510 520 530 540 550
520 530 540 550 560 570
pF1KF0 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARGRRTRSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVP
560 570 580 590 600 610
580 590 600 610 620 630
pF1KF0 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTRERKNSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGG
620 630 640 650 660 670
640 650 660 670 680 690
pF1KF0 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEAGELPSIGEATAALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEE
680 690 700 710 720 730
700 710 720 730 740 750
pF1KF0 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSSTESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEM
740 750 760 770 780 790
760 770 780 790 800 810
pF1KF0 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDKEAEALETETKLFEDLEF
800 810 820 830 840 850
820 830 840 850 860 870
pF1KF0 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLA
860 870 880 890 900 910
880 890 900 910
pF1KF0 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKE------------------
::::::::::::::::::::::::::::::::::::::::::
XP_005 RDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEMEKLLLPAVDLEQWYQEL
920 930 940 950 960 970
920 930 940
pF1KF0 -----------------------------VYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
:::::::::::::::::::::::::::::::
XP_005 MAGLGTGPAAASPHSSPPPLPAKASRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSS
980 990 1000 1010 1020 1030
950 960 970 980 990 1000
pF1KF0 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSQLSVATLGRSPSPKSALLTQNGTGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRR
1040 1050 1060 1070 1080 1090
1010 1020 1030 1040 1050 1060
pF1KF0 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLAELKQKAAAEAQCQWDALHGAAPFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYD
1100 1110 1120 1130 1140 1150
1070 1080 1090 1100 1110 1120
pF1KF0 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSLESSDSMETSISTGGNSACSPDNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESRE
1160 1170 1180 1190 1200 1210
1130 1140 1150 1160 1170 1180
pF1KF0 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REMELRRQALEEERRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRK
1220 1230 1240 1250 1260 1270
1190 1200 1210 1220 1230 1240
pF1KF0 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYY
1280 1290 1300 1310 1320 1330
1250 1260 1270 1280 1290
pF1KF0 VDKHETKLKGVIYFQAIEEVYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYM
:::::::::::::::::::::::::::::: :::::::::::::::::::
XP_005 VDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYM
1340 1350 1360 1370 1380 1390
1300 1310
pF1KF0 VAPSAEAMRIWMDVIVTGAEGYTQFMN
:
XP_005 VAPSAEAMRIWMDVIVTGAEGYTQFMN
1400 1410 1420
1319 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:35:42 2016 done: Sat Nov 5 06:35:45 2016
Total Scan time: 21.090 Total Display time: 0.690
Function used was FASTA [36.3.4 Apr, 2011]