Result of FASTA (omim) for
pF1KE9668
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9668, 1362 aa
1>>>pF1KE9668 1362 - 1362 aa - 1362 aa
Library: /omim/omim.rfq.tfa
60892289 residues in 85410 sequences
Statistics: Expectation_n fit: rho(ln(x))= 18.6842+/-0.000501; mu= -35.7325+/- 0.032
mean_var=999.8351+/-204.379, 0's: 0 Z-trim(126.4): 277 B-trim: 0 in 0/60
Lambda= 0.040561
statistics sampled from 51959 (52345) to 51959 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.818), E-opt: 0.2 (0.613), width: 16
Scan time: 22.740
The best scores are: opt bits E(85410)
XP_011526156 (OMIM: 608749) PREDICTED: bromodomain (1362) 9465 570.4 3e-161
NP_490597 (OMIM: 608749) bromodomain-containing pr (1362) 9465 570.4 3e-161
XP_011526158 (OMIM: 608749) PREDICTED: bromodomain ( 722) 4847 300.0 4.2e-80
NP_055114 (OMIM: 608749) bromodomain-containing pr ( 722) 4847 300.0 4.2e-80
NP_001317313 (OMIM: 608749) bromodomain-containing ( 794) 4848 300.1 4.3e-80
XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 1747 118.6 1.7e-25
NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 1747 118.6 1.7e-25
XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 1747 118.6 1.7e-25
XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 1742 118.3 2.1e-25
XP_016870655 (OMIM: 601541) PREDICTED: bromodomain ( 405) 1392 97.6 2e-19
NP_001278915 (OMIM: 601540) bromodomain-containing ( 681) 1101 80.7 3.9e-14
NP_001186385 (OMIM: 601540) bromodomain-containing ( 754) 1101 80.8 4.2e-14
NP_001106653 (OMIM: 601540) bromodomain-containing ( 801) 1101 80.8 4.4e-14
NP_005095 (OMIM: 601540) bromodomain-containing pr ( 801) 1101 80.8 4.4e-14
NP_001186384 (OMIM: 601540) bromodomain-containing ( 836) 1101 80.8 4.6e-14
NP_001229739 (OMIM: 602144) bromodomain testis-spe ( 874) 961 72.6 1.4e-11
NP_001229736 (OMIM: 602144) bromodomain testis-spe ( 901) 961 72.7 1.4e-11
NP_001229737 (OMIM: 602144) bromodomain testis-spe ( 901) 961 72.7 1.4e-11
NP_001717 (OMIM: 602144) bromodomain testis-specif ( 947) 961 72.7 1.5e-11
XP_011540334 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
XP_006710918 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
NP_001229734 (OMIM: 602144) bromodomain testis-spe ( 947) 961 72.7 1.5e-11
XP_011540335 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
XP_011540337 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
NP_997072 (OMIM: 602144) bromodomain testis-specif ( 947) 961 72.7 1.5e-11
XP_011540336 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
XP_006710916 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
XP_006710917 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
XP_006710920 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
XP_011540338 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
XP_006710919 (OMIM: 602144) PREDICTED: bromodomain ( 947) 961 72.7 1.5e-11
NP_001229735 (OMIM: 602144) bromodomain testis-spe ( 951) 961 72.7 1.5e-11
XP_011542539 (OMIM: 606373,616193) PREDICTED: form (1360) 605 52.0 3.6e-05
XP_016857327 (OMIM: 606373,616193) PREDICTED: form (1384) 605 52.0 3.6e-05
XP_016857326 (OMIM: 606373,616193) PREDICTED: form (1417) 605 52.0 3.7e-05
NP_001292353 (OMIM: 606373,616193) formin-2 isofor (1726) 605 52.0 4.3e-05
NP_064450 (OMIM: 606373,616193) formin-2 isoform 2 (1722) 596 51.5 6.2e-05
NP_006239 (OMIM: 168810) basic salivary proline-ri ( 416) 551 48.4 0.00013
NP_998754 (OMIM: 609035) ras-associated and plecks (1250) 567 49.7 0.00016
XP_011509950 (OMIM: 609035) PREDICTED: ras-associa (1275) 567 49.7 0.00016
XP_011509949 (OMIM: 609035) PREDICTED: ras-associa (1277) 567 49.7 0.00016
XP_005246836 (OMIM: 609035) PREDICTED: ras-associa (1302) 567 49.7 0.00016
XP_006712758 (OMIM: 609035) PREDICTED: ras-associa (1302) 567 49.7 0.00016
XP_011509948 (OMIM: 609035) PREDICTED: ras-associa (1302) 567 49.7 0.00016
XP_005246834 (OMIM: 609035) PREDICTED: ras-associa (1302) 567 49.7 0.00016
XP_016857330 (OMIM: 606373,616193) PREDICTED: form (1102) 556 49.0 0.00022
XP_016857329 (OMIM: 606373,616193) PREDICTED: form (1102) 556 49.0 0.00022
XP_016857328 (OMIM: 606373,616193) PREDICTED: form (1159) 556 49.0 0.00023
XP_016860308 (OMIM: 188840,600334,603689,604145,60 (35622) 610 53.4 0.00035
NP_001254479 (OMIM: 188840,600334,603689,604145,60 (35991) 610 53.4 0.00035
>>XP_011526156 (OMIM: 608749) PREDICTED: bromodomain-con (1362 aa)
initn: 9465 init1: 9465 opt: 9465 Z-score: 3015.8 bits: 570.4 E(85410): 3e-161
Smith-Waterman score: 9465; 100.0% identity (100.0% similar) in 1362 aa overlap (1-1362:1-1362)
10 20 30 40 50 60
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360
pF1KE9 LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
::::::::::::::::::::::::::::::::::::::::::
XP_011 LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
1330 1340 1350 1360
>>NP_490597 (OMIM: 608749) bromodomain-containing protei (1362 aa)
initn: 9465 init1: 9465 opt: 9465 Z-score: 3015.8 bits: 570.4 E(85410): 3e-161
Smith-Waterman score: 9465; 100.0% identity (100.0% similar) in 1362 aa overlap (1-1362:1-1362)
10 20 30 40 50 60
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_490 RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360
pF1KE9 LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
::::::::::::::::::::::::::::::::::::::::::
NP_490 LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
1330 1340 1350 1360
>>XP_011526158 (OMIM: 608749) PREDICTED: bromodomain-con (722 aa)
initn: 4847 init1: 4847 opt: 4847 Z-score: 1559.1 bits: 300.0 E(85410): 4.2e-80
Smith-Waterman score: 4847; 100.0% identity (100.0% similar) in 719 aa overlap (1-719:1-719)
10 20 30 40 50 60
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
XP_011 PA
>>NP_055114 (OMIM: 608749) bromodomain-containing protei (722 aa)
initn: 4847 init1: 4847 opt: 4847 Z-score: 1559.1 bits: 300.0 E(85410): 4.2e-80
Smith-Waterman score: 4847; 100.0% identity (100.0% similar) in 719 aa overlap (1-719:1-719)
10 20 30 40 50 60
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
NP_055 PA
>>NP_001317313 (OMIM: 608749) bromodomain-containing pro (794 aa)
initn: 4847 init1: 4847 opt: 4848 Z-score: 1558.9 bits: 300.1 E(85410): 4.3e-80
Smith-Waterman score: 4848; 97.7% identity (98.1% similar) in 741 aa overlap (1-741:1-738)
10 20 30 40 50 60
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
. : :: . .: :
NP_001 FCT-SGDFVSPG--PSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPHRQSAAGPAITWAP
730 740 750 760 770
>>XP_006717354 (OMIM: 601541) PREDICTED: bromodomain-con (726 aa)
initn: 2726 init1: 939 opt: 1747 Z-score: 578.7 bits: 118.6 E(85410): 1.7e-25
Smith-Waterman score: 2537; 58.0% identity (74.8% similar) in 731 aa overlap (26-733:1-701)
10 20 30 40 50
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQ-PANAASTNPPPPETSNPNKPKRQ
:::. . : ::. . .::::::.:::.:: :.
XP_006 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRK
10 20 30
60 70 80 90 100 110
pF1KE9 TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
::::::. ::.:::::::::::: :::::.:::::::.::::.::::::::::::::::
XP_006 TNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYY
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE9 WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGR
:.:.::.:::::::::::::::: :::::::.::::.::::. ..: ::.:.. ::.
XP_006 WSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGK
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE9 GRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVM
:: . .:. . :.. : ....: : : : :: :. :: .:. :::
XP_006 GR-KPAAGAQSAGTQQVAAVSSVS--PATPF-QSVPPTVSQTP---------VIAATPVP
160 170 180 190 200
240 250 260 270 280 290
pF1KE9 TVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT
:.. : :::: ::: :: : :.. :: :: :::::::::::::::
XP_006 TITANV---TSVPVPPAAAPPP-PATPIV----PVVPPTP-PVVKKKGVKRKADTTTPTT
210 220 230 240 250
300 310 320 330 340 350
pF1KE9 ID-PIHEPPSLPP--EPKTTKLGQRRESS-RPVKPPKKDVPDSQQHPAPEKSSKVSEQLK
. : :: .:: .:. ::::. ::.::::::. :.. :..:.::.:.
XP_006 SAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLR
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE9 CCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDA
:..::.::..:::::::::::::::.::: :::: ::::::::.::.: :...::: ::
XP_006 YCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDA
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE9 QEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPP
: :.:::::::::::::::::::::::::::::::::::::::::: : .::.:
XP_006 QGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEP------VEAPALPA
380 390 400 410 420
480 490 500 510 520 530
pF1KE9 PTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNK
:. .. .. .: :. :.:::...::::::: ::::::::::::::::::::: ::
XP_006 PAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNK
430 440 450 460 470 480
540 550 560 570 580
pF1KE9 PKKK----EKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKT---KKNNSSNSNVSKKEP
:::: ::.::.: :::.:.:..:. ....::: :: : :: ....: .
XP_006 PKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAG
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE9 APMKS---KPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLK
.:. . .:.::::.. ::::.::::::::::.::::::::::::::::::::.
XP_006 RQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLR
550 560 570 580 590 600
650 660 670 680 690
pF1KE9 NSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKP-------QAEKVDVIAGSSKMKG
.:::::::::::::::.::::::::: :::.:: ::: :: : .. : :
XP_006 DSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKE
610 620 630 640 650 660
700 710 720 730 740 750
pF1KE9 FSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQP
. . .. :.. ::: . . . : : .: :.:
XP_006 LEKRLQDVSGQLSSSKKPARKEK--PGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDS
670 680 690 700 710 720
760 770 780 790 800 810
pF1KE9 PPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVF
XP_006 E
>>NP_031397 (OMIM: 601541) bromodomain-containing protei (726 aa)
initn: 2726 init1: 939 opt: 1747 Z-score: 578.7 bits: 118.6 E(85410): 1.7e-25
Smith-Waterman score: 2537; 58.0% identity (74.8% similar) in 731 aa overlap (26-733:1-701)
10 20 30 40 50
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQ-PANAASTNPPPPETSNPNKPKRQ
:::. . : ::. . .::::::.:::.:: :.
NP_031 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRK
10 20 30
60 70 80 90 100 110
pF1KE9 TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
::::::. ::.:::::::::::: :::::.:::::::.::::.::::::::::::::::
NP_031 TNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYY
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE9 WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGR
:.:.::.:::::::::::::::: :::::::.::::.::::. ..: ::.:.. ::.
NP_031 WSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGK
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE9 GRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVM
:: . .:. . :.. : ....: : : : :: :. :: .:. :::
NP_031 GR-KPAAGAQSAGTQQVAAVSSVS--PATPF-QSVPPTVSQTP---------VIAATPVP
160 170 180 190 200
240 250 260 270 280 290
pF1KE9 TVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT
:.. : :::: ::: :: : :.. :: :: :::::::::::::::
NP_031 TITANV---TSVPVPPAAAPPP-PATPIV----PVVPPTP-PVVKKKGVKRKADTTTPTT
210 220 230 240 250
300 310 320 330 340 350
pF1KE9 ID-PIHEPPSLPP--EPKTTKLGQRRESS-RPVKPPKKDVPDSQQHPAPEKSSKVSEQLK
. : :: .:: .:. ::::. ::.::::::. :.. :..:.::.:.
NP_031 SAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLR
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE9 CCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDA
:..::.::..:::::::::::::::.::: :::: ::::::::.::.: :...::: ::
NP_031 YCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDA
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE9 QEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPP
: :.:::::::::::::::::::::::::::::::::::::::::: : .::.:
NP_031 QGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEP------VEAPALPA
380 390 400 410 420
480 490 500 510 520 530
pF1KE9 PTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNK
:. .. .. .: :. :.:::...::::::: ::::::::::::::::::::: ::
NP_031 PAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNK
430 440 450 460 470 480
540 550 560 570 580
pF1KE9 PKKK----EKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKT---KKNNSSNSNVSKKEP
:::: ::.::.: :::.:.:..:. ....::: :: : :: ....: .
NP_031 PKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAG
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE9 APMKS---KPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLK
.:. . .:.::::.. ::::.::::::::::.::::::::::::::::::::.
NP_031 RQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLR
550 560 570 580 590 600
650 660 670 680 690
pF1KE9 NSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKP-------QAEKVDVIAGSSKMKG
.:::::::::::::::.::::::::: :::.:: ::: :: : .. : :
NP_031 DSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKE
610 620 630 640 650 660
700 710 720 730 740 750
pF1KE9 FSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQP
. . .. :.. ::: . . . : : .: :.:
NP_031 LEKRLQDVSGQLSSSKKPARKEK--PGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDS
670 680 690 700 710 720
760 770 780 790 800 810
pF1KE9 PPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVF
NP_031 E
>>XP_011517354 (OMIM: 601541) PREDICTED: bromodomain-con (726 aa)
initn: 2726 init1: 939 opt: 1747 Z-score: 578.7 bits: 118.6 E(85410): 1.7e-25
Smith-Waterman score: 2537; 58.0% identity (74.8% similar) in 731 aa overlap (26-733:1-701)
10 20 30 40 50
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQ-PANAASTNPPPPETSNPNKPKRQ
:::. . : ::. . .::::::.:::.:: :.
XP_011 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRK
10 20 30
60 70 80 90 100 110
pF1KE9 TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
::::::. ::.:::::::::::: :::::.:::::::.::::.::::::::::::::::
XP_011 TNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYY
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE9 WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGR
:.:.::.:::::::::::::::: :::::::.::::.::::. ..: ::.:.. ::.
XP_011 WSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGK
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE9 GRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVM
:: . .:. . :.. : ....: : : : :: :. :: .:. :::
XP_011 GR-KPAAGAQSAGTQQVAAVSSVS--PATPF-QSVPPTVSQTP---------VIAATPVP
160 170 180 190 200
240 250 260 270 280 290
pF1KE9 TVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT
:.. : :::: ::: :: : :.. :: :: :::::::::::::::
XP_011 TITANV---TSVPVPPAAAPPP-PATPIV----PVVPPTP-PVVKKKGVKRKADTTTPTT
210 220 230 240 250
300 310 320 330 340 350
pF1KE9 ID-PIHEPPSLPP--EPKTTKLGQRRESS-RPVKPPKKDVPDSQQHPAPEKSSKVSEQLK
. : :: .:: .:. ::::. ::.::::::. :.. :..:.::.:.
XP_011 SAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLR
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE9 CCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDA
:..::.::..:::::::::::::::.::: :::: ::::::::.::.: :...::: ::
XP_011 YCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDA
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE9 QEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPP
: :.:::::::::::::::::::::::::::::::::::::::::: : .::.:
XP_011 QGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEP------VEAPALPA
380 390 400 410 420
480 490 500 510 520 530
pF1KE9 PTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNK
:. .. .. .: :. :.:::...::::::: ::::::::::::::::::::: ::
XP_011 PAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNK
430 440 450 460 470 480
540 550 560 570 580
pF1KE9 PKKK----EKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKT---KKNNSSNSNVSKKEP
:::: ::.::.: :::.:.:..:. ....::: :: : :: ....: .
XP_011 PKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAG
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE9 APMKS---KPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLK
.:. . .:.::::.. ::::.::::::::::.::::::::::::::::::::.
XP_011 RQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLR
550 560 570 580 590 600
650 660 670 680 690
pF1KE9 NSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKP-------QAEKVDVIAGSSKMKG
.:::::::::::::::.::::::::: :::.:: ::: :: : .. : :
XP_011 DSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKE
610 620 630 640 650 660
700 710 720 730 740 750
pF1KE9 FSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQP
. . .. :.. ::: . . . : : .: :.:
XP_011 LEKRLQDVSGQLSSSKKPARKEK--PGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDS
670 680 690 700 710 720
760 770 780 790 800 810
pF1KE9 PPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVF
XP_011 E
>>XP_016870654 (OMIM: 601541) PREDICTED: bromodomain-con (725 aa)
initn: 2177 init1: 939 opt: 1742 Z-score: 577.1 bits: 118.3 E(85410): 2.1e-25
Smith-Waterman score: 2539; 58.1% identity (74.9% similar) in 730 aa overlap (26-733:1-700)
10 20 30 40 50
pF1KE9 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQ-PANAASTNPPPPETSNPNKPKRQ
:::. . : ::. . .::::::.:::.:: :.
XP_016 MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRK
10 20 30
60 70 80 90 100 110
pF1KE9 TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
::::::. ::.:::::::::::: :::::.:::::::.::::.::::::::::::::::
XP_016 TNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYY
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE9 WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGR
:.:.::.:::::::::::::::: :::::::.::::.::::. ..: ::.:.. ::.
XP_016 WSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGK
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE9 GRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVM
:: . .:. . :.. : ....: : : : :: :. :: .:. :::
XP_016 GR-KPAAGAQSAGTQQVAAVSSVS--PATPF-QSVPPTVSQTP---------VIAATPVP
160 170 180 190 200
240 250 260 270 280 290
pF1KE9 TVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTT
:.. : :::: ::: :: : :.. :: :: :::::::::::::::
XP_016 TITANV---TSVPVPPAAAPPP-PATPIV----PVVPPTP-PVVKKKGVKRKADTTTPTT
210 220 230 240 250
300 310 320 330 340 350
pF1KE9 ID-PIHEPPSLPP--EPKTTKLGQRRESS-RPVKPPKKDVPDSQQHPAPEKSSKVSEQLK
. : :: .:: .:. ::::. ::.::::::. :.. :..:.::.:.
XP_016 SAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLR
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE9 CCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDA
:..::.::..:::::::::::::::.::: :::: ::::::::.::.: :...::: ::
XP_016 YCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDA
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE9 QEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPP
: :.:::::::::::::::::::::::::::::::::::::::::: : .::.:
XP_016 QGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEP------VEAPALPA
380 390 400 410 420
480 490 500 510 520 530
pF1KE9 PTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNK
:. .. .. .: :. :.:::...::::::: ::::::::::::::::::::: ::
XP_016 PAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNK
430 440 450 460 470 480
540 550 560 570 580
pF1KE9 PKKK----EKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKT---KKNNSSNSNVSKKEP
:::: ::.::.: :::.:.:..:. ....::: :: : :: ....: .
XP_016 PKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAG
490 500 510 520 530 540
590 600 610 620 630 640
pF1KE9 APMKS---KPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLK
.:. . .:.::::.. ::::.::::::::::.::::::::::::::::::::.
XP_016 RQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLR
550 560 570 580 590 600
650 660 670 680 690
pF1KE9 NSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKP------QAEKVDVIAGSSKMKGF
.:::::::::::::::.::::::::: :::.:: ::: :: : .. : : .
XP_016 DSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSSGKKQAAKSKEELAQEKKKEL
610 620 630 640 650 660
700 710 720 730 740 750
pF1KE9 SSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPP
. .. :.. ::: . . . : : .: :.:
XP_016 EKRLQDVSGQLSSSKKPARKEK--PGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
670 680 690 700 710 720
760 770 780 790 800 810
pF1KE9 PPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFD
>>XP_016870655 (OMIM: 601541) PREDICTED: bromodomain-con (405 aa)
initn: 1731 init1: 716 opt: 1392 Z-score: 469.9 bits: 97.6 E(85410): 2e-19
Smith-Waterman score: 1401; 60.6% identity (77.1% similar) in 388 aa overlap (364-733:1-380)
340 350 360 370 380 390
pF1KE9 DVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDI
:..:::::::::::::::.::: :::: ::
XP_016 MLSKKHAAYAWPFYKPVDAEALELHDYHDI
10 20 30
400 410 420 430 440 450
pF1KE9 IKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMR
::::::.::.: :...::: ::: :.::::::::::::::::::::::::::::::::::
XP_016 IKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMR
40 50 60 70 80 90
460 470 480 490 500 510
pF1KE9 FAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAE
:::::::: : .::.: :. .. .. .: :. :.:::...::::::: ::::
XP_016 FAKMPDEP------VEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAE
100 110 120 130 140
520 530 540 550 560
pF1KE9 LQEQLKAVHEQLAALSQPQQNKPKKK----EKDKKEKKKEKHKRKEEVEENKKSKAKEPP
::::::::::::::::: :::::: ::.::.: :::.:.:..:. ....::: :
XP_016 LQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP
150 160 170 180 190 200
570 580 590 600 610 620
pF1KE9 PKKT---KKNNSSNSNVSKKEPAPMKS---KPPPTYESEEEDKCKPMSYEEKRQLSLDIN
: : :: ....: . .:. . .:.::::.. ::::.::::::::::
XP_016 PAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDIN
210 220 230 240 250 260
630 640 650 660 670 680
pF1KE9 KLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKK-RKP-
.::::::::::::::::::::..:::::::::::::::.::::::::: :::.:: :::
XP_016 RLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPF
270 280 290 300 310 320
690 700 710 720 730
pF1KE9 ------QAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQ
:: : .. : : . . .. :.. ::: . . . : : .: :.:
XP_016 SASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEK--PGSAPSGGPSRLS
330 340 350 360 370 380
740 750 760 770 780 790
pF1KE9 KKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKS
XP_016 SSSSSESGSSSSSGSSSDSSDSE
390 400
1362 residues in 1 query sequences
60892289 residues in 85410 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Dec 21 11:12:59 2016 done: Wed Dec 21 11:13:02 2016
Total Scan time: 22.740 Total Display time: 0.330
Function used was FASTA [36.3.4 Apr, 2011]