FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6622, 306 aa
  1>>>pF1KE6622     306 - 306 aa - 306 aa
Library: /omim/omim.rfq.tfa
  64369986 residues in 92320 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.9104+/-0.000345; mu= 1.6880+/- 0.022
 mean_var=266.7611+/-54.494, 0's: 0 Z-trim(122.7): 8  B-trim: 1006 in 1/55
 Lambda= 0.078526
 statistics sampled from 42930 (42938) to 42930 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.465), width:  16
 Scan time:  4.090

The best scores are:                                      opt bits E(92320)
NP_777568 (OMIM: 607453,611051) coiled-coil domain ( 306) 2016 240.9 2.7e-63
NP_848018 (OMIM: 607453,611051) coiled-coil domain ( 482) 1098 137.1 7.4e-32
XP_011510762 (OMIM: 607453,611051) coiled-coil dom ( 329)  980 123.5   6e-28


>>NP_777568 (OMIM: 607453,611051) coiled-coil domain-con  (306 aa)
 initn: 2016 init1: 2016 opt: 2016  Z-score: 1258.0  bits: 240.9 E(92320): 2.7e-63
Smith-Waterman score: 2016; 100.0% identity (100.0% similar) in 306 aa overlap (1-306:1-306)

               10        20        30        40        50        60
pF1KE6 MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_777 MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 QLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_777 QLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 LQEEKKRKKHFPEFPATRAYADSYYYEDGGMKPRVMKEAVSTPSRMAHRDQEWYDAEIAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_777 LQEEKKRKKHFPEFPATRAYADSYYYEDGGMKPRVMKEAVSTPSRMAHRDQEWYDAEIAR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE6 KLQEEELLATQVDMRAAQVAQDEEIARLLMAEEKKAYKKAKEREKSSLDKRKQDPEWKPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_777 KLQEEELLATQVDMRAAQVAQDEEIARLLMAEEKKAYKKAKEREKSSLDKRKQDPEWKPK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE6 TAKAANSKSKESDEPHHSKNERPARPPPPIMTDGEDADYTHFTNQQSSTRHFSKSESSHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_777 TAKAANSKSKESDEPHHSKNERPARPPPPIMTDGEDADYTHFTNQQSSTRHFSKSESSHK
              250       260       270       280       290       300

             
pF1KE6 GFHYKH
       ::::::
NP_777 GFHYKH
             

>>NP_848018 (OMIM: 607453,611051) coiled-coil domain-con  (482 aa)
 initn: 1059 init1: 1059 opt: 1098  Z-score: 693.5  bits: 137.1 E(92320): 7.4e-32
Smith-Waterman score: 1098; 88.1% identity (94.1% similar) in 185 aa overlap (122-306:298-482)

             100       110       120       130       140       150 
pF1KE6 QEKLAIEAERRRIQEKKDEDIARLLQEKELQEEKKRKKHFPEFPATRAYADSYYYEDGGM
                                     : :.....: :. :      .. . .:.::
NP_848 QSRHQDRLSPKSSQKAGLHCKEVVYGRDHGQGEHRKRRHRPRTPPFSESEEQLHLHDAGM
       270       280       290       300       310       320       

             160       170       180       190       200       210 
pF1KE6 KPRVMKEAVSTPSRMAHRDQEWYDAEIARKLQEEELLATQVDMRAAQVAQDEEIARLLMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 KPRVMKEAVSTPSRMAHRDQEWYDAEIARKLQEEELLATQVDMRAAQVAQDEEIARLLMA
       330       340       350       360       370       380       

             220       230       240       250       260       270 
pF1KE6 EEKKAYKKAKEREKSSLDKRKQDPEWKPKTAKAANSKSKESDEPHHSKNERPARPPPPIM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 EEKKAYKKAKEREKSSLDKRKQDPEWKPKTAKAANSKSKESDEPHHSKNERPARPPPPIM
       390       400       410       420       430       440       

             280       290       300      
pF1KE6 TDGEDADYTHFTNQQSSTRHFSKSESSHKGFHYKH
       :::::::::::::::::::::::::::::::::::
NP_848 TDGEDADYTHFTNQQSSTRHFSKSESSHKGFHYKH
       450       460       470       480  

>--
 initn: 1004 init1: 967 opt: 980  Z-score: 621.3  bits: 123.7 E(92320): 7.9e-28
Smith-Waterman score: 989; 56.8% identity (70.2% similar) in 322 aa overlap (1-305:1-288)

               10        20        30        40        50        60
pF1KE6 MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 QLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_848 QLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKE
               70        80        90       100       110       120

              130       140       150           160       170      
pF1KE6 LQEEKKRKKHFPEFPATRAYADSYYYEDGGM----KPRVMKEAVSTPSRMAHRDQEWYDA
       ::::::::::::::::::::::::::::: .    . : .  . : : :.          
NP_848 LQEEKKRKKHFPEFPATRAYADSYYYEDGDQPGSRRARELGSGFSRPCRL----------
              130       140       150       160       170          

        180       190       200       210       220       230      
pF1KE6 EIARKLQEEELLATQVDMRAAQVAQDEEIARLLMAEEKKAYKKAKEREKSSLDKRKQDPE
                     : : ....  ...    :   :: . . ..:.  .:: . . .:  
NP_848 --------------QRDGKTVKHKKEKPEHPLENLEEPEQHCSSKRSLSSSSSGKGRD--
                            180       190       200       210      

        240       250       260       270                280       
pF1KE6 WKPKTAKAANSKSKESDEPHHSKNERPARPPPPIMT---------DGEDADYTHFT-NQQ
        .:.        ..:. : ..: .::: ::  : ..         :  ..  .: : : .
NP_848 -NPHI-------NNEQHERKRSTQERPRRPLLPTISGEVFLSTECDDWETKINHQTRNWE
                  220       230       240       250       260      

        290          300                                           
pF1KE6 SSTRH---FSKSESSHKGFHYKH                                     
       ...::   .: . :.. :.: :                                      
NP_848 KQSRHQDRLSPKSSQKAGLHCKEVVYGRDHGQGEHRKRRHRPRTPPFSESEEQLHLHDAG
        270       280       290       300       310       320      

>>XP_011510762 (OMIM: 607453,611051) coiled-coil domain-  (329 aa)
 initn: 1004 init1: 967 opt: 980  Z-score: 623.3  bits: 123.5 E(92320): 6e-28
Smith-Waterman score: 989; 56.8% identity (70.2% similar) in 322 aa overlap (1-305:1-288)

               10        20        30        40        50        60
pF1KE6 MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 QLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKE
               70        80        90       100       110       120

              130       140       150           160       170      
pF1KE6 LQEEKKRKKHFPEFPATRAYADSYYYEDGGM----KPRVMKEAVSTPSRMAHRDQEWYDA
       ::::::::::::::::::::::::::::: .    . : .  . : : :.          
XP_011 LQEEKKRKKHFPEFPATRAYADSYYYEDGDQPGSRRARELGSGFSRPCRL----------
              130       140       150       160       170          

        180       190       200       210       220       230      
pF1KE6 EIARKLQEEELLATQVDMRAAQVAQDEEIARLLMAEEKKAYKKAKEREKSSLDKRKQDPE
                     : : ....  ...    :   :: . . ..:.  .:: . . .:  
XP_011 --------------QRDGKTVKHKKEKPEHPLENLEEPEQHCSSKRSLSSSSSGKGRD--
                            180       190       200       210      

        240       250       260       270                280       
pF1KE6 WKPKTAKAANSKSKESDEPHHSKNERPARPPPPIMT---------DGEDADYTHFT-NQQ
        .:.        ..:. : ..: .::: ::  : ..         :  ..  .: : : .
XP_011 -NPHI-------NNEQHERKRSTQERPRRPLLPTISGEVFLSTECDDWETKINHQTRNWE
                  220       230       240       250       260      

        290          300                                           
pF1KE6 SSTRH---FSKSESSHKGFHYKH                                     
       ...::   .: . :.. :.: :                                      
XP_011 KQSRHQDRLSPKSSQKAGLHCKEVVYGRDHGQGEHRKRRHRPRTPPFSESEEQLHLHDAG
        270       280       290       300       310       320      




306 residues in 1 query   sequences
64369986 residues in 92320 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Oct 24 21:51:54 2019 done: Thu Oct 24 21:51:54 2019
 Total Scan time:  4.090 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]