Result of FASTA (omim) for
pF1KE5572
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5572, 461 aa
1>>>pF1KE5572 461 - 461 aa - 461 aa
Library: /omim/omim.rfq.tfa
61989856 residues in 87180 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9633+/-0.000589; mu= 9.1162+/- 0.035
mean_var=211.9874+/-43.732, 0's: 0 Z-trim(111.8): 529 B-trim: 453 in 2/52
Lambda= 0.088088
statistics sampled from 20052 (20690) to 20052 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.592), E-opt: 0.2 (0.237), width: 16
Scan time: 8.860
The best scores are: opt bits E(87180)
NP_000124 (OMIM: 122700,300746,300807,306900) coag ( 461) 3183 418.5 1.9e-116
NP_001300842 (OMIM: 122700,300746,300807,306900) c ( 423) 2258 300.9 4.4e-81
XP_005262454 (OMIM: 122700,300746,300807,306900) P ( 418) 1978 265.3 2.2e-70
NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 790 114.4 6.7e-25
XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 790 114.4 6.9e-25
XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 766 111.5 6.1e-24
NP_001299603 (OMIM: 227600,613872) coagulation fac ( 444) 762 110.8 7.7e-24
NP_000495 (OMIM: 227600,613872) coagulation factor ( 488) 749 109.2 2.6e-23
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 689 101.5 4.4e-21
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 689 101.5 4.7e-21
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 685 100.9 6e-21
NP_001299604 (OMIM: 227600,613872) coagulation fac ( 332) 655 97.1 8e-20
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 619 92.7 2.2e-18
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 619 92.7 2.2e-18
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 623 93.5 2.4e-18
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 619 92.9 2.8e-18
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 619 92.9 2.9e-18
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 619 92.9 2.9e-18
NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 612 91.4 2.9e-18
NP_062562 (OMIM: 227500,608446,613878) coagulation ( 444) 612 91.8 4.2e-18
NP_001290343 (OMIM: 167800,601564) trypsin-2 isofo ( 261) 596 89.4 1.2e-17
NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 590 88.7 2e-17
NP_000122 (OMIM: 227500,608446,613878) coagulation ( 466) 592 89.3 2.5e-17
XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 590 89.0 3e-17
NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 580 87.4 4.8e-17
NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 580 87.4 4.9e-17
NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 580 87.4 5.1e-17
NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 580 87.5 5.6e-17
XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 580 87.5 5.9e-17
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 571 86.6 1.7e-16
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 570 86.5 1.9e-16
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 564 85.9 3.6e-16
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 563 85.7 3.9e-16
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 560 85.3 5e-16
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 544 83.1 1.5e-15
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 544 83.2 1.8e-15
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 544 83.2 1.8e-15
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 549 84.2 1.8e-15
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 549 84.2 1.8e-15
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 549 84.2 1.8e-15
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 549 84.2 1.8e-15
XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 549 84.3 1.9e-15
XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 549 84.3 1.9e-15
XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 549 84.3 1.9e-15
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 543 83.0 1.9e-15
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 544 83.2 1.9e-15
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 545 83.5 2e-15
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 541 82.9 2.5e-15
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 545 83.7 2.6e-15
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 545 83.8 2.7e-15
>>NP_000124 (OMIM: 122700,300746,300807,306900) coagulat (461 aa)
initn: 3183 init1: 3183 opt: 3183 Z-score: 2211.8 bits: 418.5 E(87180): 1.9e-116
Smith-Waterman score: 3183; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461)
10 20 30 40 50 60
pF1KE5 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
370 380 390 400 410 420
430 440 450 460
pF1KE5 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
:::::::::::::::::::::::::::::::::::::::::
NP_000 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
430 440 450 460
>>NP_001300842 (OMIM: 122700,300746,300807,306900) coagu (423 aa)
initn: 2258 init1: 2258 opt: 2258 Z-score: 1576.9 bits: 300.9 E(87180): 4.4e-81
Smith-Waterman score: 2787; 91.8% identity (91.8% similar) in 461 aa overlap (1-461:1-423)
10 20 30 40 50 60
pF1KE5 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
:::::::::::::::::::::::::::::::::
NP_001 ERECMEEKCSFEEAREVFENTERTTEFWKQYVD---------------------------
70 80 90
130 140 150 160 170 180
pF1KE5 FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------VTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
100 110 120 130 140
190 200 210 220 230 240
pF1KE5 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE5 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE5 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE5 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
330 340 350 360 370 380
430 440 450 460
pF1KE5 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
:::::::::::::::::::::::::::::::::::::::::
NP_001 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
390 400 410 420
>>XP_005262454 (OMIM: 122700,300746,300807,306900) PREDI (418 aa)
initn: 2857 init1: 1945 opt: 1978 Z-score: 1384.6 bits: 265.3 E(87180): 2.2e-70
Smith-Waterman score: 2775; 90.7% identity (90.7% similar) in 461 aa overlap (1-461:1-418)
10 20 30 40 50 60
pF1KE5 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
:::::::::: :::::::
XP_005 FGFEGKNCEL-------------------------------------------VPFPCGR
130
190 200 210 220 230 240
pF1KE5 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE5 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE5 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE5 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
320 330 340 350 360 370
430 440 450 460
pF1KE5 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
:::::::::::::::::::::::::::::::::::::::::
XP_005 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
380 390 400 410
>>NP_000303 (OMIM: 176860,612283,612304) vitamin K-depen (461 aa)
initn: 870 init1: 272 opt: 790 Z-score: 568.2 bits: 114.4 E(87180): 6.7e-25
Smith-Waterman score: 993; 35.8% identity (65.3% similar) in 447 aa overlap (29-454:25-445)
10 20 30 40 50 60
pF1KE5 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
.:: . : :...: :: :: :::. ...:
NP_000 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSF-LEELRHSSL
10 20 30 40 50
70 80 90 100 110
pF1KE5 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNP--------CLNGGSCKDDI
::::.:: :.::::.:.:.:.. : ::...:::::: : : . :.: : :
NP_000 ERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGI
60 70 80 90 100 110
120 130 140 150 160
pF1KE5 NSYECWCPFGFEGKNCELDVT---CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKS
.:. : : :.::. :. .:. :.. :: : ..: . . . :::. ::.:... .
NP_000 GSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 CEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVG
:.::: ::::: . .: .. . .. . : .: :..
NP_000 CHPAVKFPCGRPWKRMEKKRSHLKR--------DTEDQEDQVD------------PRLID
180 190 200 210
230 240 250 260 270 280
pF1KE5 GEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETE
:. .. :. :::::: ..: ::. ... .:..:::::.. . :. : ::..... :
NP_000 GKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWE
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE5 HTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL-K
. : .. ... : ::. . . ..:::::.: .: .:.. ..:::. :. .. : .
NP_000 KWELDLDIKEVFVHPNYSKSTT--DNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQ
280 290 300 310 320 330
350 360 370 380 390
pF1KE5 FGS-GYVSGWGRVFHKGRS-------ALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF
:. :.::: .:..: ..::.....:.: . : . . . .::.:::.
NP_000 AGQETLVTGWG--YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGI
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE5 HEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK
.:.:.:::::: :. .:: ::.:..:::: :.. .::.:::::::..::
NP_000 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIR
400 410 420 430 440 450
460
pF1KE5 LT
NP_000 DKEAPQKSWAP
460
>>XP_005263774 (OMIM: 176860,612283,612304) PREDICTED: v (482 aa)
initn: 870 init1: 272 opt: 790 Z-score: 568.0 bits: 114.4 E(87180): 6.9e-25
Smith-Waterman score: 993; 35.8% identity (65.3% similar) in 447 aa overlap (29-454:46-466)
10 20 30 40 50
pF1KE5 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQG
.:: . : :...: :: :: :::. ..
XP_005 CASASRMWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSF-LEELRHS
20 30 40 50 60 70
60 70 80 90 100 110
pF1KE5 NLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNP--------CLNGGSCKD
.:::::.:: :.::::.:.:.:.. : ::...:::::: : : . :.: :
XP_005 SLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCID
80 90 100 110 120 130
120 130 140 150 160
pF1KE5 DINSYECWCPFGFEGKNCELDVT---CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQ
:.:. : : :.::. :. .:. :.. :: : ..: . . . :::. ::.:...
XP_005 GIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE5 KSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRV
.:.::: ::::: . .: .. . .. . : .: :.
XP_005 LQCHPAVKFPCGRPWKRMEKKRSHLKR--------DTEDQEDQVD------------PRL
200 210 220 230
230 240 250 260 270 280
pF1KE5 VGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEE
. :. .. :. :::::: ..: ::. ... .:..:::::.. . :. : ::.....
XP_005 IDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE5 TEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL
:. : .. ... : ::. . . ..:::::.: .: .:.. ..:::. :. .. :
XP_005 WEKWELDLDIKEVFVHPNYSKSTT--DNDIALLHLAQPATLSQTIVPICLPDSGLAEREL
300 310 320 330 340 350
350 360 370 380 390
pF1KE5 -KFGS-GYVSGWGRVFHKGRS-------ALVLQYLRVPLVDRATCLRSTKFTIYNNMFCA
. :. :.::: .:..: ..::.....:.: . : . . . .::.::
XP_005 NQAGQETLVTGWG--YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCA
360 370 380 390 400
400 410 420 430 440 450
pF1KE5 GFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEK
:. .:.:.:::::: :. .:: ::.:..:::: :.. .::.:::::::..::
XP_005 GILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGH
410 420 430 440 450 460
460
pF1KE5 TKLT
XP_005 IRDKEAPQKSWAP
470 480
>>XP_016859994 (OMIM: 176860,612283,612304) PREDICTED: v (542 aa)
initn: 836 init1: 272 opt: 766 Z-score: 551.0 bits: 111.5 E(87180): 6.1e-24
Smith-Waterman score: 969; 35.8% identity (65.1% similar) in 436 aa overlap (40-454:117-526)
10 20 30 40 50 60
pF1KE5 ESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKC
.: :: :: :::. ...:::::.:: :
XP_016 QVPVPPECGSSQASCCSWPPGEFPAHQLLLVLRIRKRANSF-LEELRHSSLERECIEEIC
90 100 110 120 130 140
70 80 90 100 110 120
pF1KE5 SFEEAREVFENTERTTEFWKQYVDGDQCESNP--------CLNGGSCKDDINSYECWCPF
.::::.:.:.:.. : ::...:::::: : : . :.: : :.:. : :
XP_016 DFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRS
150 160 170 180 190 200
130 140 150 160 170
pF1KE5 GFEGKNCELDVT---CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPC
:.::. :. .:. :.. :: : ..: . . . :::. ::.:... .:.::: :::
XP_016 GWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPAVKFPC
210 220 230 240 250 260
180 190 200 210 220 230
pF1KE5 GRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQF
:: . .: .. . .. . : .: :.. :. .. :.
XP_016 GRPWKRMEKKRSHLKR--------DTEDQEDQVD------------PRLIDGKMTRRGDS
270 280 290 300
240 250 260 270 280 290
pF1KE5 PWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVI
:::::: ..: ::. ... .:..:::::.. . :. : ::..... :. : ..
XP_016 PWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIK
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE5 RIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL-KFGS-GYVSG
... : ::. . . ..:::::.: .: .:.. ..:::. :. .. : . :. :.:
XP_016 EVFVHPNYSKSTT--DNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTG
370 380 390 400 410 420
360 370 380 390 400
pF1KE5 WGRVFHKGRS-------ALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQ
:: .:..: ..::.....:.: . : . . . .::.:::. .:.:.
XP_016 WG--YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACE
430 440 450 460 470 480
410 420 430 440 450 460
pF1KE5 GDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
:::::: :. .:: ::.:..:::: :.. .::.:::::::..::
XP_016 GDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSW
490 500 510 520 530 540
XP_016 AP
>>NP_001299603 (OMIM: 227600,613872) coagulation factor (444 aa)
initn: 1035 init1: 495 opt: 762 Z-score: 549.2 bits: 110.8 E(87180): 7.7e-24
Smith-Waterman score: 1137; 41.6% identity (67.9% similar) in 449 aa overlap (14-459:9-423)
10 20 30 40 50 60
pF1KE5 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
:.. : : :: .: ..:. .:.::.:: : : :: :::. .:.:
NP_001 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
::::::: ::.::::::::....:.:::..: ::::::..:: : :.::: .. : : :
NP_001 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL
60 70 80 90 100 110
130 140 150 160 170
pF1KE5 FGFEGKNCEL-DVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCG
::::::::: : :. .. . ... : : : .. . .:
NP_001 EGFEGKNCELWPYPC----GKQTLERRKRSVAQATSSSGE----APDSITWKPY------
120 130 140 150
180 190 200 210 220 230
pF1KE5 RVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFP
... : .:. : .:. : :: .. :..::.:::.. : :. :
NP_001 -----DAADLDPTENPFDLLDF-----------NQTQPERGDNNLTRIVGGQECKDGECP
160 170 180 190 200
240 250 260 270 280 290
pF1KE5 WQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIR
::..: : . ..::::.:..: .:.:::::. . .. : .:..: :. : : ..:
NP_001 WQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEV
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE5 IIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-NIFLKFGSGYVSGWG
.: :. .. . :. :::.:.: :... :.: :. ..... . .. .: :::.:
NP_001 VIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFG
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE5 RVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVT
:. .:::.. :..:.:: ::: .: :..: : .::::::. .:.:::::::::::
NP_001 RTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVT
330 340 350 360 370 380
420 430 440 450 460
pF1KE5 EVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
. . : :.:::.:::: :: ::::::::::. ...:: .. :
NP_001 RFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSS
390 400 410 420 430 440
NP_001 PLK
>>NP_000495 (OMIM: 227600,613872) coagulation factor X i (488 aa)
initn: 1211 init1: 495 opt: 749 Z-score: 539.8 bits: 109.2 E(87180): 2.6e-23
Smith-Waterman score: 1365; 46.3% identity (72.6% similar) in 464 aa overlap (14-459:9-467)
10 20 30 40 50 60
pF1KE5 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
:.. : : :: .: ..:. .:.::.:: : : :: :::. .:.:
NP_000 MGRPLHLVLLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHL
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
::::::: ::.::::::::....:.:::..: ::::::..:: : :.::: .. : : :
NP_000 ERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCL
60 70 80 90 100 110
130 140 150 160 170
pF1KE5 FGFEGKNCELDVT--CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPC
::::::::: . :.. :: :.:::.. .:.:::::..:: ::.: :.: :. :.::
NP_000 EGFEGKNCELFTRKLCSLDNGDCDQFCHEE-QNSVVCSCARGYTLADNGKACIPTGPYPC
120 130 140 150 160 170
180 190 200 210 220
pF1KE5 GRV-------SVSQ-TSKLTRAE---TVFP-DVDYVNSTEAE-TILD-NITQSTQSFNDF
:. ::.: ::. .: : : :. .. :: .:: : :: .. :..
NP_000 GKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE5 TRVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHN
::.:::.. : :. :::..: : . ..::::.:..: .:.:::::. . .. : .:..:
NP_000 TRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRN
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE5 IEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-
:. : : ..: .: :. .. . :. :::.:.: :... :.: :. .....
NP_000 TEQEEGGEAVHEVEVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAE
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE5 NIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEG
. .. .: :::.::. .:::.. :..:.:: ::: .: :..: : .::::::.
NP_000 STLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTK
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE5 GRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
.:.:::::::::::. . : :.:::.:::: :: ::::::::::. ...:: .. :
NP_000 QEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRG
420 430 440 450 460 470
NP_000 LPKAKSHAPEVITSSPLK
480
>>NP_001254483 (OMIM: 227500,608446,613878) coagulation (382 aa)
initn: 1036 init1: 310 opt: 689 Z-score: 499.7 bits: 101.5 E(87180): 4.4e-21
Smith-Waterman score: 984; 39.1% identity (65.4% similar) in 379 aa overlap (93-456:22-365)
70 80 90 100 110 120
pF1KE5 ECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFG
::::: :.:: :::::::...:: :.: .
NP_001 MVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLPA
10 20 30 40 50
130 140 150 160 170
pF1KE5 FEGKNCEL----DVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPC
:::.::: .. : .:: :::.:.. . .: : : ::: : . :: :.: .::
NP_001 FEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPC
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE5 GRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQF
:.. : .. :... . :.:::. :.
NP_001 GKI---------------PILEKRNASKPQG----------------RIVGGKVCPKGEC
120 130 140
240 250 260 270 280 290
pF1KE5 PWQVVLNGKVDAFCGGSIVNEKWIVTAAHC---VETGVKITVVAGEHNIEETEHTEQKRN
::::.: . .:::...: :.:.:::: ... .. .: :::.. : . ::.:
NP_001 PWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRR
150 160 170 180 190 200
300 310 320 330 340 350
pF1KE5 VIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADK---EYTNIFLKFGSGY
: ..: .: . . :::::::.: .:.::...:.:.:. .. : : :..: .
NP_001 VAQVIIPSTYVPGTT--NHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRF--SL
210 220 230 240 250
360 370 380 390 400
pF1KE5 VSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFT-----IYNNMFCAGFHEGGRDSC
:::::... .: .:: :. : :: . ::.... . : . :::::. .:..:::
NP_001 VSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSC
260 270 280 290 300 310
410 420 430 440 450 460
pF1KE5 QGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
.:::::::.:. .:: .::::.:::. :: :..:.::.::.:..:...
NP_001 KGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVL
320 330 340 350 360 370
NP_001 LRAPFP
380
>>XP_011535777 (OMIM: 227500,608446,613878) PREDICTED: c (433 aa)
initn: 1036 init1: 310 opt: 689 Z-score: 499.1 bits: 101.5 E(87180): 4.7e-21
Smith-Waterman score: 912; 35.7% identity (59.8% similar) in 415 aa overlap (93-456:37-416)
70 80 90 100 110 120
pF1KE5 ECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFG
::::: :.:: :::::::...:: :.: .
XP_011 QGQHCRDFIMVSQALRLLCLLLGLQGCLAADGDQCASSPCQNGGSCKDQLQSYICFCLPA
10 20 30 40 50 60
130 140
pF1KE5 FEGKNCELD----------------------------------------VTCNIKNGRCE
:::.::: . . : .:: ::
XP_011 FEGRNCETQESPASWRRLKREASCWSSGSRMPGDLCSALVPSSPDKDDQLICVNENGGCE
70 80 90 100 110 120
150 160 170 180 190 200
pF1KE5 QFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYV
:.:.. . .: : : ::: : . :: :.: .:::.. : ..
XP_011 QYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKI---------------PILEKR
130 140 150 160 170
210 220 230 240 250 260
pF1KE5 NSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWI
:... . :.:::. :. ::::.: . .:::...: :.
XP_011 NASKPQG----------------RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWV
180 190 200 210
270 280 290 300 310
pF1KE5 VTAAHC---VETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALL
:.:::: ... .. .: :::.. : . ::.: : ..: .: . . :::::::
XP_011 VSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTT--NHDIALL
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE5 ELDEPLVLNSYVTPICIADK---EYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
.: .:.::...:.:.:. .. : : :..: . :::::... .: .:: :. : ::
XP_011 RLHQPVVLTDHVVPLCLPERTFSERTLAFVRF--SLVSGWGQLLDRGATALELMVLNVPR
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE5 VDRATCLRSTKFT-----IYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISW
. ::.... . : . :::::. .:..:::.:::::::.:. .:: .::::.::
XP_011 LMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSW
340 350 360 370 380 390
440 450 460
pF1KE5 GEECAMKGKYGIYTKVSRYVNWIKEKTKLT
:. :: :..:.::.::.:..:...
XP_011 GQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
400 410 420 430
461 residues in 1 query sequences
61989856 residues in 87180 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon May 22 10:34:20 2017 done: Mon May 22 10:34:21 2017
Total Scan time: 8.860 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]