Result of FASTA (omim) for
pF1KE4513
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4513, 542 aa
1>>>pF1KE4513 542 - 542 aa - 542 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1831+/-0.000361; mu= 20.0269+/- 0.022
mean_var=79.0492+/-16.738, 0's: 0 Z-trim(114.2): 195 B-trim: 1571 in 2/54
Lambda= 0.144253
statistics sampled from 23680 (23893) to 23680 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.28), width: 16
Scan time: 10.030
The best scores are: opt bits E(85289)
NP_001171661 (OMIM: 607581) solute carrier family ( 542) 3624 764.1 0
NP_004245 (OMIM: 607581) solute carrier family 22 ( 542) 3624 764.1 0
NP_001171662 (OMIM: 607581) solute carrier family ( 451) 2973 628.5 1.3e-179
NP_001171665 (OMIM: 607581) solute carrier family ( 419) 2743 580.6 3.2e-165
XP_011543666 (OMIM: 607581) PREDICTED: solute carr ( 419) 2743 580.6 3.2e-165
NP_695008 (OMIM: 607582) solute carrier family 22 ( 550) 1655 354.3 5.6e-97
XP_016874051 (OMIM: 607582) PREDICTED: solute carr ( 551) 1648 352.9 1.5e-96
NP_004781 (OMIM: 607582) solute carrier family 22 ( 563) 1642 351.6 3.7e-96
NP_695009 (OMIM: 607582) solute carrier family 22 ( 506) 1391 299.3 1.8e-80
NP_695010 (OMIM: 607582) solute carrier family 22 ( 519) 1391 299.3 1.9e-80
NP_653186 (OMIM: 220150,607096) solute carrier fam ( 553) 1356 292.1 3e-78
NP_060954 (OMIM: 607097) solute carrier family 22 ( 550) 1333 287.3 8.3e-77
NP_001129978 (OMIM: 611698) solute carrier family ( 552) 1226 265.0 4.2e-70
NP_543142 (OMIM: 607579) solute carrier family 22 ( 553) 1195 258.6 3.7e-68
XP_016873188 (OMIM: 607580) PREDICTED: solute carr ( 489) 1192 257.9 5.2e-68
NP_001034841 (OMIM: 607580) solute carrier family ( 541) 1192 257.9 5.6e-68
XP_011543318 (OMIM: 607580) PREDICTED: solute carr ( 541) 1192 257.9 5.6e-68
NP_004247 (OMIM: 604047) solute carrier family 22 ( 551) 1135 246.1 2.1e-64
NP_955384 (OMIM: 610792) solute carrier family 22 ( 547) 1121 243.2 1.6e-63
XP_016873176 (OMIM: 610792) PREDICTED: solute carr ( 547) 1121 243.2 1.6e-63
XP_011543469 (OMIM: 607097) PREDICTED: solute carr ( 417) 1049 228.1 4.2e-59
XP_016873264 (OMIM: 611696) PREDICTED: solute carr ( 354) 1031 224.3 5e-58
NP_006663 (OMIM: 604995) solute carrier family 22 ( 546) 1020 222.2 3.4e-57
XP_016873265 (OMIM: 611696) PREDICTED: solute carr ( 323) 1002 218.2 3.1e-56
NP_696961 (OMIM: 604995) solute carrier family 22 ( 548) 1003 218.6 3.9e-56
XP_006715034 (OMIM: 604995) PREDICTED: solute carr ( 549) 1001 218.2 5.2e-56
XP_006715033 (OMIM: 604995) PREDICTED: solute carr ( 551) 987 215.3 4e-55
XP_011512559 (OMIM: 604995) PREDICTED: solute carr ( 607) 966 211.0 8.8e-54
NP_003049 (OMIM: 602608) solute carrier family 22 ( 555) 954 208.4 4.7e-53
XP_016865690 (OMIM: 604995) PREDICTED: solute carr ( 420) 950 207.5 6.7e-53
XP_011512563 (OMIM: 604995) PREDICTED: solute carr ( 420) 950 207.5 6.7e-53
XP_016865689 (OMIM: 604995) PREDICTED: solute carr ( 543) 950 207.6 8.1e-53
XP_011512558 (OMIM: 604995) PREDICTED: solute carr ( 610) 950 207.6 8.9e-53
XP_016865687 (OMIM: 604995) PREDICTED: solute carr ( 602) 945 206.6 1.8e-52
NP_068812 (OMIM: 604842) solute carrier family 22 ( 556) 925 202.4 3.1e-51
XP_016872648 (OMIM: 607579) PREDICTED: solute carr ( 445) 918 200.9 7.1e-51
NP_003048 (OMIM: 602607) solute carrier family 22 ( 554) 910 199.3 2.7e-50
NP_001263255 (OMIM: 220150,607096) solute carrier ( 519) 888 194.7 6e-49
XP_006718494 (OMIM: 220150,607096) PREDICTED: solu ( 543) 884 193.8 1.1e-48
XP_006718493 (OMIM: 220150,607096) PREDICTED: solu ( 578) 884 193.9 1.2e-48
NP_700357 (OMIM: 220150,607096) solute carrier fam ( 332) 879 192.6 1.6e-48
NP_003051 (OMIM: 212140,603377) solute carrier fam ( 557) 850 186.8 1.5e-46
XP_005267163 (OMIM: 604842) PREDICTED: solute carr ( 425) 843 185.2 3.4e-46
NP_001294914 (OMIM: 607097) solute carrier family ( 442) 833 183.2 1.5e-45
XP_016873180 (OMIM: 610792) PREDICTED: solute carr ( 452) 825 181.5 4.8e-45
XP_016873179 (OMIM: 610792) PREDICTED: solute carr ( 452) 825 181.5 4.8e-45
XP_016873178 (OMIM: 610792) PREDICTED: solute carr ( 466) 825 181.5 4.9e-45
XP_016873177 (OMIM: 610792) PREDICTED: solute carr ( 477) 825 181.5 5e-45
XP_016866692 (OMIM: 604842) PREDICTED: solute carr ( 404) 817 179.8 1.4e-44
XP_011534378 (OMIM: 604842) PREDICTED: solute carr ( 404) 817 179.8 1.4e-44
>>NP_001171661 (OMIM: 607581) solute carrier family 22 m (542 aa)
initn: 3624 init1: 3624 opt: 3624 Z-score: 4076.7 bits: 764.1 E(85289): 0
Smith-Waterman score: 3624; 100.0% identity (100.0% similar) in 542 aa overlap (1-542:1-542)
10 20 30 40 50 60
pF1KE4 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
490 500 510 520 530 540
pF1KE4 SS
::
NP_001 SS
>>NP_004245 (OMIM: 607581) solute carrier family 22 memb (542 aa)
initn: 3624 init1: 3624 opt: 3624 Z-score: 4076.7 bits: 764.1 E(85289): 0
Smith-Waterman score: 3624; 100.0% identity (100.0% similar) in 542 aa overlap (1-542:1-542)
10 20 30 40 50 60
pF1KE4 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
490 500 510 520 530 540
pF1KE4 SS
::
NP_004 SS
>>NP_001171662 (OMIM: 607581) solute carrier family 22 m (451 aa)
initn: 2973 init1: 2973 opt: 2973 Z-score: 3345.6 bits: 628.5 E(85289): 1.3e-179
Smith-Waterman score: 2973; 100.0% identity (100.0% similar) in 451 aa overlap (92-542:1-451)
70 80 90 100 110 120
pF1KE4 LPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKL
::::::::::::::::::::::::::::::
NP_001 MEPCLDGWVYNSTKDSIVTEWDLVCNSNKL
10 20 30
130 140 150 160 170 180
pF1KE4 KEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRF
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE4 LCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLT
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE4 VSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE4 QKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQII
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE4 FGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGC
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE4 LSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGIT
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE4 ALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGS
400 410 420 430 440 450
pF1KE4 S
:
NP_001 S
>>NP_001171665 (OMIM: 607581) solute carrier family 22 m (419 aa)
initn: 2743 init1: 2743 opt: 2743 Z-score: 3087.4 bits: 580.6 E(85289): 3.2e-165
Smith-Waterman score: 2743; 100.0% identity (100.0% similar) in 419 aa overlap (124-542:1-419)
100 110 120 130 140 150
pF1KE4 PCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPIL
::::::::::::::::::::::::::::::
NP_001 MAQSIFMAGILIGGLVLGDLSDRFGRRPIL
10 20 30
160 170 180 190 200 210
pF1KE4 TCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE4 LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKAL
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE4 KILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLA
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE4 WFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLA
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE4 GGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWT
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE4 RVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLR
340 350 360 370 380 390
520 530 540
pF1KE4 AKKPKQEPEVEKASQRIPLQPHGPGLGSS
:::::::::::::::::::::::::::::
NP_001 AKKPKQEPEVEKASQRIPLQPHGPGLGSS
400 410
>>XP_011543666 (OMIM: 607581) PREDICTED: solute carrier (419 aa)
initn: 2743 init1: 2743 opt: 2743 Z-score: 3087.4 bits: 580.6 E(85289): 3.2e-165
Smith-Waterman score: 2743; 100.0% identity (100.0% similar) in 419 aa overlap (124-542:1-419)
100 110 120 130 140 150
pF1KE4 PCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPIL
::::::::::::::::::::::::::::::
XP_011 MAQSIFMAGILIGGLVLGDLSDRFGRRPIL
10 20 30
160 170 180 190 200 210
pF1KE4 TCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE4 LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKAL
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE4 KILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLA
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE4 WFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLA
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE4 GGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWT
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE4 RVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLR
340 350 360 370 380 390
520 530 540
pF1KE4 AKKPKQEPEVEKASQRIPLQPHGPGLGSS
:::::::::::::::::::::::::::::
XP_011 AKKPKQEPEVEKASQRIPLQPHGPGLGSS
400 410
>>NP_695008 (OMIM: 607582) solute carrier family 22 memb (550 aa)
initn: 1821 init1: 1513 opt: 1655 Z-score: 1862.1 bits: 354.3 E(85289): 5.6e-97
Smith-Waterman score: 1851; 50.8% identity (79.0% similar) in 547 aa overlap (1-533:1-541)
10 20 30 40 50
pF1KE4 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-
:.:...:..::..:.:: ..:... ::.: ::.:: :: :::: :.:::::: .:. .
NP_695 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 -----WVLPMGPNGKPERCLRFVHP----P--NASLPNDTQRAMEPCLDGWVY-NST-KD
: :: .:.:: ::::. : : :.. : : : ::: :::.: ::: .
NP_695 GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 SIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG
.:::::::::. :...:::..:.:.:.:..:.: :.::.::: .: .:: :.::.
NP_695 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP
:::.:.:::: .::.: :....::.:. . :::::.: . :: ..: .:: :..:::.:
NP_695 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK
:.:::.:.:: ::: :: :::.::. ::. :: :: ::. . .:. :.::: .:::.
NP_695 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM
::: .::.: :. .::::....:.. .: .:.: : ::.. .:::. ::::.::::.:.:
NP_695 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD
.. :::..:..:.:::.::.:::.. .: .. :::. .: ::::::: :: .: :
NP_695 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT
. ::: :::.:::::..::.:.::::.:::::.:::::::... .::::.:::::..:
NP_695 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMT
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE4 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKA
.:. : .: .::: . . .......:::::.::::.:..::: : ..:. .:. : .:
NP_695 AELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE--SRKGKQTRQQQEHQK-
480 490 500 510 520 530
530 540
pF1KE4 SQRIPLQPHGPGLGSS
.:::
NP_695 -YMVPLQASAQEKNGL
540 550
>>XP_016874051 (OMIM: 607582) PREDICTED: solute carrier (551 aa)
initn: 1099 init1: 791 opt: 1648 Z-score: 1854.2 bits: 352.9 E(85289): 1.5e-96
Smith-Waterman score: 1844; 50.7% identity (79.0% similar) in 548 aa overlap (1-533:1-542)
10 20 30 40 50
pF1KE4 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-
:.:...:..::..:.:: ..:... ::.: ::.:: :: :::: :.:::::: .:. .
XP_016 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 -----WVLPMGPNGKPERCLRFVHP----P--NASLPNDTQRAMEPCLDGWVY-NST-KD
: :: .:.:: ::::. : : :.. : : : ::: :::.: ::: .
XP_016 GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 SIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG
.:::::::::. :...:::..:.:.:.:..:.: :.::.::: .: .:: :.::.
XP_016 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP
:::.:.:::: .::.: :....::.:. . :::::.: . :: ..: .:: :..:::.:
XP_016 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK
:.:::.:.:: ::: :: :::.::. ::. :: :: ::. . .:. :.::: .:::.
XP_016 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EEGERLSLEE-LKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLA
::: .::.:. :. .::::....:.. .: .:.: : ::.. .:::. ::::.::::.:.
XP_016 EEGAKLSMEQVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLV
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 MGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPL
: .. :::..:..:.:::.::.:::.. .: .. :::. .: ::::::: :: .:
XP_016 MDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQ
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 DLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKI
: . ::: :::.:::::..::.:.::::.:::::.:::::::... .::::.:::::..
XP_016 DQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSM
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE4 TGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEK
:.:. : .: .::: . . .......:::::.::::.:..::: : ..:. .:. : .:
XP_016 TAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE--SRKGKQTRQQQEHQK
480 490 500 510 520 530
530 540
pF1KE4 ASQRIPLQPHGPGLGSS
.:::
XP_016 --YMVPLQASAQEKNGL
540 550
>>NP_004781 (OMIM: 607582) solute carrier family 22 memb (563 aa)
initn: 1843 init1: 1500 opt: 1642 Z-score: 1847.3 bits: 351.6 E(85289): 3.7e-96
Smith-Waterman score: 1838; 50.4% identity (78.2% similar) in 550 aa overlap (1-535:1-546)
10 20 30 40 50
pF1KE4 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-
:.:...:..::..:.:: ..:... ::.: ::.:: :: :::: :.:::::: .:. .
NP_004 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 -----WVLPMGPNGKPERCLRFVHP----P--NASLPNDTQRAMEPCLDGWVY-NST-KD
: :: .:.:: ::::. : : :.. : : : ::: :::.: ::: .
NP_004 GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 SIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG
.:::::::::. :...:::..:.:.:.:..:.: :.::.::: .: .:: :.::.
NP_004 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP
:::.:.:::: .::.: :....::.:. . :::::.: . :: ..: .:: :..:::.:
NP_004 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK
:.:::.:.:: ::: :: :::.::. ::. :: :: ::. . .:. :.::: .:::.
NP_004 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM
::: .::.: :. .::::....:.. .: .:.: : ::.. .:::. ::::.::::.:.:
NP_004 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD
.. :::..:..:.:::.::.:::.. .: .. :::. .: ::::::: :: .: :
NP_004 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT
. ::: :::.:::::..::.:.::::.:::::.:::::::... .::::.:::::..:
NP_004 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMT
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE4 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLEN-WSLRAKKPKQEPEVEK
.:. : .: .::: . . .......:::::.::::.:..:::. :. :. :. :
NP_004 AELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPR--K
480 490 500 510 520 530
530 540
pF1KE4 ASQRIPLQPHGPGLGSS
..: : :
NP_004 GKQTRQQQEHQKYMVPLQASAQEKNGL
540 550 560
>>NP_695009 (OMIM: 607582) solute carrier family 22 memb (506 aa)
initn: 1669 init1: 1265 opt: 1391 Z-score: 1565.6 bits: 299.3 E(85289): 1.8e-80
Smith-Waterman score: 1616; 47.3% identity (72.4% similar) in 547 aa overlap (1-533:1-497)
10 20 30 40 50
pF1KE4 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-
:.:...:..::..:.:: ..:... ::.: ::.:: :: :::: :.:::::: .:. .
NP_695 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 -----WVLPMGPNGKPERCLRFVHP----P--NASLPNDTQRAMEPCLDGWVY-NST-KD
: :: .:.:: ::::. : : :.. : : : ::: :::.: ::: .
NP_695 GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 SIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG
.:::::::::. :...:::..:.:.:.:..:.: :.::.::: .: .:: :.::.
NP_695 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP
:::.:.:::: .::.: :....::.:. . :::::.: . :: ..: .:: :..:::.:
NP_695 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK
:.:::.:.:: ::: :: :::.::. ::. :: :: ::. . .:. :.::: .:::.
NP_695 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM
::: .::.: :. .::::....:.. .: .:.: : ::.. .:::. ::::.::::.:.:
NP_695 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD
.. :::..:..:.:::.::.:::.. .: .. :::. .: ::::::: :: .: :
NP_695 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT
. ::: :::.:::::..::.:.::::.:::::.::
NP_695 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------------------------
420 430 440 450
470 480 490 500 510 520
pF1KE4 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKA
..:.: :::::.::::.:..::: : ..:. .:. : .:
NP_695 ------------AVTVL--------LPETLGQPLPDTVQDLE--SRKGKQTRQQQEHQK-
460 470 480 490
530 540
pF1KE4 SQRIPLQPHGPGLGSS
.:::
NP_695 -YMVPLQASAQEKNGL
500
>>NP_695010 (OMIM: 607582) solute carrier family 22 memb (519 aa)
initn: 1655 init1: 1265 opt: 1391 Z-score: 1565.5 bits: 299.3 E(85289): 1.9e-80
Smith-Waterman score: 1603; 46.9% identity (71.6% similar) in 550 aa overlap (1-535:1-502)
10 20 30 40 50
pF1KE4 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGP-
:.:...:..::..:.:: ..:... ::.: ::.:: :: :::: :.:::::: .:. .
NP_695 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 -----WVLPMGPNGKPERCLRFVHP----P--NASLPNDTQRAMEPCLDGWVY-NST-KD
: :: .:.:: ::::. : : :.. : : : ::: :::.: ::: .
NP_695 GGLEVW-LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTG-ATEPCTDGWIYDNSTFPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 SIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSG
.:::::::::. :...:::..:.:.:.:..:.: :.::.::: .: .:: :.::.
NP_695 TIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 AAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILP
:::.:.:::: .::.: :....::.:. . :::::.: . :: ..: .:: :..:::.:
NP_695 AAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKK
:.:::.:.:: ::: :: :::.::. ::. :: :: ::. . .:. :.::: .:::.
NP_695 GVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 EEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAM
::: .::.: :. .::::....:.. .: .:.: : ::.. .:::. ::::.::::.:.:
NP_695 EEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 GVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD
.. :::..:..:.:::.::.:::.. .: .. :::. .: ::::::: :: .: :
NP_695 DLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQD
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 LQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKIT
. ::: :::.:::::..::.:.::::.:::::.::
NP_695 QSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR------------------------
420 430 440 450
470 480 490 500 510 520
pF1KE4 GEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLEN-WSLRAKKPKQEPEVEK
..:.:: ::::.::::.:..:::. :. :. :. :
NP_695 ------------AVTVLL--------PETLGQPLPDTVQDLESRWAPTQKEAGIYPR--K
460 470 480 490
530 540
pF1KE4 ASQRIPLQPHGPGLGSS
..: : :
NP_695 GKQTRQQQEHQKYMVPLQASAQEKNGL
500 510
542 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:40:02 2016 done: Mon Nov 7 00:40:03 2016
Total Scan time: 10.030 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]