FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4379, 399 aa
  1>>>pF1KE4379 399 - 399 aa - 399 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.3930+/-0.000427; mu= 7.4212+/- 0.027
 mean_var=140.5793+/-27.549, 0's: 0 Z-trim(114.4): 78  B-trim: 260 in 2/51
 Lambda= 0.108172
 statistics sampled from 24155 (24233) to 24155 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.284), width:  16
 Scan time:  6.580

The best scores are:                                      opt bits E(85289)
NP_001223 (OMIM: 114251,604772,611938) calsequestr ( 399) 2657 426.5 5.5e-119
NP_001222 (OMIM: 114250,616231) calsequestrin-1 pr ( 396) 1797 292.3 1.4e-78
NP_055866 (OMIM: 609170) endoplasmic reticulum res ( 406)  211 44.8 0.00045


>>NP_001223 (OMIM: 114251,604772,611938) calsequestrin-2  (399 aa)
 initn: 2657 init1: 2657 opt: 2657  Z-score: 2257.2  bits: 426.5 E(85289): 5.5e-119
Smith-Waterman score: 2657; 100.0% identity (100.0% similar) in 399 aa overlap (1-399:1-399)

               10        20        30        40        50        60
pF1KE4 MKRTHLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDLLCLYYHEPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRTHLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDLLCLYYHEPV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 SSDKVTQKQFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSDKVTQKQFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 RTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFFKSEDSEYYK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFFKSEDSEYYK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 AFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKPYTEEELVEF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKPYTEEELVEF
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 VKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 LSILWIDPDDFPLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDDLPTAEELED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSILWIDPDDFPLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDDLPTAEELED
              310       320       330       340       350       360

              370       380       390         
pF1KE4 WIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE
       :::::::::::::::::::::::::::::::::::::::
NP_001 WIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE
              370       380       390         

>>NP_001222 (OMIM: 114250,616231) calsequestrin-1 precur  (396 aa)
 initn: 1797 init1: 1797 opt: 1797  Z-score: 1531.9  bits: 292.3 E(85289): 1.4e-78
Smith-Waterman score: 1797; 68.4% identity (91.3% similar) in 367 aa overlap (15-381:30-396)

                              10        20        30        40     
pF1KE4                MKRTHLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQV
                                    :. ...:::.:: ::: :::.... ::.:.:
NP_001 MSATDRMGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNV
               10        20        30        40        50        60

          50        60        70        80        90       100     
pF1KE4 LKKYDLLCLYYHEPVSSDKVTQKQFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKK
       .:::..: : ::::  .::..:.::...:..:::.::::: :..:: .::..:.: .:::
NP_001 FKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKK
               70        80        90       100       110       120

         110       120       130       140       150       160     
pF1KE4 LGFDEEGSLYILKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYI
       ::. :  :.:..:::..::.::::.::..::::::..:::::.: .. :.:::: ::: :
NP_001 LGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEI
              130       140       150       160       170       180

         170       180       190       200       210       220     
pF1KE4 KLIGFFKSEDSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPI
       ::::.:::.:::.:::::.:::.:.::: ::::::. :::::.::.::.:::: ::.::.
NP_001 KLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPV
              190       200       210       220       230       240

         230       240       250       260       270       280     
pF1KE4 AIPNKPYTEEELVEFVKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFL
       .::.:: .:::.:.::.::.: :::.:.:: :.::::::..:::::::::..::::.:::
NP_001 TIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFL
              250       260       270       280       290       300

         290       300       310       320       330       340     
pF1KE4 EILKQVARDNTDNPDLSILWIDPDDFPLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWME
       : :: ::.:::.::::::.::::::::::: :::::: :::  :::::::::::::::::
NP_001 ETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWME
              310       320       330       340       350       360

         350       360       370       380       390         
pF1KE4 IPDDDDLPTAEELEDWIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE
       . :..:::.:::::::.:::: :.:::::::.::::                  
NP_001 MDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD                  
              370       380       390                        

>>NP_055866 (OMIM: 609170) endoplasmic reticulum residen  (406 aa)
 initn:  70 init1:  70 opt: 211  Z-score: 194.1  bits: 44.8 E(85289): 0.00045
Smith-Waterman score: 235; 21.3% identity (57.7% similar) in 366 aa overlap (34-391:31-377)

            10        20        30        40        50         60  
pF1KE4 THLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDL-LCLYYHEPVSS
                                     ..::. .:. ..:.. :. :  .: .    
NP_055 MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
               10        20        30        40        50        60

             70         80        90       100       110       120 
pF1KE4 DKVTQKQFQ-LKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGDR
       ... .  :.  .... :   .  :.... :. ::  ... .:..  ...  .: ....  
NP_055 SQMLHPIFEEASDVIKEEFPN--ENQVV-FARVDCDQHSDIAQRYRISKYPTLKLFRNGM
               70        80           90       100       110       

               130       140       150       160       170         
pF1KE4 TI--EFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFFKSEDSEYY
        .  :. :. .. .:.... .   ::.. : .  :. ...: .  :  ::.:...::. :
NP_055 MMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNI--IGYFEQKDSDNY
       120       130       140       150       160         170     

     180       190       200       210       220       230         
pF1KE4 KAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKPYTEEELV-
       ..::..:. ..    :...:   :.:    . ... .  :  . :  .    .:. ... 
NP_055 RVFERVANILHDDCAFLSAFGD-VSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTY
         180       190        200       210       220       230    

      240       250       260       270       280       290        
pF1KE4 EFVKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARD-NTD
       ......  : .:..  :.  :  :. :    .. :  : : .. :...  ..:::.  ..
NP_055 NWIQDKCVPLVREITFENGEELTEEGLP--FLILFHMKEDTESLEIFQ--NEVARQLISE
          240       250       260         270       280         290

       300       310         320       330       340       350     
pF1KE4 NPDLSILWIDPDDF--PLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDDLPTA
       .  ...:  : : :  :::  . .::   :   : :..    :.    . . :  :.   
NP_055 KGTINFLHADCDKFRHPLL--HIQKT-PADC--PVIAI----DSFRHMYVFGDFKDVLIP
              300         310          320           330       340 

         360       370       380       390                         
pF1KE4 EELEDWIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE                
        .:.... :. :::.. :     :  :    :. .:                        
NP_055 GKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLR
             350       360       370       380       390       400 

NP_055 DRDEL
            




399 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 23:01:09 2016 done: Sat Nov  5 23:01:10 2016
 Total Scan time:  6.580 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]